Bioreactors Market

Bioreactors Market: Industry Trends and Global Forecasts, till 2035 - Distribution by Fabrication Material (Glass, Stainless Steel and Single use), Type of Bioprocess (Batch, Fed-batch and Continuous), Type of Biologic (Antibodies, Vaccines, Cell Therapies and Other Biologics), and Key Geographical Regions (North America, Europe, Asia-Pacific, and Rest of the World)

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Bioreactors Market Size Outlook

The bioreactors market size is estimated to grow from $16.7 billion in 2024 to $51.7 billion by 2035, representing a CAGR of 11.1% during the forecast period from 2024 to 2035.

Bioreactors Market, By Fabrication Material, 2024-2035

Bioreactors are specialized vessels used in upstream biomanufacturing to cultivate cells (microorganisms, plant and animal cells), and tissues, under controlled conditions. They are designed to provide the ideal growth environment with ambient temperature, pH, pressure, aeration and nutrients to the live cells or cellular components for converting the substrates into various types of biological products. These biological products can range from therapeutic proteins such as vaccines, fusion proteins, antibodies, hormones, interleukins and enzymes to several advanced medicinal products (ATMPs), namely cell-based and oligonucleotide-based therapies, retroviral vectors for gene therapy and in vitro models of 2D and 3D tissue constructs, mimicking the natural physiological state for drug discovery purposes. Typically, the stainless steel bioreactors are cylindrical in shape, the size of bioreactors can vary, ranging from milliliters to several liters, depending on the design and mode of operation across different types of bioprocesses.

The global expansion of biopharmaceutical products has led to significant growth in the bioprocessing supplies market. Over the past two decades, this market has consistently grown at an annual rate of between 12 and 14%.
With companies either establishing their own biopharmaceutical manufacturing facilities or outsourcing production to biologics contract manufacturing organizations (CDMOs / CMOs), the demand for clinical and commercial-scale bioreactors has surged considerably. In fact, our research suggests that the current bioreactors capacity, including the captive and outsourced capacity, amounts to over 13 million liters, globally.

Given the immense demand, the bioreactors market has grown to be competitive market with a large number of active companies possessing the expertise to design, engineer and manufacture diverse types of bioreactors (in term of design and mechanism of action) for varying applications. Some examples of their offerings include stainless steel bioreactors, disposable / single use bioreactors, stirred-tank bioreactors, small scale bioreactors, air lift bioreactors, perfusion bioreactors, bubble column bioreactors, and photobioreactors.

Bioreactors Market Share Insights

The market research report presents an in-depth analysis of the various companies that are engaged in the bioreactors industry, across different segments, as defined in the table below:

Global Bioreactors Market: Report Attributes / Market Segmentations

Key Report Attribute Details
Historical Trend 2018-2023
Base Year 2024
Forecast Period 2024-2035
Market Size 2024 $ 16.7 Billion
CAGR 11.1%
Fabrication Material
  • Stainless Steel
  • Single Use
  • Glass
Type of Bioprocess
  • Batch and Fed-batch
  • Continuous
Type of Biologic
  • Antibodies
  • Vaccines
  • Cell Therapies
  • Other Biologics
Key Geographical Regions
  • North America
  • Europe
  • Asia-Pacific
  • Rest of the World
Key Companies Profiled
  • Applikon Biotechnology
  • Bionet
  • Cytiva
  • Eppendorf
  • Merck
  • Ollital Technology
  • Parr Instrument Company 
  • Sartorius
  • Shanghai Bailun Biological Technology
  • Solaris Biotech
  • Solida Biotech
  • Zhengzhou Laboao Instrument Equipment (LABAO)
(Full list of 250 companies captured is available in the report)
Customization Scope

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Excel Data Packs (Complimenary)
  • Market Landscape Analysis
  • Company Competitiveness Analysis
  • Capacity Analysis
  • Market Forecast and Opportunity Analysis

One of the key objectives of this market report was to estimate the current market size, opportunity and the future growth potential for bioreactor manufacturers, over the forecast period. Based on multiple parameters, likely adoption trends and through primary validations, we have provided an informed estimate on the market evolution during the forecast period 2024-2035.

The market report also features the likely distribution of the current and forecasted opportunity within the bioreactors market across various segments, such as fabrication material (stainless steel bioreactors, single use bioreactors and glass bioreactors), type of bioprocess (batch and fed-batch, and continuous), type of biologic (antibodies, vaccines cell therapies and other biologics), and key geographical regions (North America, Europe, Asia-Pacific, and Rest of the World).

In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

The opinions and insights presented in the bioreactors market report were influenced by discussions held with stakeholders in the industry. The report features detailed transcripts of interviews held with the following industry stakeholders:

  • Director and Business Unit Head, Power and Energy, Oil and Gas, and Renewable Energy, Small Company, India
  • Founder and Director, Mid-sized Company, India
  • Chief Executive Officer, Small Company, Denmark
  • Chief Commercial Officer, Small Company, Denmark

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Bioreactors Market Segmentation Overview

Market Share by Fabrication Material

Based on the fabrication material, the global bioreactor market is categorized into stainless steel bioreactors, single use bioreactors and glass bioreactors. The stainless steel bioreactors segment occupies the highest share in 2024. Further, the single use / disposable bioreactors segment is anticipated to show the highest market growth potential during the forecast period. This surge in the market is attributed to the increasing demand for emerging biologic modalities such as cell and gene therapy products as well as antibody drug conjugates, which require more flexible and smaller-scale production solutions. Single use / disposable bioreactors offer quick turnaround times, scalability, flexibility, and reduced risk of cross-contamination, making them ideal for multiproduct facilities in bioprocessing. Recently, ABEC introduced its 4000-L and 6000-L disposable bioreactors, and Thermo Fisher unveiled its 5000-L disposable bioreactor, addressing unmet market needs for high volume single use bioreactors which can deliver performance comparable to that of stainless steel bioreactors.

Market Share by Type of Bioprocess

Based on type of bioprocess, the bioreactors market is categorized into batch and fed-batch, and continuous. The batch and fed-batch bioreactors segment currently occupies the highest market share and this trend is expected to remain same during the forecast period. Further, the continuous bioreactors segment is projected to grow at a relatively higher growth rate during the forecast period. Continuous bioprocessing integrates sequential steps, thereby reducing downtime, streamlining labor-intensive processes, and mitigating contamination risks. Many biopharmaceutical companies, particularly large contract manufacturers, are either adopting or contemplating the implementation of continuous bioprocessing technologies including the perfusion bioreactors. In December 2022, Merck acquired Erbi Biosystems, a developer of the 2 ml continuous perfusion cell culture platform technology, enabling scalable perfusion bioreactor processes from 2 ml to 2,000 L with rapid lab-scale process development.

Market Share by Type of Biologic

Based on the type of biologic, the bioreactors market is segmented into antibodies, vaccines, cell therapies and other biologics. Presently, the market is dominated by revenues generated from the sales of bioreactors for manufacturing antibodies. Antibodies are experiencing rapid growth in the biomanufacturing industry due to their versatility, specificity, and efficacy in targeting diseases. According to the Umabs Antibody Therapies Database, till 2023, over 170 therapeutic antibodies have been approved by at least one regulatory agency in the world, whereas several hundred are in development. Beyond the traditional monoclonal antibodies, these modalities are available / under development  in various formats, including bi-specific antibodies, antibody-drug conjugates (ADCs), antibody fragments, and Fc fusion proteins, thereby offering tailored approaches to address different diseases and therapeutic challenges, contributing to the growing traction of antibodies in the biomanufacturing landscape.

Market Share by Key Geographical Regions

Based on the key geographical regions, the global bioreactors market is segmented into North America, Europe, Asia-Pacific and Rest of the World. Europe dominated the bioreactor market and accounted for the largest revenue share in 2024. It is worth noting that the US has the highest count for bioprocessing facilities, while Europe, known for its large-scale plants, holds the largest capacity. Further, the Asia-Pacific region is rapidly expanding the number of biomanufacturing facilities, although with relatively lower capacities.

Bioreactors Market Key Insights

The “Bioreactors Market: Distribution By Fabrication Material (Glass, Stainless Steel and Single use), Type of Bioprocess (Batch, Fed-batch and Continuous), Type of Biologic (Antibodies, Vaccines, Cell Therapies and Other Biologics), and Key Geographical Regions (North America, Europe, Asia-Pacific, and Rest of the World)” market report features an extensive study of the current market landscape, market size, market forecast and future opportunities for the bioreactor manufacturers. The market report highlights the efforts of several bioreactor developers engaged in this rapidly growing segment of the biomanufacturing equipment industry. Key takeaways of the market report are briefly discussed below.

Market Landscape Analysis: Bioreactor Manufacturers

The bioreactors market landscape features around 250 companies, which claim to possess the necessary technical expertise for manufacturing high-quality bioreactors to serve the needs of a wide range of end users, including biopharmaceutical companies, CMOs and CROs, and academic and research institutes. The players can either be original equipment manufacturers (OEMs) that produce different components of bioreactors, and / or engineering, procurement, and construction (EPCs) companies that integrate all the equipment designed by OEM engineers into a complete performing system. According to our research, the Asia-Pacific region has emerged as the key hub in this domain, featuring the presence of 122 bioreactor manufacturers.

The demand for high throughput bioreactor systems has led to the establishment of several start-ups in this field, which constitute 54% of the overall players engaged in this domain. While commercial scale capacity predominates globally, nearly 75% of the companies are involved in manufacturing bioreactors for preclinical purposes, primarily for drug screening, efficacy / toxicity testing, working with microbiological process for small biotech production facilities, and scientific and laboratory research.

Market Drivers Analysis: The Expansion of CMO Services to Encompass a Broader Range of Biopharmaceutical Products is Propelling the Bioreactors Market

As biomanufacturing demands substantial capital investment, there's a growing trend towards outsourcing various operations to CMOs and CDMOs, particularly specialized, repetitive, or non-core activities. Currently, over 305 biologics contract manufacturers offer diverse services for biologics, indicating a thriving outsourcing market. This trend is expected to continue, with outsourcing projected to outpace captive biopharmaceutical growth, driving increased demand for bioreactors. Additionally, factors like the COVID-19 pandemic, which initially boosted the bioreactors market due to their role in efficient vaccine production further contribute to the demand for bioreactors.

Further, the growth of the market is closely linked to the increasing popularity of biosimilars and biobetters, particularly following the patent expiration of blockbuster biologics. After 2025, several high-profile biologics, such as Humira (adalimumab) and Rituxan (rituximab), are expected to lose patent protection, opening up opportunities for biosimilar manufacturers to enter the market. Moreover, as biosimilars and biobetters gain acceptance in the healthcare industry due to their cost-effectiveness and therapeutic advantages, the demand for bioprocessing technologies to support the production of these next-generation biopharmaceuticals is likely witness substantial growth.

Market Trends Analysis: Emphasis on Automation and Sustainability in Bioreactors Market

The bioreactors market is witnessing a significant shift towards sustainable practices, evident in the development of bioreactors designed to minimize energy consumption, waste generation, and environmental impact. This emphasis on sustainability has led to the increased adoption of single use / disposable bioreactors, which offer benefits such as a 45% reduction in water and energy consumption and a 40% decrease in initial investment costs. In fact, two-thirds of clinical bioproduction processes leverage single use components. Our research suggests that nearly 25% of the bioreactor manufacturers provide single use / disposable bioreactors.

Moreover, there is a growing investment by stakeholders engaged in this domain in enhancing bioprocessing efficiency through automation, advanced control systems, and data analytics. More than 60% of bioreactor manufacturers now offer fully automated bioreactors. These are often integrated with digital biomanufacturing technologies like Process Analytical Technology (PAT) systems which enable real-time monitoring and control of critical process parameters (CPPs) like temperature, pH, dissolved oxygen, and biomass concentration throughout the bioprocess. Additionally, Cleaning in Place (CIP) and Sterilization in Place (SIP) features are becoming the mainstream requirements in bioreactor specifications, owing to the strict guidelines set by GMP and FDA standards. The industry is also embracing modular bioreactors that can be configured sequentially or in parallel, facilitating comparative studies and parallel experiments with ease and consistency.

Bioreactors Market Size Analysis: Batch and Fed-batch Holds the Largest Market Share

Batch and fed-batch bioprocess currently hold the majority share within the global bioreactors market. These methods, although traditional, are still viewed as simpler, cost-effective, and associated with fewer failures. In addition, fed-batch processing has led to an improvement in product titer, as well as the molecule’s key quality attributes.

Key Manufacturers in Bioreactors Market

The key players engaged in this domain (which have also been captured in this report) include Applikon Biotechnology, Bionet, Cytiva, Eppendorf, Merck, Ollital Technology, Parr Instrument Company, Sartorius, Shanghai Bailun Biological Technology, Solaris Biotech, Solida Biotech and Zhengzhou Laboao Instrument Equipment (LABAO). This market report includes an easily searchable, excel database of all the bioreactor manufacturers, worldwide.

Bioreactors Market Report Coverage

The report presents an in-depth bioreactors market analysis, highlighting the capabilities of various stakeholders engaged in this domain, across different regions. Amongst other elements, the report includes:

  • An executive summary of the insights captured during our research, offering a high-level view on the current state of the global bioreactors market and its likely evolution in the mid-long term.
  • A general introduction to bioreactors, along with details related to the components of a bioreactor. Additionally, the chapter presents information on different types of bioreactors based on type of bioprocess and mode of action. Further, it concludes with a discussion on applications of bioreactors and future perspectives in this domain. 
  • A detailed assessment of the overall market landscape of companies manufacturing bioreactors, based on several relevant parameters, such as year of establishment, company size (in terms of number of employees), region of headquarters, geographical reach (North America, Europe, Asia-Pacific and Rest of the World), capacity (micro-mini, small-scale, bench-scale, lab-scale, pilot-scale and large-scale), scale of operation (preclinical, clinical and commercial), scalability, type of bioprocess (batch, fed-batch and continuous), type of cell culture (2D cell culture, 3D cell culture and 4D cell culture), mode of operation (manual, semi-automatic and automatic) and type of end user (academic institutes and research laboratories, biopharmaceutical and pharmaceutical industries, contract manufacturing organizations, and contract research organizations).
  • A detailed competitiveness analysis of bioreactor manufacturers based on manufacturer strength (in terms of years of experience and company size), portfolio strength (considering geographical reach, number of products in portfolio, type of bioreactor, capacity, scale of operation, scalability, type of bioprocess, type of cell culture, mode of operation and end users).
  • Elaborate profiles of key players manufacturing bioreactors (shortlisted on the basis of cumulative strength of manufacturers and product portfolio); each profile includes a brief overview of the company, along with information on its financial information (if available), product portfolio, recent developments and an informed future outlook. 
  • An estimate of the global installed bioreactors capacity of biologics, based on information provided by various industry stakeholders in the public domain. It also features distribution of the available capacity on the basis of fabrication material (glass, stainless steel and single use), source of cell culture (mammalian, microbial and others), reactor volume (less than 2,000 L, 2,000 to 5,000 L, 5,001 to 10,000 L and more than 10,000 L), type of manufacturer (in-house, hybrid and CMOs) and key geographical regions (North America, Europe, and Asia-Pacific and Rest of the World).
  • A case study on the market landscape of bioprocess controllers and automation systems, providing information on scale of operation (laboratory, clinical, and commercial), key features (scalability / ease to use, visual data display, remote accessibility, built-in system control sensors, expansive I/O compatibility and provisions for alarms / alerts), compatibility with bioreactor system (stirred tank (glass), single use bioreactor, stirred tank (steel), rocking motion), type of bioprocess (batch, fed-batch and perfusion), and type of process controlled (cell cultivation and microbial fermentation). In addition, the chapter presents details of companies involved in the development of bioprocess control software, upstream and downstream controllers, including information on their year of establishment, company size, and location of headquarters.
  • A detailed market forecast analysis in order to estimate the existing market size and future opportunity for the bioreactors market over the next 11 years. Based on multiple parameters, likely adoption trends and through primary validations, we have provided an informed estimate on the market size during the forecast period 2024-2035. The chapter presents detailed projections of the current and future opportunity within the market across different fabrication material (glass, stainless steel and single use), type of bioprocess (batch, fed-batch and continuous), type of biologic (antibodies, vaccines, cell therapies and other biologics), and key geographical regions (North America, Europe, Asia-Pacific, and Rest of the World).

Recent Developments In Global Bioreactors Market

Several recent developments have taken place in the field of bioreactors. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall bioreactors market trends that have been outlined in our analysis.

  • In December 2023, Cellexus BioreactorSystems presented their proprietary airlift single use disposable bioreactor systems at the CPHI Barcelona 2023.
  • In October 2023, the Washington State University researchers announced the development of a minifridge-sized bioreactor capable of manufacturing T cells at 95% of the maximum growth rate, which is about 30% faster than the current technologies.
  • In April 2023, Cytiva launched the 50 or 200 L size X-platform bioreactors, which claim to increase process efficiency through ergonomic improvements.  
  • In April 2023, BioMADE announced the commencement of five new projects that focus on developing more efficient, lower-cost, flexible, and re-deployable bioreactors to advance the US bioeconomy and biomanufacturing goals.

Author(s): Jasparam Kaur, Simriti Gupta

Frequently Asked Questions

Question 1: What is the global bioreactors market size?

Answer: The current bioreactors market size is anticipated to be USD 16.7 billion in 2024.

Question 2: Which are the top players in the bioreactors market?

Answer: Presently, 250 companies are engaged in manufacturing bioreactors, worldwide. The top players engaged in this domain (which have also been captured in this report) include Applikon Biotechnology, Bionet, Cytiva, Eppendorf, Merck, Ollital Technology, Parr Instrument Company, Sartorius, Shanghai Bailun Biological Technology, Solaris Biotech, Solida Biotech and Zhengzhou Laboao Instrument Equipment (LABAO).

Question 3: What are the factors driving the bioreactors industry?

Answer: Advancement in bioprocessing technologies, and the surge in demand for novel biopharmaceuticals, such as precision and regenerative medicine.

Question 4: Which region has the highest market share in bioreactors market?

Answer: North America and Europe capture around 60% market share.

Question 5: What are the leading market segments in bioreactors industry?

Answer: Currently, in terms of fabrication material, stainless steel bioreactors capture the largest bioreactors market share.

Question 6: Which segment, in terms of bioreactor capacity, accounts for the largest share in the market?

Answer: At present, the global bioreactors market is dominated by laboratory-scale bioreactors. This category considers bioreactors in the volume range of 1 L to 299 L.

Question 7: Which segment, in terms of type of manufacturer, accounts for the largest share in the current global bioreactors capacity?

Answer: The maximum bioreactors capacity (63%) is installed with in-house biologics manufacturing facilities. This is followed by the capacity installed for these reactors in contract manufacturing and hybrid facilities.

Question 8: How much does a bioreactor cost?

Answer: The bioreactor price can vary widely depending on factors such as bioreactor sizes (in terms of its capacity), features, and brand. Small-scale benchtop bioreactors can range from a few thousand dollars to tens of thousands of dollars, while larger industrial-scale bioreactors can cost hundreds of thousands to millions of dollars.

Question 9: What is the growth rate (CAGR) in the global bioreactors market?

Answer: The bioreactors market size is projected to grow at a CAGR of 11.1% in the coming years.


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