Automatic Aseptic Sampling Market

Automatic Aseptic Sampling Market: Industry Trends and Global Forecasts, till 2035 - Distribution by Type of Monitoring Method (On-line, Off-line, and At-line), Bioprocessing Method (Upstream and Downstream), Working Volume (Less than 10 mL, 10-50 mL, 51-100 mL, and more than 100 mL), Scalability (Lab Scale, Pilot Scale and Commercial Scale), Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World)

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Automatic Aseptic Sampling Market Overview

The automatic aseptic sampling market is expected to grow from USD 136 million in 2024 to reach USD 961 million by 2035, growing at a CAGR of 20% during the forecast period.

In recent years, the pharmaceutical industry has been widely influenced by the increasing demand for biologics and target-specific therapeutic drugs. Biopharmaceutical drugs or complex medicine require a controlled manufacturing environment to prevent spoilage and maintain biocompatibility. During the biopharmaceutical manufacturing process, sampling is the most crucial step. The manual sampling technique is fraught with several challenges, including human errors, risk of contamination, operator-to-operator deviation, and lower sample frequency rates. The challenges are associated with manual processing, which necessitates integrating automated aseptic sampling systems in biopharmaceutical manufacturing. Automated aseptic sampling includes collecting samples for analysis, testing, and drug development without human intervention.

These automated aseptic sampling techniques prevent microbial invasion and other contaminants that may damage the sample integrity. Aseptic sampling is also essential to maintain product safety and quality, specifically in the pharmaceutical industry. Furthermore, automated aseptic sampling offers several advantages, including real-time monitoring, improved productivity by up to 80%, and reduced deviation by around 65%. Considering the benefits, several pharmaceutical companies continue to integrate these advanced technologies to manufacture drugs with precise limits. Driven by the increasing usage, several companies engaged in this market accelerated the production of automatic sampling systems and automatic sample preparation systems that can be utilized for various biopharmaceutical manufacturing tasks. Additionally, the system offers diverse applications for lab automation, including analyte monitoring, bioprocessing, fraction collection, data management, and advanced process control /feedback in the biotechnology, pharmaceutical, cosmetic, and food industries.

Moreover, these systems utilize process analytical technology that is easily integrated within the bioprocessing unit with the aim of improving scalability. Given the ongoing requirement and advances, the automatic aseptic sampling market is witnessing innovations to deliver the best solutions. Furthermore, the changing regulatory guidelines for biopharmaceutical bioprocessing, specifically for digitization, automation, and process transparency, are driving the market. It is worth noting that various laboratory equipment manufacturers are developing automated, controlled, and user-friendly systems that facilitate the sampling process. Owing to the increasing interest of industrial leaders towards technological adoption and advancements of these systems, the market for automatic sampling systems is expected to witness steady growth during the forecast period.

Automatic Aseptic Sampling Market Segmentation Insights

The market report presents an in-depth analysis of the various companies that are involved in the field across different segments, as defined in the table below:

Automatic Aseptic Sampling Market: Report Attributes / Market Segmentations

Key Report Attribute Details
Historical Trend 2019-2023
Base Year 2023
Forecast Period 2024-2035
Market Size 2024 USD 136 million
Market Size 2035 USD 961 million
Type of Monitoring Method
  • Online
  • Off-line
  • At-line
Bioprocessing Method
  • Upstream 
  • Downstream
Working Volume
  • Less than 10 ml 
  • 10-50 ml
  • 51-100ml
  • More than 100 ml
Scalability
  • Lab Scale
  • Pilot Scale
  • Commercial Scale
Key Geographical Regions 
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World
Key Companies Profiled
  • Agilent Technologies
  • Biotage
  • Cytiva
  • Flownamics
  • MGI Tech
  • Mettler Toledo
  • Pall Corporation
  • Shimadzu
  • SOTAX
(A full list of key companies captured is available in the report)
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Excel Data Packs
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  • Market Landscape
  • Companies Competitiveness Analysis
  • Partnerships and Collaborations Analysis 
  • Patent Analysis 
  • SWOT Analysis 
  • Porters Five Force Analysis 
  • Market Forecast and Future Opportunity Analysis


The key objective of the market report is to provide a detailed market analysis in order to estimate the existing market size, market value, statistics, and future opportunities. We have provided informed estimates of the likely evolution of the market in the short to mid-term and long-term for the forecast period 2024-2035. Our year-wise projections of the current and future opportunity have further been segmented based on relevant parameters, such as type of monitoring method (on-line, off-line and at-line), bioprocessing method (upstream and downstream), working volume (less than 10 ml, 10-50 ml, 51-100 ml and more than 100 ml), scalability (lab scale, pilot scale and commercial scale), and key geographical regions (North America, Europe, Asia-Pacific and Rest of the World).

In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base, and optimistic scenarios, representing different tracks of the industry's growth. All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market research report are in USD unless otherwise specified.

Automatic Aseptic Sampling Market Share Insights

Market Share by Type of Monitoring Method

Based on the type of monitoring method, the automatic aseptic sampling market is segmented into on-line, off-line, and at-line monitoring methods. The online monitoring method is likely to dominate the market and is poised to capture 59% of the overall revenue share by 2035. The at-line method will expand at a higher CAGR of 21% during the forecast period.

Market Share by Bioprocessing Method

The automatic aseptic sampling market is distributed in upstream and downstream processing based on the bioprocessing method. Currently, the upstream segment is dominating the market and is poised to hold the largest share (60%) of the overall market.

Market Share by Working Volume

Based on the working volume, the automatic aseptic sampling  systems market is segmented into less than 10 ml, 10-50 ml, 51-100 ml, and more than 100 ml. Presently, 10-50 ml working volume dominates the market and is estimated to hold 38% of the overall market share by 2035. In the long run, 51-100 ml working volume will grow at a higher CAGR of 22% during the forecast period.

Market Share by Scalability

The automatic aseptic sampling market is segmented into lab scale, pilot scale, and commercial scale. Currently, the lab scale dominates the market and is poised to capture 49% of the overall revenue share by 2035. Pilots will show great growth potential and are estimated to grow 23% from 2024-2035.

Market Share by Key Geographical Region

This segment highlights the distribution of the automatic aseptic sampling market across various geographies, such as North America, Europe, Asia-Pacific, and the Rest of the World. According to our projections, North America will likely capture the majority of the share in 2024, and this trend is unlikely to change. It is also worth highlighting that the market in North America is expected to hold 53% of revenue share by 2035. Notably, in Asia and the rest of the world, the market is likely to grow at a CAGR of 25% from 2024-2035.

Automatic Aseptic Sampling Market: Key Insights

The market report features an extensive study of the current market landscape, market size, market share, market forecast, market outlook and future opportunities for automatic aseptic sampling systems. Due to the growing demand for biologics and stringent regulatory guidelines, the biopharmaceutical industry has shifted to using automatic sampling methods, which offer reliable systems for transferring bioprocess samples directly from bioreactors to analytical devices while maintaining the process sterility and integrity. In addition, it features an elaborate discussion on the likely opportunity for the players engaged in providing automatic aseptic sampling systems over the next decade.

Competitive Landscape of Automatic Aseptic Sampling Market

Currently, the market features several industrial and non-industrial leaders with the required expertise to develop automatic aseptic sampling solutions. Overall, the market is well-fragmented and features small, mid-sized, and large companies holding technical expertise. In pursuit of building a competitive edge, stakeholders in this domain are striving to enhance their product portfolio and upgrade their automatic sampling systems with advanced features. It is worth highlighting here that the majority of the players in this market are headquartered in North America. Moreover, over 55 automatic sampling systems are commercially available in different regions of the globe; a relatively larger proportion of these players are mid-sized companies.

Automatic Aseptic Sampling Market Size

The global automatic aseptic sampling market is estimated to be worth USD 136 million in 2024. Driven by the increasing demand for advanced techniques to reduce human errors during sampling and handle large volumes with accuracy, the market is anticipated to grow at a robust rate during the forecast period. It is interesting to note here that the key players in the market are expanding their research efforts to develop novel technologies and equipment for error-free sampling. Majority of the automatic sampling systems (83%) allow on-line real-time monitoring and continuous process control / continuous manufacturing; pharma and biotech companies have emerged as the biggest end-users of these systems.

Market Trend Analysis: Technological Advances to Streamline Biopharmaceuticals Manufacturing

The automatic aseptic sampling market is witnessing technological advancements that contribute to the growth of this field. Key players active in this domain are currently focusing on developing innovative aseptic sampling techniques that improve operational efficiency and reduce the chances of errors and dependency on skilled personnel. These ongoing advancements unleash various opportunities for the leading industrial players to make significant advancements in the research and development of advanced automated sampling technologies. For instance, closed-loop sampling techniques have been developed to obtain representative samples without exposing the entire product to the environment. This technique helps to reduce the risk of contamination and enhance the accuracy of the results. Further, the emphasis of top players will be on the development of automated sampling systems that can handle large-scale operations with high sample throughput while maintaining speed and accuracy.

Automatic Aseptic Sampling Market: Partnerships and Collaborations Analysis

It is worth noting here that the market has witnessed partnerships and collaborations over the past few decades. The aim of partnerships is to enhance product portfolios and increase innovations in the industry to deliver premium sampling solutions. Notably, over 35% of the partnerships were signed for product distribution purposes, and stakeholders based in North America have signed maximum agreements related to automatic sampling. Furthermore, the rising adoption of automatic sampling systems across the pharmaceutical industry is projected to create enormous opportunities for business expansion—ongoing opportunities in this field are anticipated to increase mergers and acquisitions for a profitable business, which is likely to drive the automatic aseptic sampling market growth during the forecast period.

Regional Analysis: North America to Hold the Largest Automatic Aseptic Sampling Market Share

According to our research analysis, North America will dominate the market, and the trend will remain unchanged during the forecast period. Further, the market in North America is expected to hold 53% of the revenue share by 2035. In Asia Pacific and the rest of the world, the automatic aseptic sampling systems market is anticipated to demonstrate lucrative growth owing to the increasing interest of key players for the development of advanced technologies for sampling  biopharmaceutical drugs.

Key Companies in Automatic Aseptic Sampling Market

Examples of key companies engaged in providing automatic aseptic sampling systems (which have also been profiled in this market report; the complete list of companies is available in the full report) include Agilent Technologies, Biotage, Cytiva, Flownamics, MGI Tech, Mettler Toledo, Pall Corporation, Shimadzu and SOTAX. This market report includes an easily searchable Excel database of all the companies providing automatic aseptic samplers for upstream and downstream biologics manufacturing worldwide.

This image provides list of Automatic Sampling Systems. Presently, more than 55 automatic sampling systems are commercially available in different regions of the globe; a relatively larger proportion of these players are mid-sized companies This image presents market landscape of automatic sampling systems. Majority of the automatic sampling systems (83%) allow on-line real-time monitoring and continuous process control; pharma and biotech companies have emerged as the most prominent end users of these systems This image provides list of Automatic Sample Collection / Preparation Systems. More than 80% of the automatic sample collection / preparation system manufacturers were established before 2000; majority of them are based in North America


Automatic Aseptic Sampling Market Report Coverage

Amongst other elements, the market research report includes:

  • A detailed assessment of the current market landscape of automatic sampling systems, featuring a detailed analysis of these systems based on several parameters, such as type of monitoring method, type of sampling unit(s), availability of pump / probe, type of module, automated software, type of vessel, vessel fabrication material, type of analyte monitored, type of analyzer, number of sampling vessels, working volume, operating temperature, end-user industry, scalability and applications of the system. In addition, the chapter includes an analysis of automatic sampling system developers, along with information on their year of establishment, company size, location of headquarters, and leading players (in terms of number of systems being offered).
  • A competitiveness analysis of automatic sampling systems manufacturers based on various relevant parameters, such as the overall experience of the company (in terms of the number of years since it was established), product portfolio strength (in terms of the number of automatic sampling systems manufactured and type of monitoring method) and portfolio diversity (in terms of the type of sampling unit, end-user industry, scalability, and applications).
This image highlights competitiveness analysis of Automatic Sampling System Manufacturers. In pursuit of building a competitive edge, stakeholders in this domain are striving to enhance their product portfolio and upgrade their automatic sampling systems with advanced features This image highlights various developments / recent trends related to automatic sampling systems, offering insights on recent global events related to automatic sampling systems. The growing interest is also reflected by the events organized for automatic sampling systems, providing an opportunity to product developers to share their ideas and develop a better understanding of such systems This image provides information on partnership activities observed in the domain of automatic sampling systems. Over 35% of the partnerships were signed for product distribution purposes; stakeholders based in North America have signed maximum agreements related to automatic sampling

 

  • Elaborate profiles of prominent players engaged in the automatic aseptic sampling market. Each profile includes a brief overview of the company, details related to its financial information (if available), information on product portfolio, recent developments, and an informed future outlook.
  • A detailed market landscape of automatic sample collection / preparation systems based on several relevant parameters, such as system category, system classification, type of monitoring method, type of sampling unit, type of module, working volume, type of analyzer, end-user industry, and scalability of the products. In addition, the chapter includes a list of players engaged in developing automatic sample collection / preparation systems along with information on their year of establishment, company size, location of headquarters. Further, it also highlights the leading manufacturers of automatic sample collection / preparation systems (in terms of the number of systems manufactured).
  • Detailed profiles of the players offering automatic sample collection / preparation systems. It includes a brief overview of the company, details of its product portfolio, and a section on recent developments and an informed future outlook.
  • An insightful analysis of the patents filed / granted for automatic sampling systems since 2016, taking into consideration various relevant parameters, such as type of patent, publication year, geographical location, CPC symbols, emerging focus areas, type of organization, leading players (in terms of number of patents granted / filed in the given time period) and patent characteristics. In addition, the chapter includes detailed patent benchmarking and an insightful valuation analysis.
  • An analysis of various developments / recent trends related to automatic sampling systems, offering insights on recent global events related to automatic sampling systems and partnerships and collaborations established within the industry.
  • A discussion on affiliated trends, key drivers, and challenges under a SWOT framework, featuring a Harvey ball analysis, highlighting the relative impact of each SWOT parameter on the overall automatic sampling systems market.
  • A qualitative analysis highlighting the five competitive forces prevalent in the automatic aseptic sampling market, including threats of new entrants, bargaining power of customers, bargaining power of automatic sampling system manufacturers, threats of substitute products, and rivalry among existing competitors.
This image represents qualitative analysis, highlighting the five competitive forces prevalent in automatic sampling systems domain. The increasing adoption of automatic sampling systems in the biopharmaceutical industry is anticipated to create profitable business opportunities for the system manufacturers This image provides information on the growth of the market of automatic sampling systems. Given the requirement of systems that can transfer bioprocess samples directly from bioreactors to analyzers while maintaining the process sterility, the adoption of automatic sampling is anticipated to rise significantly This image highlights the market segments of automatic sampling systems domain. The market is likely to grow at an annualized rate of more than 15% by 2035; the opportunity is likely to be well distributed across different geographies, and other important market segments


Recent Developments in Automatic Aseptic Sampling Market

Several recent developments have taken place in the field of automatic aseptic sampling systems. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In August 2023, Rentschler Biopharma collaborated with Cell and Gene Therapy Catapult (CGT Catapult) and Refeyn to use automated and digital technologies to improve AAV manufacturing for gene therapies. 
  • In February 2023, Biosero collaborated with AltemisLab with an aim to streamline sample management automation for customers.

Frequently Asked Questions

Question 1: What is automatic aseptic sampling?

Answer: An automatic sampler is a device that is coupled with another analytical device in order to provide samples on a periodic basis for analytical procedures in biologics manufacturing.

Question 2: How big is the automatic aseptic sampling market?

Answer: The automatic aseptic sampling market size is estimated to be worth $136 million in 2024.

Question 3: What is the projected market growth of the automatic aseptic sampling market?

Answer: The automatic aseptic sampling systems market is expected to grow at a compounded annual growth rate (CAGR) of 20% during the forecast period 2024- 2035.

Question 4: Who are the leading players manufacturing automatic aseptic samplers?

Answer: Agilent Technologies, Biotage, Cytiva, Flownamics, MGI Tech, Mettler Toledo, Pall Corporation, Shimadzu and SOTAX.

Question 5: How many companies presently claim to provide automatic samplers?

Answer: Presently, over 40 companies are engaged in the automatic aseptic sampling market, providing more than 55 systems globally.

Question 6: Which region is the hub for companies engaged in providing automatic aseptic sampling systems?

Answer: North America presently harbors the majority of the companies with close to 40% of the companies being established in this region.

Question 7: How many patents related to automatic samplers have been filed / granted over the last few years?

Answer: Since 2016, over 400 patents related to automatic samplers have been filed / granted, worldwide.

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