It has been estimated that over 300 million people (considering all age groups) suffer from depression worldwide. Depressive disorders are estimated to be responsible for an economic burden of up to USD 210 billion per year in the US. Since the 1950s, around 30 branded drugs and more than 150 generic products have been approved by the FDA to treat various forms of depression. Despite the availability of generics and other branded drugs, patients have voiced the need for better antidepressants.
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Owing to lack of effective treatment options and limited understanding of the disease pathology, depression, a commonly diagnosed mental health disorder, presently imposes a significant burden on the modern healthcare system
Over the past few years, the depressive disorders market has witnessed multiple clinical stage drug failures; amongst the various reported reasons, inability to achieve specific clinical endpoints was the most common
The current market landscape is fragmented, featuring small companies and established pharma giants, which are engaged in the development of over 65 drug candidates for treating different forms of depression
Several molecules in the development pipeline are in the late stages of clinical development; majority of the drugs are monotherapies and designed for delivery via oral route
Although clinical studies are registered across various geographies, maximum number of trials are based in North America; over 70% of clinical trials are evaluating drugs in Phase II / Phase III
In lieu of the growing product landscape, drug developers are putting in significant efforts to ensure that their candidates are clinically and commercially competent
A substantial proportion of partnerships in this domain are focused on digital therapeutics initiatives; with over USD 3 billion investment since 2010, companies have received active support from the investors
Stakeholders are exploring diverse commercialization strategies across different stages of a product’s launch cycle; with drugs nearing patent expiry, developers are expected to adopt lifecycle management approaches
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