// changes done below on July 01 2024 // till here on July 01 2024

Top 5 ADC Manufacturers Offering Contract Services

Published: June 2024


These players are engaged in offering contract services for the analytical development and manufacturing of antibody drug conjugates across multiple scales of operation. We analyzed 30 companies that are focused on offering contract manufacturing and bioconjugation services for antibody drug conjugates. In this article, discover the 5 leading ADC manufacturers and their service portfolios.


In the last decade, the healthcare industry has witnessed a substantial increase in the global cancer disease burden, which reflects population growth and ageing. Therefore, in order to address the growing impact of cancer, industry stakeholders are actively pursuing efficient and targeted treatment approaches. Amidst the rapid innovation and advancements, the healthcare domain has witnessed the emergence of a key therapeutic modality, antibody drug conjugate, that has demonstrated its potential in the precise treatment across several oncological conditions. Spurred by superior clinical profiles, coupled with minimal immunogenicity and a long circulating half-life, antibody drug conjugates are widely being studied for their targeted treatment potential. In this context, the current clinical landscape of antibody drug conjugate features the presence of over 260 candidates, along with 23 ADC therapeutics already being approved by regulatory authorities.

Despite their potential, the ADC manufacturing process is fraught with several complexities, owing to the manufacturing requirement for multiple process components including antibody, ADC payload / warheads and linker. Further, the drug / linker side reactions, contamination chances, associated toxicity and up-scaling are a few other challenges associated with the manufacturing of antibody drug conjugates. Therefore, outsourcing manufacturing operations is the most preferred choice for ADC developers, which enables cost-saving and the use of advanced technologies and expertise available with contract service providers. It is worth mentioning that ADC manufacturers providing services are actively aiming at becoming one-stop shops, in order to mitigate challenges related to scale-up and technology transfer. Considering the increasing demand for ADCs and the manufacturing advantages offered by service providers, the ADC contract manufacturing market is anticipated to grow substantially in the coming years.

Roots Analysis has conducted an exhaustive study on ADC Contract Manufacturing Market featuring the current market landscape and future opportunity for the service providers involved in the ADC contract manufacturing domain, over a span of 10 years.

Table of Contents

The top 5 ADC manufacturers are listed below (in decreasing order of competitiveness score):

Table 1: List of Top 5 ADC Manufacturers Offering Contract Servicesx`

S.No. ADC Contract Manufacturers Year of Establishment Location of Headquarters (Country) Location of Headquarters (Region)
1 MabPlex 2013 Yantai, China Asia-Pacific
2 Lonza 1897 Basel, Switzerland Europe
3 Abzena 2014 California, US North America
4 GBI 1992 Florida, US North America
5 CARBOGEN AMCIS 2000 Bubendorf, Switzerland Europe

 

Interested in exploring all the ADC manufacturers offering contract services?

Discover the Details on 5 ADC Manufacturers

This article highlights the top 5 players to watch out for in this industry. These companies were chosen based on our proprietary competitiveness analysis that are presently offering antibody drug conjugation services at commercial scale. It is essential to note that the selection of top players can differ substantially according to the defined criteria.

MabPlex, a China Based ADC Manufacturer Offering Contract Services

Mabplex - Top ADC Manufacturers Offering Contract


MabPlex is a privately held biotechnology company, focused on providing contract manufacturing services for the development of mAbs, recombinant proteins, ADCs and bispecific antibodies. Additionally, the company claims to be one of the few ADC manufacturing one-stop-shops equipped to manufacture ADCs at large scale, offering contract services from DNA to finished products to its clients. It is worth mentioning that, in September 2023, the company received the Top 5 CMOs in China, 2023 award for being in the forefront of manufacturing pharmaceuticals and making an impact in the pharma industry.

MabPlex offers following ADC related Services:

  • Antibody Production
  • HPAPI / Payload Synthesis
  • Linkers
  • Conjugation
  • Fill / Finish

Location of Manufacturing Facilities:

  • Antibody Production: Shandong, China and California, US
  • HPAPI and Payload Synthesis: Shandong, China and California, US
  • Linkers: Shandong, China and California, US
  • Conjugation: Shandong, China and California, US
  • Fill / Finish: Shandong, China and California, US

GMP / non-GMP Manufacturing: GMP Manufacturing

Recent Developments:

  • The company is engaged in providing various services related to the manufacturing and development of mAbs, recombinant proteins, ADCs and bispecifics. It is worth mentioning that the company hosted the Biopharmaceutical CMC Summit in Yantai, China, as it strives to build a reputation within the ADC contract development and manufacturing market. The summit featured the presence of over 200 industry experts engaged in biomedical industry and CMC strategy development.
  • Further details on recent initiatives taken by MabPlex as well as other ADC manufacturers have been provided in detail in the report.

Lonza, Expanding to Meet the Global Biomanufacturing Demand

Lonza - Top ADC Manufacturers Offering Contract


Lonza is a Switzerland based company that is engaged in providing services for the development of various pharmaceuticals and biotech solutions. With the acquisition of Capsugel in 2017, Lonza expanded its product and services portfolio from the custom development and manufacturing of APIs to innovative dosage forms for the pharma and consumer health and nutrition industries. It is worth mentioning that the company operates through more than 120 sites and offices located, globally.

Lonza offers following ADC related Services:

  • Antibody Production
  • HPAPI / Payload Synthesis
  • Linkers
  • Conjugation
  • Fill / Finish

Location of Manufacturing Facilities:

  • Antibody Production: Visp, Switzerland , Slough, UK  and Tuas, Singapore 
  • HPAPI and Payload Synthesis: Visp, Switzerland
  • Linkers: Visp, Switzerland
  • Conjugation: Visp, Switzerland
  • Fill / Finish: Visp, Switzerland

GMP / non-GMP Manufacturing: GMP Manufacturing

Recent Developments:

  • In April 2024, the company announced the appointment of Wolfgang Wienand as the chief executive officer of Lonza.
  • In October 2023, the company entered into a manufacturing agreement with an undisclosed biopharmaceutical partner in order to boost-up its commercial ADCs supply.
  • Further, in October 2023, the company announced extension of an agreement with a major biopharmaceutical partner for the filling of ADCs for commercial supply.
  • Further details on recent initiatives taken by Lonza as well as other ADC manufacturers have been provided in detail in the report.

Abzena, a Bioconjugates and Biologics Focused CDMO Offering End-to-End Services from Discovery through Commercialization

Abzena - Top ADC Manufacturers Offering Contract


Abzena is a US based firm that claims to offer an array of ADC development services, ranging from early discovery to launching the products at commercial scales. Furthermore, the company collaborates with various corporations and academic institutions all over the world (which includes the majority of the top 20 biopharmaceutical companies) to facilitate the research, development and manufacturing of better treatments for patients.

Abzena offers following ADC related Services:

  • Antibody Production
  • HPAPI / Payload Synthesis
  • Linkers
  • Conjugation
  • Fill / Finish

Location of Manufacturing Facilities: 

  • Antibody Production: San Diego, California, US , Cambridge, UK 
  • HPAPI and Payload Synthesis: Bristol, Pennsylvania, US , San Diego, California, US 
  • Linkers: Bristol, Pennsylvania, US , San Diego, California, US 
  • Conjugation: Cambridge, UK , Bristol, Pennsylvania, US 
  • Fill / Finish: San Diego, California, US

GMP / non-GMP Manufacturing: GMP and non-GMP Manufacturing

Recent Developments:

  • In March 2024, the company announced an investment of USD 5 million for the expansion of their bioconjugation site in Pennsylvania, US. The new facility is expected to increase the company’s existing bioconjugation and ADC capabilities and capacities to address the increasing industry demand. 
  • In June 2023, the company announced the appointment of Thomas Castellano as the Chief Financial Officer
  • Further details on recent initiatives taken by Abzena as well as other ADC manufacturers have been provided in detail in the report.

GBI (formerly known as Goodwin Biotechnology), Supporting Complex Biologic Therapy Developers

GBI - Top ADC Manufacturers Offering Contract

GBI is a US based contract service provider, primarily focused on the development and manufacturing of cytotoxic products. Additionally, the company offers cGMP manufacturing of ADCs, radioimmunoconjugates, and other protein bioconjugates from preclinical development to commercial product supply. It is also worth mentioning that the company is engaged in offering analytical method development, assay verification and characterization services to various research institutions and established multinational corporations.

GBI offers following ADC related Services:

  • Antibody Production
  • HPAPI / Payload Synthesis
  • Linkers
  • Conjugation
  • Fill / Finish

Location of Manufacturing Facilities: 

  • Antibody Production: Plantation, Florida, US  and Lexington, Kentucky, US 
  • HPAPI and Payload Synthesis: Plantation, Florida, and Lexington, Kentucky, US 
  • Linkers: Plantation, Florida and Lexington, Kentucky, US 
  • Conjugation: Plantation, Florida and Lexington, Kentucky, US
  • Fill / Finish: Plantation, Florida and Lexington, Kentucky, US

GMP / non-GMP Manufacturing: GMP Manufacturing

Recent Developments:

  • In February 2023, the company participated in the Next-Generation Conjugate Summit at Massachusetts, US.
  • In February 2022, the company appointed Darrin Schellin as the new Chief Executive Officer.
  • Further details on recent initiatives taken by GBI as well as other ADC manufacturers have been provided in detail in the report.

CARBOGEN AMCIS, Offering Wide Spectrum Services for the Pharma industry

CARBOGEN AMCIS - Top ADC Manufacturers Offering Contract


CARBOGEN AMCIS, a subsidiary of Dishman Carbogen Amcis, claims to be a leading contract service provider, offering services related to drug-development and commercialization to the pharmaceutical and biopharmaceutical industries. Additionally, the company is also engaged in offering services, such as HPAPI manufacturing, ADC manufacturing and bioconjugation, chromatography, crystallization investigations and stability studies. With an experience of over 30 years, the company offers integrated services for drug products and provide innovative solutions to support drug development. It is worth highlighting that in June 2023, the company received Manufacturing and Resource Efficiency Award at the prestigious Chemistry Industry Awards.

CARBOGEN AMCIS offers following ADC related Services:

  • HPAPI / Payload Synthesis
  • Linkers
  • Conjugation
  • Fill / Finish

Location of Manufacturing Facilities:

  • HPAPI and Payload Synthesis: Bubendorf, Switzerland, Neuland, Switzerland, Vionnaz, Switzerland and Shanghai, China
  • Linkers: Vionnaz, Switzerland
  • Conjugation: Bubendorf, Switzerland and Saint-Beauzire, France
  • Fill / Finish: Riom, France and Saint-Beauzire, France

GMP / non-GMP Manufacturing: GMP Manufacturing

Recent Developments:

  • In February 2023, the company announced the opening of a new facility for sterile liquid drug product manufacturing in Saint-Beauzire, France.
  • Further details on recent initiatives taken by Carbogen Amcis as well as other ADC manufacturers have been provided in detail in the report.

What About the Other ADC Manufacturers?

The above presentation features 5 ADC manufacturers selected from a pool of 30 contract manufacturers that we have compiled. If you are interested, you can download the Sample Report on “ADC Contract Manufacturing Market (6th Edition)” by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

About Author

Dhriti_Gulati

Dhriti is a Senior Business Analyst, working as an integral part of the Roots Analysis team since 2021. Passionate about the intersection of science and industry, she holds a Bachelor’s degree in biotechnology from a renowned university. Possessing keen interest in the pharma domain, Dhriti initiated her professional journey with a strong academic foundation. Her passion to learn more about the emerging trends and technological advancements has enabled her to provide comprehensive insights through syndicate reports and consulting. The unique blend of scientific knowledge and business acumen has enabled her to provide insightful analysis in the ever-evolving life-sciences domain. Till date, she has earnestly contributed to over 8 in-depth market research reports on trending topics, ranging from non-hormonal therapies for women health, oligonucleotide synthesis, RNAi therapeutics and technologies, cell therapy manufacturing, deep learning in drug discovery and diagnostics, RNA therapeutics and RNA vaccines to ADC contract manufacturing market.

Sources

  1. Top 5 CMOs in China, 2023
  2. CMC Summit in Yantai, China
  3. acquisition of Capsugel
  4. 120 sites and offices
  5. Wolfgang Wienand
  6. manufacturing agreement
  7. filling of ADCs
  8. research, development and manufacturing
  9. investment of USD 5 million
  10. Thomas Castellano
  11. Darrin Schellin
  12. Manufacturing and Resource Efficiency Award
  13. sterile liquid drug product manufacturing

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