Published: July 2019
Advances in biotechnology and genome analysis have enabled the identification of several novel cancer biomarkers, which are presently being used for a variety of purposes, including diagnosis, drug development, and to facilitate therapy related decisions
Roots Analysis has announced the addition of “Cancer Biomarkers Market: Focus on TMB, MSI / MMR and TILs Testing, 2019 – 2030” report to its list of offerings.
Over time. pharmaceutical players have demonstrated significant interest in this domain and have launched clinical research initiatives to investigate the relevance and applications of these novel biomarkers. Several companies have already developed / are developing analytical tests for novel cancer biomarkers (TMB, MSI / MMR and TILs), intended to assist physicians in making personalized treatment decisions.
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Key Market Insights
Close to 90 tests are available for the assessment of TMB / MSI / MMR and TILs
More than 50% of the aforementioned tests use next generation sequencing (NGS) technology, followed by tests based on polymerase chain reaction (22%) for the assessment of biomarker expression levels in cancer tissue samples. Examples of NGS based tests include (in alphabetical order, no specific selection criteria) FoundationOne® CDx™ (Foundation Medicine), Guardant360 (Guardant Health), NeoTYPE® Discovery Profile (NeoGenomics Laboratories).
More than 180 novel biomarker related research articles have been published since 2016
Majority (~37%) of published scientific articles are focused on the potential use of these biomarkers in evaluating how patients are likely to respond to various types of immunotherapies, such as immune checkpoint inhibitors; in this context, it is worth highlighting that several such tests are available to assess the likely response to anti PD-1 / PD-L1 therapies. Further, close to 25% of such publications discuss the potential of novel biomarker testing in colorectal cancer, followed by lung cancer (nearly 20%).
Over 170 clinical trials have been initiated over the last 5 years
In fact, leading industry players, such as (in alphabetical order, no specific selection criteria) Bristol-Myers Squibb, Merck Sharp & Dohme, Merck KgaA, Novartis, Pfizer and Roche / Genentech have been involved in most of the novel biomarker related clinical research initiatives.
North America (primarily the US) is expected to capture the majority share (~43%) of the forecasted opportunity in 2030
This growth is anticipated to be driven by the approval of more biomarker-based tests for guiding cancer treatment related decisions in the near future. Further, the market for tests designed for lung cancer and colon / colorectal cancer, is expected to capture the majority share in the coming decade.
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Key Questions Answered
The USD 860 million (by 2030) financial opportunity within the cancer biomarkers market has been analyzed across the following segments:
The research includes detailed profiles, featuring an overview of the company, its financial information (if available), and a description of the service(s) offered. Each company profile includes recent developments related to cancer biomarkers and an informed opinion on the likely strategies that may be adopted by these players to fuel growth in the foreseen future.
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