DNA Synthesis Market

DNA Synthesis Market, Distribution by Method of DNA Synthesis, Key Applications Areas, Company Size, and Key Geographies: Industry Trends and Global Forecasts, 2022-2035

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DNA Synthesis Market Overview

The DNA synthesis market is estimated to be worth $669 million in 2022 and is expected to grow at compounded annual growth rate (CAGR) of more than 20% during the forecast period. DNA or RNA molecules find a variety of applications in the biopharmaceutical industry for genetic testing, medical research, therapeutic development, forensic investigation, and other analytical processes. It is worth highlighting that several research studies are being conducted to evaluate the use of oligonucleotides, especially DNA, as a therapeutic intervention for treatment of various medical conditions. The approval of the first antisense oligonucleotide drug, Fomivirse, in 1998, led to a surge in the demand of DNA-based interventions. In addition to the application of DNA in therapy development, these entities are also being deployed in genetic diagnostics and have already proven their use in identifying patients across a diverse range of diseases including breast cancer, dyslexia, ovarian cancer, Parkinson’s disease and psoriasis. The advances in medical research have led to establishment of several technologies that can sequence, analyze, and edit different forms of DNA. This, coupled to the increasing use of DNA across diverse range of applications, have urged industry experts to actively look for efficient DNA synthesis and DNA replication technologies that not only facilitate parallelized synthesis of DNA but also provide unmatched precision, scalability, and speed. 

It is worth noting that several DNA synthesis companies have developed proprietary enzymatic DNA synthesis platforms offering distinct advantages (such as the potential to increase length of DNA fragment, greater accessibility and convenience) over conventional DNA synthesis and DNA replication methods. Given the known merits of such technologies, a significant proportion of medical researchers and therapy / diagnostic developers prefer to outsource DNA synthesis and DNA replication operations to third party platforms / service providers who claim to provide the expertise in DNA synthesis and production. Presently, there are over 65 DNA synthesis companies that offer DNA synthesis technologies / services, and these players are actively undertaking efforts to build / expand their existing capabilities, in order to cater to the growing demand for DNA synthesis and DNA replication. Given the rising need for DNA across a wide range of applications, we are led to believe that the DNA synthesis and DNA replication platforms and services industry is likely to witness noteworthy market growth durign the forecast period.

The image provides context of DNA Synthesis Technologies and Services Market. DNA synthesis has demonstrated to play a vital role in molecular and synthetic biology; various DNA synthesis technologies facilitate the use of DNA across several applications, including drug discovery, genetic engineering and clinical diagnosis / treatment This image provides list of DNA Synthesis Technologies and Services Providers. Around 65 companies presently claim to have the required expertise for DNA synthesis technologies and affiliated services; of these, more than 50% players are small companies and have recently been established The image provides details on the current market landscape of DNA Synthesis Technologies and Services. These technology and service providers claim to employ different cost-effective methods for the synthesis of DNA, having applications in various biomedical fields

Key Companies in DNA Synthesis Market 

Examples of key companies engaged in DNA synthesis market (which have also been profiled in this market report; the complete list of companies is available in the full report) include Ajinomoto Bio-Pharma Services, ATUM, DNA Script, Eurofins Genomics, Gene Universal, GenScript and Synbio Technologies. This market report includes an easily searchable excel database of all the DNA synthesis companies providing DNA synthesis technologies and services, worldwide.

Recent Developments in DNA Synthesis Market:

Several recent developments have taken place in the field of DNA synthesis. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In August 2023, Camena Bioscience closes USD 10 million in Series A funding round as demand for DNA synthesis technology grow.  
  • In May 2023, GenScript announced the debut of GenTitan gene fragments service with an aim to expedite gene synthesis at lower cost.
This image looks at the various publications released related to DNA Synthesis domain. There has been a notable increase in the published scientific literature related to DNA synthesis technologies and services in the last few years; such articles have been published in over 50 countries This infographic looks at the various partnership deals inked by stakeholders in the DNA synthesis domain. The growing interest in DNA synthesis technologies and services is reflected by the increase in partnership activity in the recent past; in fact, between 2019 and 2021, the partnership activity increased at a CAGR of 18% This image looks at the details of grants related to DNA Synthesis. Over the past few years, 150 academic grants have been awarded to various organizations in order to support the ongoing efforts related to research and innovation in the field of DNA synthesis technologies

Scope of the Report

The “DNA Synthesis Market, Distribution by Method of DNA Synthesis (Chemical Method and Enzymatic Method), Key Applications Areas (Research & Diagnostics and Therapeutic Applications), Company Size (Small, Mid-sized and Large), and Key Geographies (North America, Europe, Asia-Pacific and Rest of the World): Industry Trends and Global, 2022-2035” market report features report features a detailed study of the current market landscape, market size, market forecast and future opportunities for the DNA synthesis technologies and service providers. Further, the market research report underlines an in-depth analysis, highlighting the capabilities of service providers engaged in DNA synthesis market.

In addition to other elements, the market research report covers:  

  • A detailed assessment of the overall landscape of the DNA synthesis market, providing information on type of offering, method of DNA synthesis (chemical method and enzymatic method), type of DNA molecule, custom offerings, and application area. Additionally, the report provides information on drug developer(s) involved in DNA synthesis market, along with analyses based on a number of relevant parameters, such as year of establishment, company size and geographical location of headquarters.
  • Elaborate profiles of the key players involved in providing technologies and services in the DNA synthesis market. Each profile features a brief overview of the company, its financial information, details on its technology / service portfolio, financial information, and recent developments and an informed future outlook.
  • A detailed overview of the current market landscape of oligonucleotide manufacturers focused on research and diagnostic applications, based on several relevant parameters, such as year of establishment, company size, scale of operation (preclinical, clinical, and commercial), location of headquarters, number of manufacturing facilities, along with information on the location of facility (country-wise), regulatory accreditations and certifications received, type of oligonucleotide manufactured (antisense oligonucleotides, aptamers, decoys, miRNA, shRNA, siRNA, specialty amidites and others), type of offering (custom synthesis, modification and purification), type of manufacturing service(s) offered (process development and characterization, method validation and testing, analytical development, sequencing capabilities, stability studies, quality assurance and control, fill / finish, regulatory support, data analytics and reporting, and others) and type of modification(s) offered (amino modifiers, backbone modifications, fluorescent probes, dyes and quenchers, modified bases, phosphorylation, thiol modifications and others).
  • A detailed overview of the current market landscape of oligonucleotide manufacturers focused on therapeutic applications, based on several relevant parameters, such as year of establishment, company size, scale of operation (preclinical, clinical, and commercial), location of headquarters, number of manufacturing facilities, along with information on the location of facility (country-wise), regulatory accreditations and certifications received, type of oligonucleotide manufactured (antisense oligonucleotides, aptamers, decoys, miRNA, shRNA, siRNA, specialty amidites and others), type of offering (custom synthesis, modification and purification), type of manufacturing service(s) offered (process development and characterization, method validation and testing, analytical development, sequencing capabilities, stability studies, quality assurance and control, fill / finish, regulatory support, data analytics and reporting, and others) and type of modification(s) (amino modifiers, backbone modifications, fluorescent probes, dyes and quenchers, modified bases, phosphorylation, thiol modifications and others).
  • An analysis of the partnerships established between various stakeholders in DNA synthesis market, during the period 2017-2022, covering product development and commercialization agreements, R&D agreements, technology licensing agreements, other licensing agreements, mergers and acquisitions, and other relevant types of deals. 
  • A review of the funding and investments made in the DNA synthesis market, in the period between 2017 and 2022, including seed financing, venture capital financing, debt financing, grants, capital raised from IPOs and subsequent offerings, at various stages of development. The analysis has been done on the basis of several parameters, such as number of funding instances, amount invested, type of funding, leading players and investors, and geographical analysis.
  • An in-depth analysis of grants that have been awarded to various research institutes for projects related to DNA synthesis technologies and services, in the period between 2017 and 2022, on the basis of important parameters, such as year of grant award, grant amount awarded, administering institute center, support period, type of grant application, grant activity code, emerging focus area, purpose of grant award, type of recent organization, popular NIH department and prominent program officers. 
  • A detailed review of more than 12,000 peer-reviewed, scientific articles related to research on DNA synthesis technologies, which have been published between 2017 and 2022, including analysis based on parameters, such as year of publication, key focus area, type of article, popular keywords, popular authors, therapeutic area, geography and key journals (in terms of number of articles published in this domain and impact factor of the journal).
  • An in-depth analysis of the patents related to DNA synthesis technologies, filed / granted till 2022, based on various parameters, such as patent publication year, geographical location / patent jurisdiction, CPC symbols, emerging focus areas, and type of applicant, and leading players (by number of patents). In addition, it features a patent valuation analysis which evaluates the qualitative and quantitative aspects of the patents.

One of the key objectives of this market report is to provide a detailed market forecast analysis in order to estimate the existing market size and future opportunity in DNA synthesis market, over the next decade. Based on multiple parameters, such as number of projects and service-based cost distribution we have developed informed estimates on the evolution of the market for the forecast period 2022-2035. The market research report also features the likely distribution of the current and forecasted opportunity across methods of DNA synthesis (chemical method and enzymatic method), application areas (research & diagnostics and therapeutic applications), company size (small, mid-sized and large) and key geographical regions (North America, Europe and Asia-Pacific and RoW). To account for the future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, portraying different tracks of the anticipated industry’s growth.

This infographic looks at the funding raised by players in the DNA synthesis domain. Several investors, having realized the future opportunity associated with DNA synthesis technologies and services market, have invested more than USD 750 million in the past five years This image looks at the details of patents related to DNA synthesis. More than 11,000 patents have been filed / granted related to DNA synthesis technologies since 2016, establishing a strong portfolio of intellectual property within this industry This image provides details on DNA synthesis domain. The DNA synthesis services market is expected to witness an annualized growth rate of more than 15% till 2035; the opportunity is likely to be distributed across methods of synthesis applications, company sizes and geographies

The report also features detailed transcripts of interview(s) held with representatives of renowned organizations that are engaged in the DNA synthesis technologies and services industry.

All actual figures have been sourced and analyzed from publicly available information forums. Financial figures mentioned in this market research report are in USD, unless otherwise specified.

Frequently Asked Questions

Question 1: What is DNA synthesis?

Answer: DNA synthesis is the natural or synthetic process of creating deoxyribonucleic acid molecules that can be used as potential therapeutic candidates in gene therapies.

Question 2: How big is the DNA synthesis market?

Answer: The DNA synthesis market size is estimated to be worth $669 million in 2022.

Question 3: What is the projected market growth of the DNA synthesis market?

Answer: The DNA synthesis market is expected to grow at compounded annual growth rate (CAGR) of more than 20% during the forecast period 2022 - 2035.

Question 4: Who are the leading DNA synthesis companies in the DNA synthesis market?

Answer: Examples of key DNA synthesis companies engaged in DNA synthesis market (which have also been profiled in this market report; the complete list of companies is available in the full report) include Ajinomoto Bio-Pharma Services, ATUM, DNA Script, Eurofins Genomics, Gene Universal, GenScript and Synbio Technologies.

Question 5: How many DNA synthesis companies are currently engaged in the DNA synthesis market?

Answer: Presently, over 65 DNA synthesis companies are engaged in the DNA synthesis market, providing various technologies and services.

Question 6: How much money has been invested in the DNA synthesis market over the last few years?

Answer: Till date, more than USD 750 million has been invested by various industry and non-industry players in the DNA synthesis market, highlighting the growing research efforts related to DNA synthesis.

Question 7: Which region is the hub for DNA synthesis companies engaged in the DNA synthesis market?

Answer: North America emerged as the hub for DNA synthesis companies engaged in the DNA synthesis market, with over 55% of the companies established in the region.

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