Conjugation and Labeling Services Market Revenue to Cross US$ 2.9 billion by 2035

Published: December 2023

According to a recently published report by Roots Analysis, the growing complexities with click-chemistry and demand for bioconjugation capabilities is driving the conjugation and labeling services market growth

Conjugation and Labeling Services Industry Overview

The global conjugation and labeling services market is anticipated to grow at a CAGR of 10.2% from 2023-2035, reaching USD 2.9 billion by 2035.

The growing interest of various stakeholders in conjugated and labeled molecules for therapeutic and diagnostic applications had led to a surge in demand for these complex molecules. The conjugates / labels incorporated in the molecules are known to offer target specificity, bioavailability, improved pharmacokinetic property and membrane permeability. Moreover, these bioconjugates support the robust and sensitive detection of the target molecule of interest. The construction of homogenous bioconjugates require multidisciplinary expertise and advanced bioconjugation technologies that can be accessed through service providers. The service providers tend to be equipped with established methodologies, along with a wide range of reagent systems and conjugates required for the chemical modification of different biomolecules. These factors together will be responsible for market growth through increased outsourcing of protein labeling, antibody labeling and antibody conjugation services to the CROs.

Browse 65+ figures and 75+ market data tables spread across 190+ pages and detailed Table of Content on “Conjugation and Labeling Services Market (Focus on Protein Labeling, Peptide Labeling, Small Molecule Conjugation and Antibody Conjugation) by Type of Molecule Supported, Type of Molecular Conjugate / Label and Key Geographical Regions: Industry Trends and Global Forecasts, 2023-2035” here:

Market Drivers

The bioconjugation field has witnessed several advancements and garnered significant attention over the last few years owing to its potential in the therapeutic, diagnostic and theranostic areas. Conjugated therapeutics have demonstrated their superiority over conventional drug products for the treatment of various diseases. They have been reported to increase the drug targeting, therapeutic window and lower the side-effects in the patient’s body. The growing bioconjugated drugs pipeline is expected to translate into huge business opportunities for contract service providers. These service providers possess the required technical expertise to mitigate the click-chemistry related concerns observed during the conjugation process. Further, these players offer solutions for conjugation of various conjugates (including enzymes, photoreactives, isotopes and quantum dots), with the molecule of interest and have dedicated facilities to carry out complex conjugation operations. Therefore, in order to mitigate the process-related complexities, companies engaged in this domain are outsourcing their operations to contract service providers.

Market Restraints

Despite several advantages, the conjugation and labeling services domain still faces certain limitations. For instance, maintenance of quality of the conjugated molecule poses a concern amongst service providers. The conjugation process may lead up to formation of heterogeneous mixtures of unconjugated, over-conjugated and under-conjugated molecules, due to similarity in different functional groups of various molecules (such as protein) present in the mixture. Therefore, owing to non-specific conjugation, the probability of usage of such products as therapeutics can be reduced. Moreover, significant efficacy variation between different batches of conjugated products poses a concern. The contract service providers need to ensure the formation of homogenous mixture and batch quality. Apart from availability of specialized technologies, strict regulatory guidelines, highly skilled professionals, high capital and need for  conjugates, such as radioactive isotopes and quantum dots, also pose a restraint.

Growth Factors

Despite the challenges, several growth factors continue to drive the conjugation and labeling services market forward. The significant rise in popularity of conjugated biomolecules for therapeutics and diagnostics (including bioimaging) has led to substantial growth of the conjugation and labeling services market in recent years. Such service providers also offer a quick turnaround time after the receipt of the molecule, for a lower cost. Specifically, the availability of low-cost outsourcing options in emerging geographies has led to a noteworthy rise in outsourcing budgets. With the increasing dependency on contract service providers, the need for cost effective and high-quality operations is likely to rise. Further, in order to meet the growing requirements of their clients and improve their capabilities, several contract service providers have entered into partnerships with stakeholders in order to provide end-to-end solutions for their clients’ product development needs.

Conjugation and Labeling Services Market Segments

Based on the type of molecule supported, the market is segmented into Proteins, Peptides, Small Molecules, Antibodies and Other Molecules.

  • The protein labeling segment led the conjugation and labeling services market, capturing the largest revenue share of 45.0% in 2023.
  • In fact, the peptide labeling segment is anticipated to show the highest market growth potential during the forecast period of over 11% annually.

Based on the type of molecular conjugate / label, the market is segmented into Polymers, Haptens, Enzymes, Fluorescent Tags, Bead Coupling / Particle Conjugates, Quantum Dots, Isotopes and Other Molecular Conjugates / Labels.

  • The polymers segment led the conjugation and labeling services market, capturing the largest revenue share of close to 25.0% in 2023.
  • The quantum dots segment is anticipated to show the highest market growth potential at a CAGR of over 15% during the forecast period.

Based on the Regional Insights, the market is segmented into North America, Europe, Asia-Pacific, Middle East and North Africa, and Latin America

  • North America dominated the conjugation and labeling services market and accounted for the largest revenue share of close to 45.0% in 2023.
  • In Europe, the conjugation and labeling services market is anticipated to demonstrate lucrative growth during the forecast period.

Key Companies Profiled

The conjugation and labeling services market report also includes detailed profiles of key players (listed below) that offer services for conjugation and labeling of biomolecules:

  • Amoy AltaBioscience
  • Bachem
  • Bio-Synthesis
  • Cayman Chemical
  • CliniSciences
  • Eurogentec
  • GBI
  • Mimotopes
  • Peptide Institute
  • piCHEM

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