Buffer Preparation Market Revenue to Cross over $13 billion by 2035 | Roots Analysis

Published: August 2023

According to a recently published report by Roots Analysis, the growing demand for buffers and challenges associated with buffer manufacturing are anticipated to be drive the buffer preparation market growth

Buffer Preparation Industry Overview

The global buffer preparation market is anticipated to grow at a CAGR of 5.9% from 2023-2035, reaching USD 13 billion by 2035.

Buffer preparation has been one of the most crucial processes in the biopharmaceutical industry with wide range of applications. Within the pharmaceutical industry, buffers are used for a wide range of applications, such as maintaining the stability / solubility of drug components, enhancing yield of desired products, maintaining defined purification conditions and stabilizing the final product while maintaining its functional characteristics. The conventional buffer manufacturing process is fraught with several challenges, including high cost of buffer production, time-consuming manufacturing process, batch-to-batch variations, and the need for large floor space. In order to deal with the aforementioned challenges, a number of pharmaceutical companies prefer to either install novel buffer manufacturing systems with advanced technologies in their manufacturing facility or outsource their buffer manufacturing requirements to specialized service providers.

Browse 90+ figures and 65+ market data tables spread across 155+ pages and detailed Table of Content on “Buffer Preparation Market: Focus on Buffer Manufacturing Systems and Service Providers - Distribution by Scale of Operation (Preclinical / Clinical and Commercial) Type of System Component (Single-use Buffer Mixing / Preparation Equipment and Reusable Buffer Mixing / Preparation Equipment) and Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World): Industry Trends and Global Forecasts, 2023-2035” here: https://www.rootsanalysis.com/reports/buffer-preparation-market.html

Market Drivers

Several factors are propelling the growth of the buffer preparation market. The growing demand for buffers and challenges associated with buffer manufacturing has prompted various pharmaceutical companies to leverage the expertise of players offering novel buffer manufacturing systems and related services. It is worth highlighting that the novel buffer manufacturing systems are integrated with a wide range of features, including conductivity sensors, pressure sensors, temperature sensors, pH sensors and filters. Notably, a large number of buffer manufacturing systems have been developed to operate in an automated mode, reducing the risk of errors prone to human interface. In addition, over 20% of the buffer manufacturing systems offer preparation of both diluted and conditioned buffers, offering flexibility to users.  Driven by the growing demand for buffers, and ongoing efforts of buffer manufacturing service providers, the market is anticipated to witness steady growth in the coming decade.

Market Restraints

While the buffer preparation market is experiencing substantial growth, it is not without its challenges. One of the primary restraints is the complications associated with the buffer preparation. Biochemical reactions  during biologic manufacturing are especially sensitive to pH. Additionally, the buffer preparation market is  highly competitive in nature which is expected to hamper the market growth. Complexities associated with the preparation of buffer solutions are expected to challenge the market growth during the forecast period.

Growth Factors

Despite the challenges, several growth factors continue to drive the buffer preparation market forward. In order to address the challenges associated with conventional buffer preparation methods and buffer storage, several players have developed novel buffer preparation systems / in-line conditioning systems which enable simultaneous preparation of buffer from raw materials and their use in upstream and downstream applications. Integrated with automated technology platforms and sensors, such systems have allowed precise and controlled production of buffers in timebound manner. It is worth highlighting that the use of novel buffer preparation systems / inline buffer conditioning systems has already demonstrated promising results in buffer manufacturing, in terms of process automation, time reduction and buffer quality. Owing to these reasons, the buffer preparation systems market is anticipated to witness steady growth in the forecast period.

Buffer Preparation Market Segments

Based on the scale of operation, the market is segmented into Preclinical / Clinical and Commercial.

  • Buffer preparation systems used for commercial manufacturing of buffers are anticipated to capture the largest share (83%) of the overall market; this trend is unlikely to change in the foreseen future as well. This can be attributed to the growing demand for commercially manufactured biopharmaceuticals and small molecules.
  • Further, systems used for manufacturing buffers at preclinical / clinical scale are also expected to capture a considerable share of the overall market by 2035.

Based on the type of system, the market is segmented into Single-use Buffer Mixing / Preparation Equipment and Reusable Buffer Mixing / Preparation Equipment.

  • Reusable buffer mixing / preparation equipment holds the largest market share, accounting for 81% of the overall buffer preparation market.
  • Further, this trend is unlikely to change significantly in the coming years as single-use buffer preparation systems are likely to be used for smaller scale buffer preparations, while reusable buffer preparation systems continue to be the preferred option for large scale manufacturing of buffer.

Based on the Regional Insights, the market is segmented into North America, Europe, Asia Pacific, Latin America, and Middle East & North Africa

  • North America and Europe dominate the global buffer preparation systems market, accounting for around 65% share of the market in 2023.
  • Asia-Pacific is likely to capture 28.4% share of the buffer preparation systems market by 2035 growing at a CAGR of 6.4%, during the forecasted period.

Key Companies Profiled

The buffer preparation market report also includes detailed profiles of key players (listed below) that offer buffer preparation systems and services:

  • Asahi Kasei
  • Avantor
  • Canvax
  • Cytiva
  • Lonza
  • Merck
  • Pall Corporation
  • Thermo Fisher Scientific 
  • Uniogen

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About Roots Analysis

Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports provided by us are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research / consulting services dedicated to serve our clients in the best possible way.

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Gaurav Chaudhary
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+44 (122) 391 1091
Email: Gaurav.chaudhary@rootsanalysis.com or sales@rootsanalysis.com


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