Oligonucleotide Synthesis Market Growth

Oligonucleotide Synthesis Market Growth to Drive Technological Advancements; Market Size to Cross USD 13.5 billion by 2035 | Roots Analysis

According to a recently published report by Roots Analysis, the increase in demand for efficient and high-quality oligonucleotide therapies, and the ongoing research and innovation have led to the growing pipeline of oligonucleotides, creating lucrative opportunities for oligonucleotide synthesis providers

Oligonucleotide Synthesis Industry Overview

The global oligonucleotide synthesis market is expected to reach USD 13.5 billion by 2035, growing at a CAGR of 7.9% in the forecast period 2026-2035. 

Oligonucleotides are one of the fastest growing segments in the pharmaceutical industry. These molecules are widely used in biopharmaceutical and biotechnology industries for a wide range of applications, including research and genetic testing, forensic analysis and other analytical procedures. Presently, researchers are actively exploring the use of oligonucleotides as a pharmacological intervention, for the treatment of a myriad of disease indications. Further, as the oligonucleotide synthesis industry evolves, several commercially available automatic oligo synthesizers have been integrated with large-scale manufacturing operations for the development and production of oligonucleotide therapeutics. These synthesizers are capable of executing steps, such as molecule synthesis, removal of protecting groups, purification, desalting and lyophilization with increased efficiency. However, the aforementioned processes have certain technical requisites and face several unique challenges. For instance, these processes typically require special safety and analytical considerations, which are known to involve significant capital investments (in manufacturing facilities and purification equipment). As a result, outsourcing oligonucleotide synthesis operations is a popular business strategy being adopted by several researchers and therapy developers.

Browse 155+ figures and 185+ market data tables spread across 320+ pages and detailed Table of Content on “Oligonucleotide Synthesis Market: Industry Trends and Global Forecasts, till 2035, by Application Area, Type of Product Synthesized, Type of Oligonucleotide Synthesized, Scale of Operation, Therapeutic Area, End-users, Company Size and Key Geographical Regions” here: https://www.rootsanalysis.com/reports/oligonucleotide-synthesis/304.html

Market Drivers

Given the development of rapid, accurate diagnostic tests, surge in antisense and siRNA therapy approvals, growing interest in aptamers, adoption of personalized medicines and increased extent of outsourcing, the oligonucleotide synthesis market is likely to witness significant growth in the future. In addition, various service providers are focused on developing novel technologies (enzymatic RNA oligonucleotide synthesis technology, microchip-based oligo synthesis technology) to streamline oligonucleotide manufacturing processes, increase production efficiency and improve yield of oligonucleotide therapies. 

Market Restraints

While the oligonucleotide synthesis market is experiencing substantial growth, there are various restraints that can hinder the growth of the industry. One of the primary restraints in this domain is the high cost involved in maintaining the well-equipped facilities, integrating sophisticated technologies and advanced equipment. Another factor is the limited availability of raw materials and inadequate global manufacturing capability, which hinders the clinical development and commercial manufacturing of oligonucleotides. Further, companies lacking required technological know-how may struggle to optimize the oligonucleotide synthesis process, thereby resulting in low yield and wastage of resources.

Growth Factors

Despite the challenges and various market restraints, several factors continue to drive the oligonucleotide synthesis market growth. Notably, oligonucleotides are widely used in the treatment of myriad of chronic indications (including oncological disorders and infectious diseases), targeting larger patient populations, thereby increasing the demand for oligonucleotide based therapies. Additionally, the exponential rise in the number of clinical trials and approvals received by oligonucleotide therapies in recent years, have captivated the stakeholders to invest in research and development of various oligonucleotide therapies. Considering the increased pace of innovation, research activity and ongoing collaborations between various stakeholders, the oligonucleotide synthesis market is anticipated to witness a steady growth in the foreseen future.

Oligonucleotide Synthesis Market Segments

Based on the application area, the market is segmented into research and diagnostics and therapeutics

• The research and diagnostics segment led the oligonucleotide synthesis market, capturing the largest revenue share of 59%.
• Therapeutics segment is anticipated to witness the highest market growth rate of 9.9%, annually during the forecast period.

Based on the type of product synthesized, the market is segmented into active pharmaceutical ingredients and finished dosage forms

• The Active Pharmaceutical Ingredients segment led the oligonucleotide synthesis market, capturing the largest revenue share of 62%.
• The Finished Dosage Forms segment is anticipated to witness the highest market growth rate of 9.9%, annually during the forecast period.

Based on the type of oligonucleotide synthesized, the market is segmented into antisense, siRNA, DNA and others

• The antisense oligonucleotides segment capture the largest revenue share of close to 63% in the oligonucleotide synthesis market.
• Both DNA and siRNA segments are anticipated to witness the highest market growth rate of 10.2%, annually during the forecast period.

Based on the scale of operation, the market is segmented into Clinical and Commercial

• The commercial scale of operation segment capture the largest revenue share of close to 80% in the oligonucleotide synthesis market,.
• Clinical scale of operation segment is anticipated to witness the highest market growth rate of 12.3%, annually during the forecast period.

Based on the therapeutic area, the market is segmented into cardiovascular disorders, genetic disorders, liver disorders, rare diseases and other disorders

• The rare diseases segment capture the largest revenue share of close to 43% in the oligonucleotide synthesis market.
• In fact, cardiovascular, genetic and liver disorders segments are anticipated to witness the highest market growth rate of 10.2%, each during the forecast period.

Based on the end-users, the market is segmented into pharmaceutical / biopharmaceutical companies, academic and research institutes and hospitals

• The pharmaceutical / biopharmaceutical companies capture the largest revenue share of close to 65% in the oligonucleotide synthesis market.
• In fact, both pharmaceutical / biopharmaceutical companies and academic and research institutes segments are anticipated to witness the highest market growth rate of 10.0%, annually during the forecast period.

Based on the company size, the market is segmented into small companies, mid-sized companies, and large and very large companies

• The large and very large companies segment capture the largest revenue share of close to 75% in the oligonucleotide synthesis market.
• The mid-sized companies segment is anticipated to witness the highest market growth rate of 14.1%, annually during the forecast period.

Based on the Regional Insights, the market is segmented into North America, Europe, Asia-Pacific and Rest of the World

• North America dominated the oligonucleotide synthesis market and accounted for the largest revenue share of about 45%.
• In Asia-Pacific, the oligonucleotide synthesis market is anticipated to demonstrate lucrative growth during the forecast period.

Key Companies Profiled 

The oligonucleotide synthesis market report also includes detailed profiles of key players (listed below) that offer oligonucleotide synthesis services:

• Agilent Technologies
• Ajinomoto Bio-Pharma Services
• CordenPharma
• Integrated DNA Technologies
• Kaneka Eurogentec
• LGC Biosearch Technologies
• Microsynth
• Nitto Avecia
• Merck
• Thermo Fisher Scientific
• TriLink BioTechnologies

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