{"id":11556,"date":"2020-05-19T11:34:05","date_gmt":"2020-05-19T06:04:05","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=11556"},"modified":"2026-07-30T19:07:51","modified_gmt":"2026-07-30T13:37:51","slug":"neoantigen-targeted-therapies-pave-the-way-to-personalized","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/neoantigen-targeted-therapies-pave-the-way-to-personalized\/","title":{"rendered":"Neoantigen Targeted Therapies: Personalized Anti-cancer Therapy"},"content":{"rendered":"\n<h2 class=\"wp-block-heading\"><strong>Neoantigen\nTargeted Therapies Pave the Way to Personalized Anti-cancer Therapy<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">There is an urgent unmet need for developing innovative and effective <a href=\"https:\/\/www.rootsanalysis.com\/reports\/cancer-stem-cell-therapies-market\/183.html\">cancer therapeutics<\/a> for the treatment of patients with late-stage and refractory cancer. Amidst the widespread initiatives to develop more targeted <a href=\"https:\/\/en.wikipedia.org\/wiki\/Chemotherapy\">anti-cancer therapies<\/a>, immunotherapy emerged as a highly specific and potent option to eradicate tumor cells with minimal side effects. Harnessing the underlying potential of the immune system to fight progressive diseases, such as cancer, forms the principle behind immunotherapy. Such therapies aim to educate the immune system with the knowledge of tumor antigens, thereby, stimulating its effector to attack those cells that contain the specific target antigens.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The term neoantigens is used to refer to the subset of tumor antigens that are encoded by tumor-specific (mutated) genes, which remain unrecognized by the immune system. These antigens may be related to viral proteins (in cancers that are caused by viral infections) or altered proteins formed post tumorigenesis. The immune system is generally primed to fight infections by differentiating body\u2019s own cells from foreign agents. It recognizes foreign protein fragments (antigens) and mounts an immune response against them. However, when normal cells become cancerous, due to genetic mutations, the transformed (cancer) cells are often able to thrive because of their ability to hide from the immune system. Apart from this, these genetic mutations can also give rise to foreign proteins \/ new cancer antigens, called neoantigens, which stimulate an immune response to eliminate the cancer cells.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Next-generation Sequencing of Neoantigen<\/strong> <strong>Targeted Therapies<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">Several researchers have started using whole-genome sequencing to identify non-synonymous mutations in the tumor DNA. The mutated genes are made to undergo in silico analysis for prediction of high-affinity epitopes that are capable of binding to MHC molecules. <\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"360\" height=\"408\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Steps-involved-in-Next-Generation-Sequencing-of-Neoantigen-Therapy-Roots.webp\" alt=\"schematic flow of sequencing of neoantigens \" class=\"wp-image-17403\" style=\"object-fit:contain;width:500px;height:568px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Steps-involved-in-Next-Generation-Sequencing-of-Neoantigen-Therapy-Roots.webp 360w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Steps-involved-in-Next-Generation-Sequencing-of-Neoantigen-Therapy-Roots-265x300.webp 265w\" sizes=\"auto, (max-width: 360px) 100vw, 360px\" \/><figcaption class=\"wp-element-caption\"> Steps involved in next-generation sequencing of neoantigens <\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">For additional details on <a href=\"https:\/\/www.rootsanalysis.com\/blog\/neoantigen-targeted-therapies-a-potential-weapon-in-the-fight-against-cancer\/\">neoantigen vaccines<\/a>, click here.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Companies\nwith Multiple Neoantigen Targeted Therapies in their Pipeline<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">There are several companies that are developing more than three neoantigen targeted therapies, either as a monotherapy or in combination with immune checkpoint inhibitors.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"595\" height=\"258\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Companies-Developing-Neoantigen-Targeted-Therapies-Roots.webp\" alt=\"neoantigen list of companies and focus on different combinations as well as target indications \" class=\"wp-image-17404\" style=\"object-fit:contain;width:800px;height:348px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Companies-Developing-Neoantigen-Targeted-Therapies-Roots.webp 595w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Companies-Developing-Neoantigen-Targeted-Therapies-Roots-300x130.webp 300w\" sizes=\"auto, (max-width: 595px) 100vw, 595px\" \/><figcaption class=\"wp-element-caption\"> Companies developing neoantigen targeted therapies <\/figcaption><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Click <a href=\"https:\/\/www.rootsanalysis.com\/reports\/neoantigen-targeted-therapies-market-2019-2030\/257.html\">here<\/a> to know about the companies involved in the development of neoantigen targeted therapies.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Researchers\nare Exploiting the Untapped Potential of Neoantigens<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">The fact that more than 350 research \/ review papers have been published, in various reputed journals, in a span of five years is evident of the huge potential of neoantigens.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"300\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Publication-Analysis-on-various-Neoantigen-Targeted-Therapies-Roots.webp\" alt=\"Distribution by publication analysis, therapies and key cancer indications in Neoantigen target therapy market\" class=\"wp-image-17405\" style=\"object-fit:contain;width:800px;height:402px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Publication-Analysis-on-various-Neoantigen-Targeted-Therapies-Roots.webp 602w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/09\/Publication-Analysis-on-various-Neoantigen-Targeted-Therapies-Roots-300x150.webp 300w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><figcaption class=\"wp-element-caption\"> Publication Analysis <\/figcaption><\/figure>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Conclusion<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Given the increasing interest in personalized therapies in the research community, the <a href=\"https:\/\/www.rootsanalysis.com\/reports\/neoantigen-targeted-therapies-market-2019-2030\/257.html\">neoantigen targeted therapies market<\/a> is set to bring about a paradigm shift in cancer therapy. With the first product being expected to be commercialized in 2023, this novel approach is anticipated to become the next breakthrough in the field of medicine.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To get an elaborate list of publications related to neoantigen targeted therapies, you can also download the&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/reports\/257\/request-sample.html\">SAMPLE REPORT<\/a>&nbsp;on neoantigen therapies by Roots Analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Neoantigen Targeted Therapies Pave the Way to Personalized Anti-cancer Therapy There is an urgent unmet need for developing innovative and effective cancer therapeutics for the treatment of patients with late-stage and refractory cancer. Amidst the widespread initiatives to develop more targeted anti-cancer therapies, immunotherapy emerged as a highly specific and potent option to eradicate tumor [&hellip;]<\/p>\n","protected":false},"author":35,"featured_media":11563,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[410,409,406],"tags":[408,407,151,346],"class_list":["post-11556","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-anti-cancer","category-anti-cancer-therapy","category-therapies","tag-anti-cancer","tag-anti-cancer-therapy","tag-market-research-report","tag-therapies"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Neoantigen Targeted Therapies: Personalized Anti-cancer Therapy<\/title>\n<meta name=\"description\" content=\"According to Roots Analysis, more than 350 research articles \/ 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