Published: May 2022
The approval and success of Soliris® and other complement therapeutics has paved for the development of several drugs targeting different pathways of complement system for the treatment of a wide range of disease conditions
The potential of complement therapeutics to ease the treatment of complement-associated diseases has greatly expedited the progress of these therapeutics into clinical stages of development. Since the complement system is a complex and multidimensional system, many different therapeutic targets are likely to be discovered for a variety of disease indications, such as paroxysmal nocturnal hemoglobinuria, hereditary angioedema, renal diseases and several others, in the future. The main focus is to develop innovative therapies targeting proteins other than C5, with reduced cost and increased safety.
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Presently, 190+ complement therapeutics have been marketed / are being evaluated across different phases of development for the treatment of various disease indications
Close to 80% of the pipeline candidates are under clinical evaluation. Further, therapeutics, namely Berinert®, Cinryze®, ORLADEYO®, Ruconest® and TAKHZYRO®, have been approved for the treatment of Hereditary Angioedema. Majority (84%) of these candidates are biologics, followed by small molecules (16%).
Around 50 industry and non-industry players are engaged in the development of next generation complement therapeutics
North America has emerged as the hub, featuring the presence of approximately 50% developers. The market is currently dominated by the presence of mid-sized players (37% of the total number of stakeholders). Interestingly, 15% of the players are big pharma companies engaged in the development of such therapeutics for multiple therapeutic areas.
More than 850 clinical trials have been registered for the evaluation of next generation complement therapeutics, worldwide
The clinical research activity, in terms of number of trials registered, is reported to have increased at a CAGR of 21%, during the period 2017-2021 (till October). Of the total number of trials registered, close to 60% have already been completed, while 24% of the studies are actively recruiting participants.
Close to 1,450 articles related to next generation complement therapeutics, have been published in reputed scientific journals, since 2017
More than 40% of the articles focused on next generation complement therapeutics were published post-2019. Popular journals that have published multiple articles include Frontiers in Immunology, Allergy & Asthma Proceedings, Journal of Immunology and Molecular Immunology.
Close to 1,250 grants have been awarded to support research on next generation complement therapeutics, since 2017
Grants worth USD 835 million have been awarded to various companies / organizations working in this domain during 2017-2021. Around 20% of the grants were funded by the National Cancer Institute.
Over 3,490 patents have been filed / granted related to next generation complement therapeutics, since 2016
More than 650 patents were filed / granted in 2021 (till November). Further, around 45% of the patents were filed in Europe It is worth highlighting that majority of the patents were granted / filed for indications, including angioedema, meningitis, microangiopathy, neuromyelitis optica, periodontitis and psoriasis.
Partnership activity in this field has increased at a CAGR of nearly 55%, between 2017 and 2021 (till November)
More than 45% of the reported deals were product development and commercialization agreements. Further, majority of the agreements were signed by players based in North America (66%).
Close to USD 14 Billion has been invested by both public and private investors for the development of next generation complement therapeutics
Around 40% of the companies engaged in this domain primarily received funding through secondary offerings. Further, 70% of the funding instances were reported by players headquartered in North America.
North America is anticipated to capture over ~80% of the global market share for phase III complement therapeutics, by 2035
In 2035, close to XX% of the market revenues are expected to be generated from sales of therapeutics intended for infectious diseases. Further, therapies designed for subcutaneous route of administration are expected to occupy a larger share (XX%) of the overall market in 2035.
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The financial opportunity within the next generation complement therapeutics market has been analyzed across the following segments:
The research also includes detailed profiles of the key players (listed below) engaged in the development of next generation complement therapeutics; each profile features an overview of the company, its financial information (if available), details on product portfolio, recent developments and an informed future outlook.
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