NGS Library Preparation Kits: Current Scenario and the Future
Since the introduction of a gene sequencing method by Frederick Sanger in 1977, the field of genomic data collection and analysis has evolved significantly. Advancement in DNA sequencing technologies have resulted in noteworthy developments in various healthcare-related research fields, such as next generation drug conjugates and personalized medicine. However, the conventional nucleotide library preparation process has several challenges, including requirement of huge amount of starting materials, inadequate throughput and deteriorated quality of the product. Moreover, the manual protocols require extensive manipulation, costly reagents and long duration of skilled genomic library production. As a result, NGS library preparation kits have emerged as an innovative technology to overcome the challenges associated with conventional library preparation protocols. These kits require less input sample, produce sufficient DNA / RNA libraries with minimum errors and are compatible with a broad range of input samples, including blood, cells, plasma and saliva. It is important to highlight that several companies are providing NGS library preparation kits to identify the novel COVID-19 virus and monitor its mutation events.
Advantages of Next Generation Sequencing
Next generation sequencing is a renowned tool in functional genomics with numerous opportunities in clinical practice. The various advantages of NGS are briefly described below:
Diverse Landscape of NGS Library Preparation Kits
During our research, we came across more than 55 players, which claim to offer 280+ NGS library preparation kits. As per our analysis, majority of the kits use purified RNA / DNA as the input sample. This is followed by kits that use other starting materials, such as bacterial colonies, formalin-fixed paraffin-embedded (FFPE) tissue, fresh frozen tissue, hair and tongue swabs.
Product Competitiveness Analysis
Several NGS library preparation kit providers are constantly making efforts to expand current capabilities to enhance their respective product portfolios and comply to evolving industry benchmarks.
NGS Service Providers
Approximately 70 industry players claim to provide various NGS based services, supporting a variety of second and third generation sequencing technologies. As per our analysis, majority of these players are located in North America, followed by Asia Pacific.
Concluding Remarks
The evolution of NGS technologies has made it possible to sequence thousands of genes with a suspected genetic disease predisposition, in a very short period of time and at minimal costs. Over the years, several established players, as well as start-ups, have emerged in this domain to offer various types of NGS kits for library preparation of nucleotides. Driven by the increasing demand for gene therapies, favourable regulatory scenario and reduced cost of sequencing, the demand within the NGS kits market is likely to increase in the coming years.
For more details, you can also download the SAMPLE REPORT on NGS library kits by Roots Analysis.
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About Author
Arun_Gupta
Arun is an enthusiastic professional and has been associated with Roots Analysis since the very early years. He has led multifaceted roles over the years be it business research, consulting, competitive intelligence, IT & technology, sales and marketing. He currently drives strategic thinking and execution within the sales and marketing domain. With educational background in life sciences from Thapar University and digital marketing credentials from Indian School of Business, he has led a lot of critical initiatives at the organization. His background in life sciences has been one of the key reasons for quick understanding and implementation of customized marketing strategies. During his early years, he has led multiple consulting assignments for global clients ranging from competitive landscaping, deal structuring and preparing go-to-market strategy for his clients.