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Report Description
Given the intricacy of the anatomy and physiology of the eye, it is quite challenging to deliver an ophthalmic drug effectively to a specific ocular site. Several barriers have to be overcome for a successful ocular drug delivery. These include dilution of a drug by tears, clearance of a drug by the lymphatic system of conjunctiva and drug permeation issues with respect to the cornea, sclera and choroid. Approximately 95% of the drug, in topical eye drops, is lost due to the aforementioned barriers.
The widening gap between the demand of novel treatments and supply of drugs/ systems is going to provide a major impetus to the sustained release ocular drug delivery market in the coming decade. Different ocular drug delivery systems have been devised for supplying drugs effectively to various parts of the eye. Contact lenses and punctal plugs are used to deliver drugs to the anterior segment of the eye while intravitreal implants and injectable particulate systems are used for drug delivery into the posterior segment of the eye. There are both advantages and disadvantages of the existing drug delivery systems; advancements are being made to enhance ocular bioavailability and retention time of the drug.
In the past few years, these implants and inserts have become one of the key focus areas of researchers and companies alike. Several venture capital firms have backed the smaller organizations working in this field. In addition, partnerships and collaborations have played a pivotal role in the advancement of the market.
Scope of the Report
The ‘Sustained Release Ocular Drug Delivery Systems, 2015 – 2025 (2nd edition)’ report provides an extensive study of the emerging market of implants and particulate drug delivery systems (DDS) for ophthalmic diseases. The focus of this study is on commercial implants and those under development, their applications and the likely mid-term and long-term evolution. It is widely anticipated that such drug delivery systems have tremendous potential as they provide improved retention time compared to topical applications and offer convenience over regular intravitreal injections, mainly for posterior eye diseases.
The report covers various aspects such as technological progress, product pipeline, target indications, industry and academic research programs to assess new evolving opportunities. We have provided a competitive spider web analysis to compare different implants based on technical parameters (drug elution rate, amount of drug delivered, life of implant etc.) and their likely user friendliness. Our opinion and insights, presented in this study, were influenced by the discussions that we conducted with different ophthalmic implant developers in this industry.
The base year for the report is 2014. The report provides market forecasts for the following two time horizons: 2015 - 2020 and 2020 - 2025. In addition to the above, we have also provided our own independent perspective on the key drivers behind the growth of this market, likely challenges and potential threats. The research, analysis and insights presented in this report include the sales potential of various marketed and late stage pipeline ocular sustained drug delivery systemsbased on the current expected launch timelines, adoption rates and the estimated end-use price points.The figures mentioned in this report are in USD, unless otherwise specified.
Contents
Chapter 2 provides an executive summary of the insights captured in our research. The summary offers a high level view on where the ophthalmic drug delivery systemsmarket is headed in the short, mid and long term.
Chapter 3 provides a general introduction to the ophthalmic drug delivery market. We have discussed, in detail, the anatomy of the eye. The chapter also outlines details on different types of ocular drug delivery implants. In addition, several ocular indications, which are being targeted by sustained release implants, are also covered in this chapter.
Chapter 4 provides an overview of the ophthalmic drug delivery systems market with respect to the available marketed technologies and companies active in the field. We have provided a detailed pipeline of systems that are either marketed or are under clinical/ preclinical development. The chapter includes pipeline analysis by phase of development, system type, and indications targeted. It also covers the sustained release systems that are currently being evaluated by academic researchers and universities. In addition, we have also provided information on gene therapies that are being developed to provide a controlled treatment to several ocular indications.
Chapter 5 provides detailed profiles of 13 systems which are marketed and/ or arein late stages of clinical development (Phase II and Phase III). These profiles cover information on underlying technologies, development history, principal features (size of the implant, drug elution rate, life of the implant, related patents and intellectual property, nature of the insert) and current status of development. For each system, we have also estimated the future sales potential over the next ten years. Given the uncertainty surrounding the adoption rates, we have done a multivariate sensitivity analysis to present different tracks of industry’s evolution.
Chapter 6 reviews the 13 leading companies which are active in the area of ophthalmology sustained release drug delivery technology. Each company profile includes information on the company overview, financial performance, marketed / pipeline systems, fundings, partnerships, and recent developments.
Chapter 7 provides information on several investment instances which have driven research in the area of sustained release ocular drug delivery systems. These investments are a testament to the growing interest of different stakeholders in this industry.
Chapter 8 covers details on the recent partnerships which have taken place in this industry. We have discussed the various partnerships models in existence and the most common forms of deals / agreements which have evolved over time.
Chapter 9 provides our analysis of the strengths, weaknesses, opportunities and threats in the ophthalmology drug delivery systems market, capturing the key elements likely to influence future growth.
Chapter 10 is a collection of transcripts based on our discussion with some of the leading players in the industry. Examples of companies interviewed include Neurotech Pharmaceuticals, Mati Therapeutics, On Demand Therapeutics and Euclid Systems.
Chapter 11 summarizes the overall report. In this chapter, we provide a recap of the key takeaways and our independent opinion based on the research and analysis described in previous chapters.
Chapters 12 and 13 are appendices, which provide tabulated data and a list of companies mentioned in the report.
1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Overview
3.1. Introduction
3.2. Structure of the Eye
3.3. Ocular Drug Delivery Systems
3.3.1. Implantable Ocular Drug Delivery Systems
3.3.2. Particulate Drug Delivery Systems
3.4. Ocular Drug Delivery: Commonly Targeted Ophthalmic Disorders
3.4.1. Age-related Macular Degeneration
3.4.2. Cytomegalovirus Retinitis
3.4.3. Diabetic Retinopathy
3.4.4. Diabetic Macular Edema
3.4.5. Glaucoma
3.4.6. Ocular Infection
3.4.7. Uveitis
3.4.8. Retinal Vein Occlusion
4. MARKET OVERVIEW
4.1. Scope
4.2. Limited Marketed Ocular Systems for Sustained Drug Delivery
4.3. pSivida is the Key Technology Provider
4.4. Sustained Release Ocular Drug Delivery Systems: Pipeline Analysis
4.4.1. Distribution by Phase of Development
4.4.2. Distribution by Nature of Drug Delivery Systems
4.4.3. Distribution by Intraocular Placement of Drug Delivery Systems
4.4.4. Distribution by Indication Targeted
4.4.5. Novel Implants for Ocular Drug Delivery
4.4.6. Initial Focus on Anti-Inflammatory Drugs
4.4.7. Glaucoma: The Next Big Opportunity?
4.4.8. Universities’ Interest in Ocular Sustained Drug Delivery Systems Market
4.5. Life Cycle Management Tool
4.6. Gene Therapy
5. PRODUCT PROFILES AND SALES FORECAST
5.1. Chapter Overview
5.2. Methodology and Assumptions
5.3. Overall Market Size and Forecast, 2015-2025
5.4. Retisert (Bausch & Lomb, Inc)
5.4.1. Product Overview
5.4.2. Development and Approval History
5.4.3. Product Specifications
5.4.4. Manufacturing of Retisert
5.4.5. Product Advantages
5.4.6. Associated Risks
5.4.7. Historical Sales
5.4.8. Sales Forecast, 2015-2025
5.5. Iluvien (Alimera Sciences)
5.5.1. Product Overview
5.5.2. Development and Approval History
5.5.3. Product Specifications
5.5.4. Manufacturing of Iluvien
5.5.5. Product Advantages
5.5.6. Associated Risks
5.5.7. Iluvien Contraindications
5.5.8. Historical Sales
5.5.9. Competition
5.5.10. Opportunity for Iluvien
5.5.11. Sales Forecast, 2015-2025
5.6. Ozurdex (Allergan)
5.6.1. Product Overview
5.6.2. Development and Approval History
5.6.3. Product Specifications
5.6.4. Product Advantages
5.6.5. Associated Risks
5.6.6. Historical Sales and Reimbursement
5.6.7. Competition
5.6.8. Sales Forecast, 2015-2025
5.7. IBI-10090 (Icon Bioscience)
5.7.1. Product Specifications
5.7.2. Current Status of Development
5.7.3. Clinical Trial Results
5.7.4. Advantages
5.7.5. Competition
5.7.6. Sales Forecast, 2015-2025
5.8. OTX-DP (Ocular Therapeutix)
5.8.1. Product Specifications
5.8.2. Current Status of Development
5.8.3. Clinical Trial Results
5.8.4. Product Advantages
5.8.5. Competition
5.8.6. Sales Forecast, 2015-2025
5.9. Medidur (pSivida)
5.9.1. Product Specifications
5.9.2. Current Status of Development
5.9.3. Clinical Trial Results
5.9.4. Competition
5.9.5. Sales Forecast, 2015-2025
5.10. Bimatoprost Sustained Release Implant (Allergan)
5.10.1. Product Specifications
5.10.2. Current Status of Development
5.10.3. Clinical Trial Results
5.10.4. Product Advantages
5.10.5. Competition
5.10.6. Sales Forecast, 2015-2025
5.11. NT-501 (Neurotech Pharmaceuticals)
5.11.1. Product Specifications
5.11.2. Current Status of Development
5.11.3. Phase II Clinical Trial Results
5.11.4. Product Advantages
5.11.5. Sales Forecast, 2015-2025
5.12. Punctal Plug Delivery System (Mati Therapeutics)
5.12.1. Product Specifications
5.12.2. Current Status of Development
5.12.3. Clinical Trial Results
5.12.4. Product Advantages
5.12.5. Competition
5.12.6. Sales Forecast, 2015-2025
5.13. OTX-TP (Ocular Therapeutix)
5.13.1. Product Specifications
5.13.2. Current Status of Development
5.13.3. Clinical Trial Results
5.13.4. Product Advantages
5.13.5. Competition
5.13.6. Sales Forecast, 2015-2025
5.14. NT-503 (Neurotech Pharmaceuticals)
5.14.1. Product Specifications
5.14.2. Current Status of Development
5.14.3. Phase I Clinical Trial Results
5.14.4. Product Advantages
5.14.5. Sales Forecast, 2015-2025
5.15. Unnamed, Novadur (Allergan)
5.15.1. Product Specifications
5.15.2. Current Status of Development
5.15.3. Clinical Trial Results
5.15.4. Sales Forecast, 2015-2025
5.16. ProDex (Taiwan Liposome Company)
5.16.1. Product Specifications
5.16.2. Current Status of Development
5.16.3. Product/ Technology Advantages
5.17. Comparative Analysis of Sustained Release Ocular Drug Delivery Systems
5.17.1. Biodegradable Systems
5.17.2. Non-Biodegradable Systems
6. COMPANY PROFILES
6.1. Chapter Overview
6.2. pSivida
6.2.1. Company Overview
6.2.2. Financial Performance
6.2.3. Durasert and Tethadur Technology
6.2.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.2.5. Collaborations
6.2.6. Recent Developments
6.3. Allergan
6.3.1. Company Overview
6.3.2. Financial Performance
6.3.3. Novadur Technology
6.3.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.3.5. Collaborations
6.3.6. Recent Developments
6.4. Icon Bioscience
6.4.1. Company Overview
6.4.2. Funding
6.4.3. Verisome Technology
6.4.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.4.5. Recent Developments
6.5. Ocular Therapeutix
6.5.1. Company Overview
6.5.2. Financial Performance
6.5.3. Funding
6.5.4. Hydrogel Technology
6.5.5. Sustained Release Ocular Drug Delivery Systems Portfolio
6.5.6. Recent Developments
6.6. Neurotech Pharmaceuticals
6.6.1. Company Overview
6.6.2. Funding
6.6.3. Encapsulated Cell Technology
6.6.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.6.5. Collaborations
6.7. Santen Pharmaceutical
6.7.1. Company Overview
6.7.2. Financial Performance
6.7.3. Ophthalmology: Leading Marketed Drugs
6.7.4. CHRONIJECT Microsphere Technology
6.7.5. Sustained Release Ocular Drug Delivery Systems Portfolio
6.7.6. Collaborations
6.8. Aciont Inc.
6.8.1. Company Overview
6.8.2. Funding
6.8.3. Visulex Technology
6.8.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.9. Envisia Therapeutics
6.9.1. Company Overview
6.9.2. Funding
6.9.3. Sustained Release Ocular Drug Delivery Technology
6.9.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.10. GrayBug
6.10.1. Company Overview
6.10.2. Funding
6.10.3. Sustained Release Ocular Drug Delivery Technology
6.10.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.10.5. GrayBug: In The News
6.11. Innocore Pharmaceuticals
6.11.1. Company Overview
6.11.2. Sustained Release Ocular Drug Delivery Technology
6.11.3. Sustained Release Ocular Drug Delivery Systems Portfolio
6.11.4. Collaborations
6.12. OHR Pharmaceuticals
6.12.1. Company Overview
6.12.2. Financial Performance
6.12.3. SKS Ocular Sustained Release Technology
6.12.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.12.5. Collaborations
6.13. PolyActiva
6.13.1. Company Overview
6.13.2. Funding
6.13.3. Sustained Release Ocular Drug Delivery Technology
6.13.4. Sustained Release Ocular Drug Delivery Systems Portfolio
6.13.5. Collaborations
6.14. TheraKine
6.14.1. Company Overview
6.14.2. Sustained Release Ocular Drug Delivery Technology
6.14.3. Sustained Release Ocular Drug Delivery Systems Portfolio
6.14.4. Collaborations
7. VENTURE CAPITAL SUPPORT
7.1. Chapter Overview
7.2. Instances of Investments / Grants in Sustained Release Ocular Drug Delivery Market
7.3. Growing Venture Capitalist Interest
7.4. Distribution of Funding Instances by Type of Funding
7.5. Distribution by Total Amount of Investment in a Category
8. RECENT PARTNERSHIPS
8.1. Chapter Overview
8.1.1. Partnership Models / Agreements
8.1.2. Collaborations Amongst Stakeholders are on a Rise
8.1.3. Product/ Technology Development, Acquisitions and Product/ Technology Licensing Are Preferred Modes of Collaboration
8.1.4. Most Active Companies in Sustained Release Ocular Drug Delivery Systems
9. SWOT ANALYSIS
9.1. Chapter Overview
9.2. Strengths
9.3. Weaknesses
9.4. Opportunities
9.5. Threats
10. INTERVIEW TRANSCRIPTS
10.1. Quinton Oswald, President and CEO, Neurotech Pharmaceuticals
10.2. Bob Butchofsky, Founder and CEO, Mati Therapeutics
10.3. John Santini, President and CEO, On Demand Therapeutics
10.4. Michael A Ross, Chief Executive Officer and Allan Kaplan, Chief Financial Officer, Euclid Systems
10.5. Other Anonymous Respondents
11. CONCLUSION
11.1. With A Huge Potential, Market Likely to Evolve Rapidly in Mid-Long Term
11.2. Ophthalmic Indications and Improved Patient Compliance Are Amongst the Several Growth Drivers
11.3. Key Emerging Technologies: Novel Methods for Efficient Drug Delivery
11.4. A Number of Opportunities Outweigh Existing Challenges
11.5. Concluding Remarks
12. APPENDIX 1: TABULATED DATA
13. APPENDIX 2: LIST OF COMPANIES
Figure 4.1 Ocular Drug Delivery Implants: Approval Timeline
Figure 4.2 Sustained Release Ocular Drug Delivery Systems: Distribution by Phase of Development
Figure 4.3 Sustained Release Ocular Drug Delivery Systems: Distribution by Nature of System
Figure 4.4 Sustained Release Ocular Drug Delivery Systems: Distribution by Site of Intraocular Placement
Figure 4.5 Sustained Release Ocular Drug Delivery Systems: Distribution by Target Indication
Figure 4.6 Sustained Release Ocular Drug Delivery Systems, University Research: Distribution by Target Indication
Figure 4.7 Lucentis Sales, 2010-2014 (USD Million)
Figure 4.8 Lumigan Sales, 2010-2014 (USD Million)
Figure 5.1 Overall Sales Forecast, Short-Mid Term (2014 – 2020), USD Million (Base Scenario)
Figure 5.2 Overall Sales Forecast, Mid- Long term (2020 – 2025), USD Million (Base Scenario)
Figure 5.3 Retisert Sales, 2010 – 2014 (USD Million)
Figure 5.4 Retisert Sales Forecast: Short-Mid Term, USD Million (Base Scenario)
Figure 5.5 Retisert Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.6 Iluvien Sales, 2013-2014 (USD Million)
Figure 5.7 IVT Treated DME: US Market Share by Leading Drugs (%)
Figure 5.8 Iluvien Sales Forecast: Short-Mid Term, USD Million (Base Scenario)
Figure 5.9 Iluvien Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.10 Ozurdex Development Timeline
Figure 5.11 Ozurdex Sales, 2010 – 2014 (USD Million)
Figure 5.12 Ozurdex Sales Forecast: Short-Mid Term, USD Million (Base Scenario)
Figure 5.13 Ozurdex Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.14 IBI-10090 Sales Forecast: Short-Mid Term, USD Million (Base Scenario)
Figure 5.15 IBI-10090 Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.16 OTX-DP Sales Forecast: Mid-Long Term, USD Million (Base Scenario)
Figure 5.17 Retisert, Iluvien, Ozurdex and Medidur: Percentage Share of Patients Reported to Have Developed IOP
Figure 5.18 Medidur Sales Forecast: Mid-Long Term, USD Million (Base Scenario)
Figure 5.19 Bimatoprost Sustained Release Implant Sales Forecast: Mid-Long Term, USD Million (Base Scenario)
Figure 5.20 NT-501 Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.21 PPDS Sales Forecast: Mid-Long Term, USD Million (Base Scenario)
Figure 5.22 OTX-TP Sales Forecast: Mid-Long Term, USD Million (Base Scenario)
Figure 5.23 NT-503 Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.24 Unnamed (Novadur) Sales Forecast: Long Term, USD Million (Base Scenario)
Figure 5.25 Biodegradable Sustained Release Ocular DDS: Comparative Analysis
Figure 5.26 Non-Biodegradable Sustained Release Ocular DDS: Comparative Analysis
Figure 6.1 pSivida Revenues, 2012-Q3 2015 (USD ‘000)
Figure 6.2 Allergan Revenues, 2010-2014 (USD Million)
Figure 6.3 Allergan Revenues: Distribution by Business Segment, 2012-2014 (USD Million)
Figure 6.4 Allergan Specialty Pharmaceuticals Revenues: Distribution by Therapeutic Areas, 2014 (USD Million)
Figure 6.5 Allergan Revenues: Distribution by Sub-Segments of Medical Devices, 2014 (USD Million)
Figure 6.6 Allergan: Sales of Leading Marketed Ophthalmic Drugs (USD Million), 2013-2014
Figure 6.7 Icon Bioscience: Milestone Chart
Figure 6.8 Ocular Therapeutix Revenues, 2014 (USD’000)
Figure 6.9 Neurotech Pharmaceuticals: Milestone Chart
Figure 6.10 Santen Revenues: 2009-Q3 2015 (JPY Million)
Figure 6.11 Santen Revenues: Distribution by Business Segments, 2012-2014 (JPY Million)
Figure 6.12 Santen Revenues: Distribution by Sub-Segments of Pharmaceutical Business, 2014 (JPY Million)
Figure 6.13 Santen Revenues: Distribution by Sub-Segments of Other Businesses, 2014 (JPY Million)
Figure 6.14 OHR Pharmaceuticals: Operating Expenses, 2010- Q1 2015 (USD ‘000)
Figure 7.1 Sustained Release Ocular DDS Funding Instances: Cumulative Investments by Year, 2003-2015
Figure 7.2 Sustained Release Ocular DDS Funding Instances: Distribution by Categories
Figure 7.3 Sustained Release Ocular DDS Funding Instances: Distribution by Amount Invested in a Category (USD Million)
Figure 8.1 Sustained Release Ocular DDS Partnerships: Cumulative Partnerships by Year, 2001-2014
Figure 8.2 Sustained Release Ocular DDS Partnerships: Distribution by Type of Partnership
Figure 8.3 Sustained Release Ocular DDS Partnerships: Major Stakeholders
Figure 11.1 Ocular Drug Delivery Implants: Market Landscape And Growth Drivers
Figure 11.2 Sustained Release Ocular DDS Market, 2015, 2020, 2025 (USD Million)
Table 3.1 Eye: Description of Tissue Layers
Table 4.1 Availability of Ocular Drug Delivery Implants in the US and Europe
Table 4.2 Sustained Release Ocular Drug Delivery Systems: Pipeline
Table 4.3 Sustained Release Ocular Drug Delivery Systems: Research Projects at Universities
Table 4.4 Gene Therapies under Development for Ocular Diseases
Table 5.1 Current Development Phase and Expected Launch Year of Drug Delivery Systems (Phase II and Higher)
Table 5.2 Comparison of Iluvien with Currently Available Drugs for DME
Table 5.3 Vision Loss Associated with DME, Number of Patients in the US and Major EU Countries, 2012
Table 5.4 Market Potential for Iluvien in the US
Table 5.5 Approval of Ozurdex in Different Geographies
Table 5.6 IBI-10090: Completed Clinical Trials
Table 5.7 IBI-10090: Clinical Trial Results
Table 5.8 IBI-10090 and Marketed Topicals: Comparison of Anterior Chamber Cell Count
Table 5.9 IBI10090: Competitive Landscape
Table 5.10 OTX-DP: Ongoing Clinical Trials
Table 5.11 OTX-DP: Clinical Trial Results
Table 5.12 Medidur: Status of Development
Table 5.13 Medidur: Competitive Landscape
Table 5.14 Medidur and Available Drugs for Posterior Uveitis: Comparative Analysis
Table 5.15 Bimatoprost Implant: Patents
Table 5.16 NT-501: Ongoing Clinical Trials
Table 5.17 PPDS: Patents
Table 5.18 OTX-TP: Clinical Trials
Table 5.19 OTX-TP: Efficacy Results
Table 5.20 NT-503: Key Features
Table 5.21 NT503: Clinical Trial Result
Table 5.22 Brimonidine Implant: Patents
Table 5.23 Unnamed (Novadur): Clinical Trials
Table 5.24 Biodegradable Sustained Release Ocular DDS: Comparative Analysis
Table 5.25 Non-Biodegradable Sustained Release Ocular DDS: Comparative Analysis
Table 6.1 pSivida: Sustained Release Ocular DDS Pipeline
Table 6.2 pSivida: Revenues Received from Alimera Sciences (2009-2013), USD Million
Table 6.3 pSivida: Revenues Received from Restated Pfizer Agreement (2009-2013), USD Million
Table 6.4 Marketing Authorization Approvals: Iluvien (2014-2015)
Table 6.5 Allergan: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.6 Icon Bioscience: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.7 Ocular Therapeutix: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.8 Neurotech Pharmaceuticals: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.9 NT-501: Orphan Drug and Fast Track Designations
Table 6.10 Neurotech: Research Collaborations
Table 6.11 Santen: Pipeline of Ophthalmology Drugs/ Systems
Table 6.12 Aciont Inc: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.13 Envisia Therapeutics: Company Overview
Table 6.14 Envisia Therapeutics: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.15 GrayBug: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.16 GrayBug: In The News
Table 6.17 Innocore Pharmaceuticals: Company Overview
Table 6.18 Innocore Pharmaceuticals: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.19 OHR Pharmaceuticals: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.20 PolyActiva: Company Overview
Table 6.21 PolyActiva: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 6.22 TheraKine: Company Overview
Table 6.23 TheraKine: Sustained Release Ocular Drug Delivery Systems Pipeline
Table 7.1 List of Funding Rounds / Grants and Investors Involved
Table 8.1 Sustained Release Ocular Drug Delivery Systems: List of Partnerships
Table 9.1 Sustained Release Ocular Drug Delivery Systems: SWOT Analysis
Table 9.2 Development of Sustained Release Ocular Systems: Example Venture Capital Funding Instances
Table 12.1 Sustained Release Ocular Drug Delivery Systems: Distribution by Phase of Development
Table 12.2 Sustained Release Ocular Drug Delivery Systems: Distribution by Nature of System
Table 12.3 Sustained Release Ocular Drug Delivery Systems: Distribution by Site of Intraocular Placement
Table 12.4 Sustained Release Ocular Drug Delivery Systems: Distribution by Target Indication
Table 12.5 Sustained Release Ocular Drug Delivery Systems, University Research: Distribution by Target Indication
Table 12.8 Overall Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Base Scenario)
Table 12.9 Overall Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.10 Overall Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Conservative Scenario)
Table 12.11 Overall Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.12 Overall Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Optimistic Scenario)
Table 12.13 Overall Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.14 Retisert Sales, 2010-2014 (USD Million)
Table 12.15 Retisert Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Base Scenario)
Table 12.16 Retisert Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.17 Retisert Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Conservative Scenario)
Table 12.18 Retisert Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.19 Retisert Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Optimistic Scenario)
Table 12.20 Retisert Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.21 Iluvien Sales, 2013-2014 (USD Million)
Table 12.22 IVT Treated DME: US Market Share by Leading Drugs (%)
Table 12.23 Iluvien Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Base Scenario)
Table 12.24 Iluvien Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.25 Iluvien Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Conservative Scenario)
Table 12.26 Iluvien Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.27 Iluvien Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Optimistic Scenario)
Table 12.28 Iluvien Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.30 Ozurdex Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Base Scenario)
Table 12.31 Ozurdex Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.32 Ozurdex Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Conservative Scenario)
Table 12.33 Ozurdex Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.34 Ozurdex Sales Forecast, Short-Mid Term (2015 – 2020), USD Million (Optimistic Scenario)
Table 12.35 Ozurdex Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.36 IBI-10090 Sales Forecast, Short-Mid Term (2016 – 2020), USD Million (Base Scenario)
Table 12.37 IBI-10090 Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.38 IBI-10090 Sales Forecast, Short-Mid Term (2016 – 2020), USD Million (Conservative Scenario)
Table 12.39 IBI-10090 Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.40 IBI-10090 Sales Forecast, Short-Mid Term (2016 – 2020), USD Million (Optimistic Scenario)
Table 12.41 IBI-10090 Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.42 OTX-DP Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Base Scenario)
Table 12.43 OTX-DP Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Conservative Scenario)
Table 12.44 OTX-DP Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Optimistic Scenario)
Table 12.45 Retisert, Iluvien, Ozurdex and Medidur: % Share of Patients Reported to Have Developed IOP
Table 12.46 Medidur Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Base Scenario)
Table 12.47 Medidur Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Conservative Scenario)
Table 12.48 Medidur Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Optimistic Scenario)
Table 12.49 Bimatoprost Sustained Release Implant Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Base Scenario)
Table 12.50 Bimatoprost Sustained Release Implant Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Conservative Scenario)
Table 12.51 Bimatoprost Sustained Release Implant Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Optimistic Scenario)
Table 12.52 NT-501 Forecast, Mid-Long Term (2019 – 2025), USD Million (Base Scenario)
Table 12.53 NT-501 Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Conservative Scenario)
Table 12.54 NT-501 Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Optimistic Scenario)
Table 12.55 PPDS Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Base Scenario)
Table 12.56 PPDS Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Conservative Scenario)
Table 12.57 PPDS Sales Forecast, Mid-Long Term (2019 – 2025), USD Million (Optimistic Scenario)
Table 12.58 OTX-TP Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Base Scenario)
Table 12.59 OTX-TP Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Conservative Scenario)
Table 12.60 OTX-TP Sales Forecast, Mid-Long Term (2020 – 2025), USD Million (Optimistic Scenario)
Table 12.61 NT-503 Sales Forecast, Mid-Long Term (2021 – 2025), USD Million (Base Scenario)
Table 12.62 NT-503 Sales Forecast, Mid-Long Term (2021 – 2025), USD Million (Conservative Scenario)
Table 12.63 NT-503 Sales Forecast, Mid-Long Term (2021 – 2025), USD Million (Optimistic Scenario)
Table 12.64 Unnamed (Novadur) Sales Forecast, Mid-Long Term (2022 – 2025), USD Million (Base Scenario)
Table 12.65 Unnamed (Novadur) Sales Forecast, Mid-Long Term (2022 – 2025), USD Million (Conservative Scenario)
Table 12.66 Unnamed (Novadur) Sales Forecast, Mid-Long Term (2022 – 2025), USD Million (Optimistic Scenario)
Table 12.67 pSivida Revenues, 2012- Q3 2015 (USD’000)
Table 12.68 Allergan Revenues, 2010- 2014 (USD Million)
Table 12.69 Allergan Revenues: Distribution by Business Segment, 2012-2014 (USD Million)
Table 12.70 Allergan Specialty Pharmaceuticals Revenues: Distribution by Therapeutic Areas, 2014 (USD Million)
Table 12.71 Allergan Revenues: Distribution by Sub Segments of Medical Devices, 2014 (USD Million)
Table 12.72 Allergan: Sales for Leading Marketed Ophthalmic Drugs, 2013-2014 (USD Million)
Table 12.73 Ocular Therapeutix Revenues, 2014 (USD’ 000)
Table 12.74 Santen Revenues, 2009- Q3 2015 (JPY Million)
Table 12.75 Santen Revenues: Distribution by Business Segments, 2012-2014 (JPY Million)
Table 12.76 Santen Revenues: Distribution by Sub-Segments of Pharmaceutical Business, 2013-2014 (JPY Million)
Table 12.77 Santen Revenues: Distribution by Sub-Segments of Other Businesses, 2013-2014 (JPY Million)
Table 12.78 OHR Pharmaceuticals: Operating Expenses, 2010-Q1 2015 (USD’000)
Table 12.79 Sustained Release Ocular DDS Funding Instances: Cumulative Investments by Year, 2003-2015
Table 12.80 Sustained Release Ocular DDS Funding Instances: Distribution by Categories
Table 12.81 Sustained Release Ocular DDS Funding Instances: Distribution by Amount Invested In a Category (USD Million)
Table 12.82 Sustained Release Ocular DDS: Cumulative Partnerships by Year, 2001-2014
Table 12.83 Sustained Release Ocular DDS Partnerships: Distribution by Type of Partnership
Table 12.84 Sustained Release Ocular DDS Partnerships: Major Stakeholders
The following companies and organizations have been mentioned in the report.
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