Drug Bioavailability Enhancement Market

Drug Bioavailability Enhancement Market: Industry Trends and Global Forecasts, till 2035 - Distribution by Type of Drug Class (New Drug Approvals and Generics), Type of BCS Classification (BCS II Drugs and BCS IV Drugs), Type of Bioavailability Enhancement Approach (Solid Dispersion, Size Reduction, Lipid-based, and Other Approaches), Type of Dosage Form (Liquids, Solids, Semi-Solids, and Fine Particles), Key Geographical Regions (North America, Europe and Asia Pacific, Latin America, Middle East, and North Africa)

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Drug Bioavailability Enhancement Market Size Overview

The global drug bioavailability enhancement market size is estimated to be worth USD 3.20 billion in 2024 and is expected to reach USD 10.22 billion by 2035 at a CAGR of 11.11% during the forecast period 2024 to 2035.

Drug bioavailability enhancement is a technique used to increase the amount of drug that reaches the systemic circulation when administered. It is a significant pharmacokinetic parameter for assessing the efficacy and safety of a drug. A search study found that most candidates fail during the early phases of clinical trials. The failure of drugs can be ascribed to problems associated with pharmacokinetic profiles, toxicity-related concerns, ADME (distribution, metabolism, absorption, and excretion), and properties such as molecular structure, solubility, and crystallinity. The study also underscored that almost 90% of New Chemical Entities (NCEs) in pre-clinical and clinical stages face solubility or permeability challenges.

Consequently, there has been a notable surge among drug developers in exploring reformulation strategies to boost bioavailability. The 505(b)(2) pathway has seen increased usage for approving novel formulations containing previously approved active pharmaceutical ingredients (APIs). Moreover, with a growing emphasis on lipophilic drug compounds, numerous pharmaceutical companies are striving to research bioavailability enhancement techniques to address such challenges. In addition, various therapeutic intervention developers are opting to outsource their bioavailability enhancement operations to contract service providers. This trend is fueled by the specialized facilities, equipment, and established processes these providers offer that facilitate quicker achievement of development goals. Consequently, numerous bioavailability-focused service providers for APIs have emerged globally in recent years, seeking to meet the escalating demand for effective therapeutics. These stakeholders are actively developing proprietary technologies based on sustained release principles and bioavailability enhancers to maintain their competitive advantage in this rapidly evolving market.

Drug Bioavailability Enhancement Market Segmentation Insights

The market research report presents an in-depth analysis of the various companies that are engaged in the global market of drug bioavailability enhancement, across different segments, as defined in the table below:

Global Drug Bioavailability Enhancement Market: Report Attributes / Market Segmentations

Key Report Attribute Details
Historical Trend 2018-2023
Base Year 2023
Forecast Period 2024-2035
Market Size by 2035 USD 10.22 Billion
CAGR 11.11%
Type Of Drug Class
  • New Drug Approvals 
  • Generics
Type of BCS Classification 
  • BCS II Drugs 
  • BCS IV Drugs
Type of Bioavailability
Enhancement Approach
  • Solid Dispersion
  • Size Reduction
  • Lipid-based and other approaches
Type of Dosage Form
  • Liquids
  • Solids
  • Semi-Solids
  • Fine Particles
Key Geographical Regions
  • North America
  • Europe
  • Asia Pacific
  • Latin America 
  • Middle East and North Africa
Key Companies Profiled (A full list of operating companies captured is available in the report)
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Customization Scope 15% Free Customization 
Excel Data Packs
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  • Market Landscape Analysis for Drug Bioavailability
    Enhancement Service Providers and Technology Providers
  • Key Insights
  • Company Benchmark Analysis
  • Partnerships and Collaborations
  • Publication Analysis
  • Patent Analysis
  • Clinical Trial Analysis
  • Demand Analysis
  • Market Forecast and Future Opportunity Analysis

One of the key objectives of this market report was to estimate the current market size, opportunity, and future growth potential of the drug bioavailability enhancement market, over the forecast period. Based on multiple parameters, likely adoption trends, and through primary validations, we have provided an informed estimate of the market evolution during the forecast period 2024-2035. 

The market report also features the likely distribution of the current and forecasted opportunity within the drug bioavailability enhancement industry across various segments, such as type of drug class (new drug approvals and generics), type of BCS classification (BCS  ii drugs, and BCS iv drugs), type of bioavailability enhancement approach (solid dispersion, size reduction, lipid-based, and other approaches), type of dosage form (liquids, solids, semi-solids, and fine particles), and key geographical regions (North America, Europe and Asia Pacific, Latin America, Middle East, North Africa and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base, and optimistic scenarios, representing different tracks of the industry’s growth.

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD unless otherwise specified.

Drug Bioavailability Enhancement Market Share Insights

Market Share by Type of Drug Class

The global drug bioavailability enhancement market is segmented into two types of drug classes, New Drug Approvals and Generics. Based on the types of drug class, NCE candidates capture 85.5% of the market share and are anticipated to propel the market growth at a CAGR of 11.52% over this forecast period. The growth of the segment is attributed to its unique characteristics and market potential of NCE. As NCEs show new chemical compounds that have not been previously used in therapeutic applications, these novel compounds may offer unique opportunities for bioavailability enhancement through innovative drug delivery systems.

Market Share by Type of BCS Classification 

Based on the type of BCS classification, the drug bioavailability enhancement market is fragmented into BCS II Drugs and BCS IV Drugs. As per market research, BCS-II drugs account for 77.6% of the total market share and are projected to accelerate the market at 11.22% CAGR throughout the forecast period. BCS class II compounds, characterized by low solubility but high permeability, dominate the drug bioavailability enhancement market due to their prevalence, clinical significance, development opportunities, and regulatory considerations. Also, improving the bioavailability of BCS class II compounds is essential as it remarkably impacts their therapeutic efficacy and commercial success.

Market Share by Type of Bioavailability Enhancement Approach

In the drug bioavailability enhancement market, several BA enhancement approaches are being adopted such as Solid Dispersion, Size Reduction, Lipid-based, and other approaches. According to market research, solid dispersion is one of the most popular approaches in the drug bioavailability enhancement market. This method involves dispersing the drug in a solid matrix to increase its solubility and dissolution rate, thereby improving its bioavailability. These formulations can be tailored to suit the drug’s specific physicochemical properties and can enhance its absorption and therapeutic effectiveness.

Market Share by Dosage Form

This segment describes the distribution of the market based on dosage forms such as Liquid, Solids, Semi-Solids, and Fine Particles. According to our projection, the liquid segment dominates the market with the largest (63.18%) drug bioavailability enhancement market share and is expected to continue to lead the market at a CAGR of 12.04% throughout this forecast period 2024-2040. Liquid dosage forms are used as drugs or medications for consumption or administration which are prepared by dissolving the active drug substance in either an aqueous or nonaqueous solvent. Due to this, the advantages of the liquid dosage form such as faster absorption than solid drugs, more flexibility in achieving the proper medication dose, and the best option for children and old age people, are likely to fuel the drug bioavailability enhancement market growth in the future.

Market Share by Type of Key Geographical Regions

This segment highlights the distribution of the market across various geographies, such as North America, Europe, Asia-Pacific Latin America, Middle East, and North Africa. According to our projections, North America is likely to dominate the global market for drug bioavailability enhancement with the largest share of 34.37%. 

Additionally, Asia Pacific is anticipated to boost the market growth with 13.53% CAGR during the forecast period owing to the expanding pharmaceutical industry, with increasing healthcare expenditure in emerging nations. The rising outsourcing of pharmaceutical services coupled with the growing investment in research and development programs are attributed to promoting the growth of the drug bioavailability enhancement market in the Asia Pacific region.

Drug Bioavailability Enhancement Market Key Insights

The “Drug Bioavailability Enhancement Market: Industry Trends and Global Forecasts, till 2035” market report features an extensive study of the current market landscape, market size, market forecast and future opportunities for the companies providing technologies and services for drug bioavailability enhancement. Key takeaways of the market size, competitive landscape, and geographical regions in the market report are briefly discussed below.

Competitive Landscape of Drug Bioavailability Enhancement Service Companies

The market for drug bioavailability enhancement is highly competitive with the presence of several small and big size companies. Close to 115 companies are involved in providing services associated with drug bioavailability enhancement. With the emergence of outsourcing models for drug bioavailability, the market has been evolving exponentially due to which small and very small companies are expanding their portfolio by offering a wide range of services based on the bioavailability enhancement principles. 

Nearly 80% of the companies are providing bioavailability enhancement services by employing solid dispersion approaches due to the mounting emphasis on improving drug solubility. Some of the key players are Adare Pharma Solutions, Ascendia Pharmaceuticals, Catalent, Lonza, Lubrizol Life Science Health, and Pace Life Sciences. Moreover, majority (46%) of the companies are based in North America. These market players are adopting various strategies to retain their position in the global marketplace. For instance, prominent companies are constantly expanding their investment in R&D programs to innovate multiple high-value technologies and strong intellectual property portfolios. With regard to this, around 9900 patents have been registered till date by the leading companies which will stimulate the growth of the market during the forecast 2024-2040.

Trends Analysis in Drug Bioavailability Enhancement Market: Growing Advances in Bioavailability Enhancement to Enable Novel Formulations

Advancements in bioavailability research have led to the emergence of new trends and technologies that seek to improve the efficacy and safety of drug therapy. In this context, innovation of advanced formulation technologies, such as liposomes, micelles, cyclodextrin complexes and solid lipid nanoparticles in drug delivery, to overcome the challenges associated with low solubility and permeability of drug compounds have expanded the market potential. 

Specialized drug delivery technologies enhance drug stability, solubility, absorption, and targeting which ultimately enhance the therapeutic effectiveness and patient outcomes of pharmaceutical products. Additionally, the growing interest in personalized therapy is one of the significant trends in the market. The personalized medicine approaches, targeted to specific patients and tailored formulations to optimize drug delivery methods are expanding the scope of the market.

Regional Analysis: North America is Expected to Dominate the Market with the Largest Number of Active Clinical Trials

With regard to regional insights, North America has been a prominent region in the global market for drug bioavailability enhancement and is poised to dominate the market in the future as well. The growth of the market in the region is attributed to several factors. For instance, the well-established pharmaceutical industry in North America and strong R&D base of various biotech firms, pharma contract research organizations (CROs), and academic institutions conduct cutting-edge research in drug delivery and formulation science, drive innovation, and facilitate the development of novel bioavailability enhancement strategies. Besides this, the region conducted the majority of the clinical trials for evaluating novel therapeutics drugs.

Furthermore, encouraging regulatory environments such as the existence of the FDA in the region, fosters investment in bioavailability enhancement technologies and accelerates the market entry of innovative products. Additionally, the high prevalence of diseases coupled with rising demand for therapeutic treatment, strategic collaborations, and market competitiveness are likely to position North America as a leader in the drug bioavailability enhancement market during this forecast.

Key Players in Drug Bioavailability Enhancement Market 

Examples of key companies engaged in the drug bioavailability enhancement industry (which have also been profiled in this market report; the complete list of companies is available in the full report) include Adare Pharma Solutions, Ascendia Pharmaceuticals, Catalent, Lonza, Lubrizol Life Science Health, Pace Life Sciences, Quotient Sciences and WuXi STA (A Subsidiary of WuXi AppTec). This market report includes an easily searchable excel database of all the companies providing services and technologies in the drug bioavailability enhancement market.

Drug Bioavailability Enhancement Market Report Coverage

Amongst other elements, the market report features:

  • An executive summary of the insights captured in our research. It offers a high-level view on the current state of bioavailability enhancement technologies and services market and its likely evolution in the mid-long term.
This image provides list of Bioavailability Enhancement Service Providers. Outsourcing has emerged as a popular model for improving drug bioavailability, with nearly 115 companies offering a wide range of services based on different bioavailability enhancement principles This image represents the market landscape of bioavailability enhancement service providers. At present, more than 80% of the players are offering bioavailability enhancement services focused on improving the drug solubility, primarily by adopting the solid dispersion approach This image provides list of Bioavailability Enhancement Technologies. Advances in bioavailability enhancement technologies have enabled the development of novel formulations with improved pharmacokinetic properties, resulting in lucrative business opportunities for technology providers
  • A general introduction to bioavailability enhancement, featuring information on the historical overview of bioavailability, assessment of drug bioavailability, need for bioavailability enhancement, and general factors affecting drug bioavailability. Additionally, the chapter includes details on the various types of bioavailability enhancement approaches / technologies employed by various industry stakeholders. The chapter concludes with a discussion on the key growth drivers, as well as upcoming trends in drug bioavailability enhancement market.
  • A detailed assessment of the overall market landscape of bioavailability enhancement service providers, based on several relevant parameters, such as year of establishment, company size (in terms of number of employees), location of headquarters, bioavailability enhancement principle supported (solubility enhancement, absorption enhancement, sustained release and others), bioavailability enhancement approach employed, including [A] solid dispersion (spray-dried dispersion, hot melt extrusion, polymers, agglomeration / granulation, lyophilization, inclusion complexes, supercritical fluid, solvent evaporation and other solid dispersion approaches), [B] size reduction (conversion to nanotechnology-based formulation, high pressure homogenization / micronization, bead layering, microfluidics, and other miscellaneous size reduction approach), [C] lipid-based (liposomes, self-emulsifying drug delivery system, excipients, micelles, lipid-nanotechnology based formulations and other lipid-based formulations), and other bioavailability enhancement approaches (co-crystallization, chemical modification, and other miscellaneous bioavailability enhancement technologies), type of dosage form supported (solids, liquids, fine particles and semi-solids), and route of administration of drug product (oral, topical, parenteral and others).
  • A detailed assessment of the current market landscape of bioavailability enhancement technology providers, featuring analysis based on several parameters, such as year of establishment, company size (in terms of employee count) and location of headquarters. In addition, the chapter highlights an in-depth analysis of various bioavailability enhancement technologies based on bioavailability enhancement principle supported (solubility enhancement, absorption enhancement, sustained release, and others), bioavailability enhancement approach employed (solid dispersion, nanotechnology, lipid-based, other size reduction, chemical modification, and others), type of molecule (small molecules and biologics), type of dosage form supported (solids, liquids, fine particles, and semi-solids), route of administration (oral, topical, parenteral, and others), availability for license and associated intellectual property rights.
  • An in-depth analysis, highlighting the contemporary market trends, using six schematic representations, including [A] a world map representation depicting the region-wise distribution of various stakeholders engaged in offering bioavailability enhancement services, on the basis of their company size, [B] a waffle chart representation, highlighting the regional distribution of bioavailability enhancement service providers, based on various types of bioavailability enhancement approaches employed by them,  [C] a heat map representation of bioavailability enhancement service providers, based on bioavailability enhancement approaches and type of dosage form, [D] a horizontally grouped bar chart, highlighting the distribution of bioavailability enhancement service providers based on their company size and type of bioavailability enhancement principles, [E] an insightful tree map representation of bioavailability enhancement service providers (in terms of bioavailability enhancement principles employed and bioavailability enhancement approaches offered),  as well as [F] a 3D bubble analysis comparing the key players engaged in drug bioavailability enhancement market, based on several relevant parameters (such as year of establishment, company size, number of bioavailability enhancement approaches offered and region).
This image provides information on the completed, ongoing, and planned clinical studies related to bioavailability enhancement of various drug compounds and / or candidates. In the past decade, several clinical trials have been registered for evaluating novel therapeutic interventions with improved bioavailability, across different geographical regions This image represents the analysis of patents that have been filed / granted for bioavailability enhancement approaches and technologies. Bioavailability enhancement domain is characterized by extensive R&D activity, leading to the development of multiple high value technologies and a strong intellectual property portfolio; we identified over 9,900 such patents This image provides information on Technology Evaluation Framework along with the Key Factors Impacting the Success of Bioavailability Enhancement Technology. With the market evolving at a steady pace, emerging players need to incorporate innovative bioavailability enhancement technologies to augment their service portfolio and surpass the competition
  • Elaborate profiles of various prominent players that are engaged in offering bioavailability enhancement technologies and services. Each profile features a brief overview of the company (including information on year of establishment, number of employees, location of headquarters and key executives), details related to its financial performance (if available), bioavailability enhancement services portfolio, recent developments and an informed future outlook.
  • A company benchmarking analysis of various players engaged in the drug bioavailability enhancement market. It highlights the capabilities of industry players in terms of their expertise across various services related to bioavailability enhancement of drug compounds and / or drug candidates. The analysis allows companies to compare their existing capabilities within and beyond their peer groups and identify opportunities to gain a competitive edge in the industry.  
  • An analysis of partnerships that have been inked between several stakeholders engaged in providing bioavailability enhancement services and technologies, during the period 2013-2022, covering mergers and acquisitions, licensing agreements, alliances, product development and manufacturing agreements, research and development agreements, product development and commercialization agreements, service agreements, and other agreements.
  • A detailed review of more than 5,800 peer-reviewed, scientific articles related to research on bioavailability enhancement of drug compounds and / or drug candidates, based on parameters, such as year of publication, type of publication and popular keywords. The chapter also provides information on top journals, top publishers and top copyright holders (in terms of number of articles published)
  • An in-depth analysis of the patents that have been filed/granted for bioavailability enhancement approaches and technologies since 2003, based on important parameters, such as type of patent, patent application year, patent publication year, bioavailability enhancement approach, CPC symbols, geography, emerging focus area, type of organization, leading industry and non-industry players (in terms of number of patents filed/granted), and individual patent assignees (in terms of size of intellectual property portfolio). The chapter also includes an insightful benchmarking and valuation analysis.
  • An in-depth analysis of completed, ongoing, and planned clinical studies related to bioavailability enhancement of various drug compounds and / or candidates, based on several relevant parameters, such as trial registration year, trial phase, current recruitment status, enrolled patient population, study design, type of sponsor / collaborator, leading industry and non-industry players (in terms of number of registered trials conducted), type of molecule and key geographies.
  • An insightful framework evaluating the bioavailability enhancement approaches based on various parameters, such as number of technologies, number of approved drugs, trends highlighted in published literature and patents, and business models adopted by industry stakeholders. It also provides a value addition matrix for respective bioavailability enhancement approaches currently employed by stakeholders.
  • An elaborate analysis in order to estimate the current and future demand for bioavailability enhancement technologies and services, based on several relevant parameters, such as drug class (new drug approvals and generics), BCS classification (BCS II drugs and BCS IV drugs) and dosage form (liquids, solids, semi-solids, and fine particles / powders) for the period 2022-2035. Kindly note that input parameters considered for this analysis include the number of New Chemical Entity (NCE) candidates and generic / reformulated drug products that are likely to undergo formulation development over the period of next 13 years.
This image highlights the the current and future demand for bioavailability enhancement technologies and services. Considering the concerns related to low solubility / permeability of certain marketed drugs and a large number of NCEs, the demand for bioavailability enhancement technologies and services is anticipated to rise in the future This image provides information on the current as well as future market scenario of bioavailability enhancement technologies and services domain. Driven by the increase in number of BCS II and BCS IV molecules being evaluated in early phases of development, the bioavailability enhancement domain is likely to grow at CAGR of ~11%, till 2035 This image highlights the market segments of bioavailability enhancement technologies and services domain. The estimated market opportunity is expected to be well distributed across different types of drug classes, dosage forms and key geographical regions

Recent Developments In Drug Bioavailability Enhancement Market

In the past few years, the market for drug bioavailability enhancement has been blooming. Several ongoing innovations and developments are projected to boost market potential. These developments, even if they took place post the release of our market report, substantiate the overall trends that have been outlined in our drug bioavailability enhancement market analysis.

  • In February 2024, Zerion Pharma A/S ("ZERION") announced a partnership with DSM-Firmenich to leverage ZERION's expertise and its Dispersome® technology to enhance the bioavailability of cannabinoids.
  • In August 2023, Mountain Valley MD published Soluvec™ Trial Data in Therapeutic Delivery demonstrating significant enhancement in Ivermectin solubilization and bioavailability. 
  • In July 2023, Zeon Lifesciences launched liquid-filled capsules. These capsules have capability to offer a unique delivery system enclosing a host of advantages including enhanced bioavailability and absorption rate. 
  • In May 2023, AustinPx announced the expansion of its capabilities by installing PROCEPT modular 4M8-Trix with an aim of developing spray-dried amorphous solid dispersions. This will strengthen the company's portfolio of bioavailability enhancement technologies. 

Frequently Asked Questions

Question 1: What is bioavailability of drugs?

Answer: Drug bioavailability refers to the amount of drug or other pharmaceutical entity that is available in the bloodstream to reach the intended target destination.

Question 2: What is the projected drug bioavailability enhancement market size?

Answer: The size of the drug bioavailability enhancement industry (for technologies and services) is estimated to reach $10.22 billion by 2035.

Question 3: What is the projected drug bioavailability enhancement market growth?

Answer: The drug bioavailability enhancement industry is expected to grow at compounded annual growth rate (CAGR) of 11.11% during the forecast period 2024 - 2035.

Question 4: Who are the leading players in the drug bioavailability enhancement industry?

Answer: Adare Pharma Solutions, Ascendia Pharmaceuticals, Catalent, Lonza, Lubrizol Life Science Health, Pace Life Sciences, Quotient Sciences and WuXi STA (A Subsidiary of WuXi AppTec).

Question 5: What are the driving factors for the growth of drug bioavailability enhancement market?

Answer: Growing clinical pipeline, increasing complexity of the drugs under development, large size of the biologics and availability of novel technologies for bioavailability enhancement.

Question 6: Which region is the hub for players providing drug bioavailability enhancement technologies and services?

Answer: North America presently harbors the majority of the players providing drug bioavailability enhancement technologies and services, with close to 50% of the companies established in this region.

Question 7: How many clinical trials have been conducted for evaluating improved bioavailability?

Answer: Till date, over 4,500 clinical trials have been conducted for evaluating novel therapeutic interventions for improved bioavailability, highlighting the ongoing research in this field.

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