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Research Insights

In 1973, a group of scientists reported that individual genes can be cloned and isolated by cleaving DNA enzymatically into DNA fragments. Over time, gene and DNA cloning has proved to be an important tool for researchers in their studies focused on genetics. The evolution of genetic engineering and cloning techniques has allowed for alterations in the genome of microorganisms, thereby enabling the production of substances having various research and therapeutic applications. Further, cloning ca

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Over time, spectroscopy has emerged as an important analytical tool for accurate and rapid analysis of compounds. It finds applications in research activities in food, biotechnology, pharmaceutical and environmental industry. Spectroscopic instruments provide information on electronic and optical properties, chemical composition and crystallinity of compounds. There are several types of spectrometers, such as mass spectrometer, atomic absorption spectrometer, nuclear magnetic resonance (NMR), Ra

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Research indicates that about 6% of the individuals are expected to get affected from chronic wounds, globally. Specifically, in the US, 6.5 million individuals are estimated to be affected by chronic wounds. Financially, treatment of wound-related complications levies a burden of over USD 25 billion, annually, on the US healthcare system. In other words, treatment and care of chronic wounds is believed to account for more than 5% of the National Healthcare Service (NHS) expenditure in the afore

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Since the discovery of the first human genetic map in 1987, the field of omics-based analysis has evolved significantly. Researchers have focused their efforts from decoding the primary sequence of genes to analyzing the location and interaction of cell types, and biomarkers (primarily, DNA, RNA and proteins), through a process known as spatial phenotyping. The traditional molecular profiling analytical techniques, such as microarrays quantitative polymerase chain reaction (qPCR), flow cytometry

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During each stage of biopharmaceutical manufacturing process, it is essential to ensure that the bioprocess variables and parameters are under control. Sampling is considered to be an important step in the bioprocess. However, there are several challenges associated with conventional, manual aseptic sampling technique, such as high risk of contamination of the sample, high labor costs, operator-to-operator deviations during sampling and sample preparation, lower sample frequency rates and no rea

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The drug discovery process, which involves the identification of a relevant biological target and a corresponding pharmacological lead, is deemed crucial to the clinical success of a drug candidate. However, considering the growing complexity of modern pharmacology, the discovery of viable therapeutic candidates is very demanding, both in terms of time and capital investment. In fact, as per estimates, a therapeutic drug takes around 10 to 15 years and an average investment of USD 1 to 2 billion

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With several blockbuster therapies (such as Humira®, Rituxan®, Lantus®, Avastin®, Herceptin® and Remicade®) and a robust pipeline of product / therapy candidates, the biopharmaceutical market is anticipated to witness significant growth in the next few years. However, it has been established that biologic drug development is a complex, time-consuming and capital-intensive process. These complex molecules require highly engineered specialized equipment, innovative downstre

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According to a study published in the Canadian Journal of Infectious Disease and Medical Microbiology in 2021, more than 1.3 million cases of needlestick injuries (NSI) among health care workers (HCWs) are reported every year in the US and Europe. NSIs are known to occur frequently in healthcare settings while using injections and can lead to transmission of various blood borne pathogen. In fact, as per the estimates provided by the Centers for Disease Control and Prevention (CDC), HCWs are at a

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Over the last few decades, there have been significant advancements in the field of molecular biology. In this domain, molecular diagnostic testing has emerged an important tool for disease diagnosis and monitoring. In fact, with outbreak of COVID-19 in 2020, the industry witnessed a significant surge in the demand for molecular diagnostics. As a result of this, researchers shifted their focus on the development of more efficient molecular diagnostic methods, such as RNA extraction and RNA purif

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The oral solid dosage (OSD) market is the largest segment in the pharmaceutical industry, anticipated to reach over USD 900 billion by 2027. However, one of key concerns associated with this industry is that the active pharmaceutical ingredients (APIs) used in orally administered dosage forms inherently possess an unpleasant taste / odor. The existence of such taste in drug formulations is unappealing and has been shown to have a negative impact on patient compliance, particularly among the pedi

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The advancements in health care and available technologies have inadvertently led to an increase in the life expectancy of individuals. However, this has also led to a rise in the aging population worldwide. According to the United Nations, the aforementioned trend is one of the key transformations observed in the 21st century; it is expected to have an impact on all sections of the society. Aging is linked to a variety of diseases, including cardiovascular disorders, neurodegenerative disorders

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As per recent estimates (reported in May 2022), more than 11.6 billion doses of COVID-19 vaccines have been administered across 184 countries; this value roughly translates to 20.9 million doses per day. Vaccines have enabled the prevention of more than 37 million deaths due to various disease indications, such as cholera, diphtheria, influenza, tetanus, whooping cough and measles, between 2000 to 2019. Given the rate at which the global population is growing and taking into consideration the pr

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DNA or RNA molecules find a variety of applications in the biopharmaceutical industry for genetic testing, medical research, therapeutic development, forensic investigation, and other analytical processes. It is worth highlighting that several research studies are being conducted to evaluate the use of oligonucleotides, especially DNA, as a therapeutic intervention for treatment of various medical conditions. The approval of the first antisense oligonucleotide drug, Fomivirse, in 1998, led to a

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The field of gene cloning remained a largely unexplored area until 1973, when A. C. Y. Chang, H. W. Boyer, R. B. Helling and Stanley N. Cohen reported that individual genes can be cloned and isolated by cleaving DNA enzymatically into DNA fragments. Over time, the evolution of genome engineering techniques has allowed for alterations in the genome of microorganisms, thereby enabling the production of substances having various research and therapeutic applications. DNA cloning, which is a highly

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The biopharmaceutical industry has witnessed significant growth over the past few years. Till date, more than 620 biologics have already been approved by the USFDA, while 8,000 are under clinical evaluation. The increased number of approvals and ongoing clinical trials demonstrate the growing popularity of novel treatment options for a variety of ailments and diseases. As a result, several stakeholders have opted to modernize their conventional biomanufacturing technologies in order to cope up w

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According to the World Health Organization (WHO), cancer is the second leading causes of mortality worldwide. In this context, it is important to highlight that around 10 million cancer deaths are reported globally each year. Further, it is estimated that, by 2030, around 21.4 million new patients are likely to be diagnosed with cancer annually. In fact, the global cancer burden is likely to increase by 70%, over the next two decades. With an aim to counter the rising number of cancer cases acro

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