Given the recent approval of a number of bispecific antibodies and several ongoing R&D efforts focused on evaluating the potential of such candidates against various disease indications, this sector of the pharmaceutic industry has garnered significant interest of stakeholder
Roots Analysis has announced the addition of “Bispecific Antibodies Market, 2023-2035” report to its list of offerings.
Having demonstrated the ability to selectively target various antigens responsible for the development of oncological and non-oncological disorders, a number of bispecific antibodies have so far been evaluated and approved for the treatment of such indications, including the most recent approval of Tecvayli™ in October 2022, which was intended for the treatment of multiple myeloma. Driven by the availability of innovative technology platforms, lucrative funding and encouraging clinical trial results, the bispecific antibodies market is anticipated to grow in the long-run, as multiple drug candidates are expected to receive marketing approval in the coming decade.
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~10 bispecific antibody therapeutics have been commercialized and 220+ candidates are currently being evaluated across different stages of clinical development
In terms of clinical stage candidates, more than 45% of the bispecific antibodies are currently being investigated under phase I studies. It is interesting to note that the majority of such therapeutics are being designed for administration as monotherapy (57%), followed by combination therapies (43%).
Over 30% of the preclinical stage drug candidates are currently being evaluated under IND studies
Majority (>90%) of the candidates under preclinical stage of development are targeting oncology disorders. It is worth mentioning that, in terms of oncology disorders, the majority of such drug candidates are focused on the treatment of solid tumors (61%), followed by those targeting hematological malignancies (20%).
More than 120 players currently claim to be engaged in the bispecific antibody therapeutics domain
The maximum number of players providing such therapies are small companies (2-50 employees, 37%), followed by mid-sized players (51-500 employees, 35%). Additionally, over 45% of the developers are based in North America, followed by those who have established their headquarters in Asia (29%).
70+ bispecific antibody therapeutics are being developed by big pharma players, across the globe
Most of the big pharma players are primarily focused on targets, such as CD20 x CD3 (31%) and PD-L1 x TGFβ (19%). It is important to highlight that over 50% of the drug candidates developed by such players are based on the mechanism of t-cell retargeting / activation.
Partnership activity in this market witnessed a CAGR of nearly 35%, in the past seven years
It is worth mentioning that over 40 partnerships have been signed since January 2022. Product development and commercialization agreements have emerged as the most popular (30%) types of agreements inked between the players engaged in this domain.
Across the globe, more than 37,000 patients have been enrolled in close to 280 clinical trials
Clinical research activity, in terms of the number of trials registered, is reported to have increased over the last five years. Of the total number of trials, close to 80% of studies are active and recruiting patients, while about 20% have already been completed. It is worth mentioning that the majority (50%) of the drug candidates are currently being evaluated under phase I studies.
Players based in North America are anticipated to capture over 60% of the market share by 2035
The market in China / broader Asia-Pacific region is anticipated to grow at a relatively faster pace in the foreseen future. With a promising development pipeline and encouraging clinical results, bispecific antibodies targeting genetic disorders (32%) and hematological malignancies (30%) are expected to capture the major share of the total market in 2035.
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The financial opportunity within the bispecific antibodies market has been analyzed across the following segments:
The report features inputs from eminent industry stakeholders, according to whom, bispecific antibody therapeutics are expected to be the next big step in cancer immunotherapy. The report includes detailed transcripts of discussions held with the following experts:
The research includes profiles of key players (listed below); each profile features a brief overview of the company, details related to its financial information, about bispecific antibody portfolio, recent developments and an informed future outlook.
For additional details, please visit https://www.rootsanalysis.com/reports/view_document/bispecific-antibodies/286.html or email sales@rootsanalysis.com
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Contact:
Gaurav Chaudhary
+1 (415) 800 3415
+44 (122) 391 1091
Gaurav.chaudhary@rootsanalysis.com
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