TIL Cell Therapy: Future of Cancer Immunotherapies

Cancer is known to be one of the leading causes of deaths worldwide. In fact, as per the WHO, close to 10 million cancer related deaths were reported in 2020. Further, it is estimated that, by the end of 2040, 27.5 million new cancer cases will be added to the global numbers, exerting tremendous physical, emotional and financial strain on affected individuals, their families, communities and national health systems. Although there are several treatment options available to control disease progression and keep malignant cells from spreading throughout the body, lasting remission is difficult to achieve. In this context, immunotherapies, a relatively recent addition to the gamut of anticancer interventions, have demonstrated significant promise. Given the limitations associated with conventional cancer treatment options, there has been a surge in the need for more effective, safe and versatile alternatives, such as the TIL cell therapy.

TIL Cell Therapy – Current Market Landscape

The TIL cell therapy landscape features, close to 30 companies, across the globe claiming to be actively evaluating TIL therapies to treat advance, incurable oncological disorders. The contemporary TIL therapies market is characterized by a healthy and growing pipeline of more than 75 candidate therapies. More than 95% of the TIL cell therapy candidates, which are being developed to target a wide range of disease indications are autologous in nature.

Current Market Landscape for TIL based therapies - Roots Analysis

TIL Cell Therapy – Partnerships and Collaborations

A growing interest in this field is reflected from the increase in the partnerships focused on R&D, representing close to 40% of the total partnerships, involving both international and indigenous stakeholders. This is followed by licensing deals; most of the licensing deals are focused on the licensing of TIL cell therapy technologies.  Majority of such deals were signed between players based in North America.

TIL-based Therapies – Funding and Investments

Partnerships and Collaborations in TIL based therapies - Roots Analysis

Several investors, having realized the opportunity within this upcoming segment of T-cell therapy market, have invested USD 2.7 billion, across 30 instances, since 2013. Specifically, in last three years, industry players raised over USD 1.4 billion for the development of these therapies. In addition, majority (37%) of the companies primarily received funding through secondary offering. Further, close to 85% of the total funding instances were reported by players headquartered in the US.

Funding and Investment in TIL based therapies 2023 - Roots Analysis

TIL Cell Therapy – Patent Analysis

Majority of the patents in this domain are patent applications (72%), followed by granted patents (28%). In addition, most of the patents (60%) were filed / granted in North America. This is followed by patents filed / granted in Europe.

TIL Therapies – Patent Analysis - Roots Analysis

TIL Cell Therapy – Market Forecast and Opportunity Analysis

In the long-term, the overall projected opportunity is likely to be well distributed across key market segments, including target indications, key players and geographical regions; the TIL therapies market is expected to grow at a CAGR of ~40% by 2035.

Market Forecast of TIL based therapies 2023 - Roots Analysis

Conclusion:

Owing to their tumor-killing capability and therapeutic superiority, TIL cell therapy is being actively evaluated to treat advance, incurable oncological disorders by various researchers and industry stakeholders. Moreover, the ongoing research activity in this field has led to the discovery of several novel molecular targets, further strengthening the research pipelines of companies engaged in this market. Several clinical trials have proven the efficacy of TIL cell therapy, presenting lucrative opportunities for the players engaged in the development of these products. Driven by a promising development pipeline and encouraging clinical trial results, the TIL therapies market is likely to carve out a significant share of the multi-billion-dollar cancer immunotherapy market.

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