{"id":11711,"date":"2020-06-23T16:55:00","date_gmt":"2020-06-23T11:25:00","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=11711"},"modified":"2026-07-24T14:41:20","modified_gmt":"2026-07-24T09:11:20","slug":"targeted-protein-degradation-a-new-frontier","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/","title":{"rendered":"Targeted Protein Degradation \u2013 A New Frontier in Modern Medicine"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">The concept of targeted protein degradation (<a href=\"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-major-therapeutic-modality\/\">TPD<\/a>) presents revolutionary drug development opportunities and is anticipated to bring about a paradigm shift in modern healthcare. While conventional medicines, such as small molecule inhibitors and monoclonal antibodies, address fewer than 20% of the proteome, targeted protein degradation offers a unique means to tap into the rest of the vast, unexplored <a href=\"https:\/\/www.rootsanalysis.com\/reports\/proteome-profiling-services.html\">proteome profile<\/a>.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">The science behind this innovation revolves around the use of specially designed small molecules that are capable of recruiting the ubiquitin-proteasome system (UPS) to selectively eliminate a target protein, via proteolysis.<\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"603\" height=\"174\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Basic-Concept-of-Targeted-Protein-Degradation-Roots.webp\" alt=\"Targeted Protein Degradation \u2013 Defining a New Frontier in the Field of Medicine\" class=\"wp-image-19576\" style=\"object-fit:contain;width:800px;height:232px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Basic-Concept-of-Targeted-Protein-Degradation-Roots.webp 603w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Basic-Concept-of-Targeted-Protein-Degradation-Roots-300x87.webp 300w\" sizes=\"auto, (max-width: 603px) 100vw, 603px\" \/><\/figure>\n<\/div>\n\n\n<p class=\"wp-block-paragraph\">Over the years, significant progress has been made towards understanding the physiochemical and biological properties of these bifunctional molecules. In fact, a variety of other chemical entities and molecular glues have been developed for the treatment of a variety of clinical conditions. The growing popularity and interest in the therapeutic potential of these molecules is evident across modern scientific literature (500+ related articles on NCBI\u2019s PubMed portal), and from social media chatter (4,000+ tweets posted on the platform, Twitter, over the last three years).<\/p>\n\n\n\n<h2 class=\"wp-block-heading\"><strong>Current pipeline of targeted protein degradation-based drugs<\/strong><\/h2>\n\n\n\n<p class=\"wp-block-paragraph\">During our research, we came across close to 90 targeted protein degradation-based therapeutics that are being investigated for a wide variety of application areas. The first targeted protein degrader, called proteolysis targeting chimera (PROTAC), was developed about a decade ago, and is currently accounting for more than 30% of the pipeline drugs. These are being developed primarily to treat advanced oncological disorders (such as acute myeloid leukemia, breast cancer, lung cancer, multiple myeloma, and prostate cancer). A few drugs are also being evaluated for the treatment of non-oncological indications.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"554\" height=\"251\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Current-Market-Landscape-of-Targeted-Protein-Degradation-Roots.webp\" alt=\"Targeted Protein Degradation \u2013 Defining a New Frontier in the Field of Medicine\" class=\"wp-image-19577\" style=\"object-fit:contain;width:800px;height:362px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Current-Market-Landscape-of-Targeted-Protein-Degradation-Roots.webp 554w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Current-Market-Landscape-of-Targeted-Protein-Degradation-Roots-300x136.webp 300w\" sizes=\"auto, (max-width: 554px) 100vw, 554px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">ER+\/HER2- is the most popular target protein, as per the current drug development focus in this domain. Specifically, in the clinical pipeline, about 10 drugs are being developed to target ER+\/HER2-; examples include (<em>in decreasing order of clinical phase of development<\/em>) elacestrant (phase III), SAR439859 (phase II), G1T48 (phase I\/IIa), LSZ102 (phase I\/Ib), ARV-471 (phase I), AZD9833 (phase I), AZD9496 (phase I), D-0502 (phase I), GDC-9545 (phase I) and GDC0927 (phase I).<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"538\" height=\"253\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Distribution-by-Type-of-Protein-Degrader-Roots.webp\" alt=\"Targeted Protein Degradation \u2013 Defining a New Frontier in the Field of Medicine\" class=\"wp-image-19579\" style=\"object-fit:contain;width:800px;height:378px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Distribution-by-Type-of-Protein-Degrader-Roots.webp 538w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Distribution-by-Type-of-Protein-Degrader-Roots-300x141.webp 300w\" sizes=\"auto, (max-width: 538px) 100vw, 538px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">Most of the molecules that we came across are being evaluated as both monotherapies and combination therapies (56%), whereas around 26% are being investigated as monotherapies alone. Given that majority of the therapeutics are small molecules, the most preferred route for the delivery of targeted protein degradation-based therapeutics is oral route (over 85%), followed by the intravenous route (~11%).<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">During our research, we came across more than 60 clinical trials that have been registered across different geographical locations under the <a href=\"https:\/\/www.rootsanalysis.com\/reports\/protein-degradation-market\/289.html\">targeted protein degradation market<\/a>. Examples of the most active industry players in this domain include (<em>in decreasing order of number of clinical trials<\/em>) Celgene, Samus Therapeutics, Medivir, <a href=\"https:\/\/www.astrazeneca.com\/r-d\/next-generation-therapeutics\/protacs.html\">AstraZeneca<\/a>, Radius Pharmaceuticals, Genentech, Sanofi, Arvinas, CellCentric, and InventisBio.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"570\" height=\"287\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Targeted-Protein-Degradation-Clinical-Trial-Analysis-Roots.webp\" alt=\"Targeted Protein Degradation \u2013 Defining a New Frontier in the Field of Medicine\" class=\"wp-image-19580\" style=\"object-fit:contain;width:800px;height:405px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Targeted-Protein-Degradation-Clinical-Trial-Analysis-Roots.webp 570w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/Targeted-Protein-Degradation-Clinical-Trial-Analysis-Roots-300x151.webp 300w\" sizes=\"auto, (max-width: 570px) 100vw, 570px\" \/><\/figure>\n\n\n\n<p class=\"wp-block-paragraph\">For more details, you can also download the&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/reports\/protein-degradation-market\/request-sample.html\">SAMPLE REPORT<\/a>&nbsp;on targeted protein degradation by Roots Analysis.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring about a paradigm shift in modern healthcare. While conventional medicines, such as small molecule inhibitors and monoclonal antibodies, address fewer than 20% of the proteome, targeted protein degradation offers a unique means to tap into the rest of [&hellip;]<\/p>\n","protected":false},"author":21,"featured_media":11717,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[111,434],"tags":[188,436,435],"class_list":["post-11711","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-drug-discovery","category-protein-degradation","tag-drug-discovery","tag-medicine","tag-protein-degradation"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Targeted Protein Degradation Is Redefining Drug Design<\/title>\n<meta name=\"description\" content=\"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Targeted Protein Degradation Is Redefining Drug Design\" \/>\n<meta property=\"og:description\" content=\"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/\" \/>\n<meta property=\"og:site_name\" content=\"Blog\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/RootsAnalysis\/\" \/>\n<meta property=\"article:published_time\" content=\"2020-06-23T11:25:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2026-07-24T09:11:20+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png\" \/>\n\t<meta property=\"og:image:width\" content=\"1235\" \/>\n\t<meta property=\"og:image:height\" content=\"1280\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/png\" \/>\n<meta name=\"author\" content=\"Gaurav Chaudhary\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@RootsAnalysis\" \/>\n<meta name=\"twitter:site\" content=\"@RootsAnalysis\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Gaurav Chaudhary\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/\"},\"author\":{\"name\":\"Gaurav Chaudhary\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#\\\/schema\\\/person\\\/e8e0ebc31296140424e1e7fcc11331bc\"},\"headline\":\"Targeted Protein Degradation \u2013 A New Frontier in Modern Medicine\",\"datePublished\":\"2020-06-23T11:25:00+00:00\",\"dateModified\":\"2026-07-24T09:11:20+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/\"},\"wordCount\":484,\"publisher\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/medicine-296966_1280.png\",\"keywords\":[\"Drug Discovery\",\"Medicine\",\"Protein Degradation\"],\"articleSection\":[\"Drug Discovery\",\"Protein Degradation\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/\",\"name\":\"Targeted Protein Degradation Is Redefining Drug Design\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/medicine-296966_1280.png\",\"datePublished\":\"2020-06-23T11:25:00+00:00\",\"dateModified\":\"2026-07-24T09:11:20+00:00\",\"description\":\"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/medicine-296966_1280.png\",\"contentUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2020\\\/06\\\/medicine-296966_1280.png\",\"width\":1235,\"height\":1280,\"caption\":\"Rootsanalysis\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/targeted-protein-degradation-a-new-frontier\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Targeted Protein Degradation \u2013 A New Frontier in Modern Medicine\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#website\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/\",\"name\":\"Blog\",\"description\":\"Roots Analysis\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#organization\",\"name\":\"Roots Analysis\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/11\\\/Roots-Analysis-High-Resolution-Logo.jpg\",\"contentUrl\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/wp-content\\\/uploads\\\/2018\\\/11\\\/Roots-Analysis-High-Resolution-Logo.jpg\",\"width\":205,\"height\":61,\"caption\":\"Roots Analysis\"},\"image\":{\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/RootsAnalysis\\\/\",\"https:\\\/\\\/x.com\\\/RootsAnalysis\",\"https:\\\/\\\/www.instagram.com\\\/rootsanalysis\\\/\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/roots-analysis\\\/\",\"https:\\\/\\\/www.pinterest.it\\\/analysis1340\\\/\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCwZF57vY1lnU0bNLej2zukg\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/www.rootsanalysis.com\\\/blog\\\/#\\\/schema\\\/person\\\/e8e0ebc31296140424e1e7fcc11331bc\",\"name\":\"Gaurav Chaudhary\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g\",\"url\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g\",\"contentUrl\":\"https:\\\/\\\/secure.gravatar.com\\\/avatar\\\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g\",\"caption\":\"Gaurav Chaudhary\"}}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Targeted Protein Degradation Is Redefining Drug Design","description":"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/","og_locale":"en_US","og_type":"article","og_title":"Targeted Protein Degradation Is Redefining Drug Design","og_description":"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...","og_url":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/","og_site_name":"Blog","article_publisher":"https:\/\/www.facebook.com\/RootsAnalysis\/","article_published_time":"2020-06-23T11:25:00+00:00","article_modified_time":"2026-07-24T09:11:20+00:00","og_image":[{"width":1235,"height":1280,"url":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png","type":"image\/png"}],"author":"Gaurav Chaudhary","twitter_card":"summary_large_image","twitter_creator":"@RootsAnalysis","twitter_site":"@RootsAnalysis","twitter_misc":{"Written by":"Gaurav Chaudhary","Est. reading time":"4 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#article","isPartOf":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/"},"author":{"name":"Gaurav Chaudhary","@id":"https:\/\/www.rootsanalysis.com\/blog\/#\/schema\/person\/e8e0ebc31296140424e1e7fcc11331bc"},"headline":"Targeted Protein Degradation \u2013 A New Frontier in Modern Medicine","datePublished":"2020-06-23T11:25:00+00:00","dateModified":"2026-07-24T09:11:20+00:00","mainEntityOfPage":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/"},"wordCount":484,"publisher":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/#organization"},"image":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#primaryimage"},"thumbnailUrl":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png","keywords":["Drug Discovery","Medicine","Protein Degradation"],"articleSection":["Drug Discovery","Protein Degradation"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/","url":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/","name":"Targeted Protein Degradation Is Redefining Drug Design","isPartOf":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#primaryimage"},"image":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#primaryimage"},"thumbnailUrl":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png","datePublished":"2020-06-23T11:25:00+00:00","dateModified":"2026-07-24T09:11:20+00:00","description":"The concept of targeted protein degradation (TPD) presents revolutionary drug development opportunities and is anticipated to bring...","breadcrumb":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#primaryimage","url":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png","contentUrl":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2020\/06\/medicine-296966_1280.png","width":1235,"height":1280,"caption":"Rootsanalysis"},{"@type":"BreadcrumbList","@id":"https:\/\/www.rootsanalysis.com\/blog\/targeted-protein-degradation-a-new-frontier\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.rootsanalysis.com\/blog\/"},{"@type":"ListItem","position":2,"name":"Targeted Protein Degradation \u2013 A New Frontier in Modern Medicine"}]},{"@type":"WebSite","@id":"https:\/\/www.rootsanalysis.com\/blog\/#website","url":"https:\/\/www.rootsanalysis.com\/blog\/","name":"Blog","description":"Roots Analysis","publisher":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.rootsanalysis.com\/blog\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/www.rootsanalysis.com\/blog\/#organization","name":"Roots Analysis","url":"https:\/\/www.rootsanalysis.com\/blog\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/www.rootsanalysis.com\/blog\/#\/schema\/logo\/image\/","url":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2018\/11\/Roots-Analysis-High-Resolution-Logo.jpg","contentUrl":"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2018\/11\/Roots-Analysis-High-Resolution-Logo.jpg","width":205,"height":61,"caption":"Roots Analysis"},"image":{"@id":"https:\/\/www.rootsanalysis.com\/blog\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/RootsAnalysis\/","https:\/\/x.com\/RootsAnalysis","https:\/\/www.instagram.com\/rootsanalysis\/","https:\/\/www.linkedin.com\/company\/roots-analysis\/","https:\/\/www.pinterest.it\/analysis1340\/","https:\/\/www.youtube.com\/channel\/UCwZF57vY1lnU0bNLej2zukg"]},{"@type":"Person","@id":"https:\/\/www.rootsanalysis.com\/blog\/#\/schema\/person\/e8e0ebc31296140424e1e7fcc11331bc","name":"Gaurav Chaudhary","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/secure.gravatar.com\/avatar\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g","url":"https:\/\/secure.gravatar.com\/avatar\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g","contentUrl":"https:\/\/secure.gravatar.com\/avatar\/1661cbb4c9924618db626ec780a3daf2ebd251e93753c083102682dba715ded6?s=96&d=mm&r=g","caption":"Gaurav Chaudhary"}}]}},"_links":{"self":[{"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/posts\/11711","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/users\/21"}],"replies":[{"embeddable":true,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/comments?post=11711"}],"version-history":[{"count":6,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/posts\/11711\/revisions"}],"predecessor-version":[{"id":22534,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/posts\/11711\/revisions\/22534"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/media\/11717"}],"wp:attachment":[{"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/media?parent=11711"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/categories?post=11711"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.rootsanalysis.com\/blog\/wp-json\/wp\/v2\/tags?post=11711"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}