{"id":11033,"date":"2020-03-15T10:07:35","date_gmt":"2020-03-15T04:37:35","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=11033"},"modified":"2026-07-30T21:54:45","modified_gmt":"2026-07-30T16:24:45","slug":"cell-therapy-manufacturing","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/cell-therapy-manufacturing\/","title":{"rendered":"Cell Therapy Manufacturing: Here are the Key Innovations"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Last week, during our weekly industry update sessions, our prime focus was to understand the recent innovations in the field of cell therapy manufacturing. We were also looking out for players that are driving these innovations. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To start with, the first news that caught our attention was Novartis&#8217; <a href=\"https:\/\/www.fiercepharma.com\/manufacturing\/novartis-sidesteps-europe-travel-ban-to-provide-car-t-drug-kymriah-to-patients\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">decision <\/a>to sidestep Europe travel ban to provide <a href=\"https:\/\/www.rootsanalysis.com\/reports\/car-t-cell-therapy-market\/269.html\">CAR-T cell therapy<\/a> Kymriah to patients. Amid the growing concerns regarding the rapid rise in <a href=\"https:\/\/www.rootsanalysis.com\/blog\/coronavirus-the-world-must-unite-in-its-fight\/\">COVID-19<\/a> cases, this decision by Novartis certainly comes as a <em>much needed good news<\/em>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">In this article, we will discuss some of the key innovations in cell therapy manufacturing that have caught the industry&#8217;s attention in the last few weeks.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Cell Therapy Supply Chain<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In one of our <a href=\"https:\/\/www.rootsanalysis.com\/blog\/a-pizza-hut-prescription-for-gene-therapy-companies\/\" target=\"_blank\" rel=\"noreferrer noopener\">recent articles<\/a>, we talked about the strategies that <a href=\"https:\/\/www.rootsanalysis.com\/key-insights\/5-leading-cell-therapy-manufacturing-companies.html\">cell therapy manufacturing companies<\/a> can adopt to improve the supply chain. Some of the players, such as&nbsp;<em>(illustrative list)<\/em>&nbsp;Trakcel, Veeva, Be the Match BioTherapies have already deployed solutions efficiently manage and streamline various aspects of the complex supply chains of cell and advanced therapies. In fact, more than 160 innovative software-enabled systems have been developed for managing the cell and advanced therapies supply chain. The key supply chain challenges in cell therapies are:<\/p>\n\n\n\n<ul class=\"wp-block-list\">\n<li>Presence of multiple stakeholders<\/li>\n\n\n\n<li>Operational inefficiencies<\/li>\n\n\n\n<li>lack of real-time tracking<\/li>\n<\/ul>\n\n\n\n<p class=\"wp-block-paragraph\">Also, across the social media platforms, there has been an immense rise in the popularity of the cell therapy supply chain solutions. <\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Manufacturing-Social-Media-Analysis-Roots-1024x576.webp\" alt=\"Cell Therapy Manufacturing: Here are the Key Innovations\n\" class=\"wp-image-17435\" style=\"object-fit:contain;width:800px;height:451px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Manufacturing-Social-Media-Analysis-Roots-1024x576.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Manufacturing-Social-Media-Analysis-Roots-300x169.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Manufacturing-Social-Media-Analysis-Roots-768x432.webp 768w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Manufacturing-Social-Media-Analysis-Roots.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Last week, <a href=\"https:\/\/trakcel.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">TrakCel<\/a>, and <a href=\"https:\/\/oribiotech.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Ori Biotech <\/a>inked a non-exclusive <a href=\"https:\/\/www.genengnews.com\/topics\/bioprocessing\/trakcel-and-ori-biotech-sign-supply-chain-cell-and-gene-therapy-manufacturing-deal\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">strategic partnership <\/a>to achieve supply chain coordination within closed-system manufacturing.<\/p>\n\n\n\n<figure class=\"wp-block-embed is-type-rich is-provider-x wp-block-embed-x\"><div class=\"wp-block-embed__wrapper\">\n<blockquote class=\"twitter-tweet\" data-width=\"550\" data-dnt=\"true\"><p lang=\"en\" dir=\"ltr\">@Oribiotech1 adds traceability to cell therapy platform allowing CDMOs and CGT developers to monitor manufacturing processes in real-time using <a href=\"https:\/\/x.com\/TrakCel_?ref_src=twsrc%5Etfw\">@TrakCel_<\/a>  technologies <a href=\"https:\/\/x.com\/hashtag\/CGTmanufacturing?src=hash&amp;ref_src=twsrc%5Etfw\">#CGTmanufacturing<\/a> <a href=\"https:\/\/x.com\/hashtag\/CDMO?src=hash&amp;ref_src=twsrc%5Etfw\">#CDMO<\/a> <a href=\"https:\/\/x.com\/hashtag\/celltherapy?src=hash&amp;ref_src=twsrc%5Etfw\">#celltherapy<\/a> <a href=\"https:\/\/t.co\/kr9v7N5uAx\">https:\/\/t.co\/kr9v7N5uAx<\/a><\/p>&mdash; Oribiotech (@OriBiotech) <a href=\"https:\/\/x.com\/OriBiotech\/status\/1234657827656011776?ref_src=twsrc%5Etfw\">March 3, 2020<\/a><\/blockquote><script async src=\"https:\/\/platform.x.com\/widgets.js\" charset=\"utf-8\"><\/script>\n<\/div><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Earlier last year, Lonza <a href=\"https:\/\/www.lonza.com\/news\/2019-11-05-14-47\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">announced a collaboration <\/a>with Cryoport to Strengthens its<em> vein-to-vei<\/em>n delivery network in cell therapy manufacturing. This partnership<strong> <\/strong>incorporated Cryoport\u2019s <a href=\"https:\/\/www.cryoport.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Cryoportal\u00ae Logistics Management Platform<\/a>, SmartPak II\u2122 Condition Monitoring System and Cryoport\u2019s unique Chain of Compliance\u2122 for the regulatory solutions.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Vector Manufacturing<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One industry that has benefitted the most with the rise of cell and gene therapies is the vector manufacturing space. As a result of the growing demand for such therapies, there has been a significant increase in demand for preclinical and clinical-grade gene delivery vectors.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">One other trend that has been observed is the prominent role that the contract manufacturers (CMOs) have played. In fact, existing manufacturing concerns in this field have led many players to outsource vector to different CMOs. The recent&nbsp;<a href=\"https:\/\/www.genengnews.com\/news\/lonza-prevail-therapeutics-partner-on-gene-therapy-manufacturing\/\">deal<\/a>&nbsp;signed between Lonza and&nbsp;Prevail Therapeutics for AAV based gene therapies is a perfect example of this. Here is a quick snapshot of various CMOs that offer vector manufacturing services.<\/p>\n\n\n\n<figure class=\"wp-block-image size-large is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"1024\" height=\"576\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Vector-manufacturing-service-providers-Roots-1024x576.webp\" alt=\"Vector manufacturing service providers\" class=\"wp-image-17437\" style=\"object-fit:contain;width:800px;height:449px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Vector-manufacturing-service-providers-Roots-1024x576.webp 1024w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Vector-manufacturing-service-providers-Roots-300x169.webp 300w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Vector-manufacturing-service-providers-Roots-768x432.webp 768w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Cell-Therapy-Vector-manufacturing-service-providers-Roots.webp 1280w\" sizes=\"auto, (max-width: 1024px) 100vw, 1024px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Last month, we saw an <a href=\"https:\/\/www.labiotech.eu\/gene-cell-therapy\/univercells-gene-therapy-manufacturing\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">investment of over \u20ac50 million <\/a>by Gamma Biosciences to push to market <a href=\"https:\/\/www.univercells.com\/\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">Univercells<\/a>\u2019 manufacturing technology. The technology has been designed to reduce the costs of viral vector production for gene therapies. Several key opinion leaders have highlighted limited capacity and high cost as key concerns with vector manufacturing. In addition, the high vector manufacturing cost has also pushed several players to look beyond viral vectors.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Closed Automated Processing Platform<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Lonza <a href=\"https:\/\/www.lonza.com\/news\/2020-03-09-07-00\" target=\"_blank\" rel=\"noreferrer noopener nofollow\">recently announced <\/a>a partnership with three research institutes. It included the transfer of their preclinical immunotherapies to Lonza&#8217;s Cocoon\u2122 closed automated processing platform. The collaborators include Stanford University School of Medicine, Fred Hutchinson Cancer Research Center and Parker Institute for Cancer<strong> <\/strong>Immunotherapy. The Cocoon\u2122\u00a0system is based on an automated GMP-in-a-box concept for the patient-scale <a href=\"https:\/\/www.rootsanalysis.com\/reports\/cell-therapy-manufacturing\/285.html\">cell therapy manufacturing market<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For more details, you can also download the&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/reports\/cell-therapy-manufacturing\/request-sample.html\">SAMPLE REPORT<\/a>&nbsp;on cell therapy manufacturing by Roots Analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Last week, during our weekly industry update sessions, our prime focus was to understand the recent innovations in the field of cell therapy manufacturing. We were also looking out for players that are driving these innovations. To start with, the first news that caught our attention was Novartis&#8217; decision to sidestep Europe travel ban to [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":16424,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[101,118,47],"tags":[153,48,192],"class_list":["post-11033","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cell-therapies","category-cell-therapy","category-gene-therapy","tag-cell-therapy","tag-gene-therapy","tag-gene-therapy-supply-chain"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Inside the Latest Innovations in Cell Therapy Manufacturing<\/title>\n<meta name=\"description\" content=\"In fact, more than 160 innovative software-enabled systems have been developed for managing the cell therapy Manufacturing...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rootsanalysis.com\/blog\/cell-therapy-manufacturing\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Inside the Latest Innovations in Cell Therapy Manufacturing\" \/>\n<meta property=\"og:description\" content=\"In fact, more than 160 innovative software-enabled systems have been developed for managing the cell therapy Manufacturing...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rootsanalysis.com\/blog\/cell-therapy-manufacturing\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/RootsAnalysis\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-03-15T04:37:35+00:00\" \/>\n<meta property=\"article:modified_time\" 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