{"id":11599,"date":"2020-06-02T07:52:47","date_gmt":"2020-06-02T02:22:47","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=11599"},"modified":"2026-07-09T13:25:01","modified_gmt":"2026-07-09T07:55:01","slug":"growing-pipeline-of-microbiome-based-live-biotherapeutics-fuels-the-manufacturing-demand","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/growing-pipeline-of-microbiome-based-live-biotherapeutics-fuels-the-manufacturing-demand\/","title":{"rendered":"Microbiome Therapeutics Fuel the Manufacturing Demand"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">Microbiome therapeutics are fragile bacteria, which require ideal conditions of heat, moisture and pH of products, to survive and prevent premature germination. In fact, <a href=\"https:\/\/www.rootsanalysis.com\/blog\/microbiome-therapeutics-contract-manufacturing\/\">microbiome manufacturing<\/a> is presently one of the biggest bottlenecks in this domain; manufacturing such products is both technically challenging and financially demanding. One of the biggest challenges in the development of a <a href=\"https:\/\/www.rootsanalysis.com\/reports\/human-microbiome-market\/281.html\">human microbiome<\/a> product is related to its stability. It is very difficult to maintain the number of live bacteria during product formulation and storage. It is not easy to find contract manufacturers with sufficient capacity and capabilities to support the manufacturing of different types of bacterial strains. In addition, there is a need for additional manufacturing facilities to accommodate microbial production operations to cater to the growing demands of sponsor companies. Another key challenge is the lengthy manufacturing timelines and the evident lack of flexibility among existing service providers. As a result, innovator firms are becoming increasingly reliant on contract service providers to access specialized facilities and optimize overall costs. <\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Need for outsourcing microbiome therapeutics manufacturing operations<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">In fact, the current development pipeline of microbiome therapeutics has several promising candidates, which are anticipated to get commercialized over the next few years. Hence, the demand for R&amp;D and manufacturing services for such products is anticipated to increase beyond the capabilities of innovator companies alone. <\/p>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Service Providers Offering Microbiome Therapeutics Manufacturing<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Over 55 contract manufacturers and in-house players are engaged in the manufacturing of microbiome therapeutics, a new class of therapeutics which uses bacteria as drugs. The majority of these CDMOs have the expertise for anaerobic fermentation of microbial strains, which require strict environmental conditions.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"597\" height=\"330\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Industry-Players-Roots.webp\" alt=\"Over 95% of the Microbiome Therapeutics contract manufacturers offer services for fermentation followed by 89% for fill \/ finish\" class=\"wp-image-19006\" style=\"object-fit:contain;width:800px;height:434px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Industry-Players-Roots.webp 597w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Industry-Players-Roots-300x166.webp 300w\" sizes=\"auto, (max-width: 597px) 100vw, 597px\" \/><figcaption class=\"wp-element-caption\"> Microbiome CMOs &#8211; list of companies<\/figcaption><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">List of microbiome-based live biotherapeutics manufacturers<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">To know about the companies (CMOs \/ CDMOs \/ In-house players) that are engaged in the manufacturing of microbiome-based live biotherapeutics, check out our report&nbsp;<strong><a href=\"https:\/\/www.rootsanalysis.com\/reports\/microbiome-contract-manufacturing\/306.html\">Live<br>Biotherapeutics<\/a><\/strong><\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Recent Advances<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">One of the leading CDMO in this domain, Arranta Bio, has undertaken a number of initiatives in the last few months. In November, last year, the company&nbsp;<a rel=\"noreferrer noopener\" href=\"https:\/\/www.prnewswire.com\/news-releases\/arranta-bio-announces-the-acquisition-of-captozyme-creating-a-center-of-excellence-for-microbiome-development-and-clinical-supply-300956937.html\" target=\"_blank\">acquired&nbsp;<\/a>microbiome process development and clinical contract manufacturer,&nbsp;<a href=\"http:\/\/www.captozyme.com\/\">Captozyme<\/a>. Earlier, in April 2019, Lonza and Chr. Hansen have entered into a strategic agreement to establish a joint venture company (now named BacThera) for the manufacturing of live biotherapeutic products, with an investment of EUR 90 million.<\/p>\n\n\n\n<h2 class=\"wp-block-heading\">Examples of manufacturing agreements between developers and\nCMOs<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Capacity with the Companies \u2013\nEnough to Meet the Demand?<\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">The current, annual capacity is primarily driven by players operating at the commercial scale, which represent 88% of the total manufacturing capacity. In addition, around 62% of the capacity belongs to mid-sized manufacturers. Further, around 83% of the capacity in the <a href=\"https:\/\/www.rootsanalysis.com\/reports\/microbiome-contract-manufacturing\/306.html\">microbiome manufacturing market<\/a> is estimated to be installed in developed regions, such as North America and Europe.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"333\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Global-Production-Capacity-Roots.webp\" alt=\"North America is likely to have highest installed capacity across the globe\" class=\"wp-image-19007\" style=\"object-fit:contain;width:800px;height:440px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Global-Production-Capacity-Roots.webp 602w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Global-Production-Capacity-Roots-300x166.webp 300w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><\/figure>\n<\/div>\n\n\n<h2 class=\"wp-block-heading\">Microbiome therapeutics \u2013 manufacturing capacity<\/h2>\n\n\n\n<h3 class=\"wp-block-heading\"><strong>Likely Growth of the Microbiome\nTherapeutics Manufacturing Market <\/strong><\/h3>\n\n\n\n<p class=\"wp-block-paragraph\">Future growth of the <a href=\"https:\/\/www.rootsanalysis.com\/reports\/microbiome-contract-manufacturing\/306.html\">microbiome manufacturing market<\/a> is likely to be driven by increased demand for these therapeutics; we expect the service-based revenues to grow at an annualized rate of over 46% in the coming decade. By 2030, North America and Europe are anticipated to capture over 85% of the market opportunity.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"602\" height=\"335\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Market-Growth-Opportunities-Analysis-Roots.webp\" alt=\"The market for Microbiome Therapeutics Contract Manufacturing is fragmented across various segmentations such as type of formulation, company size and geography\" class=\"wp-image-19008\" style=\"object-fit:contain;width:800px;height:432px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Market-Growth-Opportunities-Analysis-Roots.webp 602w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Microbiome-CMOs-Market-Growth-Opportunities-Analysis-Roots-300x167.webp 300w\" sizes=\"auto, (max-width: 602px) 100vw, 602px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Microbiome-based live biotherapeutics market <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">For more details, you can also download the&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/reports\/microbiome-contract-manufacturing\/request-sample.html\">SAMPLE REPORT<\/a>&nbsp;on microbiome therapeutics by Roots Analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Microbiome therapeutics are fragile bacteria, which require ideal conditions of heat, moisture and pH of products, to survive and prevent premature germination. In fact, microbiome manufacturing is presently one of the biggest bottlenecks in this domain; manufacturing such products is both technically challenging and financially demanding. One of the biggest challenges in the development of [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":11606,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[417,413,361],"tags":[418,251,185],"class_list":["post-11599","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-biotherapeutics","category-manufacturing","category-microbiome-research","tag-biotherapeutics","tag-manufacturing","tag-microbiome"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Microbiome Therapeutics: Fuel the Manufacturing Demand<\/title>\n<meta name=\"description\" content=\"According to Roots Analysis, the microbiome therapeutics manufacturing market is likely to grow at a CAGR of over 46% in the coming decade.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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