Eli Lilly’s Weight-Loss Drug, Mounjaro, Sparks an Epic Run in Pharma Shares

Eli Lilly's Logo


Over years, Eli Lilly has undergone a significant transformation, positioning itself as the world’s most valuable drugmaker. Renowned for psychiatric drugs such as Prozac, the company faced several challenges in revenue generation during the 2010s due to patent expiration of its innovative drugs. However, a strategic shift and a focus on innovative treatments have catapulted Eli Lilly to unprecedented heights, especially in the field of anti-obesity drugs. This shift has not only solidified Eli Lilly’s heavyweight status but also sparked an epic run in the pharmaceutical group’s shares.

Resilience of Eli Lilly in the Face of Challenges

The latter half of the previous decade witnessed Eli Lilly grappling with stagnant market value and declining revenue, hovering around the USD 100 billion mark. The need for reinvention became evident as the company sought to navigate the evolving pharmaceutical landscape. Resilience in the face of these challenges became a hallmark of Lilly’s journey, setting the stage for its resurgence, unexpectedly fueled by the pressing issue of America’s obesity epidemic.

The Turning Point: Ozempic, Wegovy, and the Emergence of Tirzepatide

The pivotal year of 2023 witnessed Lilly’s triumph with Ozempic and Wegovy, two drugs instrumental in addressing the obesity epidemic. However, the spotlight now shifts to tirzepatide, a drug developed by Lilly and approved in 2022 under the brand name Mounjaro for treating type 2 diabetes. With approval for obesity treatment in 2023 under the name Zepbound, tirzepatide is poised to revolutionize the pharmaceutical landscape.

Market Valuation Surge: A Remarkable Rally in Shares of Eli Lilly

Tirzepatide’s approval and optimistic market expectations have ignited an extraordinary surge in Lilly’s stock. In a notable departure from the broader pharmaceutical market trend, the company’s shares surged by an impressive 60% in the past year. The market now appraises Lilly’s value more akin to a technology enterprise than a conventional pharmaceutical group, with a forward earnings multiple exceeding 50.

The substantiated evidence supporting tirzepatide’s efficacy in weight loss has captured public attention. Renowned figures such as Elon Musk and Oprah Winfrey openly discuss their experiences with the drug, sparking interest beyond its FDA-approved use. As the drug gains momentum, the demarcation between medical and cosmetic applications becomes increasingly nuanced.

Global Expansion and Negotiation Challenges for Eli Lilly

Eli Lilly’s future plans encompass the expansion of its weight-loss drug Mounjaro to new countries in 2024. However, the expansion encounters challenges beyond market entry, with negotiations on reimbursement emerging as a pivotal factor. Ilya Yuffa, President of Lilly International, sheds light on the intricate process during the World Economic Forum annual meeting in Davos.

Ethical Considerations and Formal Communications

Amidst the triumphs, Eli Lilly confronts ethical considerations surrounding the utilization of Mounjaro and Zepbound for cosmetic weight loss. The company recently released a formal communication, taking a principled stand against the drugs’ application for non-approved indications, emphasizing its commitment to responsible pharmaceutical practices.


In conclusion, Eli Lilly’s journey from an industry underdog to a pharmaceutical powerhouse is a testament to its ability to adapt and innovate. The trajectory of its success, particularly in the realm of anti-obesity drugs, positions the company as a leader in addressing pressing health concerns. As Eli Lilly continues to shape the pharmaceutical landscape, its enduring legacy underscores the critical role of research, innovation, and ethical considerations in the pursuit of groundbreaking medical solutions. The clamor for anti-obesity drugs may have set Eli Lilly on an epic run, but it is the company’s commitment to responsible healthcare practices that will likely secure its enduring status as a key player in the pharmaceutical industry.