{"id":11578,"date":"2020-05-25T13:28:00","date_gmt":"2020-05-25T07:58:00","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=11578"},"modified":"2026-07-09T15:11:22","modified_gmt":"2026-07-09T09:41:22","slug":"rapid-response-to-covid-19-with-oligonucleotide-chemistries","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/rapid-response-to-covid-19-with-oligonucleotide-chemistries\/","title":{"rendered":"Oligonucleotides: A Response to COVID-19 Pandemic"},"content":{"rendered":"\n

Never before, scientists say, the universal community of researchers have put a halt to all other ongoing research and have urgently focused towards swiftly evolving health emergency. In the past few months, scientists have been repurposing their research efforts towards oligonucleotides contributing to the global effort in response to developing coronavirus preventive vaccines<\/a>. <\/p>\n\n\n\n

For the purpose of mitigating COVID-19, scientists are racing up the experimental studies to find a suitable and promising drug class that might be effective in tackling the highly contagious virus. Specifically, researchers are developing rapid, laboratory diagnostic kits that involve the use of mission-critical oligonucleotide drugs<\/a>.<\/p>\n\n\n\n

Apart from the diagnostic applications, a major proportion\nof the demand for oligonucleotides comes from different research projects. Over\nthe past few years, multiple initiatives have been undertaken to develop oligonucleotide-based\ninterventions in order to treat a myriad of chronic clinical conditions.\nExperts believe that oligonucleotides are likely to evolve into one of the key\ntherapeutic classes of the future, given their high specificity and favorable\nbiological tolerance profiles. <\/p>\n\n\n\n

Recent Advances<\/strong><\/h2>\n\n\n\n

Significant advances have been made in enhancing the drug-like properties of oligonucleotides, including tissue targeting capability, cellular internalization feature, endosomal escape capability, target binding specificity, and resistance to nucleases. <\/p>\n\n\n\n

In this context, bioconjugation chemistry has played an important role in oligonucleotides – based therapy development, offering the means to combine the target specificity of these molecules with the therapeutic benefits of other potent drug substances. In fact, many are led to believe that oligonucleotides drug conjugates market is poised to witness significant growth in future. <\/p>\n\n\n\n

Further, several new companies have come up with innovative technologies to develop oligonucleotides – based therapeutics. In recent times, such innovator companies have started investing heavily in R&D and have resulted in the establishment of a rich pipeline of oligonucleotides – based drug products. In order to meet the growing demand, a number of small- to mid-sized companies have begun outsourcing their manufacturing operations to contract \/ custom service providers. <\/p>\n\n\n\n

In fact, several big pharma companies,\ndespite having proprietary manufacturing capabilities, are known to outsource\nmore than half of their clinical stage oligonucleotide manufacturing\noperations. In the foreseen future, we anticipate the demand and opportunities\nfor contract manufacturing organizations (CMO) in this domain to rise. <\/p>\n\n\n\n

Service Providers Offering Oligonucleotides Manufacturing<\/strong><\/h2>\n\n\n\n

Currently, close to 80 service providers claim to offer oligonucleotides synthesis, modification and purification services for various research, diagnostic and therapeutic applications, across the globe.<\/p>\n\n\n\n

\"Sample
List of Oligonucleotide Manufacturers<\/figcaption><\/figure>\n\n\n\n

To know about the companies that are engaged in the manufacturing of oligonucleotides, check out our report – Oligonucleotide Synthesis<\/a>.<\/p>\n\n\n\n

Capacity with the Companies (in kgs)<\/em> – Enough to\nMeet the Demand?<\/strong><\/h2>\n\n\n\n

The current, annual capacity is primarily driven by players operating at the commercial scale, which represent 96% of the total manufacturing capacity. In addition, around 82% of the capacity belongs to large-scale manufacturers of oligonucleotides. Further, around 92% of this capacity is estimated to be installed in developed regions, such as North America and Europe.<\/p>\n\n\n\n

\"Oligonucleotides
Oligonucleotides – manufacturing capacity<\/figcaption><\/figure>\n\n\n\n

Likely Growth of the Oligonucleotide Manufacturing Market<\/strong><\/h2>\n\n\n\n

North America (primarily the US) is the current market leader in the oligonucleotide synthesis market<\/a>; this developed market is anticipated to grow at an annualized rate of 8.7%, till 2030. Due to relatively low labor costs and less stringent regulatory guidelines, the market in Asia-Pacific is expected to grow at a significantly faster rate in the coming decade.<\/p>\n\n\n\n

\"Oligonucleotide
Oligonucleotide synthesis market<\/figcaption><\/figure>\n\n\n\n

To get a detailed information on the key players, recent developments, capacity available and manufacturing demand for oligonucleotides and the likely market evolution, you can also download the SAMPLE REPORT<\/a> on oligonucleotides by Roots Analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"

Never before, scientists say, the universal community of researchers have put a halt to all other ongoing research and have urgently focused towards swiftly evolving health emergency. In the past few months, scientists have been repurposing their research efforts towards oligonucleotides contributing to the global effort in response to developing coronavirus preventive vaccines. For the […]<\/p>\n","protected":false},"author":21,"featured_media":11582,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[385,411,416],"tags":[387,151,414,202],"class_list":["post-11578","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-covid-19","category-covid19","category-oligonucleotides","tag-covid19","tag-market-research-report","tag-oligonucleotide","tag-research"],"yoast_head":"\nOligonucleotides: A Response to COVID-19 Pandemic<\/title>\n<meta name=\"description\" content=\"According to Roots Analysis, the oligonucleotides synthesis market is anticipated to grow at an annualized rate of 8.7%, till 2030.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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