DNA Replication Demand: Driving Contract Manufacturing Market

Since the approval of the first antisense therapy in 1998, DNA replication has been in light for their capabilities as therapeutic agents. DNA replication provides a short synthetic nucleotide chain with immense potential in the diagnosis and treatment of a myriad of disease indications. In addition to therapeutics, these complex molecules act as a significant resource in various research applications. The onset of the COVID-19 pandemic has contributed greatly to the increasing demand of gene cloning – based products, consequently, proposing lucrative opportunities for custom / contract service providers engaged in the DNA replication market.

It is worth highlighting that DNA replication is a complex and labor-intensive process. It involves chemical synthesis of nucleic acid fragments with a defined chemical structure and varying length and sequence. However, with the introduction of advanced technologies, involving the use of phosphoramidite monomers and tetrazole catalysis, has made this process more convenient and efficient. The overall DNA manufacturing involves the following steps.

Owing to the incessant demand for DNA replication – based products, several small to mid-sized companies and certain pharma giants, have begun outsourcing their manufacturing operations to contract service providers. Outsourcing offers several benefits to the developers including cost saving opportunities, increased operational efficiencies, expedited time-to-market, access to advanced capabilities and technologies, validated quality control setup, flexibility, risk sharing and, in several cases, regulatory support. Despite the advantages of outsourcing complex manufacturing operations offered, a number of parameters add on to the complexity of selecting an appropriate service provider. Some of the commonly considered parameters include

The selection of a wrong / improper service provider partner can prove to be disastrous in the long run, wherein issues, such as delays and cost overruns, crop up. Therefore, it is of utmost importance to access the expertise and capabilities of potential service providers.

It is worth highlighting that a wide variety of DNA replication – based interventions have been developed in the past few years. Further, it is believed that, given their high specificity and favorable biological tolerance profiles, the DNA synthesis market is likely to evolve into one of the key interest for stakeholders in the near future.

For additional details, you can also download the SAMPLE REPORT on DNA replication by Roots Analysis.

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