Month: October 2023

In the past few years, Next Generation RNA therapeutics have emerged as one of the key therapeutic modalities in the modern healthcare industry. These RNA based therapeutics play a crucial role in protein production and regulation of gene functions. In addition, they offer enhanced therapeutic and safety profiles as compared to traditional treatment approaches. However,

Over the past decade, the rise of this digital technology has transformed various sectors, from finance to healthcare. One particular area that has seen significant innovation is the realm of clinical trials. Traditionally conducted at centralized sites like hospitals or clinics, the latest trend is moving towards decentralized clinical trials (DCTs). Clinical trials are prospective

On 26 October 2023, Eisai and Biogen’s Alzheimer’s drug, Leqembi, was found to be as effective as the current intravenous administration in removing toxic brain plaques. However, the review conducted by the drugmakers revealed that the rates of serious side effects were higher when using the drug in its subcutaneous injection form. The company’s analysis

On 24 October 2023, BioNtech announced the preliminary results of phase I/II trial evaluating BNT.221-01, a combination of Claudin 6 (CLDN6)-targeted CAR T cell therapy and the mRNA-based CAR T booster CarVac at ESMO conference in Madrid. BioNtech reported acceptable safety and tolerability data and first hints to efficacy in solid tumours. The CAR T

On 23 October 2023, Merck announced a development agreement for Daiichi Sankyo’s clinical-phase antibody-drug conjugate, namely patritumab deruxtecan (HER3-DXd), ifinatamab deruxtecan (I-DXd), and raludotatug deruxtecan (R-DXd), targeting cancer. Merck has invested $5.5 billion to jointly develop three of its candidate cancer drugs and is likely to invest up to $22 billion in addition depending on

The limitations of stainless-steel bioreactors such as high risk of contamination, process related challenges and high operational cost have prompted innovators to develop more advanced single use bioreactor in order to meet the rising demand for safe and efficacious biotherapeutics. Conventional stainless-steel bioreactors require more energy as compared to the single use bioreactor for sterilization,

Owing to the advancement in clinical pharmacology and oncology domain, and the rising demand for targeted therapeutics and precision medicines, high potency active pharmaceutical ingredients (HPAPIs) and cytotoxic drugs have become one of the key areas of interest to researchers and drug manufacturers across the globe. HPAPIs, due to their selective mode of action, are

RNA therapeutics are a novel class of biopharmaceuticals that harness the power of RNA molecules for the treatment and prevention of a wide range of disorders, including oncological, and genetic disorders as well as infectious diseases. These therapeutics are broadly classified into two categories, namely coding RNAs and non-coding RNAs. Coding RNAs include messenger RNA

Bacteria plays a crucial role in maintaining the ecosystem balance. However, there are few species of bacteria that can cause several infectious diseases (such as strep throat, salmonellosis, tuberculosis, whooping cough). These are mainly transmitted through air, water, living organisms, and food. Further, the spread of infections to a larger population is attributed to the

DNA cloning refers to the process of generating multiple copies of a particular DNA segment. DNA and Gene Cloning involves the isolation of a DNA sequence of any species and its insertion into a vector to enable growth without any alteration in the original DNA sequence. Once isolated, molecular clones can be used to generate

Biopharmaceutical filtration is a critical step in the production of biopharmaceuticals, including proteins, antibodies, and vaccines. It involves the separation of unwanted particles from biological materials to obtain contaminant free products. Filtration plays a crucial role in ensuring the safety, efficacy, and quality of biopharmaceutical products. The biopharmaceutical industry uses different filtration systems depending on

Over the last two decades the pharmaceutical industry has observed a paradigm shift from conventional drug delivery strategies to more enhanced, potent, and targeted therapeutics. This led the researchers to find alternative pathways and drug delivery strategies to enhance the potent delivery of the drug to the site of action. As a result, in late

Digital twins is a rapidly emerging space and there are several start-ups working to provide novel solutions. In this article, we’ve looked at a method of company valuation. Berkus start-up valuation is a method developed by the American venture capitalist and angel investor, Dave Berkus in the mid 1990’s. The Berkus method was designed to

The introduction of the Green Revolution in the late 1960s led to a substantial agricultural intensification. The primary objective of the initiative was to feed a growing population with limited land resources and enhanced crop yields. Consequently, the use of agrochemicals, such as chemical pesticides and fertilizers, became an integral part of this industrialized approach.

Driven by the increasing need for safe and efficient medical devices and drug delivery systems, the pharmaceutical polymers / medical grade polymers domain is advancing significantly. There has been a rise in the development of polymers for biopharma with improved biocompatibility, biodegradability and functionality. It is worth highlighting that the manufacturing of polymers for biopharma

Bispecific antibodies are a type of antibody that can bind to two different targets at the same time. They are designed to recognize and bind to two specific molecules, such as a tumor cell and an immune cell, or two different parts of the same molecule. This allows them to potentially be more effective in

Bioreactors and fermenters are complex systems used across numerous sectors of the industry, for the production of pharmaceuticals, nutraceuticals, food, and beverages. These systems provide controlled conditions for cell growth by providing optimum nutrient supply, and oxygenation, enabling the production of biologics. Bioreactors and fermenters can range from small laboratory-scale to industrial-scale systems, and may

Nanoparticles (zero-dimensional nanomaterials) are ultra-fine particles with overall dimension ranging between 1-100 nm. Owing to their unique size and physicochemical properties (surface roughness, surface area, surface energy, crystal structure and shape), nanoparticles can be widely used as a contrasting agent in medical imaging, a vesicle to cross the blood-brain barrier and a carrier for targeted