Research Insights

Buffer Preparation Market Overview The global buffer preparation systems market is anticipated to grow at a CAGR of around 10%, till 2035. Buffers are aqueous solutions used to control pH in drug manufacturing process and are a vital component in maintaining the stability of both biologics and small molecules during production and in their final form. Moreover, buffers are used in multiple upstream and downstream bioprocesses for various applications, including maintaining the stable pH of cu

Nanoparticle Formulation Market Overview The global nanoparticle formulation market was estimated to be worth USD 1.2 billion in 2023 and is expected to grow at compounded annual growth rate (CAGR) of 10.5% during the forecast period. Over the years, nanoparticles have emerged as a versatile drug delivery system for the controlled, targeted delivery of therapeutics for the treatment of several diseases. Owing to their inherent properties, such as small size, multifunctional behavior and surfa

Conjugation and Labeling Services Market Overview Conjugation is the process of formation of a single, stable hybrid, wherein one of the entities is a molecule, such as protein, antibody, peptide and small molecule. These molecules can be conjugated with various modalities, such as haptens, enzymes, isotopes, fluorescent tags, carrier proteins, polymers, particle conjugates and photoreactive molecules. Bioconjugation is a subset of conjugation where one of the entity is a biomolecule, such as

Bispecific Antibody Therapeutics Market Overview Bispecific antibodies (BsAbs) represent a novel class of antibodies that act by simultaneously attaching to two separate / distinct antigens or different epitopes of the same antigen. These drugs primarily function by redirecting immune effector cells to effectively eliminate cancer cells using various mechanisms, such as antibody-dependent cell mediated cytotoxicity (ADCC), antibody dependent cellular phagocytosis (ADCP), and complement depend

Owing to the growing demand for complex biopharmaceuticals, the number of laboratories providing analytical and product development solutions has increased significantly across the globe. During each step of a laboratory process, it is essential to ensure that all the variables and parameters are under control. However, there are several challenges associated with conventional and manual handling, such as the high risk of sample contamination, high labor costs, time management, operator-to-opera

Cannabis Testing Overview The global cannabis testing market was valued at USD 1.72 billion in 2023 and is anticipated to grow at a CAGR of 22.8% during the forecast period 2023-2035. In the last few years, several countries across the globe have legalized the use of medical cannabis and recreational / adult use cannabis. This can be attributed to the therapeutic potential of cannabis and cannabis-infused products that has been acknowledged recently. Studies have shown that cannabis can pr

The development of a novel molecular entity (NCE), for pharmacological use, is complex as well as cost intensive. It requires close to 10 years and over USD 2.5 billion in capital investment for a prescription therapeutic to traverse from bench to the market. It is also worth highlighting that a significant proportion (40%) of the pharmaceutical R&D budget in the US is spent on clinical research, evaluating the safety and efficacy of novel therapeutic interventions in human subjects. Conduct

Bacterial infections are known to be one of the leading causes of deaths, worldwide. In fact, infections caused by bacteria are responsible for every one out of eight deaths, globally. This can be attributed to the fact that majority of the pathogenic bacteria have developed resistance against the commonly prescribed therapies. In addition, as per the Centers for Disease Control and Prevention (CDC), the annual healthcare cost associated with treatment of infections caused by six multi-drug resi

Polymers represent a versatile class of materials, as they are composed of multiple simple chemical units, commonly known as monomers. It is worth highlighting that polymers possess various favorable characteristics, such as high durability, resistance to chemicals, considerable strength, low cost and light-weight nature. As a result, polymers are used in various industries, including automotive, agriculture, construction, electronics, medical and textile. Specifically, in the medical domain, po

Driven by numerous developmental breakthroughs and encouraging clinical trial results demonstrating the vast potential of adoptive cell therapies (ACT), including CAR-T cell therapies, TCR therapies, TILs and natural killer cell therapies, this therapeutic modality has garnered considerable attention from the players engaged in the pharmaceutical industry. In fact, in the past few years, close to 30 cell and gene therapies have been approved by the US FDA. In addition, over 1,200 cell therapies

Since the outbreak of COVID-19 infection, there has been immense pressure on the biopharmaceutical industry to reduce production timelines and increase the manufacturing capacity, without compromising on the quality of the final product. Further, a surge in morbidity across the globe and enhanced interconnectivity of equipment and technologies has led to an increased burden on manufacturing operations. Other factors that influenced the market include higher competition, competitive pricing, infl

Over the years, rising complexity of active pharmaceutical ingredients (APIs) has led to the development of a myriad of novel formulations that enable efficient drug delivery to the intended site of action. Nonetheless, the demand for oral solid dosage (OSD) forms, including tablets and capsules, remains unparalleled. In fact, over two-thirds of the total drugs prescribed worldwide are dispensed in the form of oral solids. In addition to being cost effective and relatively more stable as compare

Since their introduction in 1982, biologics have gained popularity owing to their therapeutic efficacy, favorable safety profiles and ability to treat a wide variety of disease indications, which are otherwise hard to treat. In fact, in the past two decades, over 170 biopharmaceuticals have already been granted approval by the FDA and over 7,500 biological interventions are under evaluation in clinical trials. It is a well-known fact that the commercial and clinical-scale manufacturing of s

Aseptic fill finish refers to accurate and sterile filling / sealing of drug products into packaging containers, such as vials, syringes, ampoules and cartridges. These aseptic conditions during fill finish operations are not only essential for ensuring end-user’s safety, but also maintaining pharmacological efficacy and product quality. It is worth noting that aseptic fill finish operations require skilled personnel, specialized automated equipment, cleanroom setup and continuous supervis

Biologics represents one of the fastest growing segments of the healthcare sector. In last five years, over 50 biologics been approved by the Food and Drug Administration (FDA) and close to 10,000 biologics are being evaluated across different stages of development. The growing demand for biologics has consequently led to the need for development of advanced technologies for the purification of these drug substances. This need is primarily driven by the fact that biologics are sensitive to heat

RNA therapeutics are known to target specific genetic sequences of individual patients, in order to provide more effective treatment options for a wide range of disorders, with fewer side effects. These therapies are currently being developed using different types of RNA-based molecules, including coding RNAs (such as mRNA) and non-coding RNAs (such as interfering RNAs (RNAi), antisense oligonucleotides (ASO) and RNA aptamers). The development of RNA-based therapeutics initially gained momentum

Low drug solubility and its corresponding impact on bioavailability have remained a primary cause of concern with several marketed as well as clinical stage drugs. According to the Journal of Analytical and Pharmaceutical Research, 70% of the 50 drugs approved by the USFDA in 2021 were poorly soluble. Moreover, approximately 40% of marketed pharmacological products and close to 90% of drug candidates under development, have been associated with solubility and / or permeability issues, resulting

As per the data published by Centers for Disease Control and Prevention (CDC) in December 2022, oncological disorders (various types of cancer) have emerged as the second leading cause of death in the US. In fact, as per recent studies, the annual burden of oncological disorders is more than USD 185 billion in the US. In order to address the aforementioned challenge, various developers across the globe, have identified inhibition of enhancer of zeste homolog 2 (EZH2) as one of the potential targ

Thermoplastic polymers are defined as a unique group of polymers whose structure can be softened / melted under the application of heat and are then returns to its original state under cooling environment. On the other hand, thermoplastic elastomers (TPE) are defined as thermoplastics that possess the characteristics of rubber but are manufactured without the process of vulcanization. In fact, TPEs are processed with by using plastic manufacturing equipment such as, injection molding, blow moldi

Nucleic acid-based therapies have been demonstrated to be capable of targeting genetic blueprints in order to enable treatment of a range of disease indications. Over the years, an increasing number of nucleic acid-based therapies have received regulatory approval, highlighting the therapeutic potential and growing popularity of this class of therapeutics. Consequently, this has created increased demand for vectors, which can effectively deliver such therapies. In this context, it is important t