Gene Editing Service Market

Gene Editing Service Market - Focus on CRISPR, 2019-2030

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Gene Editing Service Market Overview

The CRISPR based gene editing service market is estimated to be worth $644 million in 2019 and is expected to grow at CAGR of 22% during the forecast period. The 1970s witnessed the introduction of one of the most revolutionary advances in biotechnology, when Hamilton Smith (a molecular biologist at Johns Hopkins University School of Medicine) purified the first site-specific restriction enzyme, called Hind II. This development enabled the scientific community to devise the means to manipulate living organisms at the genetic level, opening up a plethora of opportunities in fundamental and applied life science research. Soon after, in the 1980s, the US FDA approved the world’s first genetically engineered drug, which was human insulin marketed under the brand name HUMULIN®. Genetic engineering and genome editing concepts have evolved significantly over the last two decades, with the development of a variety of versatile DNA modulation technologies including zinc finger nucleases, transcription activator-like effector-based nucleases (TALENs), and the clustered regularly interspaced short palindromic repeats (CRISPR). These developments have enabled medical researchers to perform an array of gene / cell line engineering experiments, including gene knockdowns, gene overexpressions and single base editing, for a variety of R&D applications. It is worth highlighting that, of all the available genome manipulation technologies, CRISPR is currently considered to be the most popular tool, owing to its fast, accurate, and cost-effective approach. In fact, in 2018, scientists Emmanuelle Charpentier, Jennifer Doudna, and Virginijus Siksnys were felicitated for their pioneering efforts on the CRISPR-Cas9 technology, with the prestigious Kavli Prize in Nanoscience.  

This image highlights the context of Genome Editing Services Market. Increasing efforts in the generation and analysis of genomic data in biotechnology research has captured the interest of medical researchers and pharmaceutical companies alike, offering a more intricate and highly directed approach to therapy development This image provides list of CRISPR-based Genome Editing Service Providers. Leveraging the versatile CRISPR-Cas technology, several companies claim to offer elaborate portfolios of genome editing services, including cell line engineering and transgenic animal model development This image presents current market landscape of CRISPR-based Genome Editing Service Providers. The market is fragmented, featuring both small companies and established players that claim to be capable of providing a variety of genome editing services; US is currently the hub of CRISPR-focused service providers

Currently, there is an evident increase in demand for complex biological therapies (including regenerative medicine products), which has created an urgent need for robust genome editing techniques. The biopharmaceutical pipeline includes close to 500 gene therapies, several of which are being developed based on the CRISPR technology. Recently, in July 2019, a first in vivo clinical trial for a CRISPR-based therapy was initiated. However, successful gene manipulation efforts involve complex experimental protocols and advanced molecular biology centered infrastructure. Therefore, many biopharmaceutical researchers and developers have demonstrated a preference to outsource such operations to capable contract service providers. Consequently, the gene editing market was established and has grown to become an indispensable segment of the modern healthcare industry, offering a range of services, such as gRNA design and construction, cell line development (involving gene knockout, gene knockin, tagging and others) and transgenic animal model generation (such as knockout mice). Additionally, there are several players focused on developing advanced technology platforms that are intended to improve / augment existing gene editing tools, especially the CRISPR-based genome editing processes. Given the rising interest in personalized medicine, a number of strategic investors are presently willing to back genetic engineering focused initiatives. Prevalent trends indicate that the market for CRISPR-based genome editing services is likely to witness a significant market growth during the forecast period.

Recent Developments in Gene Editing Service Market:

Several recent developments have taken place in the field of gene editing service market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In June 2023, Acrobat Genomics, NanoString Technologies and Illumina Accelerator entered into a collaboration with Stanford Medicine to discover new drug targets for gene editing-based therapeutics by utilizing GeoMx® Digital Spatial Profiling (DSP) technology. Additionally, the collaboration aimed s to improve the treatment options for patients suffering from interstitial lung diseases, such as idiopathic pulmonary fibrosis. 
  • In June 2023, Bayer collaborated with Acuitas Therapeutics with the aim to support Bayer's in vivo gene editing and protein replacement programs by delivering RNA payloads to the liver. 
  • In February 2023, Moderna inked research and development agreement with Life Edit Therapeutics for the development of mRNA gene editing therapies.

Key Companies in Gene Editing Service Market 

Examples of key gene editing companies engaged in CRISPR based gene editing service market (which have also been profiled in this market report; the complete list of gene editing companies is available in the full report) include Applied StemCell, BioCat, Biotools, Charles River Laboratories, Cobo Scientific, Creative Biogene, Cyagen Biosciences, GeneCopoeia, Horizon Discovery, NemaMetrix, Synbio Technologies and Thermo Fisher Scientific. This market report includes an easily searchable excel database of all the gene editing companies, worldwide.

Sope of the Report

The “Gene Editing Service Market: Focus on CRISPR, 2019-2030” market report features an extensive study of the current market landscape, market size, market share, market growth, market trends, market value, market forecast, market outlook, statistics and future opportunities of the gene editing service market. The market research report presents an in-depth analysis, highlighting the capabilities of various stakeholders engaged in gene editing service market, across different geographical regions.

This image provides information on patents that have been filed / granted related to CRISPR technology. Over the years, more than 10,000 patents related to the CRISPR technology have been filed / granted to various industry players and academic institutions, indicative of the ongoing pace of R&D in this field of research This image provides information on grants that have been awarded to research institutes engaged in conducting projects related to CRISPR. Several non-profit organizations have extended financial support to aid research efforts in this domain; the current focus appears to be on drug development and disease modelling studies This image highlights the geographical distribution of CRISPR-based Technology Developers. Since the introduction of CRISPR, several players across the world have undertaken initiatives, funded by private and public investments, to further improve / modify the technology to be used for a diverse range of applications

Amongst other elements, the market research report includes:

  • A detailed assessment of the current market landscape, featuring an elaborate list of over 80 gene editing companies that offer CRISPR-based genome editing services, and analyses based on a number of relevant parameters, such as type of gRNA service, availability of gRNA format, type of endonuclease, type of Cas9 endonuclease format, type of cell line engineering offering, type of cell line, type of animal model generation offering, availability of CRISPR libraries and important service provider details (year of establishment, company size and location of headquarters).  
  • An insightful 2X2 representation, highlighting the competitiveness of various CRISPR-based genome editing service providers captured in our database (segregated across various peer groups based on company size), taking into consideration the supplier power and the specific genome editing capabilities (which include gRNA service(s), endonuclease service(s), cell line engineering service(s), animal model generation service(s) and availability of CRISPR library(s)) of different companies.
  • Elaborate profiles of key players (shortlisted based on strength of service portfolio), featuring a brief overview of the company, its financial performance (if available), a detailed description of its genome editing service offerings, recent developments and an informed future outlook.
  • An in-depth analysis of over 10,000 patents related to CRISPR technology that have been filed / granted, since 2006, highlighting key trends associated with these patents, across type of patent, publication year and application year, regional applicability, CPC symbols, emerging focus areas, leading patent assignees (in terms of number of patents filed / granted), patent benhcmarking and valuation.  
  • A detailed analysis of close to 2,000 grants that have been awarded to support research projects related to CRISPR, between 2015 and 2019 (till September), highlighting important parameters, such as year of award, amount awarded, administring institute center, support period, funding mechanism, type of grant application, grant activity, type of recipient organization, regional distribution of recipient organization, prominent project leaders and emerging focus areas. It also features a detailed multivariate grant attractiveness analysis based on the amount awarded, support period, grant type and funding mechanism.
  • A discussion on the advanced technologies and systems that have been developed to improve CRISPR-related processes. It includes a list of companies that have developed such innovative technology platforms, along with details on a number of relevant parameters, such as year of establishment, company size, core expertise, location of headquarters and important technology specifications (including technology name, focus area and key features). In addition, it includes short profiles of key technology providers. Further, the chapter highlights a list of companies that offer CRISPR kits and CRISPR design tools.
  • An analysis highlighting potential strategic partners, segregated based on likelihood of entering into collaboration with CRISPR-based genome editing services providers. The analysis takes into consideration multiple relevant parameters, such as type of therapy, pipeline strength, pipeline maturity, company strength and therapeutic area.
  • A discussion on important, industry-specific trends, key market drivers and challenges, under a SWOT framework, featuring a qualitative Harvey ball analysis that highlights the relative impact of each SWOT parameter on the overall market.

The key objective of gene editing service market report is to provide a detailed market analysis in order to estimate the existing market size, market share, market growth, market trends, market value, market forecast, market outlook, statistics and future opportunity for gene editing service market during the forecast period. We have provided an informed estimate of the likely evolution of the market in the short to mid-term and long term, for the forecast period 2019-2030. In addition, we have segmented the future opportunity across [A] type of services offered (gRNA construction, cell line engineering and animal model generation), [B] type of cell line used (mammalian, microbial, insect and others) and [C] different geographical regions (North America, Europe, Asia Pacific and rest of the world). To account for the uncertainties associated with the CRISPR-based genome editing services market and to add robustness to our model, we have provided three forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.

The research, analysis and insights presented in this market report are backed by a deep understanding of key insights generated from both secondary and primary research. All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market research report are in USD, unless otherwise specified.

Frequently Asked Questions

Question 1: What is CRISPR gene editing?

Answer: CRISPR gene editing technology utilizes the mechanism of bacterial defense system for gene editing. These systems allow researchers to permanently modify genes in living cells and organisms.

Question 2: How big is the CRISPR gene editing service market?

Answer: The CRISPR gene editing service market size is estimated to be worth $644 million in 2019.

Question 3: What is the projected market growth of the CRISPR gene editing service market?

Answer: The CRISPR gene editing service market is expected to grow at compounded annual growth rate (CAGR) of 22% during the forecast period 2019 – 2030.

Question 4: Who are the leading companies in the CRISPR gene editing service market?

Answer: Examples of key companies engaged in CRISPR gene editing service market (which have also been profiled in this market report; the complete list of companies is available in the full report) include Applied StemCell, BioCat, Biotools, Charles River Laboratories, Cobo Scientific, Creative Biogene, Cyagen Biosciences, GeneCopoeia, Horizon Discovery, NemaMetrix, Synbio Technologies and Thermo Fisher Scientific.

Question 5: How many companies are currently engaged in the CRISPR gene editing service market?

Answer: Presently, over 80 companies are engaged in the CRISPR gene editing service market, offering various genome editing services based on CRISPR.

Question 6: How many patents related to the CRISPR gene editing have been filed / granted over the last few years?

Answer: More than 10,000 patents related to the CRISPR gene editing have been filed / granted over the last few years, highlighting increasing innovation in the field.

Question 7: How many grants have been received by players engaged in the CRISPR gene editing market?

Answer: Over 2,000 grants have been received by players engaged in the CRISPR gene editing market to support various research programs focused on genetic modifications.

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