{"id":13096,"date":"2022-02-19T11:05:05","date_gmt":"2022-02-19T05:35:05","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=13096"},"modified":"2026-07-23T21:57:49","modified_gmt":"2026-07-23T16:27:49","slug":"growing-demand-for-oligonucleotides-proposes-shedload-of-opportunities-for-contract-manufacturers","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/growing-demand-for-oligonucleotides-proposes-shedload-of-opportunities-for-contract-manufacturers\/","title":{"rendered":"Oligonucleotide Therapeutics: A Driving Force for CMOs"},"content":{"rendered":"\n

In the 20th<\/sup> century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as Oligonucleotide therapeutics. These short, single-stranded DNA or RNA molecules, which are the product of DNA manufacturing services, have various applications in biopharmaceutical and biotechnology industries including, genetic testing, basic research, forensic analysis and other analytical procedures. Till date, 14 oligonucleotide therapeutics have been approved. Notable examples of recently approved therapies include (in reverse chronological order of year of approval<\/em>) AMONDYS 45 (2021), Oxlumo\u2122 (2020) and Viltepso\u2122 (2020). Post the onset of the COVID-19 pandemic, a significant surge in the demand for oligonucleotide-based testing kits has been observed. As a result, contract service providers engaged in the oligonucleotide therapeutics market are expanding their existing capacities and capabilities, that is likely to result in lucrative opportunities for their services, in the foreseen future.<\/p>\n\n\n\n

Recent Activity in the DNA Manufacturing Domain         <\/strong><\/h2>\n\n\n\n
\"Recent
Growing Demand for DNA Manufacturing – partnerships, expansions and recent initiatives<\/figcaption><\/figure>\n\n\n\n

The current landscape consists of more than 95 players that claim to offer DNA manufacturing services for research, diagnostic and therapeutic applications. These contract service providers are actively entering into strategic collaborations to augment their existing portfolios. Further, a number of expansion initiatives are being undertaken by several biopharmaceutical big pharma players, in order to enhance their capabilities in this rapidly evolving domain. Majority of the partnerships inked in this domain were observed to be focused on manufacturing and supply of oligonucleotide-based therapies, followed by mergers and acquisitions. The US has emerged as a prominent region in terms of partnerships and expansion activity in this domain. It is worth highlighting that most of the initiatives were carried out for the establishment of new facilities.<\/p>\n\n\n\n

Current Global Capacity for DNA Manufacturing<\/strong><\/h2>\n\n\n\n
\"Current
Growing Demand for DNA Replication<\/a> trends for capacity and key players<\/figcaption><\/figure>\n\n\n\n

Of the total global DNA manufacturing capacity, around 87% of the capacity is being installed in large companies owing to multiple facilities across several locations. Further, majority of the capacity is dedicated for commercial operations, followed by preclinical \/ clinical operations. It is worth highlighting that major share of the global DNA manufacturing capacity is installed in North America, primarily in the US. Companies based in Asia-Pacific are increasingly undertaking initiatives in order to expand their manufacturing capacities.<\/p>\n\n\n\n

Evolving Demand for Oligonucleotide-based Therapies<\/strong><\/h2>\n\n\n\n
\"Evolving
Growing Demand for Oligonucleotides – example highlights<\/figcaption><\/figure>\n\n\n\n

The global manufacturing demand for oligonucleotide-based therapies is expected to grow at an annual growth rate of 10.5% by 2031. Antisense oligonucleotides are likely to capture the highest share of the overall commercial demand. Moreover, by 2031, majority of the commercial demand is anticipated to be generated by oligonucleotides intended for neuromuscular disorders. From secondary research, it has been inferred that during the forecast period, the current supply is sufficient to cater to the demand, and the trend is unlikely to differ in the future. Nevertheless, stakeholders are rapidly installing additional capacities to ensure a stronghold in the DNA synthesis market<\/a>.<\/p>\n\n\n\n

For more details, you can also download the SAMPLE REPORT<\/a> on DNA manufacturing by Roots Analysis.<\/p>\n\n\n\n

Web: https:\/\/www.rootsanalysis.com\/<\/a><\/p>\n\n\n\n

LinkedIn: https:\/\/in.linkedin.com\/company\/roots-analysis<\/a><\/p>\n\n\n\n

Twitter: https:\/\/twitter.com\/RootsAnalysis.com<\/a><\/p>\n\n\n\n

Medium: https:\/\/medium.com\/@RootsAnalysis<\/a><\/p>\n\n\n\n


<\/p>\n","protected":false},"excerpt":{"rendered":"

In the 20th century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as Oligonucleotide therapeutics. These short, single-stranded DNA or RNA molecules, which are the product of DNA manufacturing services, have various applications in biopharmaceutical and biotechnology […]<\/p>\n","protected":false},"author":69,"featured_media":16694,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[416],"tags":[722,414,719,720],"class_list":["post-13096","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-oligonucleotides","tag-oligo-synthesis","tag-oligonucleotide","tag-oligonucleotide-synthesis","tag-oligonucleotide-therapeutics"],"yoast_head":"\nOligonucleotide Therapeutics- Driving Force for CMOs<\/title>\n<meta name=\"description\" content=\"According to Roots Analysis, more than 95 players claim to offer synthesis services for oligonucleotide therapeutics\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" 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