{"id":10640,"date":"2019-11-09T09:56:53","date_gmt":"2019-11-09T04:26:53","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=10640"},"modified":"2026-07-08T22:13:46","modified_gmt":"2026-07-08T16:43:46","slug":"car-t-pipeline-update-celgene-posts-pivotal-data-ahead-of-fda-filing","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/car-t-pipeline-update-celgene-posts-pivotal-data-ahead-of-fda-filing\/","title":{"rendered":"CAR-T Pipeline Update: Celgene posts pivotal data ahead of FDA filing"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Celgene has recently published positive data&nbsp;from a pivotal trial (<a href=\"https:\/\/clinicaltrials.gov\/ct2\/show\/NCT02631044\">NCT02631044<\/a>) of its CAR-T therapy. As per the <a href=\"https:\/\/www.fiercebiotech.com\/biotech\/celgene-posts-pivotal-car-t-data-ahead-fda-filing\">reports<\/a>, the data look competitive against Gilead\u2019s Yescarta and Novartis\u2019 Kymriah, leading analysts to predict Celgene will win FDA approval next year. This is a big news for the overall CAR-T pipeline.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As per the reported data, the response rates are around 20 percentage points higher than those on the Kymriah label and one or two percentage points above the results achieved by Yescarta. As the three drugs were studied in different trials, factors other than their efficacy may account for the differences.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For more, check out the coverage <a href=\"https:\/\/www.fiercebiotech.com\/biotech\/celgene-posts-pivotal-car-t-data-ahead-fda-filing\">here<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>How many approved CAR-T therapies are available:<\/strong>&nbsp;We currently have 2 approved&nbsp;products, namely&nbsp;<a href=\"https:\/\/www.fda.gov\/vaccines-blood-biologics\/cellular-gene-therapy-products\/kymriah-tisagenlecleucel\">KYMRIAH<\/a>\u00ae (Novartis) and&nbsp;<a href=\"https:\/\/www.fda.gov\/news-events\/press-announcements\/fda-approves-car-t-cell-therapy-treat-adults-certain-types-large-b-cell-lymphoma\">YESCARTA<\/a>\u00ae (Gilead Sciences).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>How many CAR-T therapies are in development:<\/strong>&nbsp;There are currently more than 530+ CAR-T therapies in development. Below is the distribution of the CAR-T pipeline by the phase of development:<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"465\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/CAR_T_Pipeline_RootsAnalysis-1024x465.webp\" alt=\"Distribution of CAR-T pipeline by phase of development\" class=\"wp-image-16251\" style=\"object-fit:contain;width:800px;height:357px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/CAR_T_Pipeline_RootsAnalysis-1024x465.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/CAR_T_Pipeline_RootsAnalysis-300x136.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/CAR_T_Pipeline_RootsAnalysis-768x349.webp 768w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/CAR_T_Pipeline_RootsAnalysis.webp 1428w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">To get more insights about the CAR-T pipeline, check out the detailed report\u00a0<a href=\"https:\/\/www.rootsanalysis.com\/reports\/car-t-cell-therapy-market\/269.html\">Car_T Therapy Market 2nd Edition<\/a>.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Celgene has recently published positive data&nbsp;from a pivotal trial (NCT02631044) of its CAR-T therapy. As per the reports, the data look competitive against Gilead\u2019s Yescarta and Novartis\u2019 Kymriah, leading analysts to predict Celgene will win FDA approval next year. This is a big news for the overall CAR-T pipeline. As per the reported data, the [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":17030,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,118],"tags":[161,162],"class_list":["post-10640","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cell-therapies","category-cell-therapy","tag-car-t","tag-t-cell"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CAR-T Pipeline Update: Celgene posts pivotal data ahead of FDA filing | Blog Cell Therapies<\/title>\n<meta name=\"description\" content=\"There are currently more than 530+ CAR-T therapies in development. 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