September 22, 2023

The Future Of Healthcare: Wearable Injectors Unveiled

By  WEARABLE INJECTORS  0 Comments
In the continuous evolving landscape of healthcare, wearable injectors have emerged as transformative devices with the potential to redefine patient care. These innovative instruments combine precision, convenience, and patient-centered design to revolutionize drug delivery. In this detailed blog, we will delve deeply into the world of wearable injectors, exploring their underlying technology, advantages, limitations, diverse
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September 21, 2023

Cannabis Testing / Hemp Testing: Unlocking the Future Opportunities in Healthcare

By  Cannabis  0 Comments
Cannabis testing belongs to a class of flowering plants famous for its psychoactive properties and recreational uses. Cannabis sativa is the most widely used variety of the plant; other forms such as Cannabis indica and Cannabis ruderalis are also popular in different regions.  In earlier times, cannabis was used primarily for recreational purposes, however, medical
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September 20, 2023

Advancements In Automation Of Manufacturing Processes: Key Value Driver For Escalated Interest In The Cell Therapy Domain

By  Cell Therapies, Cell Therapy Manufacturing  0 Comments
Cell therapies are based on the premise that the patient’s own cells (autologous), or those from a healthy donor (allogeneic), can be genetically re-programmed to combat various diseases. In this form of therapy, patients are injected with living and intact human cells that are deemed to be capable of providing therapeutic benefit. It is important
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September 19, 2023

Cryomacs Freezing Bags – A Critical Component in the Successful Delivery of Biological Samples and Therapies

By  Cryomacs Freezing Bags, Cryopreservation Bags  0 Comments
This is a feature image for blog article Cryomacs Freezing Bags at Roots Analysis
Owing to the ability to preserve a wide variety of elements for such a long period of time, including cells, tissues, blood and DNA, cryopreservation has emerged as a key focus area for stakeholders in the biopharmaceutical industry. It is worth mentioning that it is extremely difficult to store biological components, such as stem cells
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September 18, 2023

The Future of Drug Delivery: Exploring Large Volume Wearable Injectors

By  WEARABLE INJECTORS  0 Comments
This is a feature image for blog article Large Volume Wearable Injectors at Roots Analysis
With the increasing global population, the incidence rates of several chronic disease indications, such as diabetes, heart disorders, neurological disorders and oncological disorders, are on the rise. Therefore, medical technology is rapidly evolving, enabling more advanced and patient-friendly methods of drug delivery. In the pursuit of creating patient-centric healthcare solutions, the medical industry has witnessed
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September 13, 2023

Conjugation and Labeling of Molecules: A Burgeoning Approach in Therapeutics Development and Molecular Imaging

By  Canjugation, Conjugation and Labeling of Molecules  0 Comments
This is a feature image for blog article Conjugation and Labelling Molecules at Roots Analysis
Conjugation is the process of formation of a single, stable hybrid, wherein one of the entities is a molecule, such as protein, antibody, peptide and small molecule. These molecules can be conjugated with various modalities, such as haptens, enzymes, isotopes, fluorescent tags, carrier proteins, polymers, particle conjugates and photoreactive molecules. Bioconjugation is a subset of
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September 5, 2023

How Can Quantum Computing Technology Help In Pharmaceutical R&D?

By  Quantum Computing, Quantum Technology  0 Comments
This is a feature image for blog article Quantum Computing Technology at Roots Analysis
The early stages of research related to drug discovery, including the identification of a relevant biological target and a viable lead compound, play a crucial role in the overall success of a drug candidate in preclinical and clinical studies. It is also worth noting that the process of drug discovery is extremely demanding, both in
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September 4, 2023

Companion Diagnostics Services: Future of Outsourcing

By  Companion Diagnostics, Diagnostics  0 Comments
This is a feature image for blog article Companion Diagnostics Services at Roots Analysis
In the recent years, service industry has become a fast-growing segment in the overall healthcare domain – thanks to the steady increase in demand for contract research organizations (CROs) and contract manufacturing organizations. The need to focus on developing more efficient interventions, within stipulated timelines and budget constrains is the key driver for outsourcing operations
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September 1, 2023

Breaking the Waves: How Blue Ocean Strategy in Healthcare Can Propel Pharma / Biotech Companies to Success

By  Red and Blue Ocean Strategy  0 Comments
This is a feature image for blog article Blue Ocean Strategy at Roots Analysis
In the fiercely competitive landscape of the pharma and biotech industries, standing out from the crowd is crucial for success. One strategy that has gained traction in recent years is the Blue Ocean Strategy. By charting new waters and creating uncontested market spaces, companies can differentiate themselves and unlock unprecedented growth opportunities. In this blog
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August 31, 2023

Nutrigenomics: The Future of Personalized Nutrition

By  Nutrigenomics  0 Comments
This is a feature image for blog article Nutrigenomics at Roots Analysis
Recent advances in DNA sequencing technologies have led to significant developments in healthcare-focused research on precision medicine and diagnostics. Given the recent shift from the one-size-fits-all model to a more personalized mode of treatment, there has been a growing interest for identification and adoption of novel techniques. According to a study, around 20,000 genes are
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August 30, 2023

Digital Biomanufacturing – Current Scenario and Future Trends

By  BIOMANUFACTURING  0 Comments
This is a feature image for blog article Digital Biomanufacturing at Roots Analysis
Breakthroughs in the biotechnology industry, over the last few decades, has provided a considerable boost to the overall development landscape of biopharmaceutical drugs. In 2022, a milestone was witnessed when the number of approvals received by biologics narrowly outpaced those reported by small molecules. Further, in the same year, nearly half of the biologic approvals
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August 30, 2023

Biopharmaceutical Contract Manufacturing: Transforming Promise into Reality

By  Biopharmaceutical, Contract Manufacturing  0 Comments
This is a feature image for blog article Biopharmaceutical CMO at Roots Analysis
Over the last few decades, the development landscape of small molecule drugs has been significantly impacted by various biotechnology breakthroughs. Further, with the advent of novel technologies, biologics have made a significant impact in the pharmaceutical domain, delivering ground-breaking treatment for a myriad of disease indications, including immunological, oncological and rare disorders. In this context,
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August 29, 2023

Cell Therapy Consumables Industry: Current Scenario and Future Trends

By  Cell Therapy  0 Comments
This is a feature image for blog artical Cell Free Systems at Roots Analysis
Cell therapy is the therapeutic approach which involves the injection of healthy cells in the human body, in order to replace the diseased / non-functioning cells to regulate certain functions. Driven by the benefits offered by cellular therapies and recent approvals by regulatory authorities, the demand for such therapies has increased considerably. This trend has
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August 29, 2023

Cell Therapy and Gene Therapy Contract Research Organizations: The Next Growth Opportunity

By  cell and gene therapy, Cell Therapies, Cell Therapy, Gene Therapies, Gene Therapy  0 Comments
This is a feature image for blog article Cell and Gene CRO at Roots Analysis
Over the years, cell and gene therapies (CGT) and other advanced therapy medicinal products (ATMPs) have managed to capture the interest of both drug developers and healthcare investors. Their popularity can be attributed to various factors, such as minimal side effects, clinical efficacy and their personalized nature. However, there are several complexities associated with the
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August 21, 2023

Novel Spectrometry Platforms: Key Advancements

By  Future Perspectives, Spectrometry  0 Comments
this is a feature image for blog article Novel Spectrometry Platforms at Roots Analysis
Spectrometry is an analytical technique that is used to analyze the fundamental components of a radiation or ion beam’s spectrum. There are two main divisions of spectrometry, which involve the use of electromagnetic radiation and ionization (also known as mass spectrometry), respectively. The former division of spectrometry uses electromagnetic radiation from different regions of an
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August 18, 2023

Organ-on-Chip: Rising Need of Products and Technologies

By  organ on chip, Uncategorized  0 Comments
This is a feature image for blog article Organ on Chip at Roots Analysis
The process of drug development and safety testing is extremely expensive and time-consuming. Animal testing is a vital part of drug development process, which is beneficial for researchers in understanding the cause, diagnosis, and treatment of various medical conditions. However, there are several concerns over the validity of animal research; drugs that seem to be safe
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August 18, 2023

RNA Sequencing Service Providers: Growth Opportunities

By  Contract Service Providers, mRNA, Next Generation Sequencing, Service Providers, SINGLE CELL SEQUENCING, Uncategorized  0 Comments
This is a feature image for blog article RNA Sequencing at Roots Analysis
Genome sequencing has historically been classified into DNA sequencing and RNA sequencing. DNA sequencing generates data that is very robust, reproducible, insightful, and can be applied to genes having different expression level by selecting genomic region. Inspite of several developments made to increase the efficiency of DNA sequencing even further, there are certain challenges associated
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August 17, 2023

Market Landscape of Blockchain Technology used in Drug Discovery and Clinical Trials

By  Blockchain  0 Comments
This is a feature image for blog article Blockchain Technology in healthcare at Roots Analysis
In recent years, blockchain has garnered significant interest of researchers, as well as industry players, as it has proven to be a versatile tool for decentralized monetary transactions and data exchange in various industries, such as banking, cyber security, supply chain management, government and healthcare. Several stakeholders in healthcare have adopted blockchain for various operations,
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August 16, 2023

mRNA: A New Era in Biopharmaceutical Contract Manufacturing Market

By  BIOMANUFACTURING, Continuous Manufacturing, Contract Manufacturing, Manufacturing, mRNA  0 Comments
This is a feature image for blog article mRNA Therapeutics at Roots Analysis
mRNA has completely revolutionized the field of medicine and significantly influenced the study and treatment of human diseases. The success of COVID-19 vaccines paved the path for mRNA-based drug products. Safety, efficacy and rapid production of mRNA drives the interest in this domain. However, synthesis and manufacturing of mRNA is fraught with several challenges as
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August 15, 2023

Transforming Biomanufacturing: Potential of Cell Free Systems

By  BIOMANUFACTURING, Cell Free Systems  0 Comments
This is a feature image for blog artical Cell Free Systems at Roots Analysis
Overview of Cell Free Systems Cell-free systems are ­in-vitro platforms which allow occurrence of biochemical reactions in the absence of living cells. These expression systems utilize bio machinery harvested from the lysate of disrupted cells for the manufacturing of a wide array of macromolecular and small molecule products. Biomanufacturing utilizing cell free systems is an
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August 14, 2023

Manufacturing Execution Systems: A Necessity for Healthcare Industry

By  BIOMANUFACTURING, Continuous Manufacturing, Manufacturing, Manufacturing Execution Systems  0 Comments
This is a feature image for blog article mRNA Synthesis at Roots Analysis
Like any other industry, the healthcare industry is drastically growing in its way. Thus, manufacturers need to update themselves with the new technologies and tools to stay relevant and competitive with the current market trends. Manufacturing execution systems (MES) play a crucial role in achieving long term competitive advantages in the healthcare industry. MES is
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August 14, 2023

Novel Antibody Therapies: Addressing Unmet Needs for Oncological Disorders

By  Antibodies, Antibody Discovery, Antibody Therapy  0 Comments
This is a feature image for blog article Novel Antibody Therapy at Roots Analysis
Antibodies are key components of the immune system that bind to specific markers on cells or tissues, thereby offering first line of defense against multiple disorders. The novel antibody therapies include different classes of antibodies, that are responsible for killing or inhibiting disease-causing agents. These therapies target proteins that are expressed on the surface of
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August 10, 2023

Manufacturing Execution Systems: A Step Towards Smart Manufacturing in Healthcare Sector

By  BIOMANUFACTURING, Continuous Manufacturing, Manufacturing, Manufacturing Execution Systems  0 Comments
This is a feature image for blog article Manufacturing Execution Systems at Roots Analysis
The continuously growing demand for healthcare products and present economic environment drives the need for adoption of automated tool and technologies in order to improve manufacturing, process, increase throughput reduce cycle time, maintain quality and to get the best out of the available resources to eliminate unnecessary production costs. It is worth mentioning that in
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August 9, 2023

Novel Antibody Therapies: Current Scenario and Future Potential

By  Antibody Discovery, Antibody Drug, Antibody Humanization, Antibody Purification, Antibody Therapy  0 Comments
This is a feature image for blog article Conjugation and Labelling Molecules at Roots Analysis
Novel antibody therapies are chimeric proteins having antibodies attached lethal effector molecules. Currently, six of these therapies are commercially available, while around 140 molecules are under development majorly for oncological disorders. Multiple novel antibody formats have been engineered to enhance therapeutic efficacy. This has opened a new target space for the development of antibody therapeutics
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August 9, 2023

Liposome: A Novel Drug Delivery System

By  Liposomes, lipososomes  0 Comments
This is a feature image for blog article Cell Therapy Manufacturing at Roots Analysis
Introduction to Liposome Liposome was initially identified and described as swollen phospholipid systems, called Banghasomes, by British hematologist Alec D. Bangham, in 1961 at the Babraham Institute, University of Cambridge. Later, the structural description of liposomes was revealed as small systems constituting one or more closed phospholipid bilayers. The liposomal vesicles are considered as either
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August 8, 2023

Transformation of Biopharmaceuticals Manufacturing Through Single-use Bioreactors

By  BIOMANUFACTURING, Bioreactors, Contract Manufacturing, Manufacturing, Single-use Bioreactors, Single-use Technology  0 Comments
This is a feature image for blog article Single-use Bioreactors at Roots Analysis
Recently, in the biopharmaceutical industry an increasing demand for quality biologics has been observed, where Single-Use-Systems (SUSs) Bioreactors have emerged as one of the most prominent and reliable solution for biomanufacturing. Disposable bioreactors have transformed the process of conventional biomanufacturing, and their adoption is increasing rapidly for production of various biologics, such as antibody, recombinant proteins,
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August 8, 2023

Medical Device Coating and Surface Modification Technologies: Current Market Landscape and Emerging Opportunities

By  Medical Device, Medical Device Coatings, Medical Devices and Technology  0 Comments
This is a feature image for blog article Bioavailability Enhancement Market at Roots Analysis
Over the past 50 years, the medical device industry has seen several notable developments. In fact, the use of biomedical devices, such as medical implants, surgical instruments, and prostheses has increased substantially over the time. Every year, millions of individuals undergo surgeries and implantations. Cardioverter defibrillators, prosthetic hips and knees, contact lenses, and cardiac pacemakers
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August 7, 2023

Cell Free System market: Current Landscape, Growth Opportunities and Future Market Outlook

By  Cell Free Systems  0 Comments
This is a feature image for blog article AAV Vector market at Roots Analysis
In recent years, cell free systems / cell free expression systems have emerged as a promising alternative for the conventional cell-based biomanufacturing process. It is a well-known fact that traditional biomanufacturing is a complex process that requires living cells and specific conditions in order to maintain proper homeostasis for cell growth. Moreover, cell based biomanufacturing
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June 30, 2023

Next Generation Biomanufacturing – The Upcoming Era of Digital Transformation

By  BIOMANUFACTURING, Continuous Manufacturing, Contract Manufacturing, DNA Manufacturing, Manufacturing, Manufacturing Execution Systems, Microbial Manufacturing, Uncategorized, Vector Manufacturing  0 Comments
This is a feature image for blog article Next Generation Biomanufacturing at Roots Analysis
Upon realizing the potential of digital biomanufacturing over traditional processes, players are actively undertaking initiatives to adopt advanced platforms to drive operational excellence, visibility, control and synchronization in bioprocessing. Industry 4.0: An amalgamation of physical equipment and smart software Digital biomanufacturing offers real-time process optimization based on factors, such as anticipated product quality and batch
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April 6, 2023

Antiviral Drugs: The Unmet Requirement in the Pharmaceutical Space

By  antiviral drugs  0 Comments
This is a feature image for blog article Monkeypox Treatment at Roots Analysis
Over the past few years, a number of antiviral drugs targeting a myriad of infectious diseases, including human immunodeficiency virus (HIV) infection, hepatitis, herpes simplex virus (HSV) infection, cytomegalovirus (CMV) infection, influenza, coronavirus infection (COVID-19) and others, have received approvals from various regulatory authorities, globally. However, it is important to note that, currently, the approved
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April 5, 2023

Key Trends in Non-Viral Transfection Market

By  cell and gene therapy, Gene Technologies, Gene Therapies, Gene Therapy, Viral Diseases  0 Comments
This is a feature image for blog article Non-Viral Transfection Market at Roots Analysis
In order to manipulate the cells, genetic material / nucleic acid is artificially introduced into the cells by using specific carriers / vectors. This process is known as transfection. It does not use viral components for transfection and are aimed at circumventing the challenges, such as inflammation, immunogenicity and non-specific transduction, associated with viral vectors.
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April 4, 2023

Deep Learning-based Interoperability: Advanced Neural Networks Mimicking the Human Brain

By  artificial intelligence, Digital Therapeutics  0 Comments
This is a feature image for blog article Deep Learning-based Interoperability at Roots Analysis
Artificial intelligence is the ability of a system to think like humans, discover the meaning, and execute the tasks. Recent advancements in the AI domain (e.g. deep learning, machine learning) have contributed to an invariable increase in the popularity of this technology across several industries, having impacted the healthcare industry at a significant scale. Machine
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March 17, 2023

mRNA Therapeutics and mRNA Vaccines Industry: Current Scenario and Future Trends

By  mRNA  0 Comments
This is a feature image for blog article mRNA Therapeutics at Roots Analysis
Messenger ribonucleic acid (mRNA) is a single-stranded molecule that is complementary to a gene’s DNA. It is important in the process of protein synthesis because mRNA is responsible for transferring genetic information from DNA to ribosomes, which then decodes the genetic information into a protein. In the last few years, researchers have become interested in
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March 16, 2023

Novel Cell Cytometers: Need of the Hour

By  Cell Cytometers  0 Comments
This is a feature image for blog article Novel Cell Cytometers at Roots Analysis
The domain of novel cell cytometers has attracted much attention of within the global biopharmaceutical industry in recent years. This popularity can be attributed mainly to the need of these tools to address the rising prevalence of chronic disease conditions. Cell cytometers allow for the simultaneous characterization of cells from a mixed population, thereby helping
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March 15, 2023

Patient Recruitment – Key Determinant of Successful Clinical Trials

By  Patient Recruitment  0 Comments
This is a feature image for blog article Patient Recruitment at Roots Analysis
Clinical trials are a fundamental requirement for evaluating the safety and efficacy of novel therapeutic interventions. Initiating a clinical trial is a complex and time-consuming process, involving suitable planning and execution. In addition, there are several other challenges, including inefficiencies related to data handling, and difficulties associated with patient enrollment and retainment, which further complicates
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March 14, 2023

Exploring AI-based Digital Pathology

By  Diagnostics, Digital Therapeutics, Non-Invasive Diagnostics  0 Comments
This is a feature image for blog article AI-based Digital Pathology at Roots Analysis
How is AI being used in Digital Pathology? Digital pathology is a transformative technology that has enabled pathologists to make the shift from visual inspection of tissue samples to automated image analysis. With the advent of AI, pathologists are now benefiting from computerized image analysis software that can draw conclusions and deliver diagnoses in a
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March 9, 2023

Smart pharmaceutical and healthcare labels: Lets trace medicines from its origin

By  Anti-Counterfeiting  0 Comments
This is a feature image for blog article Smart Labels Market at Roots Analysis
Traditionally, text and images were printed on pharmaceutical products to convey important information. In recent years, the use of smart labels allows the developer to convey a greater amount of information about the product to the consumers, without the need for additional packaging space. It is worth noting that smart labels contain a transponder code
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March 8, 2023

Introduction To Exosome Therapeutics

By  Exosomes, NOVEL DRUG  0 Comments
This is a feature image for blog article TCR Therapies at Roots Analysis
In  recent years, therapies utilizing extracellular vesicles have garnered significant attention among the industry stakeholders for the treatment of diverse target indication, primarily owing to the various benefits offered by them, including target specificity, enhanced tissue regeneration, and reduced inflammation and chronic pain. Over time, various research studies have demonstrated the potential of exosomes (membrane
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March 7, 2023

Unlocking the Potential of Digital Twins in Healthcare: Benefits, Challenges and Opportunities

By  Digital Therapeutics  0 Comments
This is a feature image for blog article Digital Twin Market at Roots Analysis
The application of digital twins in healthcare has the potential to revolutionize patient care, improve clinical outcomes, and reduce costs. Digital twins, or virtual replicas of physical objects and environments, are being used in many different industries, and healthcare is no exception. In healthcare, these can be used to provide better patient monitoring, improve remote
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March 3, 2023

Investment Opportunities in Women’s Digital Health

By  Digital Therapeutics, Women’s Digital Health  0 Comments
This is a feature image for blog article Women’s Digital Health at Roots Analysis
Digital health is a broad term that refers to the utilization of communication and information technologies to manage, track, and improve the overall healthcare delivery system. Owing to the potential of digital technology to optimize patient healthcare and the development of pharmaceuticals, the digital healthcare industry has witnessed significant rise in investments in the past
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March 2, 2023

Genotoxicity Testing: Unlocking the Future Safety Assessment Opportunities

By  Testing Services  0 Comments
This is a feature image for blog article Genotoxicity Testing: at Roots Analysis
Genotoxicity testing refers to the evaluation of detrimental effects of chemical or physical agents on the genetic processes and related hereditary material of living cells. On the other hand, mutagenicity is the process of inducing irreversible and transmissible alterations in the genetic material of organisms either spontaneously or through mutagenic activity. Disruption of the integrity
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March 1, 2023

Adeno-Associated Viral Vectors: Unlocking the Future Opportunities

By  Delivery Systems, Gene Therapy, Vector Manufacturing  0 Comments
This is a feature image for blog article AAV Vector market at Roots Analysis
Given the potential of gene therapies in targeting the underlying cause of a disease at cellular level,  the demand for such therapies has increased considerably over the past few years. Currently, more than 285 gene therapies are being evaluated in different phases of clinical development. Further, various gene therapy developers have raised more than USD 10 billion
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February 28, 2023

Modular Construction – Retrofitting Conventional Buildings

By  MODULAR FACILITIES  0 Comments
This is a feature image for blog article Modular Construction Market at Roots Analysis
Shifting construction away from traditional sites and into factories could dramatically change the way we build. Will off-site builds bolster construction this time around? Over the years, construction has straggled behind other sectors in terms of efficiency. Off-site builds or modular construction is a powerful way to reform construction business saving more time, labor, cost
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February 27, 2023

Long-Acting Drug Delivery: A Novel Pharmacological Strategy to Deliver Therapeutic Modalities

By  Drug Delivery, Injectors, Injectors Market, Medical Devices and Technology  0 Comments
This is a feature image for blog article Intracellular Drugs at Roots Analysis
Over the last two decades, the pharmaceutical industry has observed a paradigm shift from conventional drug delivery strategies to the long-acting drug delivery (LADD) of products to treat several disease indications, such as ophthalmic disorders, oncological disorders, neurological disorders and infectious diseases. LADD has emerged as the novel and advanced drug delivery system which manipulate
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February 24, 2023

Digital Therapies: The “Digital Pills” of current generation

By  Digital Therapeutics, Women’s Digital Health  0 Comments
This is a feature image for blog article digital health market at Roots Analysis
As per United Nation’s report, the current global population stands at around 8 billion and expected to reach 9 billion by the end of 2030. This increase in population is accompanied with a rise in the incidence of several chronic disease indications. In fact, as per a report published by National Association of Chronic Disease
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February 23, 2023

Medical Device Coatings and Modification Technologies

By  Medical Device, Medical Device Coatings, Medical Devices and Technology  0 Comments
This is a feature image for blog article Medical Devices CROs at Roots Analysis
Over the past 50 years, the medical device industry has seen several notable developments. In fact, according to the World Health Organization (WHO), presently, around two million medical devices are available across the globe. Further, since 2020, the Food and Drug Administration (FDA) has approved 125 medical devices. The growing demand for complex medical devices,
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February 16, 2023

The Future of Dentistry: Dental 3D Printing

By  3D Bioprinting, Dental 3D Printing  0 Comments
This is a feature image for blog article Dental 3D Printing at Roots Analysis
3D printing, also known as additive manufacturing, is a method of producing 3-dimensional objects layer-by-layer, using a computer aided design. Owing to its ability to print complex models using a wide range of materials, 3D printing has applications across various industries, including dental, aerospace, automotive, healthcare, food, fashion, mechanical engineering and other manufacturing industries.  In
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February 15, 2023

Bioavailability Enhancement Technologies

By  Service Providers  0 Comments
This is a feature image for blog article Bioavailability Enhancement Market at Roots Analysis
A study conducted on terminated drug development projects revealed that majority of the drug candidates fail in early drug development phases, due to the problems associated with their pharmacokinetic profiles, ADME (distribution, metabolism, absorption and excretion) properties and toxicity-related issues. Moreover, it is a well-established fact that the systemic / local absorption and distribution of
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February 14, 2023

Liposomes Development: Service Providers Landscape

By  lipososomes, Service Providers  0 Comments
This is a feature image for blog article Cell Therapy Manufacturing at Roots Analysis
In recent years, liposomes have garnered significant interest of researchers, as well as industry players, owing to their potential in diagnosis and treatment of various diseases, with a focus on delivering drugs and genetic material. Liposomes are small, artificial and lipid-based bilayered spherical vesicles, which are created spontaneously by hydrated phospholipids. Owing to their ability
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February 13, 2023

mRNA Synthesis: ManufacturingProcess of Modern Revolutionary Molecule

By  mRNA  0 Comments
This is a feature image for blog article mRNA Synthesis at Roots Analysis
Messenger ribonucleic acid (mRNA) is a single-stranded molecule, which carries coding sequence and plays a prominent role in protein synthesis. It transfers genetic information form to DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein. Structure of mRNA Post the onset of the COVID-19 pandemic mRNA has emerged as
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February 10, 2023

TIL Therapies: A New Paradigm in Cancer Treatment

By  Cancer, cancer therapeutics, T-Cell Immunotherapies, T-Cell Therapies  0 Comments
This is a feature image for blog article TIL Therapies Market at Roots Analysis
Modified tumor-infiltrating lymphocytes or TIL therapies have emerged as a viable and potent option to selectively eradicate the tumor population, with minimal side effects. Till date, several clinical trials have demonstrated the efficacy and therapeutic superiority (over conventional treatment options) of TIL-based therapies. Their tumor-cell killing efficiency is attributed to the fact that they are
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February 9, 2023

Viral Clearance and Viral Testing Services

By  Testing Services  0 Comments
This is a feature image for blog article Metabolomics at Roots Analysis
Considering the rising demand for biologics, innovators in the biopharmaceutical industry are constantly exploring avenues that would enable them to overcome the existing technical and operational challenges related to viral-clearance and testing for timely approval of biologics. Outsourcing the viral-clearance and viral testing studies has emerged as a promising alternative for most of the manufacturers.
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February 8, 2023

Artificial Intelligence (AI) In Oncology: Current Scenario And Future Potential

By  artificial intelligence, Cancer, CANCER MARKET, cancer therapeutics, Novel Cancer, Oncology  0 Comments
This is a feature image for blog article AI In Oncology at Roots Analysis
In the last decade, the popularity of AI has grown invariably. Specifically, it has made a considerable impact in the medical sector and oncologic treatment as well, due to a surge in electronic data, breakthroughs in technological infrastructure and groundbreaking research in deep learning neural networks. AI has demonstrated potential in improving tumor imaging diagnosis
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February 7, 2023

Rising Demand for Medical Devices CROs

By  Medical Device, Medical Devices and Technology  0 Comments
This is a feature image for blog article Medical Devices CROs at Roots Analysis
Over the past decade, numerous scientific and technological breakthroughs in the medical device CROs industry have resulted in an accelerated pace of research and innovation within this domain. Further, the demand for advanced and minimally invasive medical devices has been augmented due to the increase in expenditure on healthcare. However, one of the primary challenges
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February 6, 2023

SARM1 Inhibitors: A Novel Approach Against Neurodegenerative Disorders

By  Alzheimer's Disease, Alzheimer's Pipeline, Alzheimer’s Disease, Neurodegeneration, Parkinson’s Disease  0 Comments
This is a feature image for blog article SARM1 Inhibitors at Roots Analysis
Presently, several industry and non-industry stakeholders are evaluating SARM1 inhibitors as potential therapeutic agents for the treatment of neurological disorders across various preclinical studies and early stages of clinical development, worldwide. Given the encouraging research outcomes, the players in this domain have received more than USD 10 million in grants, since 2014, from the various
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February 6, 2023

TCR Therapies: An Emerging Therapeutic Modality

By  T-Cell Therapies, TCR therapies  0 Comments
This is a feature image for blog article TCR Therapies at Roots Analysis
Modified T-cell receptors or TCR therapies is an emerging class of adoptive therapy that employs genetically modified lymphocytes to target specific tumor markers. Structurally, TCR is a heterodimer comprising of two different polypeptide chains, namely the α-chain and β-chain. TCR therapies’ tumor-cell killing efficacy may be primarily attributed to the fact that they are pre-sensitized
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February 3, 2023

Cell Therapy – The Revolutionary Therapeutic Modality: All Set To Obliterate Oncological Disorders

By  Cell Therapies, Cell Therapy, Manufacturing, Stem Cell Therapy, Stem Cells, T-Cell Immunotherapies, T-Cell Therapies  0 Comments
This is a feature image for blog article Cell Therapy Manufacturing at Roots Analysis
The American Society of Gene and Cell Therapy (ASGCT) defines cell therapy as a therapeutic modality that involves the administration of either normal or modified cells to patients for the treatment of various diseases. In this form of therapy, patients are injected with living and intact human cells that are deemed to be capable of
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February 1, 2023

Applications of Blockchain in Various Sectors: An Introduction

By  Blockchain, Clinical Trials, Cybersecurity, Healthcare, virtual clinical trials  0 Comments
This is a feature image for blog article Blockchain Technology at Roots Analysis
Introduction and Applications of Blockchain The term blockchain refers to the way it stores transaction data in blocks that are linked to form a chain. This technology is also known as Distributed Ledger Technology. Since every entry is stored as a block on the chain, the length of the chain increases as more transactions are
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January 31, 2023

Intracellular Drug Delivery – Future Potential

By  CELL TARGETING, Drug Delivery, Targeting Therapies  0 Comments
This is a feature image for blog article Intracellular Drugs at Roots Analysis
Healthcare treatment is important for those having fatal diseases and so is the precision treatment in almost every case. One of such disease which has squabbled the entire humanity and accounts for the highest number of death rates globally is cancer. It’s a disease wherein the body’s abnormal cells grow uncontrollably and spread to other
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January 18, 2023

Antiviral Drugs Development: Are we Prepared for the Next Viral Pandemic?

By  COVID-19, COVID-19 Pandemic, Covid19, NOVEL DRUG  0 Comments
This is a feature image for blog article Antiviral Drug Development at Roots Analysis
Infectious diseases are known to be one of the top 10 leading causes of deaths, worldwide. In-fact, more than 40 million people are affected by various types of infectious diseases annually. Further, it has been around three years since the COVID-19 pandemic hit the world, and yet, shows no signs of disappearing. An article published
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January 17, 2023

Exploring How Artificial Intelligence Is Transforming Digital Pathology

By  artificial intelligence, Diagnostics, Non-Invasive Diagnostics  0 Comments
This is a feature image for blog article AI in digital pathology at Roots Analysis
How is AI being used in Digital Pathology? Digital pathology is a transformative technology that has enabled pathologists to make the shift from visual inspection of tissue samples to automated image analysis. With the advent of AI, pathologists are now benefiting from computerized image analysis software that can draw conclusions and deliver diagnoses in a
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January 16, 2023

At-home Self-testing: A Giant Leap Towards Transformation in Diagnostic Sector

By  At-home Self-testing, Diagnostics, Non-Invasive Diagnostics  0 Comments
This is a feature image for blog article At home Self Testing Kits at Roots Analysis
In the health industry, digitization has evolved over time with numerous advances to ensure that everyone has equitable access to health products and medical specialists.  At-home Self-testing has the ability to improve health equity and accelerate progress toward universal health coverage, and it has the capacity to alter health care. Self-testing alternatives provide individuals and
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January 13, 2023

SARM1: A Potential Therapeutic Target For Neurodegenerative Diseases

By  Neurodegeneration  0 Comments
This is a feature image for blog article SARM1 targeting therapies at Roots Analysis
Neurological disorders are considered the second leading cause of death and the primary cause of long-term disability, worldwide. In fact, over 6.5 million neurological disorder related deaths are reported annually, globally. Further, according to a report published by the United Nation (UN), close to 1 billion people, across the globe, suffer from various types of
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January 12, 2023

Advancements in Automation of Processes: Key Value Driver for Escalated Interest in Cell Therapies Manufacturing Domain

By  Cell Therapies, Cell Therapy, Contract Manufacturing  0 Comments
This is a feature image for blog article Cell Therapies Manufacturing at Roots Analysis
Considering the vast potential of cell therapies in the treatment of rare disorders and sufficient body of evidence validating the clinical benefits / therapeutic potential of this complex class of biologic drugs, cell therapies have garnered considerable attention of players engaged in the healthcare industry, in the past few years. The focus of stakeholders has
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January 11, 2023

CAR-T Cell Therapy: Addressing Key Unmet Needs Across Various Oncological Indications

By  Cell Therapies, Cell Therapy, T-Cell Therapies  0 Comments
This is a feature image for blog article CAR-T Cell Therapies at Roots Analysis
Amidst the active initiatives undertaken to develop more targeted anti-cancer therapies, CAR-T therapies have emerged as a promising option, given their ability to eradicate tumor cells from the body with minimal treatment-related side effects. Further, CAR-T cell therapy, relatively recent addition to the gamut of anticancer interventions, has demonstrated significant promise. Overall, this highly specific
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December 13, 2022

Rising Need of Organ on a Chip Products And Technologies

By  3D Bioprinting, Healthcare  0 Comments
This is a feature image for blog article Organ on a Chip at Roots Analysis
The process of drug development and safety testing is extremely expensive and time-consuming. Animal testing is a vital part of drug development process, which is beneficial for researchers in understanding the cause, diagnosis, and treatment of various medical conditions. However, there are several concerns over the validity of animal research; drugs that seem to be
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December 12, 2022

Antibody Drug Conjugates Market: The Future of Novel Therapies

By  ADC Conjugation, ADC Cytotoxic Payloads, ADC Therapeutics, ADCs Pipeline  0 Comments
This is a feature image for blog article Antibody Drug Conjugates at Roots Analysis
Antibody drug conjugates (ADCs) are an upcoming class of targeted therapeutic agents that have garnered the attention of pharmaceutical companies, and academic / research institutions across the world. Fundamentally, these complex biotherapeutic entities represent the combination of the target specificity of an antibody and the therapeutic features of a chemotherapy / cytotoxic drug. Such conjugates
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August 29, 2022

Spatial Genomics, Transcriptomics and Proteomics Solutions – An Amelioration of Tissue Analytics

By  Genomics, SPATIAL GENOMICS  0 Comments
This is a feature image for blog article Spatial Genomics at Roots Analysis
Recent advances in multi-omics approaches, including genomics, transcriptomics, proteomics, metabolomics, cytometry and imaging, in combination with bioinformatics and biostatistics, have been translated into several popular bioanalytical platforms, such as next-generation sequencing (NGS), single-cell analysis, flow cytometry and mass spectrometry. These platforms, although widely adopted, require tissue fixation and are therefore not capable of providing fundamental
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May 12, 2022

Targeted Protein Degradation Market: Riding on the Popularity of PROTAC, Market is set to Grow Exponentially

By  Degradation Market  2 Comments
This is a feature image for blog article Targeted Protein Degradation Market at Roots Analysis
Over the years, the drug hunters have tried to target the tens of thousands of proteins responsible for sickness and health. But a vast majority of them have remained out of reach. While, the scientific evolution has led to the development of potent and selective small-molecule inhibitors of protein function, but still, multiple targets of
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May 3, 2022

Is Blue Ocean Strategy The Silver Bullet For Emerging Teleradiology Players to Achieve A Breakthrough In This Highly Competitive Market?

By  Teleradiology Services Market  0 Comments
This is a feature image for blog article Teleradiology Services Market at Roots Analysis
Blue ocean strategy, a concept first introduced in 2004, by W Chan Kim, and Renee Mauborgne in their bestselling book of the same name, talks about how to achieve a breakthrough in a highly saturated market by focusing on creating a new uncontested market. Blue ocean strategy is a systematic approach that helps emerging service
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April 26, 2022

Women’s Digital Health: A New Era of Female Healthcare

By  Women’s Digital Health  0 Comments
This is a feature image for blog article Women’s Digital Health at Roots Analysis
Women’s digital health involves the initiatives taken by industry stakeholders and researchers, which include technological remedies, such as mobile apps, software, wearable devices and diagnostic tools that exclusively aid in improving female health and wellness. Since it is primarily focused on women’s healthcare, it is termed as Female Technology or FemTech. The term “FemTech” was
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April 22, 2022

Sustainable, biodegradable and Eco- Friendly Packaging: A Paradigm Shift in Healthcare Packaging

By  Healthcare Packaging  0 Comments
This is a feature image for blog article Sustainable, Biodegradable and Eco-Friendly Packaging at Roots Analysis
What is Sustainability and Why is Sustainability Important? The term sustainability is derived from the Latin word sustinere, which means to hold or support. Sustainable packaging is defined as packaging that is safe for individuals, as well as the environment, while meeting all requirements for performance, cost and ease of fabrication. Further, the product should be specially
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April 19, 2022

Single-use Technology: A Step Towards Future Transformation

By  Single-use Technology  0 Comments
This is a feature image for blog article Single-use Technology at Roots Analysis
Over the past decade, the biopharmaceutical industry has witnessed several advancements in terms of bioprocessing. Bioprocess technology is one of the integral parts of biotechnology that deals with different biological processes involving living or competent cells to get value added products at the end of the process. Recently, an increasing demand for various efficient technology
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March 28, 2022

Continuous Manufacturing:  A Magic Bullet to Meet the Demand for Pharmaceutical Products

By  Continuous Manufacturing  0 Comments
This is a feature image for blog article Continuous Manufacturing at Roots Analysis
Over the last few decades, the pharmaceutical industry has been using batch processes for production of pharmaceutical products, which is a multi-phase process. However, the surge in the demand for drugs due to COVID-19 has led the pharmaceutical industry to shift on to a more agile and flexible technique- continuous, which is a single flow
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March 25, 2022

Metabolomics: An Emerging yet Powerful Tool in Clinical Research and Development

By  Metabolomics  0 Comments
This is a feature image for blog article Metabolomics at Roots Analysis
Scientific fields involved in high throughput measurement of biological molecules are referred with the suffix-omics including, transcriptomics, genomics, proteomics and metabolomics. Genomics is the study of genetic material within a cell, and transcriptomics is the study of gene activity in different cells. Likewise, metabolomics refers to the study of byproducts of metabolism. Although, metabolomics is
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March 22, 2022

Subcutaneous Biologics: The Unmet Requirement in the Pharmaceutical Space

By  Biologics  0 Comments
This is a feature image for blog article Subcutaneous Biologics at Roots Analysis
Over the years, the incidence and prevalence of chronic diseases, have increased significantly. Presently, the recommended treatment options for such clinical conditions are mostly biologics, which need to be administered via parenteral routes to ensure maximum therapeutic benefit. Given the inherent requirement for frequent medication, patients suffering from such long-lasting clinical conditions generally end up
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March 16, 2022

Exosomes: A Deeper Look into Service Providers Market

By  Exosomes  0 Comments
This is a feature image for blog article Exosomes at Roots Analysis
Over the years, applications of exosomes in therapeutics have undergone an evolutionary change, in terms of cost of research, technology used, and duration of the study. Moreover, various startups and small firms have entered into collaborations in order to advance their innovations and offer specialized research expertise, services and technologies. In order to promote the
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March 14, 2022

Biopharmaceutical Excipient Manufacturing – Current Scenario and Future Trends

By  Biopharmaceutical  0 Comments
This is a feature image for blog article Biopharmaceutical Excipient Manufacturing at Roots Analysis
Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry. In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines and gene therapies), by the US FDA, have steadily risen. In fact, over 8,000 biological pharmaceutical products are currently
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March 11, 2022

Exosomes: A Trending Term in Therapeutic Domain

By  Exosomes  0 Comments
This is a feature image for blog article Exosomes at Roots Analysis
Exosomes have been of great interest in the recent years due to the discovery of their potential in so many research and analytic procedures. Exosomes are known to have some unique functions, such as their ability to alter recipient cell bioactivities, acting like intercellular messengers and also having therapeutic potential in disease diagnostics as well
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March 10, 2022

Biopharmaceutical Excipient Manufacturing Market: Current Scenario and Future Potential

By  Biopharmaceutical  0 Comments
This is a feature image for blog article Biopharmaceutical Excipient Manufacturing at Roots Analysis
Over the years, the rising popularity of biologics has led to a paradigm shift in the healthcare industry. In the last decade alone, the annual number of approvals of biopharmaceuticals (including monoclonal antibodies, recombinant proteins, vaccines, and gene therapies), by the US FDA, have steadily risen. In fact, over 8,000 biological pharmaceutical products are currently
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March 7, 2022

Complement Therapeutics: The Clinical Antidote for Complement-Associated Diseases

By  Complement Therapeutics  0 Comments
This is a feature image for blog article Complement Therapeutics at Roots Analysis
Complement System:  Key Component of Immune System Complement system was discovered in 19th century as a part of immune system responsible for tissue repair and homeostasis, thereby providing first line of defense against multiple infections. This complete process is in association with a complex and highly regulated assembly of proteins which involve several soluble and
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March 4, 2022

Next Generation Complement Therapeutics: Potential Life-Changing Therapies for Multiple Rare Disorders

By  Complement Therapeutics  0 Comments
This is a feature image for blog article Next Generation Complement Therapeutics at Roots Analysis
Since the approval of Soliris® in 2007, an anti-C5 antibody, the field of complement drug discovery has gained significant attention. Currently, nine complement therapeutics are commercially available, while around 190 molecules are under development for various disease indications. Some of the complement therapeutics, namely Berinert®, Cinryze®, ORLADEYO®, Ruconest® and TAKHZYRO® were approved for the treatment
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March 3, 2022

Oral Protein / Peptide-based Drugs: Addressing Key Unmet Needs Across Disease Indications

By  Oral Protein  0 Comments
This is a feature image for blog article Oral Protein / Peptide-based Drugs at Roots Analysis
Orally administrable protein / peptide-based therapeutics offer several advantages including, effective treatment of numerous clinical conditions and degenerative disorders. Interestingly, recent advances in this domain have led to the development of several treatment strategies that, according to developers, exhibit the necessary capabilities to overcome challenges posed by traditional oral protein formulations  and peptide-based therapies. One of
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March 2, 2022

Intranasal Therapeutics and Drug Delivery Systems: The Perfect Alternative to Conventional Route of Administration

By  Intranasal Therapeutics  0 Comments
This is a feature image for blog article Intranasal Therapeutics and Drug Delivery Systems at Roots Analysis
The intranasal route of administration is widely accepted as effective and non-invasive option for the local and systemic delivery of several types of active pharmaceutical ingredients (API). Majority of such formulations are designed to treat chronic obstructive pulmonary disorders (COPD), asthma and other respiratory diseases. Interestingly, over the past few years, drug developers focused on
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February 28, 2022

Container Closure Integrity Testing: A Necessity for Pharmaceutical Industry

By  integrity testing  0 Comments
This is a feature image for blog article Container Closure Integrity Testing at Roots Analysis
Over the past few years, the pharmaceutical industry is growing a tremendous pace. Considering patient’s health and safety, the drug products are expected to be free from microbial contamination and should be safe for use throughout the drug’s life cycle. Therefore, several quality checks are performed to ensure product’s sterility and stability. One of the
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February 25, 2022

Accelerating Oligonucleotide Demand: A Force Driving The Contract Manufacturing Market

By  Oligonucleotides  0 Comments
Accelerating Oligonucleotide Demand at Roots Analysis
Since the approval of the first antisense therapy in 1998, oligonucleotides have been in light for their capabilities as therapeutic agents. Oligonucleotides are short synthetic nucleotide chains with immense potential in the diagnosis and treatment of a myriad of disease indications. In addition to therapeutics, these complex molecules act as a significant resource in various
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February 24, 2022

Next Generation Sequencing (NGS) Library Preparation Kits: Revolutionizing the Field of Genetic Sciences

By  Next Generation Sequencing  0 Comments
This is a feature image for blog article Next Generation Sequencing at Roots Analysis
NGS has emerged as an evolutionary technology in modern biotechnology and healthcare research, enabling researchers to develop a better understanding of the cause and consequences of disease. Over the past few years, several companies have started offering a diverse range of genome sequencing products and services using various second and third generation sequencing technologies. Presently,
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February 23, 2022

Rising Need of Autoinjectors

By  Autoinjectors  0 Comments
This is a feature image for blog article Autoinjectors at Roots Analysis
With the increasing global population, the incidence rates of several chronic disease indications, such as diabetes, anaphylaxis, rheumatoid arthritis and psoriasis, are on the rise. This has led to a rise in the demand for effective treatment options for patients suffering from these diseases. Further, in order to improve the quality of life in these
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February 22, 2022

Next Generation Sequencing (NGS) Library Preparation Kits Market: Current Scenario and Future Potential

By  Next Generation Sequencing  0 Comments
This is a feature image for blog article Next Generation Sequencing at Roots Analysis
Since the introduction of a gene sequencing method by Frederick Sanger in 1977, the field of genomic data collection and analysis has evolved significantly. Advancement in DNA sequencing technologies have resulted in noteworthy developments in various healthcare-related research fields, such as diagnostics and personalized medicine. However, the conventional nucleotide library preparation process has several challenges,
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February 19, 2022

Growing Demand for Oligonucleotides Proposes Shedload of Opportunities for Contract Manufacturers

By  Oligonucleotides  0 Comments
This is a feature image for blog article Oligonucleotides Synthesis Market at Roots Analysis
In the 20th century, major research went into discovery of a therapeutic class with the primary purpose of interfering with the RNA expression linked to disease causing proteins, nowadays classified as oligonucleotides. These short, single-stranded DNA or RNA molecules have various applications in biopharmaceutical and biotechnology industries including, genetic testing, basic research, forensic analysis and
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February 18, 2022

MYELOID CELL TARGETING THERAPEUTICS: BUDDING THERAPY AGAINST CANCER

By  Myeloid cell targeting  0 Comments
MYELOID CELL TARGETING THERAPEUTICS: BUDDING THERAPY AGAINST CANCER
Myeloid cells represent a group of cells containing granulocytes, monocytes, macrophages, mast cells and dendritic cells, which play a key role in innate immunity. These cells are found in abundance in the tumor microenvironment and inflamed areas. The tumor recruits and modulates endogenous myeloid cells to tumor-associated macrophages, dendritic cells, myeloid-derived suppressor cells and neutrophils,
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February 16, 2022

Bringing in Light Genome Editing Techniques: ZFN, TALEN and Meganucleases

By  Genome Editing Techniques  0 Comments
This is a feature image for blog article Light Genome Editing Techniques at Roots Analysis
Presently, there are several companies and universities, which are exploring the potential of different gene editing technologies beyond CRISPR for basic research, and the development of gene editing solutions. With the development of a variety of versatile DNA modulation technologies such as include zinc-finger nucleases (ZFNs), TAL effector nucleases (TALENs), engineered endonucleases / meganucleases (EMNs)
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February 15, 2022

ADC Payload / Warheads and Rise in its Demand

By  ADC Cytotoxic Payloads  0 Comments
This is a feature image for blog article ADC Cytotoxic Payloads / Warheads at Roots Analysis
With six approved drugs, namely POLIVY™ (2019), LUMOXITI™ (2018), BESPONSA® (2017), MYLOTARG™ (2017, reapproval), KADCYLA® (2013) and ADCETRIS® (2011), and more than 300 candidates in the pipeline (clinical / preclinical stages), antibody drug conjugates (ADCs) have emerged as a promising class of therapeutics for the treatment of various disease indications. Over time, medical researchers have
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January 6, 2022

Myeloid cell targeting therapeutics: Budding therapy against cancer

By  Myeloid cell targeting  0 Comments
Myeloid cells represent a group of cells containing granulocytes, monocytes, macrophages, mast cells and dendritic cells, which play a key role in innate immunity. These cells are found in abundance in the tumor microenvironment and inflamed areas. The tumor recruits and modulates endogenous myeloid cells to tumor-associated macrophages, dendritic cells, myeloid-derived suppressor cells and neutrophils,
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January 4, 2022

Site management organizations: A deeper look into clinical trial site management landscape

By  CLINICAL TRIAL PLANNING, Clinical Trials, Site Management Organizations, virtual clinical trials  0 Comments
This is a feature image for blog article Site management organizations at Roots Analysis
Clinical trials form an integral part of the overall drug development process, enabling the necessary evaluation of the safety and efficacy of a drug candidate. Studies suggest that around 40% of the total investment made for the development of drug candidate is dedicated to clinical trials; this is equivalent to an expenditure of USD 78
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January 3, 2022

At-Home Blood Collection: New Era of Diagnosis and Testing

By  AT-HOME BLOOD COLLECTION, HOME BLOOD COLLECTION  0 Comments
This is a feature image for blog article At-Home Blood Collection at Roots Analysis
In the era of COVID-19, where the world is looking for point of care treatment, in order to avoid maintain physical distance. Post the onset of COVID-19 pandemic, there has been a decline in number of patients visiting laboratories for sample collection and testing. To avoid risk of infections, patients have postponed their routine tests
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December 28, 2021

Myeloid Cell Targeting Therapies: Budding Therapy Against Cancer

By  Anti-cancer, Anti-cancer Therapy, cancer therapeutics, CELL TARGETING  0 Comments
This is a feature image for blog article Myeloid cell targeting therapeutics at Roots Analysis
The global cancer burden is increasing rapidly with over 19 million new cancer cases and 10 million deaths reported in the year 2020. Given the rising prevalence, researchers have made significant efforts in discovering new approaches for the treatment of oncological diseases. With several programs having entered the clinical stages, myeloid cell targeting therapies have
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December 23, 2021

Regulatory T-cell Therapies: A Research Hotspot in the Field of Immunotherapy

By  Cell Therapies, Cell Therapy, T-Cell Therapies  0 Comments
This is a feature image for blog article Regulatory T-Cell Therapies at Roots Analysis
Classification of Regulatory T-Cell Therapies The Regulatory T-Cell Therapies (Tregs) are a mature subpopulation of T-cells that play a critical role in mediating immunological tolerance to self-antigens and suppress immune responses that are harmful to the host, thereby, enabling homeostasis. These mainly develop in thymus from CD4+ thymocytes and are mainly of three types: natural
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December 15, 2021

Site Management Organizations (SMOs): A Trending Term in the Clinical Trial Domain

By  Clinical Practice, CLINICAL TRIAL PLANNING, Clinical Trials, Site Management Organizations, virtual clinical trials  0 Comments
This is a feature image for blog article Site Management Organizations at Roots Analysis
Innovators in the pharmaceutical industry are constantly developing ways to improve the process of conducting clinical trials and managing research sites. Amidst other alternatives, outsourcing various trial operations to a specialized service provider, such as site management organizations (SMOs), has emerged as a viable option for various developers. The advantages of engaging such specialized service
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December 13, 2021

DNA DATA STORAGE: RESEARCH LANDSCAPE AND FUTURE PROSPECTS

By  DATA STORAGE, DNA Encoded, DNA Manufacturing  0 Comments
This is a feature image for blog article DNA Data Storage at Roots Analysis
DNA data storage involves encoding and decoding binary data to and from synthesized strands of DNA. It offers generous, long-lasting, and stable data storage solution with orders of magnitude relatively higher than current storage mediums. Owing to the numerous benefits offered by DNA data storage as compared to other mediums, it is anticipated that this
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December 10, 2021

HER2 Targeting Therapies Market: A Deeper Look into Therapy Developer Landscape and Future Opportunities

By  Anti-cancer, Anti-cancer Therapy, Cancer, cancer therapeutics, Targeting Therapies  0 Comments
This is a feature image for blog article HER2 Targeting Therapies at Roots Analysis
The epidermal growth factor receptor (EGFR is a tumor resistance biomarker which plays an essential role in the differentiation and proliferation upon activation through the binding of one of its ligands. A non-ligand-binding member of EGFR family, HER2 exerts its activity through heterodimerisation along with its other family members. HER2 is a transmembrane growth factor
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December 9, 2021

THE RISING REALM: BIOPRESERVATION MEDIA INDUSTRY

By  3D Cell Cultures, BIOPRESERVATION  0 Comments
This is a feature image for blog article Biopreservation Media at Roots Analysis
Biopreservation is the exclusive biological approach designated for the preservation of cells, tissues and organs ex-vivo for the purpose of storage, shipment and transportation. Biopreservation media is one of the most crucial entity in conferring effectiveness. The selection of the type of media depends upon the considerable time duration desired for the storage, type of
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December 1, 2021

Cell and Gene Therapy Bioassay – A Prerequisite for the ATMPs Development

By  Bioassay, Cell Therapies, Gene Therapies  0 Comments
This is a feature image for blog article Cell and Gene Therapy Bioassay at Roots Analysis
Bioassay – A Prerequisite for the Cell and Gene Therapy Development Over the past few years, investigational new drug (IND) filings for cell and gene therapy product have significantly increased. In fact, from year 2016 to 2020 more than 300 IND filing for cell and gene therapy product have been recorded, indicating that several developers
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November 24, 2021

Rising Need of Large Volume Wearable Injectors

By  Injectors, Injectors Market, WEARABLE INJECTORS  0 Comments
This is a feature image for blog article Wearable Injectors at Roots Analysis
With the increasing global population, the incidence rates of several chronic disease indications, such as diabetes, heart disorders, neurological disorders and oncological disorders, are on the rise. This has led to a rise in the demand for effective treatment options for patients suffering from these diseases. Further, in order to improve the quality of life
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November 17, 2021

Pharmaceutical Vials Witnessing High Demand Due to COVID-19 Pandemic

By  COVID-19 Pandemic, Pharmaceutical Packaging, Pharmaceutical Vials, SUSTAINABLE PACKAGING  0 Comments
This is a feature image for blog article Pharmaceutical Vials Market at Roots Analysis
Over the years, advances in drug / therapy development processes have led the pharmaceutical industry to gradually shift from a one-drug treats all model to a more personalized approach of treatment. The growing complexity of modern pharmacological interventions, such as monoclonal antibodies, and cell and gene therapies, has further prompted the drug developers to develop
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November 16, 2021

Fc Fusion Therapeutics – A New Approach to Drug Therapy

By  Antibody Discovery, Antibody Drug, Antibody Humanization, FUSION THERAPEUTICS  0 Comments
This is a feature image for blog article Fc Fusion Therapeutics at Roots Analysis
Since the approval of Enbrel®, CD4-Fc fusion protein (for the treatment of rheumatoid arthritis) in 1998, Fc fusion therapies have evolved into a prominent class of therapeutics.[1] Currently, 13 Fc fusion drugs are commercially available, while around 50 molecules are under development for various disease indications. Some of the Fc fusion therapeutics including  Arcalyst® (recurrent pericarditis,
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November 11, 2021

Pharmaceutical Vials Market: Current Scenario and Future Trends

By  Pharmaceutical Packaging, Pharmaceutical Vials, SUSTAINABLE PACKAGING  0 Comments
This is a feature image for blog article Pharmaceutical Vials Market at Roots Analysis
Primary packaging material (e.g. Pharmaceutical Vials) plays a crucial role in preserving the stability, efficacy and safety of the drug as it is in direct contact with the packaged therapeutic. Additionally, primary packaging material assists in maintaining the sterility and quality of a drug product, while also providing information related to its identity and, in
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November 10, 2021

ADC Therapeutics – Alternative to Traditional Anticancer Therapies

By  ADC Conjugation, ADC Therapeutics, ADCs Pipeline, Antibody Discovery, Antibody Drug, Antibody Humanization, Antibody Purification  0 Comments
This is a feature image for blog article Antibody Drug Conjugates at Roots Analysis
Antibody-drug conjugates (ADCs) are an upcoming class of targeted therapeutic agents that have captured the attention of both large and small pharmaceutical companies, and academic / research institutions from all across the world. Fundamentally, these complex biotherapeutic entities demonstrate the combination of target specificity of an antibody and therapeutic features of a chemotherapy / cytotoxic
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November 8, 2021

Glycoengineered Antibodies and Fc Protein – Virtue of enhanced effector functions

By  Antibodies, Antibody Discovery, Antibody Drug, Antibody Purification, Glycoengineered Antibodies  0 Comments
This is a feature image for blog article Fc Protein and Glyco-engineered Antibodies at Roots Analysis
With close to 100 approved monoclonal antibodies, and over 550 molecules in the clinical pipeline, antibody based pharmacological interventions have become one of the fast growing segment of the biopharmaceutical industry.[1] In fact, these interventions are anticipated to generate a cumulative sales of USD 300 billion by 2025.[2] Further, within the antibody therapeutics industry, engineered
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November 1, 2021

Antibody Drug Conjugates – A Potential Tool Against Cancer

By  ADC Conjugation, ADC Therapeutics, ADCs Pipeline, Antibodies, Antibody Drug  0 Comments
This is a feature image for blog article ADC Therapeutics at Roots Analysis
Over the years, various technological advancements, such as antibody engineering for site-specific conjugation and enhanced pharmacokinetic and pharmacodynamic properties, have paved the way for antibody drug conjugates (ADCs) to be recognized as potent therapies targeting a wide range of indications, including solid tumors and hematological malignancies. ADC Therapeutics are engineered therapies comprised of monoclonal antibodies
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October 28, 2021

Sustainable Packaging: Paramount for Pharmaceutical Sector

By  Pharmaceutical Packaging, SUSTAINABLE PACKAGING  0 Comments
This is a feature image for blog article Sustainable Packaging at Roots Analysis
Sustainable Packaging in pharmaceutical industry plays a crucial role in ensuring the sterility and quality of a drug product, while it also provides information related to its identity and, in certain cases, dosing instructions. Pharmaceutical packaging is typically carried out under Packagingcontrolled conditions; specifically, for therapeutics that are designed for parenteral administration, fill / finish
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October 26, 2021

Alzheimer’s Disease and Its Evolving Market

By  Alzheimer's Disease, Alzheimer's Pipeline, Alzheimer’s Disease  0 Comments
This is a feature image for blog article Alzheimer’s Disease at Roots Analysis
Alzheimer’s disease is a progressive neurological disorder characterized by the death of brain cells, eventually leading to memory loss, cognitive dysfunction and dementia. Accounting for 60-70% cases of dementia, Alzheimer’s disease is known to be the sixth leading cause of death in the US.   Presently, more than 6 million Americans of all ages are living
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October 25, 2021

Cell Therapy Packaging – Importance and Future Perspective

By  Cell Therapy, Pharmaceutical Packaging  0 Comments
This is a feature image for blog article Cell Therapy Packaging at Roots Analysis
Over the years, the pharmaceutical industry has witnessed several advancements in drug development. It has gradually shifted from a one-drug treats all model to a more personalized approach of treatment, which involves the use of personalized cell therapies for various disease indications. This shift has led to an evident change in the pharmaceutical packaging domain
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October 22, 2021

Progressive Supranuclear Palsy (PSP): A Tough Nut to Crack

By  Supranuclear Palsy  0 Comments
This is a feature image for blog article Progressive Supranuclear Palsy at Roots Analysis
Since John Steele, John Richardson, and Jerzy Olszewski first described Progressive Supranuclear Palsy (PSP) in 1964, the neuroscience community has been on the lookout to find a “miracle molecule” or an “elixir” that can cure patients diagnosed with this debilitating disease. With more than 2,000 research studies published so far, the domain has garnered significant
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October 12, 2021

Teleradiology: The Need of The Hour During COVID-19 Pandemic

By  artificial intelligence, Digital Therapeutics, Patient Monitoring, TELERADIOLOGY  0 Comments
This is a feature image for blog article Teleradiology at Roots Analysis
Teleradiology is a branch of telemedicine that uses telecommunication systems for the transmission of radiological images from one location to another. Additionally, it helps the radiologists to interpret various types of images, such as computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography (PET), ultrasound, and X-rays, remotely. As of late, teleradiology has piqued
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September 27, 2021

Bioprocess Automation: A Step Towards Digital Transformation

By  BIOPROCESS AUTOMATION  0 Comments
This is a feature image for blog article Bioprocess Automation at Roots Analysis
In the era of digitalization where the world is looking forward towards automating their manufacturing process, the bioprocess industry took a while to adopt the automation technology. The biopharmaceutical industry came across several obstacles while adopting the automated technology. Examples of which include, complexity of the processes and delicacy of the living cells and organisms
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September 23, 2021

Novel Drug Reconstitution Systems: Opportunities in Accurate Reconstitution and Drug Delivery

By  Drug Delivery, Drug Reconstitution  0 Comments
This is a feature image for blog article Novel Drug Reconstitution Systems at Roots Analysis
The novel drug reconstitution systems have emerged as a promising alternative to traditional methods of reconstitution, adding significant value to the storage and transfer of lyophilized therapeutics. These systems enhance the portability, efficiency and optimum delivery of the lyophilized drugs and have the potential to reduce the number of steps significantly, which enable the dilution
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September 20, 2021

Novel Drug Reconstitution Systems: Emerging Options for the Reconstitution of Lyophilized Drugs

By  Drug Reconstitution, NOVEL DRUG  0 Comments
This is a feature image for blog article Novel Drug Reconstitution Systems at Roots Analysis
Lyophilization of Pharmaceuticals and Drug Reconstitution In 2018, seven out of ten top-selling prescription medicines were biologics. The liquid formulations of biologics are not much stable and tend to loose efficacy with time due to the changes in their pharmacokinetic and pharmacodynamic properties. Therefore, lyophilization of such drugs is essential before their storage. Around 50%
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September 16, 2021

Squamous Non-Small Cell Lung Cancer Market: Current Scenario and Future Trends

By  Cancer, CANCER MARKET, cancer therapeutics, Novel Cancer  0 Comments
This is a feature image for blog article Squamous Non-Small Cell Lung Cancer at Roots Analysis
Close to 1.8 million fatalities reported in 2020 were observed to be associated with lung cancer, which is believed to be one of the most aggressive forms of carcinoma, globally. One of the primary reasons for the high mortality rate associated with this condition is anticipated to be late diagnosis, which eventually results in delayed
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September 14, 2021

Pharmaceutical Contract Manufacturing and The Rising Adoption of Sophisticated Processes

By  BIOMANUFACTURING, Contract Manufacturing, Manufacturing  0 Comments
This is a feature image for blog article Pharmaceutical Contract Manufacturing at Roots Analysis
Recent developments in pharmacology and biotechnology have been able to drive significant advances and innovation in understanding the root causes of various diseases; this has further aided in the discovery and development of more targeted treatment strategies. It is worth noting that such advances in the healthcare industry have made pharmaceutical development and contract manufacturing
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September 13, 2021

Remote Patient Monitoring: A Paradigm Shift in Healthcare System

By  Patient Monitoring  0 Comments
This is a feature image for blog article Remote Patient Monitoring at Roots Analysis
The development of the concept of remote patient monitoring (RPM) started nearly 200 years ago in 1800s. However, it wasn’t until the introduction of cloud computing, that the domain evolved at a significant pace. In fact, RPM solutions are gradually being integrated into mainstream healthcare systems; specifically, during the COVID-19 induced lockdown, such advanced tools
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September 2, 2021

Clinical Trial Planning and Design Services Market: What Does the Future Hold?

By  CLINICAL TRIAL PLANNING, Clinical Trials, virtual clinical trials  0 Comments
This is a feature image for blog article Clinical Trial Planning and Design at Roots Analysis
Over the years, clinical research has undergone an evolutionary change, in terms of cost of research, technology used, and duration of the study. It is worth highlighting that clinical research involves two major steps, namely study design and study reporting. Further, study design involves three key steps, theoretical design, data collection design and statistical analysis
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August 17, 2021

Pharmaceutical Contract Manufacturing: The Solution to Production of Complex Substances

By  Contract Manufacturing, Manufacturing, Market Research, Pharmaceuticals  1 Comment
This is a feature image for blog article Pharmaceutical Contract Manufacturing at Roots Analysis
The inherent expertise of CMOs and CDMOs is believed to be capable of enabling reduction in the time-to-market a product, significant cost-benefits, as well as access to larger production capacities and novel technologies.  It is worth mentioning that there has been substantial merger and acquisition activity in the pharmaceutical contract manufacturing market in the past
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July 12, 2021

Display Library Technologies: Where do we stand?

By  Display Library Technologies  0 Comments
This is a feature image for blog article Display Library Technologies at Roots Analysis
Over time, a variety of methods / approaches have been developed for the generation of viable therapeutic leads. These include the hybridoma technology, B-cell cloning, transgenic animal-based techniques, in vitro display methods (using phages, ribosomes, mRNA, and cDNA) and cell surface display methods (involving mammalian, yeast, and bacterial cells). Despite being responsible for the development
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June 29, 2021

Target Protein Degradation – Transformative Approach to Selectively Eliminate Disease-Causing Protein

By  Target Protein Degradation  0 Comments
This is a feature image for blog article Target Protein Degradation at Roots Analysis
Targeted protein degradation is an emerging therapeutic modality that has the potential to enable the treatment of difficult-to-treat diseases. While conventional medicines, such as small molecule inhibitors and monoclonal antibodies, address fewer than 20% of the proteome, TPD offers a unique means to tap into the rest of the vast, unexplored proteome. Through TPD, a
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June 22, 2021

Nothing Ventured, Nothing Gain: Bringing to Light The Continuous Manufacturing Equipment Providers

By  BIOMANUFACTURING, Contract Manufacturing, Manufacturing, Microbial Manufacturing  0 Comments
This is a feature image for blog article Continuous Manufacturing Equipment Providers at Roots Analysis
Over the years, several industries have implemented evolutionary changes in their respective manufacturing processes. One to the most rewarding advancements in this direction, is process automation. In pharmaceutical manufacturing, the automation of various aspects of the production process has led to the establishment of the continuous manufacturing paradigm. However, the transition to continuous manufacturing is
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June 21, 2021

Polycystic Ovary Syndrome (PCOS)

By  Polycystic Ovary Syndrome  2 Comments
This is a feature image for blog article Polycystic Ovary Syndrome at Roots Analysis
Polycystic Ovary Syndrome is a condition in which the ovaries produce abnormal amount of androgens (males sex hormones), higher than the amount usually present in a woman with normal ovaries. The ovaries develop fluid filled sacs, known as follicles, which contain an immature egg. However, in polycystic ovary syndrome, none of the eggs mature and
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June 16, 2021

Cell Line Development and Characterization: An Ocean of Opportunities for Service Providers

By  3D Cell, 3D Cell Cultures, Cell Line, Cell Line Development, Cell Therapies, Cell Therapy  1 Comment
This is a feature image for blog article Cell Line Development Services at Roots Analysis
The growing pipeline of monoclonal antibodies, vaccines, enzymes, biosimilars and other therapeutic proteins have created an ever- increasing demand for highly- productive and stable cell lines. Many of the recombinant biotherapeutic products, produced in cellular systems, have been translated into commercial successes; these include ALPROLIX®, ELOCTATE® and ELAPRASE®.  Given their impact on the overall quality
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June 15, 2021

Modular Facilities: A Paradigm Shift in Pharmaceutical Facility Design

By  BIOMANUFACTURING, Contract Manufacturing, DNA Manufacturing, Manufacturing, Microbial Manufacturing, MODULAR FACILITIES, Vector Manufacturing  1 Comment
This is a feature image for blog article Modular Facilities at Roots Analysis
The concept of modular building has long been employed in other sectors, but it has only recently acquired traction in the pharmaceutical business over the last two to three decades. Modular construction is a process wherein factory-produced, pre-engineered building units, which are constructed offsite under controlled plant conditions, are assembled on site to construct the
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June 14, 2021

Intracellular delivery technologies – solution to undruggable targets

By  Modern pharmaceutical industry  1 Comment
This is a feature image for blog article Intracellular delivery technologies at Roots Analysis
Over time, advances in molecular biology and pharmacological chemistry have enabled the identification of biological targets localized in the subcellular space, and development of therapeutic leads against them. In fact, there are several clinical conditions, which were previously considered undruggable since the traditional small molecule-based interventions were unable to penetrate the selectively permeable cell membrane.
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June 11, 2021

Antibody Purification: A Deeper Look into Service Providers Landscape

By  Antibody Drug, Antibody Purification  0 Comments
This is a feature image for blog article Antibody Purification at Roots Analysis
Over time, several innovative technologies have been developed to support the designing and manufacturing of various types of antibody products; however, the aforementioned processes are characterized by high costs and technical complexities, especially during the production and downstream processing steps. Therefore, it is challenging for new entrants and companies with limited resources and capital, to
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June 10, 2021

Antisense Oligonucleotides – The Revolutionizing Modalities in the Field of Gene Silencing

By  Antisense Oligonucleotide, Oligonucleotides  1 Comment
This is a feature image for blog article Antisense Oligonucleotides at Roots Analysis
Oligonucleotide (commonly referred to as oligos), are short single stranded DNA or RNA molecules, typically containing 15-20 nucleotide residues.[1],[2] In the modern biopharmaceuticals and biotechnology, the applications of these molecules are vast, including (but not limited to) genetic testing, fundamental biomolecular research, and forensic analysis. Oligonucleotides are a diverse class of therapeutics that are divided
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June 9, 2021

Non-Invasive Diagnostics for Fibrotic Disease Market: A Step Towards Painless and Specific Detection of Fibrosis

By  Non-Invasive Diagnostics  1 Comment
This is a feature image for blog article Non-Invasive Diagnostics for Fibrotic Disease Market at Roots Analysis
Advances in the field of biotechnology have enabled the development of several minimally invasive / non-invasive approaches for diagnosis of fibrotic diseases which include imaging diagnostics and biomarker-based assays. Among the biomarker-based tests, liquid biopsy (based on the analysis of biofluids such as blood, urine and / or plasma), a relatively new concept, has emerged
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June 8, 2021

Targeting the STING Pathway

By  Market Research, STING Pathway  1 Comment
This is a feature image for blog article STING Pathway at Roots Analysis
Stimulator of interferon genes or STING, discovered by the laboratory of Glen N Barber in 2008, is one of the signaling proteins that is responsible for the transcription of genes associated with the innate immunity of an individual. Amidst the recent COVID-19 pandemic, it has become even more essential to strengthen the immune system. The
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March 2, 2021

Virtual Clinical Trials: The Present And Future Of Pharmaceutical Research

By  Clinical Trials, virtual clinical trials  1 Comment
This is a feature image for blog article Virtual Clinical Trials at Roots Analysis
The lack of patient centricity in traditional clinical trials is known to inhibit trial sponsors to retain enough patients, which is critical to successfully complete safety and efficacy evaluations of novel therapeutic interventions on predetermined completion dates. In addition, the lack of participant compliance in clinical trials often leads to massive delays which are known
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February 26, 2021

Biopharmaceutical Contract Research Organizations: Fueling the research of novel biologics

By  Biopharmaceutical, Contract Research Organizations, Contract Service Providers  1 Comment
This is a feature image for blog article biopharmaceutical contract research organizations at Roots Analysis
Biologics, often referred to as biopharmaceuticals or large molecules, are manufactured in the biological system, such as microorganisms, plants, or animal cells. Biologics represent one of the fastest growing segments of the pharmaceutical industry. This can be attributed to the rapid pace of innovation in this field, driven by the need for effective and personalized
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February 16, 2021

Outlook for the contract manufacturing industry following the growing biologics pipeline

By  BIOMANUFACTURING, Contract Manufacturing, Manufacturing, Microbial Manufacturing, Vector Manufacturing  1 Comment
Rootsanalysis
The recent years have portrayed the renaissance in the domain of biologics, as pharmaceutical industry has once again gained attention towards the production of bioproducts. In fact, in 2019, a total of 28 biopharmaceutical products (including monoclonal antibodies, recombinant proteins and gene therapies) were approved in the US. Further, over 8,000 biological pharmaceutical products are
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February 15, 2021

Digital Biomarkers: Is Efficient Remote Monitoring of COVID-19 Patients Primary Reason for Incessant Rise in Demand?

By  Biomarkers  0 Comments
Contract Research Organization
Biomarkers or biological markers are distinctive physiological features in an individual, which can be detected and quantified in order to gain insights about health and disease. On the other hand, digital biomarkers are defined as digital means that are employed to collect data about these unique biomarkers. These are combination of hardware and software features,
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February 9, 2021

Artificial Intelligence in Drug Discovery – Could help Reduce Significant Capital and Time Required

By  artificial intelligence, Drug Discovery  0 Comments
Rootsanalysis
Drug discovery is a complex process which involves significant utilization of time and resources. As per several sources, on an average, the entire drug development process (from initial proof-of-concept to commercial launch) takes around 10-15 years and capital investments worth USD 4-10 billion to develop a drug from concept to commercial launch. The early stages
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February 4, 2021

mRNA: the Higgs boson of modern medicine?

By  mRNA, Vaccines  1 Comment
Rootsanalysis
Messenger RNA (mRNA) is a single-stranded molecule, which is complementary to the DNA strands of a gene. It plays a prominent role in the process of protein synthesis, wherein mRNA is responsible for transferring genetic information from DNA to ribosomes, a specialized structure, or organelle, which decodes genetic information into a protein. In the last
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February 3, 2021

Advancing Healthcare Delivery via Artificial Intelligence

By  artificial intelligence, Drug Discovery  0 Comments
Rootsanalysis Blog
Artificial Intelligence have demonstrated intelligent behavior through their ability to learn, communicate with its users and solve complex problems using highly sophisticated algorithms. AI-driven technologies have continued to evolve rapidly, with several industries increasingly deploying such solutions across key aspects of value chain. Furthermore, AI is also made with same idea of making tasks simpler
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January 6, 2021

ADC Manufacturing: How Are the Contract Manufacturers Supporting the Growing Demand

By  ADC Conjugation, ADC Therapeutics, ADCs Pipeline, Antibody Drug, Therapeutics  1 Comment
Rootsanalysis
Antibody Drug Conjugates (ADCs) known as the 21st Century Magic Bullets, have emerged as a promising class of targeted therapies being developed for the treatment of cancer. Two decades ago, in the year 2000, the domain witnessed the approval of first ADC known as Mylotarg®, by the US FDA.  This was followed by the successful
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December 21, 2020

Single-Cell Sequencing: The New Era of Gene Expression Analysis

By  Market Research, Pharmaceuticals, SINGLE CELL SEQUENCING  1 Comment
virtual-clinical-trials
For developing an improved understanding of the interactions of individual cells within their microenvironment, advanced molecular probing solutions are being used by researchers across the globe. In this context, high-throughput single-cell analysis, has emerged as a powerful analytical technique for studying individual cells, enabling researchers to study gene expression at single cell resolution. Single-cell sequencing
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October 27, 2020

Harnessing The Power of Real World Evidence to Fight COVID-19 Pandemic

By  COVID-19, Market Research, Pharmaceuticals, Real World Evidence, RWE  1 Comment
HARNESSING THE POWER OF REAL WORLD EVIDENCE TO FIGHT THE COVID-19 PANDEMIC
With the ongoing pandemic of COVID-19, there is long wait for the vaccine to be approved. Even after the vaccine gets approved, there is no assurance of the complete eradication of virus. There will still be percentage of people who contract the illness. Therefore, it is very important to trace and detect the treatments in
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October 26, 2020

Microbial Contract Manufacturing: Growing Microbial-Based Biologics Pipeline Boosts The Market

By  BIOMANUFACTURING, Contract Manufacturing, Manufacturing, Microbial Biopharma Industry, Microbial Manufacturing  1 Comment
Contract Research Organization
The recent years have portrayed the renaissance in the domain of microbial fermentation, as microbial biopharma industry has once again gained attention towards the production of biologics using microbial expression system. The modification and innovation in the microbial expression systems for the production of various biologics have side-lined some of the earlier concerns associated with
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October 20, 2020

REAL-WORLD EVIDENCE: THE GAME CHANGER IN DRUG DEVELOPMENT

By  DRUG DEVELOPMENT, Pharmaceuticals  1 Comment
Pharmaceutical and Life Sciences Real World Evidence
While the definition of real world evidence is still evolving, most proponents associate it with data that is derived from medical practice among heterogeneous sets of patients in the real world setting. It is the integration of data gathered from various sources, such as EHRs, medical charts, patient claims and billing activities, product and disease
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October 19, 2020

Are Handheld Ultrasound Imaging Devices a True Revolution in Diagnostic Imaging Domain?

By  Diagnostics, Market Research, Ultrasound  0 Comments
Are Handheld Ultrasound Imaging Devices a True Revolution in Diagnostic Imaging Domain?
Advancements in the field of disease diagnostics have led to development of point-of-care medical imaging devices; handheld ultrasound scanners have emerged as a novel solution to cater to unmet need in this domain. These handheld ultrasound imaging devices are the lightest portable ultrasound devices, which permit patient diagnosis from a single transducer and transmit images
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October 13, 2020

Digital Therapeutics: Key Concepts and Regulations to Tackle COVID-19 Pandemic

By  COVID-19, Digital Therapeutics, Therapeutics, therapeutics market  1 Comment
Digital Therapeutics: Key Concepts and Regulations to Tackle COVID-19 Pandemic
Digital therapeutics are clinically validated applications / software / online programs that have demonstrated the capability to facilitate positive outcomes when used in the prevention / treatment / management of diseases / clinical conditions. These therapeutics are designed to engage patients in personalized treatment or disease prevention programs, through mediating behavioral or psychological modifications, providing
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October 12, 2020

Inhaled and Intranasal Drug Delivery: A Deeper Look into Service Providers Landscape

By  Inhaled and Intranasal Drug Delivery, Market Research, Pharmaceuticals, Service Providers  1 Comment
Inhaled and Intranasal Products: Contract Service Providers Market
The techniques used for the drug delivery are found to be have an enormous impact on the efficacy of the treatment. In fact, the slow progression of the efficacy, has suggested the need of different approaches for the effective delivery of drug to the target area, along with the optimal bioavailability. Over the years, several
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October 7, 2020

Targeted Drug Delivery Devices: An Attractive Option for Improving the Efficacy of Biologics

By  Biologics, Drug Delivery, Medical Device, Medical Devices and Technology  1 Comment
Targeted Drug Delivery Devices: An Attractive Option for Improving the Efficacy of Biologics
The gradual shift of healthcare industry towards the development of biologics is a well-known fact. Owing to this shift, there are over 1,000 cell and gene therapies which are being developed for the treatment of various disorders, majority of them being oncological disorders, cardiovascular disorders and neurological disorders.  Additionally, over the last decade, multiple immunotherapies
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September 17, 2020

Single-Use Bioreactors on Rescue for COVID-19 Research

By  Bioreactors, COVID-19  1 Comment
Rootsanalysis
The development of single-use bioreactors started nearly 40 years ago in 1980s. It was around this time that the bio-processors began to use plastic film bags to culture cells, which were initially designed for food storage and culture media containment. Moreover, incremental evolution of the concept of disposable technologies have facilitated various advancements in development
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September 8, 2020

Nuclear Medicines And Radiopharmaceuticals: Redefining The Use Of Radioactivity In Modern Day Healthcare

By  RADIOPHARMACEUTICALS  1 Comment
Rootsanalysis
Fostered by partnerships between national laboratories, academia, and the pharmaceutical industry, the field of nuclear medicines and radiopharmaceuticals has evolved over the past few decades, in parallel with advances in imaging instrumentation, radionuclide production, and radiopharmaceutical development. Nuclear reactors and particle accelerators are presently used to produce a wide array of radionuclides for diagnostic and
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September 7, 2020

Will the Renascence of Microbial Manufacturing be Impacted by the Pandemic?

By  Contract Manufacturing, Microbial Manufacturing  1 Comment
Rootsanalysis
Since the discovery of recombinant DNA technology, several types of microbes have been established as a versatile biomolecule expression system. This can be attributed to the ease of handling of microbial cell lines, which are considered less fragile (compared to cells of higher eukaryotes); rendering them a popular choice for manufacturing operations. Moreover, incremental evolution
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August 11, 2020

Drug Repurposing – A Deeper Look into Service Providers Market

By  Drug Repurposing, Service Providers  1 Comment
This is a feature image for blog article Drug Repurposing at Roots Analysis
Over the past decade, several scientific and technological breakthroughs in the drug repurposing industry have resulted in an accelerated pace of research and innovation within this domain. Further, the demand for effective repurposed therapies in the on-going war with the pandemic, is on the rise. However, one of the primary challenges faced by this industry
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July 31, 2020

Outsourcing: An Attractive Option For Antibody Production

By  Market Research, therapeutics market  1 Comment
Rootsanalysis
In recent years, contract manufacturers have become an integral part of the overall biopharmaceutical market. This trend is also gaining popularity within the antibody therapeutics market, as developers are increasingly outsourcing their antibody production requirements to contract service providers. This can be attributed to the fact that employing such third-party service providers offers various advantages,
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July 28, 2020

Large Volume Wearable Injectors: A breakthrough to simplify Chronic Disease Management

By  Injectors, Injectors Market  1 Comment
Rootsanalysis
The last few years have witnessed a rising incidence of chronic illnesses across the globe. Long term clinical conditions, such as neurological disorders, cardiovascular disorders, chronic pain and oncological disorders, have been shown to impose a significant burden on the modern healthcare system and those who suffer from such diseases. It is reported that about
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July 27, 2020

Significant Potential of Gut Flora: Human Microbiome

By  Human Microbiome  1 Comment
Rootsanalysis
Human Microbiome Therapies are Viable Alternatives to Antibiotics, with Substantial Therapeutic Potential The term microorganisms was perceived to be synonymous to harmful, disease causing agents, until the discovery of certain beneficial microbial colonies in the human system. Currently, humans and a variety of species of bacteria, yeast and protozoa, are known to co-exist in mutually
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July 23, 2020

The Evolving Dynamics of Large Volume Wearable Injectors Market

By  Injectors, Injectors Market  1 Comment
Rootsanalysis
The field of self-injection devices has witnessed a lot of innovation in the recent years. Specifically, , large volume wearable injectors are certainly a boon due to their ability to address challenges associated with the administration of high volume formulations, viscous drug solutions and cater to frequent dosing requirements of patients suffering from chronic health
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July 17, 2020

Medical Device CROs – The next Growth Opportunity

By  Medical Device  1 Comment
Rootsanalysis
Over the past decade, numerous scientific and technological breakthroughs in the medical device industry have resulted in an accelerated pace of research and innovation within this domain. Further, the demand for high quality and efficient medical devices, driven by a growing geriatric population and increasing incidence of various chronic clinical conditions, is on the rise.
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July 9, 2020

Fill / Finish Services Industry: Impact of the Swelling Biopharmaceutical Pipelines

By  Biopharmaceutical, Biotech  1 Comment
Rootsanalysis
Biopharmaceuticals represent the most rapidly growing and high-value segment of the pharmaceutical industry. Growing at an annualized rate of ~12%, the industry stands tall with more than 5,000 biologics in development and over 300 FDA approved biologics, since 2002. Biologic drug development is characterized by high quality standards and a rapidly growing demand for novel
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July 8, 2020

In Vitro ADME Testing Services: Emerging Opportunities for Service Providers

By  Market Research, Testing Services  0 Comments
According to the US Food and Drug Administration (USFDA), less than 10% of investigational new drug (IND) candidates progress beyond the submission of a new drug application (NDA); this implies that majority of the drug / therapy candidates fail to reach the market owing to unacceptable safety and efficacy profiles and the problems associated with
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July 8, 2020

Increasing Prevalence of Chronic Diseases- Driving the Demand for Self-Administration Devices, Like Autoinjectors

By  Autoinjectors, Drug Adherence, Medical Device, Medical Devices and Technology, Therapeutics  0 Comments
This is a feature image for blog article Global Autoinjectors Market at Roots Analysis
Over the last decade, autoinjectors have emerged as a promising therapeutic commodity for safe administration of parenteral therapies. Patients who suffer from chronic diseases, such as diabetes, rheumatoid arthritis and multiple sclerosis, often require frequent dosing of medication which poses significant inconvenience to them for visiting proper healthcare centers. Hence, autoinjector devices enable such patients
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July 3, 2020

Peptide APIs – A Deeper Look Into Contract Manufacturing Market

By  Contract Manufacturing, Manufacturing  1 Comment
Rootsanalysis
The recent years have portrayed the renaissance of peptide APIs, as pharma industry has once again turned its attention towards the potential of therapeutic peptides. Adoption of peptides as therapeutic agents have side-lined some of the earlier concerns associated with them, such as bioavailability, and has led to manufacturing of high-quality peptides in a larger
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July 3, 2020

Increasing Rate of Drug Failure has Prompted the Drug Developers to Rely on CROs offering In Vitro ADME Testing Services for their Outsourcing Requirements

By  ADME Testing, Drug Discovery  1 Comment
Medical Device Coating
It is important to note that the process of drug discovery is extremely demanding, both in terms of capital and time. In fact, the overall amount spent on R&D initiatives in the pharmaceutical / biotechnology sector has increased from around USD 128 billion in 2008 to USD 165 billion in 2018. Moreover, only a small
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June 25, 2020

Targeted Protein Degradation is Anticipated to Become a Major Therapeutic Modality in the Coming Decade

By  Protein Degradation, Therapeutics  1 Comment
Rootsanalysis
The targeted protein degradation approach is believed to possess the potential to unlock the undruggable proteome, which was traditionally considered to be inaccessible. Compared to conventional inhibition strategies, degradation offers several benefits, which include the opportunity to completely remove aberrant proteins and associated systemic malfunctions. As a result, targeted protein degradation-based therapeutics have generated enthusiasm
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June 25, 2020

Rising Popularity of Drug Targeting Synthetically Lethal Targets Fuels the Battle of PARP Inhibitors for Treatment of Advanced Cancer Indications

By  Cancer, cancer therapeutics  1 Comment
Rootsanalysis
Cancer is considered to be the second leading cause of mortality, after cardiovascular diseases, accounting for every sixth reported death in the world. The International Agency for Research on Cancer (IARC) states that the number of new cancer cases is expected to grow to 27.5 million across the globe, by 2040. Experimental evidence has shown
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June 23, 2020

Targeted Protein Degradation – Defining a New Frontier in the Field of Medicine

By  Drug Discovery, Protein Degradation  1 Comment
Rootsanalysis
The concept of targeted protein degradation presents revolutionary drug development opportunities and is anticipated to bring about a paradigm shift in modern healthcare. While conventional medicines, such as small molecule inhibitors and monoclonal antibodies, address fewer than 20% of the proteome, targeted protein degradation offers a unique means to tap into the rest of the
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June 22, 2020

In Silico / Computer-Aided Drug Discovery Service Providers for Large Molecules

By  Drug Discovery  1 Comment
Rootsanalysis
Over time, the complexities associated with drug discovery have increased, especially in case of large molecule drugs, which are inherently more complex than conventional small molecules. As a result, an increase in the overall research and development (R&D) expenditure in the pharmaceutical / biotechnology sector has been witnessed. In addition to the complexities involved, the
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June 22, 2020

Computational / In Silico Drug Discovery: A Boon in Disguise for Faster Drug Discovery Operations Amidst COVID-19

By  COVID-19, Drug Discovery  1 Comment
Rootsanalysis
The COVID-19 pandemic is predicted to throw the global economy into recession, with loss of trillions of dollars. The pharmaceutical industry cannot escape the brunt of the circumstances as well. In fact, according to a survey, 95% of healthcare industry professionals are worried about the impact the pandemic is likely to have on the industry. So far,
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June 18, 2020

Next Generation Immune Checkpoint Inhibitors and Stimulators: Another Big Opportunity

By  cancer therapeutics, Therapeutics  1 Comment
Rootsanalysis
There is an urgent unmet need for developing innovative and effective cancer therapeutics for the treatment of patients with late-stage and refractory cancer. Amidst the widespread initiatives to develop more targeted anti-cancer therapies, immune checkpoint inhibitors emerged as a highly specific and potent option to eradicate tumor cells with minimal side effects. Once the body
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June 17, 2020

Favorable Demand Dynamics within the Ophthalmic Drugs Contract Manufacturing Market

By  Contract Manufacturing, Manufacturing, Ophthalmic Drugs  1 Comment
Favorable Demand Dynamics within the Ophthalmic Drugs Contract Manufacturing Market
In the past two decades, advances in optometry, along with an increased understanding of human eye and vision care, have led scientists to develop innovative treatment methods in order to treat eye disorders and to overcome the limitations offered by conventional medical practices. The current ophthalmic diseases treatment landscape is characterized by a number of
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June 17, 2020

Outsourcing has become a popular trend in ophthalmic drug development domai

By  Contract Manufacturing, Ophthalmic Drugs  1 Comment
Single-use bioreactors
Owing to various reasons, such as growing manufacturing demand, need for specialized facilities, equipment and operational expertise, and high costs of development associated with certain drugs / therapies, a number of innovator companies have demonstrated a preference to outsource certain aspects of ophthalmic drug development and production operations to contract service providers. Over 240 companies
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June 17, 2020

Microbiome-based Live Biotherapeutics Contract Manufacturing: Rising Opportunities for Specialized CMOs / CDMOs

By  Contract Manufacturing, Microbiome Research  1 Comment
Microbiome-based Live Biotherapeutics Contract Manufacturing: Rising Opportunities for Specialized CMOs / CDMOs
What is the current development pipeline of microbiome-based live biotherapeutics? With over 85 products under preclinical and clinical development, the current development pipeline of microbiome-based live biotherapeutics has several promising candidates, which are anticipated to get commercialized over the next few years. Hence, the demand for R&D and manufacturing services for such products is anticipated
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June 11, 2020

RISE OF ANTIBODY-DRUG CONJUGATES WITH THE RECENT APPROVALS

By  Antibody Drug, Healthcare, Pharmaceuticals  1 Comment
RISE OF ANTIBODY DRUG CONJUGATES WITH THE RECENT APPROVALS
Antibody-drug conjugates (ADCs) have captured the attention of both large and small pharmaceutical companies, and academic / research institutions, for more than a decade. For the past few years, several failures of clinical trials were blamed for the lack of interest of some companies in this therapeutic approach. However, after a decade-long dribble of antibody-drug
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June 11, 2020

Needle-free Injection System: A light bearer in the fight against the thick darkness of COVID-19

By  Coronavirus, COVID-19, Medical Device, Medical Devices and Technology  1 Comment
Needle-free Injection System
The apocalyptic images of the COVID-19 induced locked-down world are heart wrenching. All healthcare related domains are being created at a rapid rate. Around the world, the coronavirus pandemic is overstretching health services and reportedly more than 40 companies have boosted their R&D efforts to hit the bulls eye and deliver the much awaited vaccines
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June 8, 2020

CRISPR Can be a Solution to Address the COVID-19 Pandemic

By  Coronavirus, COVID-19, Diagnostics  1 Comment
CRISPR Can be a Solution to Address the COVID-19 Pandemic
As we know, COVID-19 is causing large scale loss of life and severe human suffering. With the pandemic spreading across the globe, researchers are racing against the clock to develop diagnostic tools, vaccines and treatments. Recently, WHO has launched a Solidarity clinical trial to assess relative effectiveness of four potential drugs against COVID-19. Further, there
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June 2, 2020

Growing Pipeline of Microbiome-based Live Biotherapeutics Fuels the Manufacturing Demand

By  Biotherapeutics, Manufacturing, Microbiome Research  1 Comment
Growing Pipeline of Microbiome-based Live Biotherapeutics Fuels the Manufacturing Demand
Live biotherapeutics are fragile bacteria, which require ideal conditions of heat, moisture and pH of products, to survive and prevent premature germination. In fact, manufacturing is presently one of the biggest bottlenecks in this domain; manufacturing such products is both technically challenging and financially demanding. One of the biggest challenges in the development of a
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May 26, 2020

Growing Oligonucleotide-based Drugs Pipeline Escalates Manufacturing Demand

By  COVID-19, Oligonucleotides  2 Comments
Rootsanalysis
As therapeutic agents, oligonucleotides are known to be associated with several unique features, such as high selectivity and potency (similar to biologics), and differentiated pharmacology, which further augment their drug-like properties. At present, eight oligonucleotide-based drugs are available in the market, namely (in reverse chronological order of year of approval) GIVLAARI™ (2019), ONPATTRO® (2018), TEGSEDI™
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May 25, 2020

Response to COVID-19 Pandemic with Oligonucleotides

By  COVID-19, Covid19, Oligonucleotides  1 Comment
Rootsanalysis
Never before, scientists say, the universal community of researchers have put a halt to all other ongoing research and have urgently focused towards swiftly evolving health emergency. In the past few months, scientists have been repurposing their research efforts towards contributing to the global effort in response to COVID-19 pandemic. For the purpose of mitigating
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May 20, 2020

How COVID-19 Poses a Sharp Challenge on China Biopharmaceutical Contract Manufacturing Market?

By  Biopharmaceutical, Contract Manufacturing, COVID-19  1 Comment
Rootsanalysis
China, epicenter of the COVID-19, is the world’s second largest pharmaceutical market and accounts for 20 % of the global output of APIs. With over 25 biologics and biosimilar products approved till date and close to 1,000 clinical trials, investigating a variety of biologics and biosimilars, being underway in this region, China’s biopharma market is
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May 19, 2020

Neoantigen Targeted Therapies Pave the Way to Personalized Anti-cancer Therapy

By  Anti-cancer, Anti-cancer Therapy, Therapies  1 Comment
rootsanalysis
Neoantigen Targeted Therapies Pave the Way to Personalized Anti-cancer Therapy There is an urgent unmet need for developing innovative and effective cancer therapeutics for the treatment of patients with late-stage and refractory cancer. Amidst the widespread initiatives to develop more targeted anti-cancer therapies, immunotherapy emerged as a highly specific and potent option to eradicate tumor
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May 7, 2020

The Future of Manufacturing: Collaborative Robots in the Factories

By  Cobots, Robots  1 Comment
Rootsanalysis Blog
The world has experienced a radical change with the advancements in technologies and systems that aid daily activities. Particularly, automation has played an important role in increasing the productivity and quality of the production process in various industries. Within the automation industry, robots have already been established; however, one of the fastest-growing segment of robotics
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April 24, 2020

COVID 19 and Vaccines: How Big Will be the Impact on Prefilled Syringes Market?

By  Coronavirus, COVID-19, Medical Device, Vaccines  1 Comment
COVID19 Roots Analysis
Coronavirus(COVID 19) is spreading around the world, with 2.6 million global active cases[TB1] . Till date, there are no approved treatments for COVID-19. However, multiple pharmaceutical companies are doing research at breakneck speed to develop therapeutics and preventive vaccines against this novel coronavirus. The pharma industry is hoping to compress the development timelines to get a
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April 6, 2020

COVID-19: Drugwatch – 6 April 2020

By  COVID-19  1 Comment
Anti-COVID-19 Drugs
To date, there are no approved treatments for COVID-19. However, the pharmaceutical industry is abuzz with activity as medical researchers strive to develop a cure, and possibly a vaccine, for the illness caused by the novel coronavirus. In this article, we have attempted to explore some of the more popular treatments / preventive measures that
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April 5, 2020

COVID-19: Where are we today?

By  Infectious Diseases  4 Comments
Coronavirus
Comparison with other communicable diseases According to worldometers.info, as of 5 April 2020 (5:30 PM GMT), the total number of COVID-19 cases rose to over a million, with a reported mortality rate of 5%. Further, a comparison with certain other communicable disease-related deaths (Figure below) presents a worrisome situation. As of 5-April 2020, the novel
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April 2, 2020

Fragment-based Drug Discovery – A Boon in Disguise to get a Breakthrough Drug Against Covid-19

By  Drug Discovery  0 Comments
RootsAnalysis Blog
With over 855,000 cases and 42,000 deaths, the novel coronavirus has taken its toll on humanity. The pandemic is predicted to throw the global economy into recession, with loss of trillions of dollars. The pharmaceutical industry cannot escape the brunt of the circumstances as well. In fact, according to a survey, 95% of healthcare industry
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March 29, 2020

COVID-19 Impact on Cell and Gene Therapy Manufacturing Market

By  Cell Therapy, Gene Therapy, Vector Manufacturing  1 Comment
With close to half-million infections and the economy showing signs of the 2008 financial crisis, COVID-19 has impacted several industries. Government institutes and industry players have announced various steps to deal with the ongoing situation. In this article, we will highlight the developments in the cell and gene therapy manufacturing industry amid the ongoing COVID-19
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March 29, 2020

Continuous Manufacturing: Solution to Pharmaceutical Manufacturing Industry’s COVID-19 Concerns

By  Contract Manufacturing, Pharmaceuticals  1 Comment
Continuous Manufacturing amid COVID-19
The ongoing COVID-19 crisis has put the pharmaceutical manufacturing supply chain under close scrutiny. The overdependence of the US on China and India to meet its API demand has been the talk of the town. However, with the number of infected cases in the US surpassing that of China, the focus has shifted from discussing
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March 29, 2020

COVID-19 Impact on Gene Therapy Market

By  Gene Therapy  2 Comments
COVID-19 Impact on Continuous Manufacturing Market
In a recent press release, bluebird bio, one of the leading gene therapy developers, announced that COVID-19 has delayed the EU launch and US filing of the company’s gene therapy candidate Zynteglo (LentiGlobin). The company now expects to dose the first commercial patient with Zynteglo in Germany in the second half of 2020. Earlier, the company had
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March 24, 2020

Contraband in the Clinical Trials -A saga of the great apes, who went on to ban the nature

By  Clinical Trials, Pharmaceuticals  3 Comments
Roots Analysis - Clinical Trials
To err is human, to rectify divine, this irony perhaps holds truer for cannabis than any other domain. After using cannabis in multiple forms for at least 10,000 years, a series of events, including spread of misinformation, anti-Mexican sentiment and fear led to the ban of nature a.k.a. cannabis. The US implemented Marijuana Tax Act
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March 16, 2020

Immuno-Oncology Biomarker: Benchmarking Big Pharma Activity

By  Diagnostics, Oncology  1 Comment
Is genomics revolution all fun and games?
Over the past few years, therapeutic advancements in conventional treatment paradigms have led to an increase in survival among cancer patients. Recent developments in the field of immuno-oncology, such as the introduction of several cancer vaccines, adoptive T-cell therapies, and checkpoint inhibition therapies, have demonstrated significant potential, and some of the aforementioned therapies have already
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March 15, 2020

Cell Therapy Manufacturing: Here are the Key Innovations

By  Cell Therapies, Cell Therapy, Gene Therapy  2 Comments
This is a feature image for blog article Digital Biomanufacturing at Roots Analysis
Last week, during our weekly industry update sessions, our prime focus was to understand the recent innovations in the field of cell therapy manufacturing. We were also looking out for players that are driving these innovations. To start with, the first news that caught our attention was Novartis’ decision to sidestep Europe travel ban to
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March 12, 2020

Microbiome Contract Manufacturing: Time to Push the Increase Capacity Button

By  Contract Manufacturing, Microbiology  1 Comment
The interest in the trillions of microbiome present in the human body has attracted a lot of research effort in the microbiome domain. The first such effort at a large scale was The Human Microbiome Project, conducted by the National Institutes of Health in the United States, which characterized the microbial communities at five major
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March 11, 2020

Cell Therapy and The Rise of Novel Technologies

By  Cell Therapies, Cell Therapy, Contract Manufacturing, Gene Therapy, Natural Killer Cells  2 Comments
Roots Analysis has actively tracked the developments in the field of cell therapy and gene therapies. The team has focused on identifying the key challenges that are hampering the growth of these revolutionary therapies. To identify the challenges, the team has interviewed several stakeholders involved in cell therapy development and manufacturing. In addition, a recent
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February 14, 2020

Is genomics revolution all fun and games? How blockchain can calm data security nerves!

By  Diagnostics, Drug Discovery, Genomics  2 Comments
Is genomics revolution all fun and games?
Have you had your genomics sequenced? If you asked this question a few years ago, people would have thought you were crazy. However, today, genetic tests are up for sale in supermarkets! Fifteen years ago, the first ever Human Genome Project was carried out, which took more than 13 years to complete. This (Human Genome
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February 4, 2020

Catalent’s Shopping List: Hinting Towards a One-Stop Cell & Gene Therapy CMO in Making

By  Cell Therapy, Gene Therapy  3 Comments
There appear to be no Monday blues for Catalent as the company announces the acquisition of MaSTherCell Global, a technology-focused cell and gene therapy contract development and manufacturing organization. Following its last year’s acquisition of Paragon Bioservices (a leading viral vector developer), Catalent’s recent acquisition has extended the company’s leadership in this already crowded space.
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January 2, 2020

Vector Manufacturing Market: Opinion Leaders Highlight Key Concerns

By  Vector Manufacturing  3 Comments
This is a feature image for blog article Blockchain Technology in healthcare at Roots Analysis
The growing pipeline of cell and gene therapies has led to an increase in demand for high-quality gene delivery vehicles and, therefore, has created significant opportunities for companies with expertise in manufacturing viral and non-viral vectors. In an article published last year, I discussed the growing cell and gene therapy market and how it has
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January 1, 2020

CMO, CMO Everywhere, Not a Single One That Fits: The Reality of Biopharma Contract Manufacturing Market

By  Biopharmaceutical  2 Comments
I was recently involved in a discussion with the global outsourcing manager of one of the big pharma companies. The premise of the discussion was around the criteria that big Biopharma Contract players follow for choosing a supplier for their products. One key question that came up in the discussion was whether one-stop-shops are really
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November 12, 2019

Evolution of Cancer Diagnostics: Rise of Novel Non-Invasive Methods

By  Cancer  0 Comments
This is a feature image for blog article Evolution of Cancer Diagnostics at Roots Analysis
Cancer diagnosis, today, employs a mix of invasive and non-invasive strategies. Invasive cancer diagnostic methods are generally expensive and uncomfortable. Biopsies have been the gold standard to determine the clinicopathological characteristics of cancer tissues for many years. The procedure is very uncomfortable and painful for patients and in many cases, the results are known to
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November 12, 2019

CAR-T Pipeline Update: Autolus Therapeutics Presents Preclinical Data on AUT06NG

By  Cell Therapies  0 Comments
This is a feature image for blog article CAR-T Pipeline at Roots Analysis
Autolus Therapeutics, a clinical-stage biopharmaceutical company developing next-generation programmed T cell therapies for the treatment of cancer, presented pre-clinical data on AUTO6NG, the company’s next-generation GD2-targeting CAR (chimeric antigen receptor) T cell therapy, at the 34th Annual Meeting of the Society for Immunotherapy of Cancer (SITC). What did the results highlight: The results demonstrated the utility
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November 11, 2019

Microbiome Research Update: New Study Uncovers Role of Bacteria in Bowel Cancer

By  Microbiome Research  0 Comments
This is a feature image for blog article Microbiome Research Update at Roots Analysis
Dr. Kaitlin, from the University of Bristol, speaking at the 2019 NCRI Cancer Conference, confirmed that they have discovered evidence of the presence of an unclassified type of bacteria from the bacterial group named ‘Bacteroidales’ increased the chances of bowel cancer by 2 to 15 percent.  The researchers employed the technique known as Mendelian randomization to
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November 11, 2019

New Research in ALS – Mitoautophagy Responsible for Development of Early Stages of Neurodegeneration

By  Neurodegeneration  0 Comments
This is a feature image for blog article Mitochondrial Diseases at Roots Analysis
Researchers at Northwestern Medicine have discovered a new phenomenon in the brain that could explain the development of early stages of neurodegeneration seen in diseases such as ALS, which affects voluntary muscle movement such as walking and talking Mitoautophagy. What is the discovery: The researchers have invented a new term to describe the discovery: Mitoautophagy,
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November 9, 2019

FDA Approves Celgene’s REBLOZYL® for the Treatment of Anemia

By  Celgene's REBLOZYL  0 Comments
This is a feature image for blog article FDA Approves Celgene’s REBLOZYL® for the Treatment of Anemia at Roots Analysis
The U.S. Food and Drug Administration (FDA) has approved Celgene’s REBLOZYL® (luspatercept-aamt) for the treatment of anemia in adult patients with beta-thalassemia who require regular red blood cell (RBC) transfusions. What is Beta-thalassemia: Beta-thalassemia is a blood disorder that reduces the body’s production of hemoglobin. Low levels of hemoglobin lead to a shortage of mature red blood cells and a lack of oxygen in
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November 9, 2019

CAR-T Pipeline Update: Celgene posts pivotal data ahead of FDA filing

By  Cell Therapies, Cell Therapy  0 Comments
This is a feature image for blog article CAR-T Pipeline Update at Roots Analysis
Celgene has recently published positive data from a pivotal trial (NCT02631044) of its CAR-T therapy. As per the reports, the data look competitive against Gilead’s Yescarta and Novartis’ Kymriah, leading analysts to predict Celgene will win FDA approval next year. This is a big news for the overall CAR-T pipeline. As per the reported data, the
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November 8, 2019

New Real-World Data Unveiled at ACAAI Indicates Comparable Clinical Practice Logistics to Implement Oral Immunotherapy and Environmental Allergy Shots

By  Clinical Practice  0 Comments
This is a feature image for blog article New Real-World Data Unveiled at Roots Analysis
In a recent press release by Aimmune Therapeutics, the company reported that the Clinical Practice logistical needs for implementing oral immunotherapy (OIT) for food allergies, such as peanut allergy, into clinical practice are comparable to those for subcutaneous immunotherapy (SCIT) for environmental allergies. These data were presented at the American College of Asthma, Allergy and Immunology
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November 8, 2019

Party Like Celebrities: American Gene Technologies Hosts a Red Carpet Event to Celebrate IND Submission

By  Gene Technologies  0 Comments
This is a feature image for blog article Gene Therapy at Roots Analysis
On November 6, 2018, American Gene Technologies (AGT) announced that it will host a red carpet event to celebrate a significant milestone in the company’s 11-year history of scientific research in cell and gene therapy. Last month, the company successfully submitted its Investigational New Drug (IND) application to the Food & Drug Administration (FDA) to
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November 8, 2019

T-Cell Therapies Funding Update: Tmunity Raises $75 Million in Series B Funding

By  T-Cell Therapies  0 Comments
This is a feature image for blog article T-Cell Therapies Funding Update at Roots Analysis
On 31st October 2019, Tmunity Therapeutics, a private biotherapeutics company focused on saving and improving lives by delivering the full potential of next-generation T cell Therapies, announced the closing of $75 million Series B financing. Who were the key investors: The financing was led by Andreessen Horowitz (also known as “a16z”). Joining the Series B
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November 8, 2019

Avantgen Enters a Strategic Collaboration Agreement for its NK Cell Engager Technology

By  Natural Killer Cells  0 Comments
This is a feature image for blog article Avantgen Enters a Strategic Collaboration Agreement for its NK Cell Engager Technology at Roots Analysis
On 7 November 2019, AvantGen, a biotechnology company with its array of technology platforms for antibody discovery, optimization, and novel NK cell engager generation, announced a strategic agreement with an undisclosed biopharmaceutical company for the purpose of generating multiple novel bi-specific NK cell engaging therapeutic antibody product candidates. Under the terms of the agreement, AvantGen
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November 4, 2019

CARsgen anti-BCMA CAR T Therapy Receives RMAT Designation

By  Cell Therapy  0 Comments
This is a feature image for blog article CARsgen anti-BCMA CAR T Therapy Receives RMAT Designation at Roots Analysis
On 28 October 2019, CARsgen Therapeutics, a clinical-stage biopharma company, announced that the FDA has granted Regenerative Medicine Advanced Therapy (RMAT) designation to its investigational CT053 CAR-T cell therapy. What is CT-053: CT053 is a fully human anti-BCMA (B Cell Maturation Antigen) autologous chimeric antigen receptor (CAR) T Cell therapy for the treatment of relapsed and/or refractory multiple
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November 3, 2019

Genome Editing Services Market Snapshot

By  Genomics  0 Comments
Genome Editing Services Market Snapshot
The rising demand for genome editing services has resulted in the rise of several players with a wide range of capabilities. Currently, there are close to 80 players that claim to offer CRISPR based genome editing services. To get more insights about the market, check out the detailed report market report – Genome Editing Services.
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November 3, 2019

More than 50 Large Volume Wearable Injectors are Available / Under Development

By  Autoinjectors  0 Comments
More than 50 Large Volume Wearable Injectors are Available / Under Development
Over time, both drug developers and medical device Injectors manufacturers, have entered into strategic alliances to combine their respective expertise and develop appropriate drug-device combination products. Presently, multiple such combinations, facilitating easy delivery of both insulin and non-insulin drugs, in large volumes, are either already available in the market or under development. Check out more
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November 2, 2019

ADCs Pipeline Update: Avacta Partners with ADC Therapeutics

By  ADCs Pipeline  0 Comments
ADCs Pipeline Update: Avacta Partners with ADC Therapeutics
On November 1, 2019, Avacta Group and ADC Therapeutics have announced a collaboration agreement for the development of novel drug candidates. What is the objective of the collaboration: The partnership will aim at the development of drugs combining ADC Therapeutics’ pyrrolobenzodiazepine-based cytotoxic warheads with Avacta’s Affimer targeting platform. What are the financial terms of the agreement: The detailed
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November 2, 2019

ADCs Pipeline Update: Daiichi Sankyo Initiates Clinical Trial

By  ADCs Pipeline  0 Comments
On October 31, 2019, Daiichi Sankyo and Sarah Cannon Research Institute announced the dosing of the first patient in a first-in-human phase 1/2 study (NCT04145622) evaluating DS-7300. What is DS-7300: DS-7300 is an investigational B7-H3 targeting antibody-drug conjugate (ADC). What is B7-H3: It is a Type I transmembrane protein belonging to the B7 family, which includes immune checkpoint
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October 30, 2019

ADCs Pipeline Update: Sutro Biopharma Presents Encouraging Data in Patients with Advanced Ovarian Cancer

By  ADCs Pipeline  0 Comments
ADCs Pipeline Update: Sutro Biopharma Presents Encouraging Data in Patients with Advanced Ovarian Cancer
Sutro Biopharma, a California based, clinical-stage company, announced initial safety data in ovarian cancer patients from its ongoing phase I study (NCT03748186) of STRO-002. The drug is a folate receptor alpha (FolRα)-targeting antibody-drug conjugate (ADC) and potent anti-tumor activity in preclinical endometrial cancer patient-derived xenograft (PDX) models. The data are being presented at the AACR-NCI-EORTC Molecular Targets
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October 30, 2019

ADCs Pipeline Update: Femtogenix Presents Novel Data on ADCs Containing Reduced Potency Payloads

By  ADCs Pipeline  0 Comments
Femtogenix, a UK based biotechnology company developing the next generation of DNA-interactive Antibody Drug Conjugate (ADC) payloads, announced data demonstrating the potent efficacy and favorable toxicity profile of a reduced potency analog from its Pyridinobenzodiazepine (PDD) ADC payload platform in solid tumor models. The presented data demonstrated that Femtogenix’s reduced potency payload has a favorable
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October 25, 2019

Antibody Drug Conjugates Market Update: Ambrx and NovoCodex Collaborate

By  Antibody Drug  0 Comments
ADC Technology Platform
Ambrx and NovoCodex Biopharmaceuticals announced that they have formed a second collaboration to develop and commercialize Ambrx’s internally developed site-specific antibody drug conjugates (ADCs). What is the focus of the agreement: Under the agreement, Ambrx and NovoCodex will join forces to continue the development of ARX305, an Ambrx enabled ADC for the treatment of CD70
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October 25, 2019

Cell Therapy Manufacturing Market Update: Compal and University to set up GTP lab

By  Cell Therapy  0 Comments
The Compal Group’s Raypal Biomedical and Kaohsiung Medical University Chung-Ho Memorial Hospital on October 22 signed an MoU to jointly set up a GTP (good tissue practice) cellular laboratory in Kaohsiung City, southern Taiwan. What are the key capabilities of Raypal: Founded in 2016, Raypal specializes in R&D of immunocyte and immunotherapy, stem cell and
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October 25, 2019

Cell Therapy Pipeline Update: Talaris Therapeutics Announces Initiation of Phase 3 Clinical Trial

By  Cell Therapy  0 Comments
Talaris Therapeutics, a late-clinical stage biotechnology company based in Boston, MA and Louisville, KY, announced the initiation of FREEDOM-1 (NCT03995901), the company’s Phase 3 clinical trial of FCR001 in living donor kidney transplant (LDKT) recipients. What is the objective of the trial: This pivotal trial will evaluate the safety and efficacy of a single dose of FCR001,
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October 25, 2019

Gene Therapy Pipeline Update: Orchard Therapeutics Presents Data on Metachromatic Leukodystrophy

By  Gene Therapy  0 Comments
Orchard Therapeutics, a commercial-stage biopharmaceutical company, announced initial results from a clinical trial (NCT03392987) with a cryopreserved formulation of OTL-200, gene therapy in development for the treatment of metachromatic leukodystrophy (MLD). Get the details of the results here. What is OTL-200: OTL-200 is autologous CD34+ cells transduced with a lentiviral vector containing human arylsulfatase A (ARSA) complementary deoxyribonucleic
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October 25, 2019

Cell Therapy Market Update: MaxCyte Advances Phase I Clinical Trial of Lead mRNA-based Cell Therapy

By  Cell Therapy  1 Comment
Cell Therapy Market Update: MaxCyte Advances Phase I Clinical Trial of Lead mRNA-based Cell Therapy
MaxCyte, the global Cell Therapy, and life sciences company, announced the initiation of dosing in the third cohort of patients of MaxCyte’s Phase I clinical trial (NCT03608618) with the next higher cell dose of MCY-M11. The dose-escalation trial is evaluating the safety and tolerability, as well as preliminary efficacy, of MCY-M11 administered intraperitoneally across a series
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October 25, 2019

Genome Editing Market Update: Intellia Therapeutics Presents Data at the 2019 Annual Congress of the European Society of Gene and Cell Therapy

By  Therapeutics  1 Comment
Intellia Therapeutics logo png
Intellia Therapeutics, one of the leading genome editing company focused on the development of curative therapeutics using CRISPR/Cas9 technology is presenting one oral presentation and four poster presentations at the 27th Annual Congress of the European Society of Gene and Cell Therapy (ESGCT) meeting taking place October 22-25, 2019, in Barcelona, Spain. Get a complete
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October 25, 2019

Gene Therapy Pipeline Update: Adverum Biotechnologies Doses First Patient for Wet AMD

By  Gene Therapy  1 Comment
Adverum Biotechnologies, a clinical-stage gene therapy company developing drugs to teated rare ocular diseases, announced that the first patient was dosed in the third cohort (n=9) of the ongoing OPTIC phase 1 clinical trial (NCT03748784) for ADVM-022 for the treatment of neovascular or wet age-related macular degeneration (wet AMD). What is ADVM-022: ADVM-022 utilizes a propriety
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October 25, 2019

Gene Therapy Pipeline Update: AVROBIO Receives Orphan-Drug Designation

By  Gene Therapy  1 Comment
AVROBIO, a US-based company, developing lentiviral-based gene therapies, has announced that the U.S. Food and Drug Administration (FDA) has granted orphan-drug designation for the Company’s investigational gene therapy, AVR-RD-02, for the treatment of Gaucher disease. What is AVR-RD-02: AVR-RD-02 consists of the patient’s own hematopoietic stem cells, genetically modified to express glucocerebrosidase (GCase), the enzyme that is deficient
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October 25, 2019

Cell Therapy Manufacturing Update: United Therapeutics Receives Permit

By  Cell Therapies, Cell Therapy, Contract Manufacturing, Stem Cells  0 Comments
Cell Therapy Manufacturing Update: United Therapeutics Receives Permit
As per recent news coverage, United Therapeutics has received a permit for $9.5 million build-out of its cell therapy facility on the second floor of Mayo Clinic’s Discovery and Innovation Building. What is the area of the facility:  The facility will have a total of 21,843-square-foot space. What are the capabilities at the facility:  The facility will house
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October 24, 2019

Gene Therapy Funding Update: With a Promise of $100 Million in Funding, US Government Bets Big on Gene Therapy

By  Gene Therapy  1 Comment
In a recent press announcement, The U.S. National Institutes of Health (NIH) has agreed to invest in the development of Gene Therapy in an attempt to cure HIV and sickle cell diseases. The program, for which NIH will partner with The Bill & Melinda Gates Foundation, will involve funding of $100 million each over the next
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October 24, 2019

Cell and Gene Therapy Technology Update: ReNeuron Presents Positive Data

By  Cell Therapies, Cell Therapy, Gene Therapy  1 Comment
Cell and Gene Therapy Technology Update: ReNeuron Presents Positive Data
ReNeuron, the UK based, clinical-stage stem cell therapeutics company, announced that new data relating to its CTX stem cell platform will be presented today at the 27th Annual Congress of the European Society of Gene and Cell Therapy (ESGCT). Dr. Steve Pells, Principal Investigator at ReNeuron, will present new data showing the phenotypic stability and scalability
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October 22, 2019

Gene Therapy Pipeline Update: AGTC Presents Promising Data of its AAV Vectors for Ocular Gene Therapy

By  Cell Therapy, Gene Therapy  1 Comment
Applied Genetic Technologies Corporation (AGTC), a clinical-stage biotechnology company, developing transformational genetic therapies for patients suffering from rare and debilitating diseases, announced new data from non-clinical studies evaluating the effect of pre-existing anti-AAV antibodies on the transduction and expression efficiency of AAV vectors. According to the company’s CSO, Preexisting immunity to AAV remains a challenge for
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October 22, 2019

Gene Therapy Pipeline Update: Rocket Pharmaceuticals Receives IND Clearance for Gene Therapy for Pyruvate Kinase Deficiency

By  Gene Therapy  1 Comment
Rocket Pharmaceuticals, a New York-based, clinical-stage company, developing first-in-class gene therapies for rare and devastating inherited diseases announced clearance of Investigational New Drug (IND) by the FDA for RP-L301 gene therapy. RP-L301 is a lentiviral vector (LVV)-based gene therapy for the treatment of Pyruvate Kinase Deficiency (PKD), a genetic rare disease. Last month, the company received
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October 22, 2019

Gene Therapy Pipeline Update: Homology Medicines Presents Data Demonstrating Preclinical Proof-of-Concept

By  Gene Therapy  1 Comment
Homology Medicines, a company using proprietary gene editing and gene therapy platform announced the presentation of preclinical data supporting its investigational gene therapy programs for the treatment of metachromatic leukodystrophy (MLD) and phenylketonuria (PKU) at the American Society of Human Genetics (ASHG) 2019 Meeting. The presented preclinical data showed the results from studies conducted in
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October 22, 2019

Alzheimer’s Pipeline Update: Biogen Takes a U-Turn on Failed Drug; Approval in Sight

By  Alzheimer's Pipeline  1 Comment
Alzheimer's Pipeline
In one of the most drastic shifts in fortune in the pharmaceutical industry, Biogen has decided to submit its previously failed Alzheimer’s drug for approval. According to the company, The Phase 3 EMERGE (NCT02484547) study met its primary endpoint showing a significant reduction in clinical decline, and Biogen believes that results from a subset of patients
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October 22, 2019

Cell Therapy Manufacturing Update: Merck Becomes the First to Introduce Acoustic Technology

By  Cell Therapy  1 Comment
With its acquisition of FloDesign Sonics earlier this month, Merck/MilliporeSigma has become the first company to introduce acoustic technology in cell therapy manufacturing. The acquisition of FloDesign Sonics is a strategic fit for Merck, strengthening its ability alongside to manufacture cell-based therapies for patients. What is Acoustic Cell Processing: Acoustic cell processing is a disruptive technology that allows
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October 22, 2019

Plasmid DNA Manufacturing Market Update: Cytovance®Introduces Integrated Single-Use Platform

By  DNA Manufacturing  1 Comment
In the ongoing shift of biologics manufacturers to single-use systems, Cytovance®, a leading biopharmaceutical CDMO, announced the addition of an integrated single-use platform for the manufacturing of plasmid DNA (pDNA) at their facilities in Oklahoma City, OK. According to the company, two grades are available (Critical Reagent Grade™, CGMP-grade) in lot sizes from 1g to 50g,
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October 22, 2019

Gene Therapy Market Update: Researchers Deliver a Cure for Epidermolysis Bullosa (EB)

By  Gene Therapy  1 Comment
In a recent news update, a team of Irish gene therapy researchers announced a breakthrough in the search for a cure for one of the worst strands of the incredibly painful skin disease, EB (epidermolysis bullosa). According to the researchers, the incredibly painful genetic condition, which affects approximately 300 people in Ireland, is caused by a
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October 21, 2019

Technological Evolution of ADC Conjugation Platforms

By  ADC Conjugation  1 Comment
ADC Technology Platform
Last week, I wrote an article on the key innovators in ADC therapeutics space, Technological highlighting the key winners at the 6th World ADC Awards. One of the winners, that has really impressed several drug developers in this space, is Zymeworks. The company has its proprietary conjugation Technological platform, ZymeLink™, which offers site-specificity and customization
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October 21, 2019

Gene Therapy Market: Big Pharma Bets Big

By  Gene Therapy  0 Comments
Last week, I came across an interesting article by Andrew Dunn titled Sanofi investing in gene therapy as R&D focus turns toward rare disease. The article caught my attention because in June, this year, Sanofi scaled back its four-year-old gene therapy alliance with Voyager Therapeutics, for the second time. If we just look at the news titles,
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October 17, 2019

10 Key Facts About ADC Market

By  Antibody Drug  0 Comments
Global Antibody Drug Conjugates ADC market is expanding and is estimated to be around USD 7.72 billion in 2023. The compound annual growth rate of ADC market is estimated to be 9.50% in the coming decade. Roots Analysis has been publishing multiple articles and key insights pack for ADC market growing potential to keep the
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October 12, 2019

Super Generics Market: The Untapped Gold Mine

By  Generics Market  0 Comments
Supergenerics Market
The Super Generics industry has enjoyed a remarkable run over the past two decades. The vast healthcare cost-saving potential of these therapies has accelerated their adoption and proven the immense potential that generics have to reach wider patient segments. The problems arrive: While the generics market is highly attractive, the increasing competition in this domain
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October 10, 2019

Growing Cell and Gene Therapy Market: Vector Manufacturers Make Merry

By  Cell Therapies, Cell Therapy, Contract Manufacturing, Gene Therapy  0 Comments
Cell and Gene Therapy are the new entrants in the pharma Superstar Club. They are selling tickets faster than a Queen’s concert in the 1980s. In fact, as per the Alliance of Regenerative Medicine’s recent findings, there has been more than 75% year on year increment in funding to support the development of various cell and gene therapies.
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October 9, 2019

Synthetic Lethality Market: Riding on the ESMO 2019 Success of PARP Inhibitors

By  Synthetic Lethality  0 Comments
Synthetic Lethality Market: Riding on the ESMO 2019 Success of PARP Inhibitors
After a strong showdown at ESMO 2019, both GSK and AstraZeneca have reignited the fight of small molecule anti-cancer drugs against the industry’s brawny immunotherapy push. Leading this fight is poly(ADP-ribose) polymerase (PARP) inhibitor, one of the leading synthetic lethality targets. These better than expected results at ESMO further validate the potential of synthetic lethality
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July 18, 2019

Abuse Deterrent Formulation Technologies: Combating Prescription Drug Abuse

By  Abuse Deterrence, Pharmaceuticals  0 Comments
Although the healthcare industry relies on the patient to take medications responsibly; in 2017, close to 18 million individuals were reported to have misused prescription drugs, in the US. In fact, data from a National Survey on Drug Use and Health conducted in the same year, showed that an estimated 2 million Americans misused prescription
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July 17, 2019

Natural Killer Cell Therapies: Pipeline Review

By  Cell Therapy, Natural Killer Cells  0 Comments
Natural killer (NK) Cell Therapies , or killer (K) cells, represent an important subset of cellular mediators of the innate immune system. These cells are known to be instrumental in containing viral infections and regulating tumor development, while the adaptive immune system generates an antigen-specific response. Several studies have demonstrated the various benefits of NK
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July 12, 2019

Vaccine Contract Manufacturing: Current Landscape and Future Potential

By  Contract Manufacturing, Vaccines  0 Comments
The global vaccines market is anticipated to generate revenues worth USD 100 billion by 2025. According to the WHO, the global vaccination rate is nearly 85%, demonstrating the high clinical demand for vaccines. In addition to meeting the growing demand for vaccines, the developers of these pharmacological interventions are also plagued by high costs of
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May 28, 2019

Neoantigen Targeted Therapies: Mapping the Future Growth Potential

By  Oncology  0 Comments
The World Health Organization has estimated the number of new cancer cases, reported across the globe, to rise by 70% over the next 20 years. Conventional treatment options, such as chemotherapy, surgery and radiation therapy, continue to demonstrate limited efficacy in late-stage cancers. Recent developments in genomic analysis and advances in bioinformatics have enabled the
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May 16, 2019

Biologics Fill / Finish Services: Current Landscape, Growth Opportunities and Future Market Outlook

By  Biologics  0 Comments
According to a recent CDMO survey, about 54% respondents claimed to have collaborated with a contract service provider for clinical and commercial-scale product development projects. Specifically, fill / finish is the final step in the production process and is considered among the most crucial stages of drug product manufacturing. Biologic drug products require special procedures
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May 9, 2019

Elastomeric Closures for Parenteral Containers: Current Market Landscape and Future Growth Opportunities

By  Pharmaceutical Packaging  0 Comments
The use of elastomeric materials, along with various types of coatings (such as FluoroTec® and Teflon®) have emerged as a promising alternative to conventional, non-coated closures used for primary packaging containers, which were prone to leaching and shedding of particulate contaminants. The advantages of using elastomeric materials in manufacturing container closures are many, including low
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April 30, 2019

Cancer Biomarkers Market: Focus on TMB, MSI / MMR and TILs Testing

By  Cancer  0 Comments
Advances in biotechnology have enabled the development of several high throughput tools, which have led to the establishment of better biomarkers based on genome / exome profiles. Novel biomarkers, such as tumour mutation burden (TMB), microsatellite instability (MSI) / mismatch repair (MMR) deficiency, tumour infiltrating lymphocytes (TILs) and certain others, are presently being investigated across
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April 29, 2019

Novel Clinical Trial Service Providers: Focus on RWD, Virtual Trials, Adaptive, Umbrella and Basket Designs

By  Clinical Trials  1 Comment
Studies suggest that each prescription drug requires around 10 years and over USD 2.5 billion in working capital before it reaches the market. Further, it is estimated that, in the US, 40% of the pharma industry’s R&D budget is spent solely on conducting clinical trials. Estimates suggest that nearly 85% of Novel Clinical trials fail
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April 2, 2019

Biopharmaceutical CMO: The Growing Need

By  Biopharmaceutical  0 Comments
Rootsanalysis
Over the years, the biopharmaceutical market has grown into a prominent and promising segment of the overall pharmaceutical industry. Owing to the growing number of start-ups that are engaged in R&D of novel biologics, there is significant opportunity for the biopharmaceutical CMOs in this domain. It is worth highlighting that, since 2000, more than 115
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March 28, 2019

The Emergence of Encapsulated Cell Therapies and Affiliated Technologies

By  Cell encapsulation, Cell Therapy  0 Comments
Extensive research on  Cell Therapies encapsulation strategies have enabled the development of a variety of technologies capable of confining therapeutic entities within biocompatible matrices / carriers. Since 2013, over 3,000 patents have been published related to the aforementioned type of therapy, indicating the rapid pace of R&D activities in this domain. I have highlighted below
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March 14, 2019

Bone Cement Delivery Systems: Current Landscape, Growth Opportunities and Future Market Outlook

By  Delivery Systems, Uncategorized  0 Comments
According to a study conducted by the International Osteoporosis Foundation (IOF), more than 200 million individuals around the world suffer from osteoporosis. In fact, a total of 8.9 million fractures per year are attributed to osteoporosis. The annual socioeconomic burden associated with this condition is estimated to be around USD 19 billion and EUR 37
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March 11, 2019

Cybersecurity in Healthcare: The Impending Threat

By  Cybersecurity, Healthcare  0 Comments
Organizations, in the process of collating and storing huge volumes of data on digital platforms, end up placing themselves at enormous risk of losing valuable information to cybercriminals. Estimated annual losses attributed to cyberattacks committed globally, amount to over USD 100 billion. The year 2017 witnessed several cyberattacks; notable examples include WannaCry and NotPetya ransomware
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March 7, 2019

Alzheimer’s Disease Market: Pipeline Review, Developer Landscape and Competitive Insights

By  Alzheimer's Disease  0 Comments
It was estimated that, in 2018, nearly 5.7 million Americans (considering all age groups) were living with Alzheimer’s disease. During the same year, Alzheimer’s Disease Market and other dementias were projected to be responsible for a healthcare burden amounting to USD 277 billion, in the US. Despite extensive research aimed at comprehending the etiopathogenesis of
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March 1, 2019

Stem Cell Therapies: Upcoming Opportunities in Cardiovascular and Metabolic Disorders (CVMD)

By  Cell Therapy, Stem Cells  0 Comments
Cardiovascular disorders and metabolic disorders are considered to be amongst the leading causes of death worldwide. In fact, approximately one-third of the annual number of deaths across the globe are attributed to cardiovascular disorders.  Likewise, a significant proportion of the global population suffers from diabetes or some form of metabolism related clinical condition. As per
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February 26, 2019

Patient Recruitment: Market Landscape and Opportunities for Contract Service Providers

By  Contract Service Providers, Patient Recruitment  0 Comments
It is estimated that 80% of clinical trials do not meet their designated patient enrolment deadlines. In addition, retaining patients is also a matter of concern, considering that the approximate dropout rate across clinical studies is around 30%. Delays in product launch, due to inability of the sponsors to recruit / retain patients, are highly
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February 20, 2019

Next Generation Contact Lenses and Visual Prosthesis: Rising Popularity to Drive a Multibillion Dollar Market

By  Ophthalmic Lenses, Visual Prosthesis  0 Comments
For more than five decades, contact lenses have primarily been used to correct vision-related disorders. The existence of several unmet needs in the field of ophthalmology, recent technological advances and the availability of new biomaterials, have substantially expanded the range of potential application areas for contact lenses. It is also worth highlighting that Visual Prosthetics,
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January 31, 2019

Drug Delivery Technologies: Emerging Paradigms Shaping the Future of Biologics

By  Biologics, Drug Delivery  0 Comments
Given their high target specificity and limited toxicity compared to small molecule drugs, biotherapeutics have revolutionized treatment paradigms across a myriad of clinical conditions, including metabolic disorders, cancers, neurological disorders and autoimmune disorders. In fact, the extent of growth of such therapies can be gauged from the fact that more than 300 biopharmaceuticals have been
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December 6, 2018

Large Volume Wearable Injectors: The Goldrush Continues

By  Drug Delivery, Medical Devices and Technology  0 Comments
The self-injection devices market is currently characterized by the presence of a myriad of advanced and innovative drug delivery solutions, equipped with a variety of user-friendly features. Notable examples of such products include prefilled syringes, reusable and disposable pen injectors, autoinjectors and large volume wearable injectors. Large volume wearable injectors are capable of drug delivery
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November 6, 2018

Genomic Data Management: Opportunities for Blockchain Platform Providers

By  Antibodies, Biologics, Cell Therapies, Contract Research Organizations, Healthcare, LIFESTYLE  0 Comments
It is estimated that, by 2025, around 15% of the world’s population will have had their genomes sequenced, resulting in the generation of several zettabytes of data. However, currently, there are not many reliable and secure data management resources that offer secure storage, seamless exchange of information, and a reliable transaction platform, for large volumes
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October 26, 2018

Drug Adherence Enhancement: Novel Approaches to Drive Future Growth

By  Drug Adherence, Medical Devices and Technology  0 Comments
It has been estimated that, of the ~4 billion annual prescriptions filled by the retailers in the US,  approximately 50% are not taken by patients in accordance to physicians’ instructions.  According to the US Centers for Disease Control and Prevention (CDC), failure to comply to prescribed treatment regimens has been identified as the cause of
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October 18, 2018

The Rise of Cell and Gene Therapy CROs

By  Cell Therapies, Contract Research Organizations, Gene Therapy  0 Comments
Over 500 cell and gene therapy candidates are being investigated in different stages of clinical development across various geographies. In fact, in the past five years alone, more than 1,000 clinical trials, that are currently active, were initiated to evaluate the potential of these therapies across multiple therapeutic indications. Due to several development challenges, such
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October 4, 2018

The Rise of Medical Device CROs

By  Contract Research Organizations, Medical Devices and Technology  0 Comments
Rootsanalysis
According to the World Bank, more than 50,000 different types of Medical Device are currently being used every day in health care facilities worldwide.  In 2018, the global medical devices market is estimated to reach a net worth of approximately USD 450 billion. However, a relatively larger proportion of device developers lack the required internal
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September 27, 2018

Pre-Sterilized / Ready-to-Use (RTU) Primary Packaging: Current Market Landscape and Future Growth Opportunities

By  Pharmaceutical Packaging, Pharmaceuticals  0 Comments
Rootsanalysis
The use of ready-to-use (RTU), or pre-sterilized / pre-treated, container-closure systems have emerged as a promising alternative to conventional primary packaging, adding significant value to streamline pharmaceutical fill / finish operations. These packaging components eliminate multiple steps in the overall fill / finish process (mainly washing, sterilizing and preparing containers), thereby, helping improve operational efficiencies
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September 27, 2018

Cold Chain Logistics for Healthcare: Emerging Opportunities in Cell Therapies, Vaccines and Human Organs

By  Cold Chain, Logistics  0 Comments
Rootsanalysis
Presently, a wide variety of pharmaceutical products, such as biologics, vaccines, human organs for transplantation and certain conventional pharmacological interventions as well, are temperature sensitive and require freezing / cryogenic holding temperatures. In fact, over 95% of all approved biologics and 90% of all vaccines are cold chain dependent.  Stakeholders in this segment have designed
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September 25, 2018

Extractables and Leachables Testing: Emerging Opportunities for Service Providers

By  Medical Devices and Technology, Pharmaceuticals  0 Comments
Rootsanalysis
During drug product manufacturing and fill / finish, it is important to consider not only the impurity profiles of the drugs, but also identify potential sources of contamination in the containers / packaging material used. due to high variability in the type of impurities (organic (volatile, non-volatile or semi- volatile compounds) or inorganic (metals or
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September 11, 2018

ADC Manufacturing: Current Landscape, Growth Opportunities and Future Market Outlook

By  Antibodies, Biologics  0 Comments
Antibody drug conjugates (ADCs) are one of the most popular classes of targeted therapeutic agents and have captured the attention of both large and small pharmaceutical companies, and academic / research institutions across the world. Owing to the fact that these novel conjugates are highly potent toxic molecules, their manufacturing requires elaborate technical capabilities, along
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September 4, 2018

Neurostimulation Devices: Competitive Landscape, Market Evolution and Opportunity Areas

By  Medical Devices and Technology  0 Comments
Extensive research in the field of Neurostimulation has demonstrated the potential of this technique in providing therapeutic relief to a number of patients, who have developed resistance to conventional medication. Since the introduction of the first neurostimulation therapy in 1960s, their numerous observed benefits, such as reversible and minimally invasive nature of the procedures (to
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