Novel Antibody Therapies: Addressing Unmet Needs for Oncological Disorders

Antibodies are key components of the immune system that bind to specific markers on cells or tissues, thereby offering first line of defense against multiple disorders. The novel antibody therapies include different classes of antibodies, that are responsible for killing or inhibiting disease-causing agents. These therapies target proteins that are expressed on the surface of the affected cells. Multiple novel antibody formats have been engineered to enhance therapeutic efficacy. This has opened a new target space for the development of antibody therapeutics and techniques, facilitating tools to uniquely distinct malignantly transformed cells from regular cells.

There are various types of antibodies, which are mentioned in the figure given below:

Types of Novel Antibody Therapies - Roots Analysis

Therapeutic Antibodies: Developmental Approaches

Over time, there has been increase in novel approaches for antibodies development; researchers have developed various therapies using these approaches for the treatment of various disorders. The developmental approach of therapeutic antibody includes Mouse hybridoma technique, Phage display, Transgenic mouse and the single B cell technique.

Image diagram explaining mouse hybridoma technique for development of therapeutic antibody - Roots Analysis
Smart diagram representing development of Novel Antibody Therapies - Roots Analysis

Advantages of Novel Antibody Therapies

Clinical researchers have focused on the immune system and developed a variety of immunotherapies that have the potential to attack cancer cells very specifically. The objective is to use immune system elements including antibodies, T cells, and / or cytokines to target and kill tumor cells. Traditional cancer treatments have already been utilized in conjunction with immunotherapies, and in certain cases, they are beginning to take their place. Some of the advantages offered by novel antibody therapies have been depicted below.

Advantages of Novel Antibody Therapies - Roots Analysis

Challenges Associated with Novel Antibody Therapies

Although recent efforts by various stakeholders have shown encouraging advances in this market, however there are several challenges in this domain.

Challenges Associated with Novel Antibody Therapies

Future Perspective of Novel Antibody Therapies

Since the novel antibody therapy techniques have taken advantage of the specificity and ease of manipulation of monoclonal antibodies and have many different therapeutic targets, for a variety of disease indications such as including leukemia, lymphoma, prostate cancer, renal cancer, skin cancer, soft tissue sarcoma and several others are likely to be discovered in the future. The main focus is to develop innovative therapies with reduced cost and increased safety.

Over time, there has been increase in novel approaches for antibodies development; researchers have developed various therapies using these approaches for the treatment of various disorders. Some of the future perspectives of novel antibody therapies are listed below:

  • Fc-enhancing technique: Recent studies have shown that this technique can increase the potency of multifunctional zed antibodies in the treatment of solid tumors.
  • High Specific Targeting of Antigen: With the advent of molecular-targeting medicine, a new class of therapeutic agents is expected with an aim to offer effective medical treatment.
  • Designing Combinatorial Therapies: It is likely to overcome the current difficulty of finding candidate antigens in exploring novel therapeutic approaches
  • Innovative Diagnostics Approaches: This improves understanding of malignant tumor tissues, leading to an era of antibody-based intracellular antigen targeting and precise tumor therapy.

Owing to the numerous advantages of novel antibody therapies, including high therapeutic efficacy, pinpoint destruction and design-related flexibility, we are led to believe that novel antibody therapies market is anticipated to witness a significant growth in the coming future.

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