Market Insights Reports

Over the last few decades, there have been significant advancements in the field of molecular biology. In this domain, molecular diagnostic testing has emerged an important tool for disease diagnosis and monitoring. In fact, with outbreak of COVID-19 in 2020, the industry witnessed a significant surge in the demand for molecular diagnostics. As a result of this, researchers shifted their focus on the development of more efficient molecular diagnostic methods, such as RNA extraction and RNA purif more

The oral solid dosage (OSD) market is the largest segment in the pharmaceutical industry, anticipated to reach over USD 900 billion by 2027. However, one of key concerns associated with this industry is that the active pharmaceutical ingredients (APIs) used in orally administered dosage forms inherently possess an unpleasant taste / odor. The existence of such taste in drug formulations is unappealing and has been shown to have a negative impact on patient compliance, particularly among the pedi more

The advancements in health care and available technologies have inadvertently led to an increase in the life expectancy of individuals. However, this has also led to a rise in the aging population worldwide. According to the United Nations, the aforementioned trend is one of the key transformations observed in the 21st century; it is expected to have an impact on all sections of the society. Aging is linked to a variety of diseases, including cardiovascular disorders, neurodegenerative disorders more

As per recent estimates (reported in May 2022), more than 11.6 billion doses of COVID-19 vaccines have been administered across 184 countries; this value roughly translates to 20.9 million doses per day. Vaccines have enabled the prevention of more than 37 million deaths due to various disease indications, such as cholera, diphtheria, influenza, tetanus, whooping cough and measles, between 2000 to 2019. Given the rate at which the global population is growing and taking into consideration the pr more

DNA or RNA molecules find a variety of applications in the biopharmaceutical industry for genetic testing, medical research, therapeutic development, forensic investigation, and other analytical processes. It is worth highlighting that several research studies are being conducted to evaluate the use of oligonucleotides, especially DNA, as a therapeutic intervention for treatment of various medical conditions. The approval of the first antisense oligonucleotide drug, Fomivirse, in 1998, led to a more

The field of gene cloning remained a largely unexplored area until 1973, when A. C. Y. Chang, H. W. Boyer, R. B. Helling and Stanley N. Cohen reported that individual genes can be cloned and isolated by cleaving DNA enzymatically into DNA fragments. Over time, the evolution of genome engineering techniques has allowed for alterations in the genome of microorganisms, thereby enabling the production of substances having various research and therapeutic applications. DNA cloning, which is a highly more

According to the World Health Organization (WHO), cancer is the second leading causes of mortality worldwide. In this context, it is important to highlight that around 10 million cancer deaths are reported globally each year. Further, it is estimated that, by 2030, around 21.4 million new patients are likely to be diagnosed with cancer annually. In fact, the global cancer burden is likely to increase by 70%, over the next two decades. With an aim to counter the rising number of cancer cases acro more

The biopharmaceutical industry has witnessed significant growth over the past few years. Till date, more than 620 biologics have already been approved by the USFDA, while 8,000 are under clinical evaluation. The increased number of approvals and ongoing clinical trials demonstrate the growing popularity of novel treatment options for a variety of ailments and diseases. As a result, several stakeholders have opted to modernize their conventional biomanufacturing technologies in order to cope up w more

RNAi therapeutics have garnered significant attention post the 2006 Nobel Prize that was awarded to Andrew Fire and Craig Mello for the discovery of RNA interference (RNAi). Subsequently, upon the approval of the first RNAi therapeutic, ONPATTRO®, in 2018, the field has witnessed a further surge in activity. Since then, three more RNAi based therapies, namely (in chronological order of approval year) GIVLAARI® (November 2019), LEQVIO® (October 2020) and OXLUMO™ (November 2020), more

Unlike the prophylactic vaccines that are designed and administered as a precautionary measure to prevent the occurrence of a disease, researchers have developed therapeutic vaccines intended to alleviate the suffering of patients already infected with the disease. Therapeutic vaccines are not as efficacious as prophylactic vaccines; however, they demonstrate safety, specificity and a long-lasting response across various clinical conditions. These vaccines help the immune system in recognizing a more

According to the World Health Organization (WHO), the prevalence of chronic diseases, such as heart diseases, cancers and diabetes, has increased at a steady pace in recent years. It is worth highlighting that six out of ten individuals in the US are anticipated to be suffering from at least one chronic disease. Specifically, such patients are required to take medication on a daily basis, necessitating frequent hospital visits. As per a recent study conducted by the US Centers for Disease Contro more

Animal testing has been the most common method in various experimental studies in biomedical research, given their resemblance to humans in terms of genetics, anatomy, and physiology. Specifically, mice genome has 80% similarity with humans, which makes them excellent models for various research purposes. However, the use of animals in scientific research is associated with several ethical concerns, which led to the establishment of the principle of 3Rs- Replacement, Reduction and Refinement, to more

Contemporary medical science has traced thousands of clinical conditions to a genetic cause. Cancer, a life-threatening disease, also has genetic origins, and is considered among the leading causes of death across the globe. In fact, the World Health Organization (WHO) has reported that close to 10 million cancer related deaths annually, across the world. Moreover, experts believe that there are over 7,000 different types of rare diseases (including some rare forms of cancer), most of which orig more

Since the initiation of the Human Metabolome Project in 2005, the metabolomics technique has gathered significant attention from the industry stakeholders. It is worth mentioning that about 40,000 small molecules constitute the human metabolome. Further, 30% of the known genetic disorders are associated with small-molecule metabolism. Therefore, metabolome profiling can assist in obtaining a better understanding of the disease. The approach has also demonstrated to be capable of identifying new more

Over the last decade, a steady rise has been observed in the annual number of approvals for various types of biologics (including monoclonal antibodies, cell therapies, recombinant proteins, vaccines and gene therapies). In addition, more than 8,000 biological therapeutics are currently being evaluated in clinical trials, being conducted across the globe. Evidently, biologics have emerged as one of the fastest growing segments in the pharmaceutical industry. Driven by several advantages offered more

The discovery and development process of a novel therapeutic candidate is often tedious and fraught with several challenges.The key concern associated with the overall process is the high attrition rate, which is often attributed to the trial-and-error approach followed for the drug discovery process.In fact, only a small proportion of pharmacological leads are translated into viable product candidates for clinical studies.  In addition, experts believe that close to 90% of the product cand more

Cancer, one of the leading causes of death worldwide, claimed  close to 10 million lives annually Although there are several treatment options available to control disease progression and keep malignant cells from spreading throughout the body, lasting remission is difficult to achieve. In this context, immunotherapies, a relatively recent addition to the gamut of anticancer interventions, have demonstrated significant promise. For instance, after multiple rounds of chemotherapy, a stem cel more

In 2020, close to 340 million tons of meat was estimated to be produced worldwide. Compared to the early 1960s (~70 million tons), this represents almost a 500% increase. Considering that the global population grew by 150% in the same time period, it is evident that meat consumption has increased at a rate that cannot be sustainable. Moreover, raising animals for slaughter is estimated to be responsible for close to 15% of global greenhouse gas emissions. Additionally, almost a third of the eart more

Cardiovascular diseases (CVD) are reported to be one of the leading causes of deaths across the globe, surpassing conditions, such as cancer and respiratory disorders.  According to the WHO, around one third of the annual global deaths (an estimated 18 million) can be attributed to cardiac disorders.  Specifically, coronary artery disease (CAD) is the most common form of cardiovascular disorder; around 11 million deaths were linked to this indication in 2020.  It is worth mentioni more
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