{"id":10709,"date":"2022-05-12T09:56:17","date_gmt":"2022-05-12T04:26:17","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=10709"},"modified":"2024-08-21T18:04:01","modified_gmt":"2024-08-21T12:34:01","slug":"targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\/","title":{"rendered":"Targeted Protein Degradation Market: Riding on the Popularity of PROTAC, Market is set to Grow Exponentially"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Over the years, the drug hunters have tried to target the tens of thousands of proteins responsible for sickness and health. But a vast majority of them have remained out of reach. While, the <a href=\"https:\/\/www.nature.com\/articles\/s41573-019-0047-y\">scientific evolution <\/a>has led to the development of potent and selective small-molecule inhibitors of protein function, but still, multiple targets of high biomedical relevance are highly challenging targets for typical small-molecule drugs. Similarly, the novel biologics, such as oligonucleotides and monoclonal antibodies have although allowed us to target some of these difficult to reach proteins, their delivery to the target site has created challenges of its own. In this article, we will evaluate the rising popularity of the concept of targeted protein degradation in overcoming the aforementioned challenges.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>What is Targeted Protein Degradation?<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Targeted protein degradation is an emerging modality that allows access to difficult-to-treat diseases. While conventional medicines such as small molecule inhibitors and monoclonal antibodies address fewer than 20% of the proteome, targeted degradation offers a unique means to tap into the rest of the vast, unexplored proteome. Through this, a disease can be addressed by controlling the amount of a harmful protein rather than trying to modulate or inhibit its function. The control of protein levels is accomplished with a small molecule drug called a protein degrader.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"151\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1-1024x151.webp\" alt=\"Growing Interest in Targeted Protein Degradation as a Therapeutic Modality\" class=\"wp-image-19052\" style=\"object-fit:contain;width:840px;height:150px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1-1024x151.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1-300x44.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1-768x113.webp 768w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1-1536x226.webp 1536w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Growing-Interest-in-Targeted-Protein-Degradation-Roots-1.webp 1908w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h3 class=\"wp-block-heading\"><strong>What is the difference between Protein Degrader and Protein Inhibitor?<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">In simple words, a&nbsp;single protein degrader drug can eliminate multiple disease-causing proteins through proteasome degradation of the target protein. However, an inhibitor drug can only block a single disease-causing protein at a time. The figure below explains the difference:<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"687\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Difference-between-Protein-Degrader-and-Protein-Inhibitor-Roots.webp\" alt=\"Difference between Protein degrader and Protein Inhibitor\" class=\"wp-image-19053\" style=\"object-fit:contain;width:840px;height:562px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Difference-between-Protein-Degrader-and-Protein-Inhibitor-Roots.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Difference-between-Protein-Degrader-and-Protein-Inhibitor-Roots-300x201.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Difference-between-Protein-Degrader-and-Protein-Inhibitor-Roots-768x515.webp 768w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<h4 class=\"wp-block-heading\"><strong>What is the History behind Targeted Protein Degradation?<\/strong><\/h4>\n\n\n\n<p class=\"wp-block-paragraph\">While the first small molecule PROTAC was developed in 2008, the history of targeted degradation goes back to 1992. The figure below presents an illustrative overview of the evolution of targeted protein degradation.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"729\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra-1024x729.webp\" alt=\"Historical Timeline of Targeted Protein Degradation\" class=\"wp-image-19054\" style=\"object-fit:contain;width:840px;height:598px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra-1024x729.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra-300x214.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra-768x547.webp 768w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra-1536x1093.webp 1536w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Illustrative-Overview-of-the-Evolution-of-Targeted-Protein-Degra.webp 1621w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\"><strong>What are the benefits of targeted protein degradation?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Compared to conventional inhibition strategies, degradation offers several benefits, which include the opportunity to completely remove aberrant proteins and associated systemic malfunctions.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>What are the key trends that are shaping up the Targeted Protein Degradation market?<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">As per a recent market <a href=\"https:\/\/www.rootsanalysis.com\/reports\/protein-degradation-market\/289.html\">report<\/a> by Roots Analysis, more than 85 small molecule protein degraders are currently being evaluated for the treatment of various disease indications. In addition, there are 25+ technology platforms available for use in therapy development efforts.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Our Social Media Platform<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Web:&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/\">https:\/\/www.rootsanalysis.com\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LinkedIn:&nbsp;<a href=\"https:\/\/in.linkedin.com\/company\/roots-analysis\">https:\/\/in.linkedin.com\/company\/roots-analysis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Twitter:&nbsp;<a href=\"https:\/\/twitter.com\/RootsAnalysis\">https:\/\/twitter.com\/RootsAnalysis<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Over the years, the drug hunters have tried to target the tens of thousands of proteins responsible for sickness and health. But a vast majority of them have remained out of reach. While, the scientific evolution has led to the development of potent and selective small-molecule inhibitors of protein function, but still, multiple targets of [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":16711,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[317],"tags":[191,190],"class_list":["post-10709","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-degradation-market","tag-protac","tag-targeted-protein-degradation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeted Protein Degradation Market Set to Grow Exponentially<\/title>\n<meta name=\"description\" content=\"Targeted protein degradation is an emerging modality that allows access to difficult-to-treat diseases. 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While conventional medicines such...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/RootsAnalysis\/\" \/>\n<meta property=\"article:published_time\" content=\"2022-05-12T04:26:17+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-21T12:34:01+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2022\/05\/RootsAnalysis_FeaturedImage_Protein.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"150\" \/>\n\t<meta property=\"og:image:height\" content=\"150\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Gaurav Chaudhary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@RootsAnalysis\" \/>\n<meta name=\"twitter:site\" content=\"@RootsAnalysis\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gaurav Chaudhary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/\"},\"author\":{\"name\":\"Gaurav Chaudhary\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#\\\/schema\\\/person\\\/e8e0ebc31296140424e1e7fcc11331bc\"},\"headline\":\"Targeted Protein Degradation Market: Riding on the Popularity of PROTAC, Market is set to Grow Exponentially\",\"datePublished\":\"2022-05-12T04:26:17+00:00\",\"dateModified\":\"2024-08-21T12:34:01+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/\"},\"wordCount\":426,\"publisher\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/05\\\/RootsAnalysis_FeaturedImage_Protein.webp\",\"keywords\":[\"PROTAC\",\"Targeted Protein Degradation\"],\"articleSection\":[\"Degradation Market\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/\",\"name\":\"Targeted Protein Degradation Market Set to Grow Exponentially\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-market-riding-on-the-popularity-of-protac-market-is-set-to-grow-exponentially\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2022\\\/05\\\/RootsAnalysis_FeaturedImage_Protein.webp\",\"datePublished\":\"2022-05-12T04:26:17+00:00\",\"dateModified\":\"2024-08-21T12:34:01+00:00\",\"description\":\"Targeted protein degradation is an emerging modality that allows access to difficult-to-treat diseases. 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