{"id":20032,"date":"2023-10-27T21:47:53","date_gmt":"2023-10-27T16:17:53","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=20032"},"modified":"2024-04-26T12:30:01","modified_gmt":"2024-04-26T07:00:01","slug":"carvac-and-bnt211-01-preliminary-results","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/carvac-and-bnt211-01-preliminary-results\/","title":{"rendered":"BioNtech Reports Preliminary Phase I\/II Results of its CAR T Cell Therapy CarVAC and BNT211-01 (NEO-PTC-01) at European Society for Medical Oncology (ESMO) Conference"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\">On 24 October 2023, BioNtech announced the preliminary results of phase I\/II trial evaluating BNT.221-01, a combination of Claudin 6 (CLDN6)-targeted CAR T cell therapy and the mRNA-based CAR T booster CarVac at ESMO conference in Madrid. BioNtech reported acceptable safety and tolerability data and first hints to efficacy in solid tumours. The CAR T cells used for the treatment were produced by an automated process. Following lymphodepletion, CAR T cells were dosed at four dose levels (DLs, 1\u00d7106 up to 2-5\u00d7108 CAR-T cells) plus \u00b1 repeat CLDN6 CARVac dosing (1\u00d750 \u03bcg, then 100 \u03bcg doses).<br><br>It is worth highlighting that 38 patients suffering from ovarian cancer and germ cell tumors were treated as of 25 July 2023. Further, 23 patients (61%) experienced grade 3 and above treatment emergent adverse events (TEAEs), including 20 (53%) with TEAEs related to CAR-T cells. Additionally, 9 of the 21 patients treated with the combination therapy reported TEAEs above grade three related to both drugs, and two (10%) to CARVac. Dose limiting toxicities occurred in two patients from different cohorts, therefore, maximum tolerated dose (MTD) could not be determined. One treatment-related death was reported after the data cut-off. However, cytokine-release syndrome, which generally occurs in patients treated with CAR T cell therapy, was predominantly (95%) grade 1 or 2 and observed in 18 (47%) patients.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">According to Roots Analysis, <a href=\"https:\/\/www.rootsanalysis.com\/reports\/car-t-cell-therapy-market\/269.html\"><strong>CAR T cell therapy market<\/strong><\/a> size is poised to reach USD 25 billion by 2035, growing at a CAGR of 20% from 2022 to 2035.<br><br>For detailed insights about this domain, check out our report on <a href=\"https:\/\/www.rootsanalysis.com\/reports\/car-t-cell-therapy-market\/269.html\"><strong>CAR T Cell Therapy Market<\/strong><\/a> or email <a href=\"mailto:sales@rootsanalysis.com\">sales@rootsanalysis.com<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>On 24 October 2023, BioNtech announced the preliminary results of phase I\/II trial evaluating BNT.221-01, a combination of Claudin 6 (CLDN6)-targeted CAR T cell therapy and the mRNA-based CAR T booster CarVac at ESMO conference in Madrid. BioNtech reported acceptable safety and tolerability data and first hints to efficacy in solid tumours. The CAR T [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":13656,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[1064,118],"tags":[854],"class_list":["post-20032","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-cell-and-gene-therapy","category-cell-therapy","tag-car-t-cells"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>CarVAC and BNT211-01 Preliminary Results<\/title>\n<meta name=\"description\" content=\"BioNtech Reports Preliminary Phase I\/II Results of its CAR T Cell Therapy CarVAC and BNT211-01 (NEO-PTC-01) at European Society for Medical\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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