{"id":9183,"date":"2018-09-11T12:05:12","date_gmt":"2018-09-11T12:05:12","guid":{"rendered":"https:\/\/www.rootsanalysis.com\/blog\/?p=9183"},"modified":"2024-08-21T17:06:55","modified_gmt":"2024-08-21T11:36:55","slug":"adc-manufacturing-current-landscape-growth-opportunities-and-future-market-outlook","status":"publish","type":"post","link":"https:\/\/www.rootsanalysis.com\/blog\/adc-manufacturing-current-landscape-growth-opportunities-and-future-market-outlook\/","title":{"rendered":"ADC Manufacturing: Current Landscape and Growth Opportunities"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><a href=\"https:\/\/www.rootsanalysis.com\/blog\/rise-of-antibody-drug-conjugate\/\">Antibody drug conjugates<\/a> (ADCs) are one of the most popular classes of targeted therapeutic agents and have captured the attention of both large and small pharmaceutical companies, and academic \/ research institutions across the world. Owing to the fact that these novel conjugates act as <a href=\"https:\/\/www.rootsanalysis.com\/reports\/hpapi-and-cytotoxic-drugs-manufacturing\/299.html\">cytoxic drugs and HPAPI<\/a> molecules, their manufacturing requires elaborate technical capabilities, along with the required expertise and manufacturing acumen related to both biologics and highly potent chemical substances. The production of the cytotoxic payloads that are used in ADCs requires specialized manufacturing facilities and equipment, highly contained production environments and experts in advanced synthetic chemistry and purification techniques. Although some big pharma companies carry out in-house manufacturing of their ADC products, the trend of outsourcing such operations is likely to flourish in the coming years.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Owing to complex development \/ production process requirements, industry stakeholders concur on the opinion that outsourcing is a beneficial business strategy for ADC products<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The contract services market is niche with limited number of players having manufacturing \/ conjugation capabilities; however, over 10 companies claim to be one-stop-shops<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The US and EU, with relatively more manufacturing facilities dedicated to the production of ADCs and their components, are the key manufacturing hubs<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Majority of ADC developers are dependent on contract manufacturers for the supply of their late-stage product candidates and their components<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"449\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Outsourced-Activity-of-Late-Stage-Molecules-Roots-2.webp\" alt=\"Over 50% of ADC therapeutics are currently in phase I of development. Additionally, close to 20% are using MMAE payload\" class=\"wp-image-17899\" style=\"object-fit:contain;width:800px;height:529px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Outsourced-Activity-of-Late-Stage-Molecules-Roots-2.webp 672w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Outsourced-Activity-of-Late-Stage-Molecules-Roots-2-300x200.webp 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/figure>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong><em>Case Study: <\/em>Presently, there are over 400 registered clinical trials with 70,000+ enrolled patients, evaluating the therapeutic potential of ADCs in multiple centers across the globe<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"437\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Clinical-Trails-Analysis-Roots.webp\" alt=\"Currently, over 35,000 patients are enrolled in clinical trials focused on ADC Therapeutics followed by over 25,000 patients in Europe.\" class=\"wp-image-17888\" style=\"object-fit:contain;width:800px;height:520px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Clinical-Trails-Analysis-Roots.webp 672w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Therapeutics-Clinical-Trails-Analysis-Roots-300x195.webp 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/figure>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>In order to keep pace with the growing demand for ADC therapeutics, several contract manufacturers have invested or entered into strategic alliances to expand existing capabilities<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The global capacity for <a href=\"http:\/\/www.adcmanufacturing.com\/\">bioconjugation<\/a> is driven by mid to large-sized CMOs; most of this capacity is installed in facilities based in Europe<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"437\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Bioconjucagation-Capacity-Analysis-Roots.webp\" alt=\"As per Roots Analysis, About 12% of total ADC contract manufacturers bioconjugation capacity is being captured by Lonza. \" class=\"wp-image-17889\" style=\"object-fit:contain;width:800px;height:521px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Bioconjucagation-Capacity-Analysis-Roots.webp 672w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Bioconjucagation-Capacity-Analysis-Roots-300x195.webp 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/figure>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>As more pipeline candidates gain approval, the commercial ADC therapeutics are anticipated to drive over 90% of the demand by 2030<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The installed capacity is sufficient to meet the current overall annual demand; however, as the demand rises, CMOs will be required to invest in installing incremental capacity<\/strong><\/p>\n\n\n<div class=\"wp-block-image\">\n<figure class=\"aligncenter size-full is-resized\"><img loading=\"lazy\" decoding=\"async\" width=\"672\" height=\"433\" src=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Demand-Vs-Supply-Analysis-Roots.webp\" alt=\"The ADC therapeutics manufacturing capacity is likely to fulfill the rising demand by 2030\" class=\"wp-image-17890\" style=\"object-fit:contain;width:800px;height:516px\" srcset=\"https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Demand-Vs-Supply-Analysis-Roots.webp 672w, https:\/\/www.rootsanalysis.com\/blog\/wp-content\/uploads\/2023\/10\/ADC-Manufacturing-Demand-Vs-Supply-Analysis-Roots-300x193.webp 300w\" sizes=\"auto, (max-width: 672px) 100vw, 672px\" \/><\/figure>\n<\/div>\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>With over 70% of the ADC manufacturing operations currently being outsourced, we expect the market to grow at an annualized rate of over 10% during the next decade<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>The market is likely to be distributed across various linker and payload types; mytansinoid and auristatin based candidates are expected to account for relatively higher market shares<\/strong>.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p class=\"wp-block-paragraph\">To learn more, please click <a href=\"https:\/\/www.rootsanalysis.com\/reports\/adc-contract-manufacturing-market\/218.html\">ADC contract manufacturing market<\/a>. For any queries \/ suggestions, please do not hesitate to contact us at <a href=\"mailto:sales@rootsanalysis.com\">sales@rootsanalysis.com<\/a>.\u00a0You can also download the\u00a0<a href=\"https:\/\/www.rootsanalysis.com\/reports\/218\/request-sample.html\">SAMPLE REPORT<\/a>\u00a0on ADC contract manufacturing by Roots Analysis.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Our Social Media Platform<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Web:&nbsp;<a href=\"https:\/\/www.rootsanalysis.com\/\">https:\/\/www.rootsanalysis.com\/<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">LinkedIn:&nbsp;<a href=\"https:\/\/in.linkedin.com\/company\/roots-analysis\">https:\/\/in.linkedin.com\/company\/roots-analysis<\/a><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Twitter:&nbsp;<a href=\"https:\/\/twitter.com\/RootsAnalysis\">https:\/\/twitter.com\/RootsAnalysis<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Antibody drug conjugates (ADCs) are one of the most popular classes of targeted therapeutic agents and have captured the attention of both large and small pharmaceutical companies, and academic \/ research institutions across the world. Owing to the fact that these novel conjugates act as cytoxic drugs and HPAPI molecules, their manufacturing requires elaborate technical [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":19171,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[102,99],"tags":[240,241],"class_list":["post-9183","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-antibodies","category-biologics","tag-adc-manufacturing","tag-market-outlook"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v28.2 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>ADC Manufacturing: Current Landscape &amp; Growth Opportunities<\/title>\n<meta name=\"description\" content=\"Antibody drug conjugates (ADC) manufacturing are one of the most popular classes of targeted therapeutic agents and have captured...\" \/>\n<meta name=\"robots\" content=\"index, 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