Protein Engineering Market

Protein Engineering Market Overview

The protein engineering market is estimated to be worth $0.5 billion in 2022 and is expected to grow at compounded annual growth rate (CAGR) of 14.1 % during the forecast period. Over the past few years, protein-based therapeutics, including peptides, hormones, vaccines, monoclonal antibodies, blood factors and therapeutic enzymes, have gained a lot of attention from clinical researchers engaged in the field of drug development. The success of these therapeutics can be attributed to the various clinical benefits offered by such products, such as high target specificity, low toxicity and favorable safety profiles. It is worth mentioning that, at present, the protein / peptide therapeutic pipeline features over 345 product candidates, which are being evaluated across more than 1,500 clinical trials worldwide. Further, over 55 such therapies have already been marketed to treat multiple therapeutic indications. However, developing a protein based therapeutic is often fraught with several challenges, such as short half-life and poor chemical and physical stability. To overcome the aforementioned challenges as well as enable the development of therapeutic proteins with improved characteristics, researchers have identified various protein design and protein engineering techniques. Protein engineering / enzyme engineering is a complex multistep process which requires high-throughput techniques and screening procedures. Additionally, protein engineering is a time and cost intensive process. Therefore, innovators in the pharmaceutical industry are constantly identifying / developing ways to improve the process of protein and enzyme engineering.

Amidst other alternatives, outsourcing protein design and engineering process to a specialized service provider, having the required capability, has emerged as a viable option for various protein / peptide therapeutic developers. Presently, over 85 protein engineering companies, along with technology providers, are actively supporting the development of novel protein / peptide therapeutics. The growing interest of pharmaceutical stakeholders in this field is also reflected from the recent rise in partnership activity related to protein design and enzyme engineering. Additionally, over 550 patents related to protein design and engineering techniques have been filed / granted in the past few years, demonstrating the continued innovation being carried out in protein engineering market. Driven by the growing demand for therapeutic proteins for personalized medicine and advancement in protein and enzyme engineering tools, protein engineering market is anticipated to witness steady market growth during the forecast period.

Key Protein Engineering Companies in Protein Engineering Market

Examples of key protein engineering companies engaged in protein engineering market (which have also been profiled in this market report; the complete list of protein engineering companies is available in the full report) include ATUM, Creative BioMart, Creative Biostructure, Creative Enzymes, Absolute Antibody, EUCODIS Bioscience, Fusion Antibodies, Innovagen, ZYMVOL, Averring Biotech, EnzymeWorks, GeNext Genomics and Quantumzyme. This protein engineering market report includes an easily searchable excel database of all the protein engineering companies, worldwide.

Recent Developments in Protein Engineering Market:

Several recent developments have taken place in the field of protein engineering market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

• In June 2023, Astellas Pharma entered into a research agreement with Cullgen in order to discover multiple innovative protein degraders. 
• In March 2023, NVIDIA announced the expansion of generative AI cloud services for customizing AI foundation models with an aim to accelerate the creation of new proteins and therapeutics.

Scope of the Report

The “Protein Design and Engineering Market by Type of Protein Engineering Approach Used (Rational Designing, Directed Evolution and Semi-Rational Designing), Type of Protein (Antibodies, Peptides, Enzymes, Vaccines and Others), Type of Application (Therapeutics and Diagnostics), Type of End User (Pharma / Biotech Firms, CROs and Research / Academic Institutes) and Key Geographies (North America, Europe, APAC, Latin America, MENA and Rest of the World)): Industry Trends and Global Forecasts, 2021-2035” market report features an extensive study of the current market landscape, market size, market forecast and future opportunities for the protein engineering companies. The market research report features an in-depth analysis, highlighting the capabilities of protein engineering companies engaged in protein engineering market.

Amongst other elements, the market report features: 

• A detailed review of the overall landscape of protein engineering companies offering protein design and engineering services to various organizations, including pharma / biotech firms, CROs and research / academic institutes, along with analysis based on various relevant parameters, such as year of establishment, company size (in terms of employee count) and location of headquarters. The chapter also provides details related to protein design and engineering service(s) offered (protein sequencing, protein library generation, protein screening, protein characterization, protein purification, de-novo protein synthesis and in-silico analysis), additional services offered (protein expression, drug discovery, protein-protein interaction analysis, protein identification, bio imaging of proteins, protein extraction and biological pathway identification), type of protein engineering approach used (directed evolution, rational designing and semi- rational designing), type of protein (antibodies, enzymes, peptides, vaccines and others), type of application (therapeutics and diagnostics) and type of protein expression (cell surface and cell free). 
• A competitiveness analysis of protein design and engineering service providers, segmented into three categories, namely small (1-50 employees), mid-sized (51-500 employees), and large companies (>500 employees). Within the peer group, protein engineering companies were ranked based on various relevant parameters, such as supplier power (based on the experience) and company competitiveness (based on parameters, such as number of protein design and engineering services offered, type of technique used, type of protein engineering approach used, number of additional services offered, application areas and type of protein expression).
• Elaborate profiles of key protein engineering companies that are engaged in offering services for protein design and engineering. Each profile features a brief overview of the company (including information on year of establishment, number of employees, location of headquarters and key executives), financial information (if available), information on services offered, recent developments and an informed future outlook.
• A detailed assessment of the current market landscape of protein design and engineering technology providers, featuring analysis based on several parameters, such as year of establishment, company size (in terms of employee count) and location of headquarters. In addition, the chapter highlights an in-depth analysis of various protein design and engineering technologies based on type of protein design and engineering service(s) supported (protein sequencing, protein library generation, protein screening, protein characterization, de novo protein synthesis and in-silico analysis), additional services supported (drug discovery, protein-protein interaction analysis and protein expression), type of protein engineering approach used (rational designing, directed evolution and semi-rational designing), type of protein (proteins / peptides, antibodies, enzymes, cytokines and viruses) and type of application (therapeutics and diagnostics).
• An insightful 2×2 matrix representation of the competitiveness analysis of various protein design and engineering technologies segregated into two peer groups based on the company size of their respective technology provider, namely small (1-50 employees) and mid-sized companies (51-500 employees). Within the peer group, technologies were ranked based on various relevant parameters, such as supplier power (based on the experience of the technology provider) and technology competitiveness (based on  parameters, including number of protein design and engineering services supported, number of additional services supported, type of protein and type of application).
• Elaborate profiles of key protein engineering companies that are engaged in offering technologies for protein design and engineering. Each profile features a brief overview of the company (including information on year of establishment, number of employees, location of headquarters and key executives), financial information (if available), information on technology offered, recent developments and an informed future outlook.
• An analysis of the partnerships that have been inked by stakeholders engaged in protein engineering market, during the period 2017-2021, covering R&D agreements, technology licensing agreements, product development and commercialization agreements, research agreements, service alliances, product development agreements, acquisitions / mergers, technology / software development agreements and other related agreements.
• An in-depth analysis of over 130 protein / peptide based therapy developers that are likely to partner with protein design and engineering services and technology providers, based on several relevant parameters, such as developer strength (based on company size and its experience), pipeline strength (based on the number of drugs in pipeline and their stage of development and therapeutic area).
• An in-depth analysis of over 550 patents filed / granted related to protein design and engineering, till 2021. The instances have been analyzed based on various relevant parameters, such as type of patent, application year, publication year, regional applicability, CPC symbols, emerging focus areas, type of applicant, leading patent assignees (in terms of number of patents filed / granted), patent benchmarking and valuation.
• A detailed analysis of completed, ongoing and planned clinical studies of various protein / peptide based therapies on relevant parameters, such as trial registration year, trial phase, trial recruitment status, type of sponsor, target patient segment, leading industry and non-industry players (in terms of number of registered trials conducted) and key geographical regions.
• A case study presenting the key characteristics of novel peptide therapeutics, along with information on their applications and advantages, as well as key challenges associated with their development process.

One of the key objectives of this market report is to provide a detailed market forecast analysis in order to estimate the existing market size and future opportunity for protein engineering market during the forecast period. Additionally, it features market size projections for the protein design and engineering services market, wherein both the current and upcoming opportunity is segmented across [A] type of protein engineering approach used (rational designing, directed evolution and semi - rational designing), [B] type of protein (antibodies, peptides, enzymes, vaccines and others), [C] type of application (therapeutics and diagnostics), [D] type of end user (pharma / biotech firms, CROs and research / academic institutes) and [E] key geographies (North America, Europe, Asia-Pacific, Latin America, MENA and rest of the world). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely the conservative, base and optimistic scenarios, which represent different tracks of the industry’s evolution.

The opinions and insights presented in this market research report were influenced by discussions conducted with multiple stakeholders in protein engineering market. The market report features detailed transcripts of interviews held with the following individuals:

• Roman Badik (Chief Executive Officer, Enantis)
• Haibin Chen (Vice President, Enzymaster)
• Naveen Kulkarni (Chief Executive Officer, Quantumzyme)

Frequently Asked Questions

Question 1: What is protein engineering?

Answer: Protein engineering is a technique to modify the proteins through modification of amino acids, helping develop altered proteins.

Question 2: How big is the protein engineering market?

Answer: The protein engineering market size is estimated to be worth $0.5 billion in 2022.

Question 3: What is the projected market growth of the protein engineering market?

Answer: The protein engineering market is expected to grow at compounded annual growth rate (CAGR) of 14.1% during the forecast period 2022 - 2035.

Question 4: Who are the leading companies in protein engineering market?

Answer: Examples of key companies engaged in protein engineering market (which have also been profiled in this market report; the complete list of companies is available in the full report) include ATUM, Creative BioMart, Creative Biostructure, Creative Enzymes, Absolute Antibody, EUCODIS Bioscience, Fusion Antibodies, Innovagen, ZYMVOL, Averring Biotech, EnzymeWorks, GeNext Genomics and Quantumzyme.

Question 5: How many patents related to protein engineering market have been filed / granted over the last few years?

Answer: Since 2019, over 550 patents have been filed / granted related to the protein engineering market.

Question 6: How many protein engineering companies are currently engaged in protein engineering market?

Answer: Over 85 protein engineering companies are currently engaged in the protein engineering market.

Question 7: Which region is the hub for companies engaged in the protein engineering market?

Answer: North America emerged as the hub for companies engaged in the protein engineering market, with close to 50% of the protein engineering market established in the region.