Novel T-cell Immunotherapies

Chapter Outlines

Chapter 2 provides an executive summary of the insights captured during our research. It offers a high-level view on the likely evolution of the novel T-cell immunotherapy market in the short to mid-term and long term.

Chapter 3 provides a general overview of novel T-cell immunotherapies, including activated T-cell, virus driven T-cells, Tregs, γδ T-cells, T-cell vaccine and NK T-cells. It also includes information on the key considerations for developing T-cell immunotherapies.

Chapter 4 includes detailed assessment on close to 205 novel T-cell immunotherapy candidates that are currently approved or are in different stages of development. It features a comprehensive analysis of pipeline molecules with respect to type of T-cell therapy (activated T-cells, virus driven T-cells, Tregs, γδ T-cells, T-cell vaccines and NK T-cells), phase of development (preclinical, phase I, phase I/II, phase II, phase III and marketed), therapeutic area (oncological disorders, infectious diseases, post-transplant infections, autoimmune disorders, metabolic disorders and neurological disorders), popular target indication (lung cancer, breast cancer, cytomegalovirus infection, glioblastoma, hepatocellular carcinoma, acute myeloid leukemia, ovarian cancer, type 1 diabetes mellitus, sarcoma, HIV infections and pancreatic cancer), source of T-cell (autologous and allogeneic), route of administration (intravenous, intratumoral, subcutaneous, inhalation and intramuscular), dose frequency (multiple dose, single dose and split dose), target patient segment (children, adults and seniors), type of therapy (monotherapy and combination therapy) and type of developer (industry and non-industry. In addition, the chapter includes details related to novel T-cell immunotherapies developers, along with information on their respective year of establishment, company size, location of headquarters and most active players (in terms of number of pipeline candidates).

Chapter 5 provides detailed profiles of clinical stage, novel T-cell therapies being evaluated in clinical stages (phase I/II or above); each profile features an overview of the therapy, current development status, key clinical trial results, dosage regimen, details related to its manufacturing information and recent developments.

Chapter 6 presents an in-depth analysis of completed, ongoing, and planned clinical studies of various novel T-cell immunotherapies, based on various relevant parameters, such as trial registration year, trial phase, trial recruitment status, study design, type of sponsor / collaborator, leading industry players (in terms of number of registered trials conducted), enrolled patient population and key geographical regions.

Chapter 7 features an elaborate discussion and analysis of the various collaborations and partnerships that have been inked amongst players in this market, during the period 2015-2021 (till March). Further, the partnership activity in this domain has been analyzed based on various parameters, such as year of partnership, type of partnership model (R&D agreements, product development agreements, product licensing agreements, acquisitions, service agreements, manufacturing agreements and others), type of T-cell, target therapeutic area and regional distribution of the collaborations.

Chapter 8 provides details on the various investments and grants that have been awarded to players focused on the development of  novel T-cell immunotherapies. It includes a detailed analysis of the funding instances that have taken place during the period 2014 to 2021 (till March), highlighting the growing interest of venture capital (VC) community and other strategic investors in this domain. 

Chapter 9 provides insights on cell therapy manufacturing, highlighting the current challenges that exist in this domain, and the pre-requisites for owning and maintaining cell therapy manufacturing sites. It includes a detailed list of various cell therapy manufacturers, covering both contract manufacturing organizations and companies with in-house manufacturing capabilities. For the players mentioned in the chapter, we have included details on location of various manufacturing facilities, the products being manufactured, scale of operation and compliance to cGMP standards.

Chapter 10 includes brief profiles of prominent players engaged in the development of novel T-cell immunotherapies. Each profile features a brief overview of the company, details related to its financials (if available), product portfolio, recent developments and manufacturing capability. 

Chapter 11 provides insights on regulatory T-cells, highlighting the mechanism of Tregs, key challenges associated with the production of such therapies and recent developments in the Tregs market.

Chapter 12 features an elaborate discussion on the future commercial opportunity offered by novel T-cell immunotherapies. It provides a comprehensive market forecast analysis for molecules that are approved or are in phase I/II and above development stages taking into consideration the target patient population, existing / future competition, likely adoption rates and the likely price of different therapies. The chapter also presents a detailed market segmentation on the basis of [A] type of T-cell therapy (activated T-cell, T-cell vaccine, Treg and virus-driven T-cell), [B] target indication (brain tumour, pancreatic cancer, breast cancer, lung cancer, nasopharyngeal cancer, multiple myeloma, hepatocellular carcinoma, post-transplant infection, diabetes and others), [C] key players and [D] key geographies (North America, Europe, Asia Pacific and rest of the world).

Chapter 13 summarizes the overall report. In this chapter, we have provided a list of key takeaways from the report, and expressed our independent opinion related to the research and analysis described in the previous chapters.

Chapter 14 provides the transcripts of interviews conducted with key stakeholders of this market. In this chapter, we have presented the details of our conversation with Peter Hoang (Chief Executive Officer, Marker Therapeutics) and Patrick Dougherty (Senior Vice President, Strategy, Planning and Operations, WindMIL Therapeutics).

Chapter 15 is an appendix, which provides tabulated data and numbers for all the figures provided in the report.

Chapter 16 is an appendix, which contains the list of companies and organizations mentioned in the report.

Table Of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Key Questions Answered
1.4. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. T-Cell Immunotherapies
3.2.1. Types of Novel T-Cell Immunotherapies
3.2.1.1. Fucosylated T-Cell Therapies
3.2.1.2. Gamma Delta T-Cell Therapies
3.2.1.3. PD-1 Knockout Engineered T-Cell Therapies
3.2.1.4. TAC T-Cell Therapies
3.2.1.5. T-Cell Vaccines
3.2.1.6. Treg Cell Therapies
3.2.1.7. Virus-Driven T-Cell Therapies

3.3. Key Considerations for Developing T-Cell Immunotherapies
3.4. Concluding Remarks

4. MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Novel T-Cell Immunotherapies: Overall Market Landscape
4.2.1. Analysis by Type of T-Cell Therapy
4.2.2. Analysis by Phase of Development
4.2.3. Analysis by Therapeutic Area
4.2.4. Analysis by Popular Target Indications
4.2.5. Analysis by Source of T-Cell
4.2.6. Analysis by Route of Administration
4.2.7. Analysis by Dose Frequency
4.2.8. Analysis by Target Patient Segment
4.2.9. Analysis by Type of Therapy
4.2.10. Analysis by Type of Developer

4.3. Novel T-cell Immunotherapies: List of Developers
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis By Company Size
4.3.3. Analysis By Location of Headquarters
4.3.4. Key Industry Players: Analysis by Number of Pipeline Candidates
4.3.5. Key Non-Industry Players: Analysis by Number of Pipeline Candidates

5. NOVEL T-CELL IMMUNOTHERAPY PROFILES
5.1. Chapter Overview
5.2. Immuncell-LC (GC Pharma)
5.2.1. Therapy Overview
5.3. Cytovir CMV T-Cells (Kuur Therapeutics)
5.3.1. Therapy Overview

5.4. TT10: EB-VST (Tessa Therapeutics)
5.4.1. Therapy Overview
5.5. Tab-cel (tabelecleucel) (Atara Biotherapeutics)
5.5.1. Therapy Overview
5.6. Viralym-M (ALVR105) (AlloVir)
5.6.1. Therapy Overview

5.7. CLBS03 (Caladrius Biosciences)
5.7.1. Therapy Overview
5.8. TVI-Brain-1 (TVAX Biomedical)
5.8.1. Therapy Overview

5.9. ATA230 (Atara Biotherapeutics)
5.9.1. Therapy Overview
5.10. MILs (WindMIL Therapeutics)
5.10.1. Therapy Overview
5.11. Tcelna (Opexa Therapeutics)
5.11.1. Therapy Overview

6. CLINICAL TRIAL ANALYSIS
6.1. Chapter Overview
6.2. Scope and Methodology
6.3. Novel T-Cell Immunotherapies: Clinical Trial Analysis
6.3.1. Analysis by Trial Registration Year
6.3.2. Analysis by Trial Registration Year and Enrolled Patient Population
6.3.3. Analysis by Trial Phase
6.3.4. Analysis by Trial Recruitment Status
6.3.5. Analysis by Study Design
6.3.6. Analysis by Type of Sponsor / Collaborator
6.3.7. Leading Industry Players: Analysis by Number of Registered Trials
6.3.8. Leading Non-Industry Players: Analysis by Number of Registered Trials
6.3.9. Analysis by Number of Registered Trials and Geography
6.3.10. Analysis by Enrolled Patient Population and Geography
6.3.11. Analysis by Trial Recruitment Status and Geography

7. PARTNERSHIPS AND COLLABORATIONS
7.1. Chapter Overview
7.2. Partnership Models
7.3. Novel T-Cell Immunotherapies Market: Partnerships and Collaborations
7.3.1. Analysis by Year of Partnership
7.3.2. Analysis by Type of Partnership
7.3.3. Analysis by Year and Type of Partnership
7.3.4. Analysis by Type of Partnership and Type of T-Cell Therapy
7.3.5. Analysis by Target Therapeutic Area
7.3.6. Most Active Players: Analysis by Number of Partnerships
7.3.7. Analysis by Geography 
7.3.7.1. Region-wise Distribution
7.3.7.2. Country-wise Distribution

8. FUNDING AND INVESTMENT ANALYSIS
8.1. Chapter Overview
8.2. Type of Funding
8.3. Novel T-Cell Immunotherapies Market: Funding and Investment Analysis
8.3.1. Analysis by Year of Investment
8.3.2. Analysis by Amount Invested
8.3.3. Analysis by Type of Funding
8.3.4. Analysis by Type of T-Cell Therapy
8.3.5. Most Active Players: Analysis by Number of Funding Instances
8.3.6. Most Active Investors: Analysis by Number of Funding Instances
8.3.7. Analysis by Type of Investor
8.3.8. Analysis by Geography

9. CASE STUDY ON CELL THERAPY MANUFACTURING
9.1. Chapter Overview
9.2. Overview of Cell Therapy Manufacturing
9.3. Cell Therapy Manufacturing Models
9.3.1. Centralized Manufacturing Model
9.3.2. Decentralized Manufacturing Model
9.4. Scalability of Cell Therapy Manufacturing Processes
9.4.1. Scale-Up
9.4.2. Scale-Out
9.5. Types of Cell Therapy Manufacturers
9.6. Key Challenges associated with Manufacturing of Cell Therapies
9.7. Factors Affecting the Cell Therapy Manufacturing Process
9.7.1. Characterization
9.7.2. Cost of Goods
9.8. Automation of Cell Therapy Manufacturing Process
9.9. Cell Therapy Manufacturing Supply Chain
9.10. Companies with In-House Capabilities
9.11. Contract Manufacturers
9.12. Regulatory Landscape

10. COMPANY PROFILES
10.1. Chapter Overview
10.2. Atara Biotherapeutics
10.3. AlloVir
10.4. Eureka Therapeutics
10.5. Eutilex
10.6. GammaDelta Therapeutics
10.7. NexImmune
10.8. OSE Immunotherapeutics
10.9. Tevogen Bio
10.10. WindMIL Therapeutics

11. CASE STUDY ON RECENT DEVELOPMENTS IN TREG TARGETTING THERAPIES
11.1. Chapter Overview
11.2. Treg Targeting Therapies
11.2.1. Mechanism of Action of Tregs
11.3 Recent Developments Related to Treg Targeting Therapies

12. MARKET SIZING AND OPPORTUNITY ANALYSIS
12.1. Chapter Overview
12.2. Scope and Limitations
12.3. Key Assumptions and Forecast Methodology

12.4. Global Novel T-Cell Immunotherapies Market
12.4.1. Novel T-Cell Immunotherapies Market: Distribution by Type of T-Cell Therapy
12.4.2. Novel T-Cell Immunotherapies Market: Distribution by Target Indications
12.4.3. Novel T-Cell Immunotherapies Market: Distribution by Key Players
12.4.4. Novel T-Cell Immunotherapies Market: Distribution by Geography
12.5. Novel T-Cell Immunotherapies Market: Value Creation Analysis

12.6. Novel T-Cell Immunotherapies Market: Product Wise Sales Forecast
12.6.1. Cytovir CMV T-Cells (Kuur Therapeutics)
12.6.1.1. Target Patient Population
12.6.1.2. Sales Forecast
12.6.1.3. Net Present Value
12.6.1.4. Value Creation Analysis

12.6.2. Immuncell-LC (GC Pharma)
12.6.2.1. Target Patient Population
12.6.2.2. Sales Forecast
12.6.2.3. Net Present Value
12.6.2.4. Value Creation Analysis

12.6.3. TT10: EB-VST (Tessa Therapeutics)
12.6.3.1. Target Patient Population
12.6.3.2. Sales Forecast
12.6.3.3. Net Present Value
12.6.3.4. Value Creation Analysis

12.6.4. TVI-Brain-1 (TVAX Biomedical)
12.6.4.1. Target Patient Population
12.6.4.2. Sales Forecast
12.6.4.3. Net Present Value
12.6.4.4. Value Creation Analysis

12.6.5. PD-1 Knockout Engineered T-Cells (Chengdu MedGenCell / Anhui Province Hospital)
12.6.5.1. Target Patient Population
12.6.5.2. Sales Forecast
12.6.5.3. Net Present Value
12.6.5.4. Value Creation Analysis

12.6.6. CLBS03 (Caladrius Biosciences)
12.6.6.1. Target Patient Population
12.6.6.2. Sales Forecast
12.6.6.3. Net Present Value
12.6.6.4. Value Creation Analysis

12.6.7. ATA230 (Atara Biotherapeutics)
12.6.7.1. Target Patient Population
12.6.7.2. Sales Forecast
12.6.7.3. Net Present Value
12.6.7.4. Value Creation Analysis

12.6.8. MILs (WindMIL Therapeutics / Bristol-Myers Squibb)
12.6.8.1. Target Patient Population
12.6.8.2. Sales Forecast
12.6.8.3. Net Present Value
12.6.8.4. Value Creation Analysis

12.6.9. Cytovir ADV T-Cells (Kuur Therapeutics)
12.6.9.1. Target Patient Population
12.6.9.2. Sales Forecast
12.6.9.3. Net Present Value
12.6.9.4. Value Creation Analysis

12.6.10. TAC01-CD19 (Triumvira Immunologics)
12.6.10.1. Target Patient Population
12.6.10.2. Sales Forecast
12.6.10.3. Net Present Value
12.6.10.4. Value Creation Analysis

12.6.11. PD-1 Knockout T Cells (Guangzhou Anjie Biomedical Technology)
12.6.11.1. Target Patient Population
12.6.11.2. Sales Forecast
12.6.11.3. Net Present Value
12.6.11.4. Value Creation Analysis

12.6.12. NEXI-0002 (NexImmune)
12.6.12.1. Target Patient Population
12.6.12.2. Sales Forecast
12.6.12.3. Net Present Value
12.6.12.4. Value Creation Analysis

12.6.13. ET140203 (Eureka Therapeutics)
12.6.13.1. Target Patient Population
12.6.13.2. Sales Forecast
12.6.13.3. Net Present Value
12.6.13.4. Value Creation Analysis

13. CONCLUDING REMARKS

14. EXECUTIVE INSIGHTS
14.1. Chapter Overview
14.2. Marker Biotherapeutics
14.2.1. Interview Transcript: Peter Hoang, Chief Executive Officer
14.3. WindMIL Therapeutics
14.3.1. Interview Transcript: Patrick Dougherty, Senior Vice President, Strategy, Planning and Operations

15. APPENDIX 1: TABULATED DATA

16. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

List Of Figures

Figure 4.1 Novel T-Cell Immunotherapies: Distribution by Type of T-Cell Therapy
Figure 4.2 Novel T-Cell Immunotherapies: Distribution by Phase of Development`
Figure 4.3 Novel T-Cell Immunotherapies: Distribution by Therapeutic Area
Figure 4.4 Novel T-Cell Immunotherapies: Distribution by Popular Target Indications
Figure 4.5 Novel T-Cell Immunotherapies: Distribution by Source of T-Cell
Figure 4.6 Novel T-Cell Immunotherapies: Distribution by Route of Administration
Figure 4.7 Novel T-Cell Immunotherapies: Distribution by Dose Frequency
Figure 4.8 Novel T-Cell Immunotherapies: Distribution by Target Patient Segment
Figure 4.9 Novel T-Cell Immunotherapies: Distribution by Type of Therapy
Figure 4.10 Novel T-Cell Immunotherapies: Distribution by Type of Developer
Figure 4.11 Novel T-cell Immunotherapies Developers: Distribution by Year of Establishment
Figure 4.12 Novel T-cell Immunotherapies Developers: Distribution by Company Size
Figure 4.13 Novel T-cell Immunotherapies Developers: Distribution by Location of Headquarters
Figure 4.14 Key Industry Players: Distribution by Number of Pipeline Candidates
Figure 4.15 Key Non-Industry Players: Distribution by Number of Pipeline Candidates
Figure 6.1 Clinical Trial Analysis: Scope and Methodology
Figure 6.2 Clinical Trial Analysis: Cumulative Distribution by Trial Registration Year, Pre-2010 - 2021
Figure 6.3 Clinical Trial Analysis: Distribution by Trial Registration Year and Enrolled Patient Population
Figure 6.4 Clinical Trial Analysis: Distribution by Trial Phase
Figure 6.5 Clinical Trial Analysis: Distribution by Trial Recruitment Status
Figure 6.6 Clinical Trial Analysis: Cumulative Distribution by Trial Registration Year and TrialRecruitment Status
Figure 6.7 Clinical Trial Analysis: Distribution by Study Design
Figure 6.8 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
Figure 6.9 Leading Industry Players: Distribution by Number of Registered Trials
Figure 6.10 Leading Non-Industry Players: Distribution by Number of Registered Trials
Figure 6.11 Clinical Trial Analysis: Distribution of Number of Registered Trials by Geography
Figure 6.12 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Geography
Figure 6.13 Clinical Trial Analysis: Distribution of Trial Recruitment Status by Geography
Figure 7.1 Partnerships and Collaborations: Cumulative Distribution by Year, 2015-2021
Figure 7.2 Partnerships and Collaborations: Distribution by Type of Partnership
Figure 7.3 Partnerships and Collaborations: Distribution by Year and Type of Partnership
Figure 7.4 Partnerships and Collaborations: Distribution by Type of Partnership and Type of T-Cell Therapy
Figure 7.5 Partnerships and Collaborations: Distribution by Target Therapeutic Area
Figure 7.6 Most Active Players: Distribution by Number of Partnerships
Figure 7.7 Partnerships and Collaborations: Distribution by Region (Continent-wise)
Figure 7.8 Partnerships and Collaborations: Distribution by Region (Country-wise)
Figure 8.1 Funding and Investment Analysis: Cumulative Distribution of Funding Instances by Year, 2014-2021
Figure 8.2 Funding and Investment Analysis: Cumulative Distribution of Amount Invested by Year, 2014-2021 (USD Million)
Figure 8.3 Funding and Investment Analysis: Distribution by Type of Funding
Figure 8.4 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding (USD Million)
Figure 8.5 Funding and Investments Analysis: Distribution of Amount Invested by Type of T-Cell Therapy (USD Million)
Figure 8.6 Most Active Players: Distribution by Number of Funding Instances
Figure 8.7 Most Active Investors: Distribution by Number of Funding Instances
Figure 8.8 Funding and Investment Analysis: Distribution by Type of Investor
Figure 8.9 Funding and Investment Analysis: Distribution by Region (Continent-wise)
Figure 8.10 Funding and Investment Analysis: Distribution by Region (Country-wise)
Figure 9.1 Steps Involved in Cell Therapy Manufacturing Process
Figure 9.2 Centralized Manufacturing: Process Model
Figure 9.3 Decentralized Manufacturing: Process Model
Figure 9.4 Cell Therapy Manufacturing: Types of Manufacturers
Figure 9.5 Cell Therapy Manufacturing: Challenges and Drivers
Figure 9.6 Cell Therapies: Potency as a Critical Quality Attribute
Figure 9.7 Cell Therapy Manufacturing: Supply Chain Model
Figure 9.8 Cell Therapy Manufacturing: Supply Chain Risk Assessment Considerations
Figure 11.1 Tregs-Cell Therapies: Mechanism of Action
Figure 12.1 Global Novel T-Cell Immunotherapies Market, 2021-2030 (USD Billion)
Figure 12.2 Novel T-Cell Immunotherapies Market: Distribution by Type of T-Cell Therapy
Figure 12.3 Novel T-Cell Immunotherapies Market: Distribution by Target Indication
Figure 12.4 Novel T-Cell Immunotherapies Market: Distribution by Key Players
Figure 12.5 Novel T-Cell Immunotherapies Market: Distribution by Geography
Figure 12.6 Cytovir CMV T-Cells (Kuur Therapeutics): Sales Forecast, till 2030 (USD Million)
Figure 12.7 Immuncell-LC (GC Pharma): Sales Forecast, till 2030 (USD Million)
Figure 12.8 TT10: EB-VST (Tessa Therapeutics): Sales Forecast, till 2030 (USD Million)
Figure 12.9 TVI-Brain-1 (TVAX Biomedical): Sales Forecast, till 2030 (USD Million)
Figure 12.10 PD-1 Knockout Engineered T-Cells (Chengdu MedGenCell / Anhui Province Hospital): Sales Forecast, till 2030 (USD Million)
Figure 12.11 CLBS03 (Caladrius Biosciences): Sales Forecast, till 2030 (USD Million)
Figure 12.12 ATA230 (Atara Biotherapeutics): Sales Forecast, till 2030 (USD Million)
Figure 12.13 MILs (WindMIL Therapeutics / Bristol-Myers Squibb): Sales Forecast, till 2030 (USD Million)
Figure 12.14 Cytovir ADV T-Cells (Kuur Therapeutics): Sales Forecast, till 2030 (USD Million)
Figure 12.15 TAC01-CD19 (Triumvira Immunologics): Sales Forecast, till 2030 (USD Million)
Figure 12.16 PD-1 Knockout T Cells (Guangzhou Anjie Biomedical Technology): Sales Forecast, till 2030 (USD Million)
Figure 12.17 NEXI-0002 (NexImmune): Sales Forecast, till 2030 (USD Million)
Figure 12.18 ET140203 (Eureka Therapeutics): Sales Forecast, till 2030 (USD Million)
Figure 13.1 Concluding Remarks: Overall Market Landscape
Figure 13.2 Concluding Remarks: Clinical Trial Analysis
Figure 13.3 Concluding Remarks: Partnerships and Collaborations
Figure 13.4 Concluding Remarks: Funding and Investment Analysis
Figure 13.5 Concluding Remarks: Market Forecast

List Of Tables

Table 4.1 Novel T-Cell Immunotherapies: Candidate Pipeline
Table 4.2 Novel T-Cell Immunotherapies: Information on Source of T-Cells, Route of Administration, Dose Frequency, Target Patient Segment and Type of Therapy
Table 4.3 Novel T-Cell Immunotherapies: List of Developers
Table 5.1 Novel T-Cell Immunotherapies: List of Therapies Profiled
Table 5.2 Therapy Profile: Immunecell-LC (GC Pharma)
Table 5.3 Therapy Profile: Cytovir CMV T-Cells (Kuur Therapeutics)
Table 5.4 Therapy Profile: TT10: EB-VST (Tessa Therapeutics)
Table 5.5 Therapy Profile: Tab-cel (tabelecleucel) (Atara Biotherapeutics)
Table 5.6 Therapy Profile: Viralym-M (ALVR105) (AlloVir)
Table 5.7 Therapy Profile: CLBS03 (Caladrius Biosciences)
Table 5.8 Therapy Profile: TVI-Brain-1 (TVAX Biomedical)
Table 5.9 Therapy Profile: ATA230 (Atara Biotherapeutics)
Table 5.10 Therapy Profile: MILs (WindMIL Therapeutics)
Table 5.11 Therapy Profile: Tcelna (Opexa Therapeutics)
Table 7.1 Novel T-Cell Immunotherapies Market: List of Partnerships and Collaborations, 2015-2021
Table 8.1 Novel T-Cell Immunotherapies: Funding and Investments, 2014-2021
Table 8.2 Novel T-Cell Immunotherapies: Summary of Investments
Table 10.1 Novel T-Cell Immunotherapy Developers: List of Companies Profiled
Table 10.2 Atara Biotherapeutics: Company Profile
Table 10.3 AlloVir: Company Profile
Table 10.4 Eureka Therapeutics: Company Profile
Table 10.5 Eutilex: Company Profile
Table 10.6 GammaDelta Therapeutics: Company Profile
Table 10.7 NexImmune: Company Profile
Table 10.8 OSE Immunotherapeutics: Company Profile
Table 10.9 Tevogen Bio: Company Profile
Table 10.10 WindMIL Therapeutics: Company Profile
Table 11.1 Treg Targeting Therapies: Candidate Pipeline
Table 11.2 Treg Targeting Therapies: Recent Developments
Table 12.1 Market Forecast of Novel T-Cell Immunotherapies: List of Molecules
Table 12.2 Cytovir CMV T-Cells (Kuur Therapeutics): Net Present Value (USD Million)
Table 12.3 Cytovir CMV T-Cells (Kuur Therapeutics): Value Creation Analysis (USD Million)
Table 12.4 Immuncell-LC (GC Pharma): Net Present Value (USD Million)
Table 12.5 Immuncell-LC (GC Pharma): Value Creation Analysis (USD Million)
Table 12.6 TT10: EB-VST (Tessa Therapeutics): Net Present Value (USD Million)
Table 12.7 TT10: EB-VST (Tessa Therapeutics): Value Creation Analysis (USD Million)
Table 12.8 TVI-Brain-1 (TVAX Biomedical): Net Present Value (USD Million)
Table 12.9 TVI-Brain-1 (TVAX Biomedical): Value Creation Analysis (USD Million)
Table 12.10 PD-1 Knockout Engineered T-Cells (Chengdu MedGenCell / Anhui Province Hospital): Net Present Value (USD Million)
Table 12.11 PD-1 Knockout Engineered T-Cells (Chengdu MedGenCell / Anhui Province Hospital): Value Creation Analysis (USD Million)
Table 12.12 CLBS03 (Caladrius Biosciences): Net Present Value (USD Million)
Table 12.13 CLBS03 (Caladrius Biosciences): Value Creation Analysis (USD Million)
Table 12.14 ATA230 (Atara Biotherapeutics): Net Present Value (USD Million)
Table 12.15 ATA230 (Atara Biotherapeutics): Value Creation Analysis (USD Million)
Table 12.16 MILs (WindMIL Therapeutics / Bristol-Myers Squibb): Net Present Value (USD Million)
Table 12.17 MILs (WindMIL Therapeutics / Bristol-Myers Squibb): Value Creation Analysis (USD Million)
Table 12.18 Cytovir ADV T-Cells (Kuur Therapeutics): Net Present Value (USD Million)
Table 12.19 Cytovir ADV T-Cells (Kuur Therapeutics): Value Creation Analysis (USD Million)
Table 12.20 TAC01-CD19 (Triumvira Immunologics): Net Present Value (USD Million)
Table 12.21 TAC01-CD19 (Triumvira Immunologics): Value Creation Analysis (USD Million)
Table 12.22 PD-1 Knockout T Cells (Guangzhou Anjie Biomedical Technology): Net Present Value (USD Million)
Table 12.23 PD-1 Knockout T Cells (Guangzhou Anjie Biomedical Technology): Value Creation Analysis (USD Million)
Table 12.24 NEXI-0002 (NexImmune): Net Present Value (USD Million)
Table 12.25 NEXI-0002 (NexImmune): Value Creation Analysis (USD Million)
Table 12.26 ET140203 (Eureka Therapeutics): Net Present Value (USDMillion)
Table 12.27 ET140203 (Eureka Therapeutics): Value Creation Analysis(USD Million)
Table 14.1 Marker Biotherapeutics: Company Snapshot
Table 14.2 WindMIL Therapeutics: Company Snapshot
Table 15.1 Novel T-Cell Immunotherapies: Distribution by Type of T-cell Therapy
Table 15.2 Novel T-Cell Immunotherapies: Distribution by Phase of Development`
Table 15.3 Novel T-Cell Immunotherapies: Distribution by Therapeutic Area
Table 15.4 Novel T-Cell Immunotherapies: Distribution by Popular Target Indications
Table 15.5 Novel T-Cell Immunotherapies: Distribution by Source of T-Cell
Table 15.6 Novel T-Cell Immunotherapies: Distribution by Route of Administration
Table 15.7 Novel T-Cell Immunotherapies: Distribution by Dose Frequency
Table 15.8 Novel T-Cell Immunotherapies: Distribution by Target Patient Segment
Table 15.9 Novel T-Cell Immunotherapies: Distribution by Type of Therapy
Table 15.10 Novel T-Cell Immunotherapies: Distribution by Type of Developer
Table 15.11 Novel T-cell Immunotherapies Developers: Distribution by Year of Establishment
Table 15.12 Novel T-cell Immunotherapies Developers: Distribution by Company Size
Table 15.13 Novel T-cell Immunotherapies Developers: Distribution by Location of Headquarters
Table 15.14 Key Industry Players: Distribution by Number of Pipeline Candidates
Table 15.15 Key Non-Industry Players: Distribution by Number of Pipeline Candidates
Table 15.16 Clinical Trial Analysis: Cumulative Distribution by Trial Registration Year, Pre-2010 - 2021
Table 15.17 Clinical Trial Analysis: Distribution by Trial Registration Year and Enrolled Patient Population
Table 15.18 Clinical Trial Analysis: Distribution by Trial Phase
Table 15.19 Clinical Trial Analysis: Distribution by Trial Recruitment Status
Table 15.20 Clinical Trial Analysis: Cumulative Distribution by Trial Registration Year and TrialRecruitment Status 
Table 15.21 Clinical Trial Analysis: Distribution by Study Design
Table 15.22 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
Table 15.23 Leading Industry Players: Distribution by Number of Registered Trials
Table 15.24 Clinical Trial Analysis: Distribution of Number of Registered Trials by Geography
Table 15.25 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Geography
Table 15.26 Clinical Trial Analysis: Distribution of Trial Recruitment Status by Geography
Table 15.27 Partnerships and Collaborations: Cumulative Distribution by Year, 2015-2021
Table 15.28 Partnerships and Collaborations: Distribution by Type of Partnership
Table 15.29 Partnerships and Collaborations: Distribution by Year and Type of Partnership
Table 15.30 Partnerships and Collaborations: Distribution by Type of Partnership and Type of T-Cell Therapy
Table 15.31 Partnerships and Collaborations: Distribution by Target Therapeutic Area
Table 15.32 Most Active Players: Distribution by Number of Partnerships
Table 15.33 Partnerships and Collaborations: Distribution by Region (Continent-wise)
Table 15.34 Partnerships and Collaborations: Distribution by Region (Country-wise)
Table 15.35 Funding and Investment Analysis: Cumulative Distribution of Funding Instances by Year, 2014-2021
Table 15.36 Funding and Investment Analysis: Cumulative Distribution of Amount Invested by Year, 2014-2020 (USD Million)
Table 15.37 Funding and Investment Analysis: Distribution by Type of Funding
Table 15.38 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding (USD Million)
Table 15.39 Funding and Investments Analysis: Distribution by Amount Invested by Type of T-Cell Therapies (USD Million)
Table 15.40 Most Active Players: Distribution by Number of Funding Instances
Table 15.41 Most Active Investors: Distribution by Number of Funding Instances
Table 15.42 Funding and Investment Analysis: Distribution by Type of Investor
Table 15.43 Funding and Investment Analysis: Distribution by Region (Continent-wise)
Table 15.44 Funding and Investment Analysis: Distribution by Region (Country-wise)
Table 15.45 Global Novel T-Cell Immunotherapies Market, Conservative, Base and Optimistic Scenarios, 2021-2030 (USD Billion)
Table 15.46 Novel T-Cell Immunotherapy Market: Distribution by Type of T-Cell Therapy
Table 15.47 Novel T-Cell Immunotherapy Market: Distribution by Target Indications
Table 15.48 Novel T-Cell Immunotherapy Market: Distribution by Key Players
Table 15.49 Novel T-Cell Immunotherapy Market: Distribution by Geography
Table 15.50 Cytovir CMV T-Cells (Kuur Therapeutics): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030: (USD Million)
Table 15.51 Immuncell-LC (GC Pharma): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.52 TT10: EB-VST (Tessa Therapeutics): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.53 TVI-Brain-1 (TVAX Biomedical): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.54 PD-1 Knockout Engineered T-Cells (Chengdu MedGenCell / Anhui Province Hospital): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.55 CLBS03 (Caladrius Biosciences): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.56 ATA230 (Atara Biotherapeutics): Sales Forecast, Conservative, Base and OptimisticScenarios, till 2030 (USD Million)
Table 15.57 MILs (WindMIL Therapeutics / Bristol-Myers Squibb): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.58 Cytovir ADV T-Cells (Kuur Therapeutics): Sales Forecast, Conservative, Base andOptimistic Scenarios, till 2030 (USD Million)
Table 15.59 TAC01-CD19 (Triumvira Immunologics): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.60 PD-1 Knockout T Cells (Guangzhou Anjie Biomedical Technology): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.61 NEXI-0002 (NexImmune): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)
Table 15.62 ET140203 (Eureka Therapeutics): Sales Forecast, Conservative, Base and Optimistic Scenarios, till 2030 (USD Million)

List of Companies

The following companies and organizations are mentioned in the report.

1. 8VC
2. Abingworth
3. Acer Therapeutics
4. Acorn Pacific Ventures
5. Adaptate Biotherapeutics
6. Agency for Science, Technology and Research (A*STAR)
7. AgenTus Therapeutics
8. Agenus
9. Alexandria Venture Investments
10. Allele Capital Partners
11. AlloVir
12. Andalusian Public Foundation for Health Research Management of Seville (FISEVI)
13. Anhui Kedgene Biotechnology
14. Anhui Provincial Hospital 
15. ARCH Venture Partners
16. ArrowMark Partners
17. ARSEP Foundation
18. Assistance Publique – Hôpitaux de Paris (AP-HP)
19. Atara Biotherapeutics
20. Austin Health
21. Autoimmunity Centers of Excellence
22. Barer & Son Capital
23. Bayer
24. Baylor College of Medicine
25. BB Pureos Bioventures
26. Beijing 302 Hospital
27. Beijing Cancer Hospital
28. Beijing Doing Biomedical Technology
29. Beijing GD Initiative Cell Therapy Technology
30. Beijing Genomics Institute
31. Beijing Mabworks Biotech
32. Beijing Tongren Hospital
33. Beijing Youan Hospital
34. Bellicum Pharmaceuticals
35. Benaroya Research Institute at Virginia Mason (BRI)
36. Besançon University Hospital
37. Beth Israel Deaconess Medical Center
38. Betta Pharmaceuticals
39. BHT Lifescience Australia
40. Bill and Melinda Gates Foundation
41. BioCentriq
42. Bios Partners
43. Biox Biosciences
44. Blood and Tissue Bank
45. Bloom Burton
46. bluebird bio
47. Bpifrance 
48. Brigham and Women's Hospital
49. Bristol Myers Squibb
50. British Society for Haematology
51. Bordeaux University Hospital Center (CHU)
52. Boston Children's Hospital
53. Cairo University
54. Caladrius Biosciences
55. California Institute for Regenerative Medicine (CIRM)
56. Cambridge University Hospitals NHS Foundation Trust
57. Cancer Prevention Research Institute of Texas
58. Cancer Research Institute
59. Cancer Research Technology
60. Case Western Reserve University
61. Celldex Therapeutics
62. Cell Medica
63. Celgene
64. Cellenkos
65. Center for Cell and Gene Therapy
66. Center for Clinical and Translational Sciences (CCTS)
67. Centre for Commercialisation of Cancer Immunotherapy (C3i)
68. Central Hospital, Nancy, France
69. Central South University
70. Charite – Universitatsmedizin Berlin
71. Changi General Hospital (CGH)
72. Chengdu MedGenCell
73. Children's Hospital Los Angeles
74. Children's Hospital of Philadelphia
75. Children's National Research Institute (CNRI)
76. Children's Oncology Group
77. Children's Research Institute
78. Chinese Academy of Medical Sciences
79. Chinese PLA General Hospital (CPGH)
80. Cincinnati Children's Hospital Medical Center
81. City of Hope 
82. Clinical Research Malaysia (CRM)
83. Cognate BioServices
84. Columbia University
85. Coya Therapeutics
86. CRISPR Therapeutics
87. Cryoport 
88. CytoMed Therapeutics
89. Dana-Farber Cancer Institute
90. DCVC Management
91. Department of Health Valencia La Fe
92. Diabetes Research Institute Foundation Canada (DRIFCan)
93. DS Asset Management
94. Duke-NUS Medical School
95. Duke University
96. Dutch Cancer Society
97. EcoR1 Capital
98. EDBI
99. Emerson Collective
100. Emmes
101. Erciyes University
102. Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
103. Euchloe Bio (acquired by Tessa Therapeutics)
104. Eureka Therapeutics
105. European Commission
106. Eutilex
107. F2 Ventures
108. Faculty of Medicine, University of Indonesia (FKUI)
109. Fate Therapeutics
110. Ferring Pharmaceuticals
111. Fidelity Management and Research
112. Fondazione IRCCS Policlinico San Matteo
113. Fred Hutchinson Cancer Research Center
114. Friedrich-Alexander University Erlangan-Nuremberg (FAU)
115. French Blood Establishment (EFS)
116. Friedreich’s Ataxia Research Alliance (FARA)
117. Fuda Cancer Hospital
118. GammaCell Bio-Technologies
119. GammaDelta Therapeutics
120. GC Pharma
121. GentiBio
122. Ghent University Hospital 
123. Gilde Healthcare
124. Gilead Sciences
125. GlaxoSmithKline
126. G.N. Tech Venture
127. GP Capital
128. Guangdong Xiangxue Precision Medical Technology
129. Guangzhou Anjie Biomedical Technology
130. Guy's and St Thomas' NHS Foundation Trust
131. Hackensack Meridian Health
132. Hangzhou Cancer Hospital
133. Hannover Medical School
134. Harbin Medical University
135. Harris Health System (formerly known as the Harris County Hospital District)
136. Heidelberg University Hospital
137. Heliconia Capital Management 
138. HengRui YuanZheng Bio-Technology
139. Heritas Capital
140. H. Lee Moffitt Cancer Center and Research Institute
141. HMP Partners
142. Hoxworth Blood Center
143. Hunan Zhaotai Yongren Medical Innovation
144. Icahn School of Medicine at Mount Sinai
145. ILTOO Pharma
146. Immune Tolerance Network
147. Immunocore
148. Imperial College London
149. InnoCare Pharma
150. International Multidisciplinary Research Foundation (IMRF)
151. IN8bio
152. Incyte
153. Innovate UK
154. Inserm
155. Institute of Hematology and Blood Diseases Hospital
156. Instituto de Investigación Sanitaria Valdecilla (IDIVAL)
157. Intrexon
158. IRCCS Company Hospital- University of Bologna
159. ITOCHU
160. Janssen Biotech
161. JDRF T1D Fund 
162. Jinan University
163. Johns Hopkins University
164. Jonsson Comprehensive Cancer Center
165. Juvenile Diabetes Research Foundation (JDRF)
166. Kaiser Permanente 
167. Karst Peak Capital
168. King’s College London
169. KK Women's and Children's Hospital
170. Knight Therapeutics
171. Kolon Investment
172. Kuur Therapeutics
173. Kyverna Therapeutics
174. LAVA Therapeutics
175. Leukemia and Lymphoma Society
176. Liana's Dream Foundation
177. Lifeforce Capital
178. Lightspeed Venture Partners
179. Lilly Asia Ventures
180. Lonza
181. Ludwig Institute for Cancer Research
182. Lupus Ventures
183. Lyell Immunopharma
184. Lymphact (acquired by GammaDelta Therapeutics)
185. Mahidol University
186. Maisonneuve-Rosemont Hospital
187. Massachusetts General Hospital
188. Matrix Capital Management
189. Mayo Clinic
190. MD Anderson Cancer Center
191. Medical College of Wisconsin
192. Medical Research Council
193. Medical University of Lublin
194. Medical University of Vienna
195. Memorial Sloan Kettering Cancer Center
196. Merck Sharp & Dohme
197. Methodist Hospitals
198. MIGAL Galilee Research Institute
199. Miltenyi Biomedicine
200. Miltenyi Biotec
201. Ministry of Science and Higher Education, Poland
202. MMH Institute for Transfusion Medicine
203. Mogrify
204. Mount Sinai Hospital
205. MPM Capital
206. MRL Ventures Fund
207. Mubadala Investment Company
208. Multiple Myeloma Research Foundation (MMRF)
209. Nanjing Drum Tower Hospital (Nanjing Gulou Yi Yuan)
210. Nanjing Medical University
211. Nantes University Hospital
212. National Cancer Institute
213. National Center for Tumor Diseases (NCT)
214. National Health and Medical Research Council (NHMRC)
215. National Heart, Lung, and Blood Institute (NHLBI)
216. National Institute for Health Research (NIHR)
217. National Institute of Allergy and Infectious Diseases (NIAID)
218. National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
219. National Institutes of Health (NIH)
220. National Marrow Donor Program
221. National University Hospital (NUH)
222. Nationwide Children's Hospital
223. ND Capital
224. Nice University Hospital
225. Neon Therapeutics
226. New Enterprise Associates
227. New York Medical College
228. NexImmune
229. Northpond Ventures
230. Northwestern University
231. Nova Immunotherapeutics 
232. Novartis Venture Fund
233. Novo Ventures
234. NYU Langone Health
235. Oceanpine Capital
236. Octagon Capital
237. Ohio University
238. Oncovir
239. Opexa Therapeutics
240. OrbiMed
241. Orca Bio
242. Ospedale San Raffaele
243. OU Health Stephenson Cancer Center
244. PapiVax Biotech
245. Pancreatic Cancer Action Network
246. University Paris-Est Creteil Val de Marne (formerly known as the Université Paris XII)
247. Parker Institute for Cancer Immunotherapy
248. Peking University People's Hospital
249. Penn State Health Milton S. Hershey Medical Center
250. Peter MacCallum Cancer Institute
251. PersonGen BioTherapeutics (Suzhou)
252. Pfizer
253. Piedmont Capital Partners
254. Pierce Phillips Charity
255. Pierre and Marie Curie University (UPMC)
256. Prometheus Laboratories
257. Providence Cancer Institute
258. Qiming Venture Partners
259. QIMR Berghofer Medical Research Institute
260. Quell Therapeutics
261. Queensland Institute of Medical Research (QIMR) Berghofer
262. RA Capital Management
263. Radboud University
264. Redmile Group
265. Rho Federal Systems Division
266. Roswell Park Cancer Institute
267. Samsara BioCapital
268. Sanford Health
269. Sangamo Therapeutics
270. Sanofi Ventures
271. Seattle Children’s Research Institute
272. Second Xiangya Hospital of Central South University
273. Sengkang General Hospital
274. Seoul National University Hospital (SNUH)
275. Shanghai General Hospital
276. Shanghai Houchao Biotechnology 
277. Shanghai iCELL Biotechnology
278. Shanghai Jiao Tong University School of Medicine
279. Shanghai Public Health Clinical Center
280. Sheffield Institute for Translational Neuroscience
281. Shenzhen Geno-Immune Medical Institute
282. Shenzhen Hornetcorn Biotechnology
283. Shenzhen Second People's Hospital
284. Shenzhen Third People's Hospital
285. Sichuan University
286. Singapore General Hospital
287. Siriraj Hospital
288. Sixth Affiliated Hospital
289. SNU Bio Angel
290. SoftBank Vision Fund
291. Solving Kids' Cancer
292. Sonoma Biotherapeutics
293. Specialized Medical Services-oncology
294. SR One
295. St. George's Hospital
296. St. Jude Children’s Research Hospital
297. Stanford University
298. Sun Yat-sen University
299. Surveyor Capital
300. Syncona
301. SYZ Cell Therapy
302. Takeda Pharmaceutical
303. Targazyme
304. Temasek
305. Tessa Therapeutics
306. Tevogen Bio
307. The Atlantic Philanthropies
308. The Egyptian IVF-ET Center
309. The First Affiliated Hospital of Xi'an Jiaotong University
310. The First Affiliated Hospital of Guangdong Pharmaceutical University
311. The First Affiliated Hospital of Guangzhou Medical University
312. The First Affiliated Hospital of Soochow University
313. The Francis Crick Institute
314. The First People's Hospital of Lianyungang
315. The Invus Group
316. The University of Alabama at Birmingham
317. The University of Kansas Medical Center
318. The University of Utah
319. The V Foundation for Cancer Research
320. Tianjin Medical University Cancer Institute and Hospital
321. TRACT Therapeutics
322. Triumvira Immunologics
323. TVAX Biomedical 
324. TxCell 
325. UBS Oncology Impact Fund
326. UCL Technology Fund
327. University College London (UCL)
328. University Health Network, Toronto
329. University Hospital Cologne
330. University Hospital of Saint-Étienne
331. University Hospital of Montpellier
332. University Hospital of Würzburg
333. University Hospital Regensburg
334. University of Alabama
335. University of Alberta
336. University of Arkansas
337. University of California
338. University of Cambridge
339. University of Cincinnati
340. University of Colorado
341. University of Kansas Medical Center
342. University of Kentucky
343. University of Liege
344. University of Maryland
345. University of Miami
346. University of Michigan
347. University of Minnesota Medical Center
348. University of Pennsylvania
349. University of Perugia
350. University of Pittsburgh
351. University of Regensburg
352. University of Sydney
353. University of Technology Sydney
354. University of Texas
355. University of Wisconsin
356. University of Wisconsin Carbone Cancer Center (UWCCC)
357. University of Wisconsin School of Medicine and Public Health
358. UW Health
359. Vall d'Hebron Institute of Oncology
360. V Foundation for Cancer Research
361. Versant Ventures
362. Vertex Ventures
363. Veterans Affairs (VA) Office of Research and Development
364. Vida Ventures
365. ViGenCell
366. Vineti
367. Vir Biotechnology
368. Viva Biotech
369. VT BIO
370. Vyriad
371. Washington University School of Medicine
372. Wellcome Trust
373. Westlake Village BioPartners
374. WindMIL Therapeutics
375. Wuhan Union Hospital
376. Xiangxue Life Science Research Center
377. Xiangxue Pharmaceutical
378. Yale University
379. Ysios Capital
380. Zhejiang Huahai Pharmaceutical
381. Zhujiang Hospital of Southern Medical University