Genome Editing Market

Genome Editing Market: Industry Trends and Global Forecast till 2035: Focus on Technology - Distribution by Type of Gene Editing Technique, Type of Therapy, Gene Editing Approach, Type of Gene Delivery Method, Gene Delivery Modality, Application Area, Type of End User, Key Geographical Regions and Distribution by Type of Payment Method Employed

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Genome Editing Market Overview

The global genome editing market size is estimated to grow from USD 3.5 billion in 2023 to USD 14.5 billion by 2035, representing a CAGR of 12.6% during the forecast period 2023-2035.

Genome Editing Market, By Gene Editing Approach,  2023-2035 (USD Billion)


Genome editing or gene editing is a genetic engineering technique that enables the modification (insertion, deletion or replacement) of a single gene or a set of genes within the genome of an organism. Over the years, the need for genome editing at the desired site in the genome has resulted in the exploration of various genome editing tools that are being developed by gene editing companies; these include zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs) and CRISPR technology. These gene editing tools have been extensively used as corrective strategies to treat the clinical conditions which develop as a result of genetic abnormalities, such as sickle cell disease, Parkinson’s disease, hearing loss, peripheral artery disease, spinal muscular atrophy, autoimmune diseases, and other genetic disorders. Amidst the current initiatives to develop targeted gene edited therapies, gene therapy has emerged as a promising option with over 300 candidates in the clinical trials (as of 2023). It is worth highlighting that prophylaxis treatment is another segment of the gene editing applications that has garnered significant attention in the gene editing market. However, the development of gene edited drug products involves a heavy investment for drug discovery, development, and manufacturing in the gene research industry.

Further, in order to ensure the efficiency, precision and safe delivery of these drugs, the pharmaceutical companies have been relying novel genome editing technologies, being developed by genome editing companies. This will eventually aid the drug developers to improve the clinical outcome of the therapeutics by achieving the desired genetic manipulation. Given the ongoing pace of innovation in this field, including encouraging results in clinical trials and accelerated drug approvals, the genome editing market is likely to witness significant market growth during the forecast period.

Key Market Insights

The Genome Editing Market: Focus on Technology - Distribution by Type of Gene Editing Technique (CRISPR-Cas System, TALENs, Meganucleases, ZFNs and Other Techniques), Type of Therapy (Cell Therapies, Gene Therapies and Other Therapies), Gene Editing Approach (Gene Knock-Out and Gene Knock-In), Type of Gene Delivery Method (Ex-vivo and In-vivo), Gene Delivery Modality (Viral Vectors and Non-Viral Vectors), Application Area (Drug Discovery and Development, and Diagnostics), Type of End User (Pharmaceutical and Biotechnology Companies, and Academic and Research Institutes), Key Geographical Regions (North America, Europe and Asia-Pacific) and Distribution by Type of Payment Method Employed (Upfront Payments and Milestone Payments): Industry Trends and Global Forecasts, 2023-2035 report features an extensive study of the current market landscape, market size and future opportunities associated with the genome editing market (technologies), during the given forecast period. Further, the genome editing market report highlights the efforts of several stakeholders engaged in this rapidly emerging segment of the pharmaceutical industry. Key takeaways of the genome editing market analysis are briefly discussed below. 

Genome Editing Market: Current Market Landscape

The genome editing market landscape is concentrated with the presence of over 110 genome editing companies (very large, large, mid-sized and small companies). Of these, 57% of the companies were established post-2016, indicating significant start-up activity in the genome editing industry. Examples of companies (established in 2022 and 2023, in alphabetical order) include Akribion Genomics, CorriXR Therapeutics, Couragene, GENETAGUS, GrittGene Therapeutics, Nvelop Therapeutics, Primera Therapeutics and SE Therapeutics. 

Moreover, some of the stakeholders engaged in genome editing market also offer gene editing services in order to optimize the use of their resources and augment their revenue generation opportunities. In Europe, Horizon Discovery (also known as Revvity) emerged as the only genetic engineering company whose business model operates via in-house development of gene edited therapies, licensing of its Pin-point™ base editing platform and through genome editing service capabilities.

Market Segmentation – CRISPR/Cas9 are the Most Sought Genome Editing Tools

Of all the genome editing tools, CRISPR technology, specifically, CRISPR-Cas9 has emerged as the leading genetic engineering technique developed by the stakeholders in the gene editing market. Recently, the domain has witnessed a paradigm shift from conventional CRISPR technology to base editing and prime editing techniques. These novel tools are aimed to improve the long-term safety and efficiency of gene delivery. In this market report, we have captured all the genome editing tools (including CRISPR technology) developed by genome editing companies that are relevant to drug discovery, regenerative medicine and diagnostic applications.

Market Segmentation - North America to Hold the Largest Market Share

Over the past few years, there has been a steady increase in the genome editing companies offering various gene editing technologies. Of these, majority of the technology developers are based in North America. It is worth noting that Intellia Therapeutics, Mammoth Biosciences and Metagenomi (arranged in alphabetical order) are the mid-sized companies based in North America that operate as base editing companies.

Genome Editing Market Trends: Technology Licensing Deals are Driving the Overall Partnership Activity

Several stakeholders have been forging alliances with other industry / non-industry players in the genome editing market for different purposes, including technology licensing, research and development, product licensing and product development. It is worth highlighting that, since 2018, over 250 strategic partnerships have been inked by the technology developers in the genome engineering market. Up lately, the pharmaceutical companies have been engaged in the acquisition of other market players engaged in the genome editing industry in order to expand their capabilities and build a comprehensive pipeline. In March 2023, WuXi AppTec acquired OXGENE and enhanced its capabilities for the development of cell and gene therapies. Earlier, in February 2023, Ensoma acquired Twelve Bio, a gene editing company working in area of the CRISPR medicines. As more drug developers license genome editing technology for evaluation, the market growth is expected to witness favorable market growth during the forecast period.

Top Gene Editing Companies Offering Genome Editing Technologies 

Examples of top market players that are engaged in offering genome editing technologies (which have also been profiled in this market report; in alphabetical order) Arcturus Therapeutics, Beam Therapeutics, Caribou Biosciences, Century Therapeutics, CRISPR Therapeutics, Editas Medicine, Graphite Bio, Intellia Therapeutics, Prime Medicine and Vor Biopharma. This market report includes an easily searchable excel database of all the genome editing companies worldwide that offer gene editing tools.

Recent Developments Driving the Market Growth of Genome Editing Market

Driven by numerous developmental breakthroughs and results of studies demonstrating the vast potential of gene therapy and cell therapy in the treatment of various diseases, gene editing tools have garnered considerable attention of various market players engaged in the healthcare industry. Several developments have taken place in the field of genome editing, over the past few years. Some of these recent initiatives have been mentioned below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that we have been outlined in our analyses.

  • In October 2023, Intellia Therapeutics announced that the European Medicines Agency (EMA) has granted priority medicine (PRIME) designation to NTLA-2002, an in vivo CRISPR based gene therapy for the treatment of hereditary angioedema.
  • In August 2023, Prime Medicine announced a strategic collaboration with Maxcyte for the development of next-generation gene therapies.
  • In June 2023, CRISPR Therapeutics and Vertex Pharmaceuticals announced that the United States Food and Drug Administration (USFDA) has accepted the Biologics License Applications (BLA) of exa-cel, an ex vivo CRSIPR based gene edited therapy for the treatment of sickle cell disease and transfusion-dependent β-thalassemia.
  • In June 2023, Editas Medicine raised an amount of USD 117.1 million in a secondary offering. It is worth noting that its pipeline candidate EDIT-301 is in early-stage clinical trials for the treatment of sickle cell disease and transfusion-dependent β-thalassemia.

Scope of The Report

The market report presents an in-depth analysis of the various firms / organizations that are engaged in this market, across different segments, as defined in the below table: 

Key Report Attributes Details

Base Year

2022

Forecast Period

2023-2035

Market Size 2023

$3.5 billion

CAGR

12.6%

Type of Gene Editing Technique

  • CRISPR-Cas System
  • TALENs
  • Meganucleases
  • ZFNs
  • Other Techniques

Type of Therapy

  • Cell Therapies
  • Gene Therapies
  • Other Therapies

Gene Editing Approach

  • Gene Knock-Out Approaches
  • Gene Knock- In Approaches

Gene Delivery Method

  • Ex-Vivo Delivery Methods
  • In-Vivo Delivery Methods

Gene Delivery Modality

  • Viral Vectors
  • Non-Viral Vectors

Application Area

  • Drug Discovery and Development
  • Diagnostics

Type of End User

  • Pharmaceutical and Biotechnology Companies
  • Academic and Research Institutes

Key Geographical Regions

  • North America
  • Europe
  • Asia-Pacific

Payment Method Employed

  • Upfront Payments
  • Milestone Payments
   

Key Companies Profiled

  • Arcturus Therapeutics
  • Avectas
  • Beam Therapeutics
  • Bio-Sourcing
  • Caribou Biosciences
  • Century Therapeutics
  • CRISPR Therapeutics
  • EdiGene
  • Editas Medicine
  • Flash Therapeutics
  • Fortgen
  • G+FLAS Life Sciences
  • Graphite Bio
  • Intellia Therapeutics
  • Ntrans Technologies
  • OXGENE
  • Prime Medicine
  • Revvity (formerly known as Horizon Discovery)
  • TargetGene Biotechnologies
  • Vor Biopharma
  • ZeClinics
Customization Scope 15% Free Customization Option (equivalent to 5 analysts’ working days)
   
PowerPoint Presentation (Complimentary)
  • Available
Excel Data Packs (Complimentary)
  • Technology Landscape Analysis
  • Technology Competitiveness Analysis
  • Partnerships and Collaborations Analysis
  • Patent Analysis
  • Funding and Investment Analysis
  • Market Forecast and Opportunity Analysis

 

This image provides context of genome editing market according to a report by Roots Analysis The image provides a list of genome editing technologies in the report by Roots Analysis The image provides details on genome editing market overview according to Roots Analysis report


The genome editing market research report presents an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this market, across different geographies. Amongst other elements, the report includes:

  • A preface providing an introduction to the full report, Genome Editing Market: Focus on Technology, 2023-2035.
  • An outline of the systematic research methodology adopted to conduct the study on genome editing market (technologies), providing insights on the various assumptions, methodologies, and quality control measures employed to ensure accuracy and reliability of our findings.
  • An overview of economic factors that impact the overall genome editing market (technologies), including historical trends, currency fluctuation, foreign exchange impact, recession and inflation measurement.
  • An executive summary of the insights captured during our research. It offers a high-level view on the current state of technologies in genome editing industry and its likely evolution in the mid to long term.
  • A general overview of genome editing, including a brief discussion on the evolution of this concept over the years. It also includes information on the various genome editing technologies and the application of genome editing in various industries like biotechnology, pharmaceutical and agriculture. Further, it highlights the various emerging genome editing technologies.
  • A detailed assessment of the current technology landscape of technologies for genome editing based on several relevant parameters, such as type of gene editing technique (CRISPR-Cas system, meganucleases, TALENs, ZFNs and other techniques), gene editing approach (gene knock-in and gene knock-out), type of gene delivery method (in-vivo and ex-vivo), type of gene delivery modality (cells, viral vectors, non- viral vectors and other modalities), highest phase of drug development supported (discovery, preclinical, clinical and commercial), therapeutic area (oncological disorders, genetic disorders, neurological disorders, hematological disorders, immunological disorders, metabolic disorders, ophthalmological disorders, infectious diseases, cardiovascular disorders, hepatic disorders, muscle-related disorders, autoimmune disorders, pulmonary disorders and other disorders) and application area (drug discovery, regenerative medicine, plant gene editing, and diagnostics). In addition, the chapter features information on various technology developers, along with analysis based on multiple parameters, such as year of establishment, company size, location of headquarters, operational model and most active players (in terms of number of technologies developed).
The image provides a product competitiveness analysis of genome editing technologies in report by Roots Analysis This image looks at the various genome editing companies that have been profiled in the report The image provides a view on partnerships that have been forged by companies providing genome editing technologies

 

  • An insightful competitiveness analysis of genome editing technologies based on developer strength (in terms of the experience of the developer) and technology strength (in terms of type of gene editing technique, gene editing approach, in-silico (CADD) analysis, type of gene delivery method, type of gene delivery modality, highest phase of development supported and application area).
  • Elaborate profiles of the prominent genome editing companies (shortlisted based on a proprietary criterion) developing genome editing technologies. Each profile features a brief overview of the company, details related to its financial information, technology portfolio, recent developments and an informed future outlook. Further, the chapter also includes profiles of other leading players developing genome editing technologies. 
  • A detailed analysis of the partnerships inked between stakeholders in genome editing market, since 2018, covering technology licensing agreements, research and development agreements, technology integration agreements, mergers and acquisitions, product development agreements and other relevant agreements.
  • An in-depth analysis of various patents that have been filed / granted by the technology developers related to genome editing, since 2018, taking into consideration parameters, such as publication year, geographical region, CPC symbols and leading players (in terms of number of patents filled / granted). In addition, the chapter includes a detailed patent benchmarking and an insightful valuation analysis, highlighting the leading patents (in terms of number of citations).
  • A detailed analysis of funding and investments raised by genome editing technology developers, based on relevant parameters such as year of funding, type of funding, amount invested, regional distribution, most active players (in terms of number of funding instances and amount raised) and most active investors (in terms of number of funding instances).
  • An in-depth analysis of the factors that can impact the growth of genome editing market (technologies). It also features identification and analysis of key drivers, potential restraints, emerging opportunities, and existing challenges.
The image highlights key acquisition targets in liquid biopsy market as per Roots Analysis report This image provides a view on patent activity in this domain as per Roots Analysis report This image looks at the level of venture capital interest in genome editing technologies


One of the key objectives of this market report was to estimate the current genome editing market size, opportunity and the future growth potential of the genome editing market (technologies), over the forecast period. We have provided informed estimates on the likely evolution of the market for the forecast period, 2023-2035. Our year-wise projections of the current and forecasted opportunity have been further segmented based on relevant parameters, such as type of gene editing technique (CRISPR-Cas System, TALENs, meganucleases, ZFNs and other techniques), type of therapy (cell therapies, gene therapies and other therapies), gene editing approach (gene knock-out approaches and gene knock-in approaches), gene delivery method (ex-vivo and in-vivo), gene delivery modality (viral vectors and non-viral vectors), application area (drug discovery and development, and diagnostics), type of end user (pharmaceutical and biotechnology companies, and academic and research institutes), key geographical regions (North America, Europe and Asia-Pacific) and payment method employed (upfront payments and milestone payments). In order to account for future uncertainties associated with some of the key parameters and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the market growth.

The opinions and insights presented in the report were influenced by discussions held with stakeholders in this industry. The report features detailed transcripts of interviews held with various industry stakeholders.

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Frequently Asked Questions

Question 1: What is genome editing?

Answer: Genome editing refers to the process of genetic engineering or a genetic engineering technique that allows the manipulation in the genome in a cell or organism.

Question 2: What are the different types of genome editing tools?

Answer: There are majorly four types of genome editing tools which also allow the insertion, removal or alteration of the genetic material at a particular location in the genome. These include meganucleases / homing endonucleases, zinc finger nucleases, transcription activator-like effector nucleases and CRISPR technology.

Question 3: Why is genome editing important?

Answer: Genome editing serves as a platform to elucidate the biological mechanisms underlying disease development and progression, and pave way for novel therapies (gene therapy and cell therapy).

Question 4: What is the current landscape of patents filed in the field of genome editing?

Answer: A total of 1,035 patents have been filed by the genome editing technology developers in this domain.

Question 5: What is the outlook for genome editing industry?

Answer: More than 100 genome editing technologies offered by the companies pertain to CRISPR technology.

Question 6: How big is the genome editing industry?

Answer: The global genome editing industry is estimated to be worth USD 3.5 billion in 2023.

Question 7: What is the anticipated genome editing market growth?

Answer: The global genome editing market is anticipated to grow at a CAGR of 12.6% during the forecast period.

Question 8: How big is the CRISPR gene editing market?

Answer: In terms of type of gene editing tool, CRISPR technology currently accounts for the largest (82%) genome editing market share.

Question 9: Which region captures the largest share in the genome editing industry (technologies)?

Answer: Presently, the genome editing market (technologies) is dominated by North America, capturing around 75% of the overall market size.

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