Single Use Bioprocessing Market

Single Use Bioprocessing Market: Industry Trends and Global Forecasts, till 2035 - Distribution by Type of Product (Single Use Bioreactors, Single Use Mixers, Single Use Media Bags, Single Use Filters, Single Use Sampling Systems, Single Use Connectors and Others), Scale of Operation and Key Geographical Regions

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Single Use Bioprocessing Market Overview

The global single use bioprocessing market size was estimated at USD 3.9 Billion in 2023 and is expected to reach over USD 15.5 Billion by 2035, growing at a compounded annual growth rate (CAGR) of 12% in the forecast period 2022-2035.

Over time, biologics have gained significant popularity owing to their therapeutic efficacy, favorable safety profiles and ability to treat a wide variety of disease indications, which are otherwise hard to treat. The success of these interventions has prompted the stakeholders to upgrade the traditional biologics manufacturing technology. The demand for increasing productivity and flexibility, greater profitability and faster time to market are further driving the replacement of traditional stainless-steel equipment with single-use technologies, including single use mixers and single use bioreactors. These single use technologies have been well-accepted in relatively shorter period of time and have become an important tool in the development of various biotechnological processes.

Moreover, the COVID-19 pandemic has prompted the biopharmaceutical industry to shift to single use technology. These single use bioprocessing technologies not only lower down the footprint requirement but also eliminate the cleaning costs in developmental stage. Additionally, the single use bioprocessing technologies have the potential to address a number of challenges associated with traditional bioprocessing systems and offer various additional benefits, such as reduced water and energy consumption (by ~45%), lower initial investment cost (by 40%), lesser time for processing of biologics (by 33%), decreased risk of cross-contamination (by 8%) and increased cost saving potential (by 30-40%).

Presently, several single use bioprocessing companies are engaged in developing and manufacturing single-use upstream bioprocessing technologies and equipment, such as single use bioreactors, single use mixers, single-use filters, single-use media bags and containers, single-use sampling systems and single-use connectors. Further, a number of these bioprocessing companies are also focusing on incorporating additional features, including provisions for alerts / alarms, built-in system process control sensors, electronic process logs, remote monitoring features, touch screens, and advanced safety provisions, in their proprietary offerings. The adoption of this single use technology is fraught with some challenges, such as risk of extractables and leachable, single use technology disposability, sterilization / irradiation issues and potential inconsistency of the resins, however, owing to the ongoing research on sustainability of this single use technology and other technical advancements, we are led to believe that the opportunity for technology providers engaged in single use bioprocessing market is likely witness a substantial market growth during the forecast period.

List of Single-use Upstream Bioprocessing Equipment from the research report of Roots Analysis List of Single-use Upstream Bioprocessing Equipment from the research report of Roots Analysis Current market landscape of Single Use Bioreactors, researched by Roots Analysis

Key Companies in Single Use Bioprocessing Market 

Examples of key bioprocessing companies engaged in single use bioprocessing market (which have also been profiled in this market report; the complete list of bioprocessing companies is available in the full report) include Avantor, Cytiva, Eppendorf, Merck KGaA, Pall, Premas Biotech, REPROCELL, Saint-Gobain, Sartorius, Satake Multimix and Thermo Fisher Scientific. This single use bioprocessing market report includes an easily searchable excel database of all the bioprocessing companies providing single use systems, worldwide.

Recent Developments in Single Use Bioprocessing Market:

Several recent developments have taken place in the field of single use bioprocessing market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In August 2023, Sartorius and Repligen Corporation announced the launch of an integrated bioreactor system that incorporates Repligen XCell® ATF upstream intensification technology into Sartorius’ Biostat STR® bioreactor, simplifying intensified seed train and N perfusion implementation for biopharmaceutical manufacturers. 
  • In June 2023, Cytiva collaborated with Culture Biosciences to advance innovation in upstream bioprocessing by providing customers greater access to predictive and robust scale-up capabilities. 
  • In April 2023, Cytiva launched X-platform bioreactors with an aim to simplify single-use upstream bioprocessing operations.
  • In April 2023, Merck Launches Ultimus® Film to Offer Superior Strength and Leak Resistance in Single-use Assemblies to support single-use bioprocessing. 
  • In April 2022, Merck Invests Approximately € 100 Million to Accelerate Single-Use Manufacturing in China.
Current market landscape of Single-use Mixers, researched by Roots Analysis Current market landscape of Single-use Upstream Bioprocessing Equipment Providers, researched by Roots Analysis This image highlights brand positioning analysis of the key industry players engaged in upstream bioprocessing

Scope of the Report

TheSingle Use Bioprocessing Market by Type of Product (Single use Bioreactors, Single use Mixers, Single-use Media Bags, Single-use Filters, Single-use Sampling Systems, Single-use Connectors and Others), Scale of Operation (Preclinical / Clinical and Commercial) and Key Geographical Regions (North America, Europe, Asia-Pacific, Latin-America, Middle East and North Africa and Rest of the World): Industry Trends and Global Forecasts, 2022-2035 market report features an extensive study of the current market landscape, market size, market forecast and future opportunities for single-use upstream  bioprocessing technology and equipment developers during the forecast period. The market research report also features an in-depth analysis, highlighting the capabilities of various industry stakeholders engaged in single use bioprocessing market.

In addition to other elements, the market research report includes:

  • A detailed assessment of the overall market landscape of single use bioreactors based on a number of relevant parameters, such as scale of operation (lab, clinical and commercial), type of cell culture system (2D culture and 3D culture), type of cell culture (mammalian, insect, microbial, viral, plant and others), type of molecule (vaccine, monoclonal antibody, recombinant protein, stem cell, cell therapy, gene therapy and others), key features (touch screen, remote monitoring, build-in system control sensors, electronic log record, alarm system), application area (stem cell research, cancer research, regenerative medicine, drug discovery and others) and end users (pharma / biopharma, contract manufacturing organization, contract research organization and academic institutes). In addition, it presents details of the bioprocessing companies developing single use bioreactors, highlighting their year of establishment, company size, and geographical presence.
  • A detailed assessment of the overall market landscape of single use mixers based on a number of relevant parameters, such as scale of operation (lab, clinical and commercial), type of mixing system (liquid / liquid, solid / liquid and powder / liquid), type of molecule (vaccines, biologics, biosimilars and monoclonal antibody), key features (visual display / touch screen, ease to use / scalability, build-in system control sensors and process automation) and application area (media preparation, formulation, buffer preparation, viral inactivation and others). In addition, it presents details of the bioprocessing companies developing single use bioreactors, highlighting their year of establishment, company size, and geographical presence.
  • A detailed assessment of the overall market landscape of single-use sensors, based on several relevant parameters, such as type of sensor (conductivity, flow, pH, pressure and temperature), type of bioprocessing, measurement range, operating temperature, sterilization technique, material used) and application area. In addition, the chapter presents details of the bioprocessing companies involved in the development of single-use sensors, including information on their year of establishment, company size, and geographical presence.
  • An overview of the overall market landscape of other single-use technologies, such as filters, sampling systems and connectors.
  • A detailed competitiveness analysis of single use bioreactors, single use mixers and single-use sensors, taking into consideration several relevant parameters. For single use bioreactors, the parameters taken into account include the product applicability (type of cell culture, type of molecule and application area) and product strength (type of cell culture system, scale of operation and key features). For single use mixers, the parameters taken into account include the product applicability (type of mixing system, type of molecule and application area) and product strength (scale of operation). For single-use sensors, the parameters taken into account include the product specificity (minimum operating temperature, maximum operating temperature, type of calibration and type of sterilization technique) and product strength (application area and type of bioprocessing).
  • Tabulated profiles of the key bioprocessing companies providing single-use upstream bioprocessing technologies, which are headquartered in North America, Europe and Asia-Pacific. Each profile includes an overview of the company, information on the financial performance (if available), service portfolio, product portfolio, recent developments, and an informed future outlook.
  • An in-depth analysis of various patents that have been filed / granted for single-use upstream bioprocessing technology, till December 2021, highlighting key trends associated with these patents, across type of patents, publication year, application year, issuing authorities involved, type of organizations, emerging focus area, patent age, CPC symbols, leading patent assignees (in terms of number of patents granted / filed), patent characteristics and geography. It also includes a detailed patent benchmarking and an insightful valuation analysis.
  • A detailed brand positioning analysis of the key industry players (including single use bioreactors developers, single use mixers developers and single-use sensors developers), highlighting the current perceptions regarding their proprietary products by taking into consideration several relevant aspects, such as experience of the manufacturer, number of products offered, product diversity, and number of patents published.
  • An insightful analysis of the cost and time saving potential of single-use upstream bioprocessing technology. 
  • An informed estimate on the current and future demand-supply scenario for single-use upstream bioprocessing technologies, for the period 2022-2035.

One of the key objectives of this market report is to provide a detailed market forecast analysis in order to estimate the existing market size and future opportunity for single use bioprocessing market. Based on multiple parameters, such as overall upstream bioprocessing equipment market, and share of single use technology, we have provided an informed estimate of the evolution of the market for the forecast period 2022-2035. Our year-wise projections of the current and future opportunity have further been segmented on the basis of [A] scale of operation (preclinical / clinical and commercial), [B] type of product (single use bioreactors, single use mixers, single-use media bags, single-use filters, single-use sampling systems, single-use connectors and others), and [C] key geographical regions (North America, Europe, Asia-Pacific, Latin America, MENA and Rest of the World). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely conservative, base and optimistic scenarios, representing different tracks of the industry’s growth.

Competitive analysis of Single-use Mixers, analyzed by Roots Analysis This image describes the current and future demand-supply scenario for single-use upstream bioprocessing technologies The current and future market trends of Single-use Upstream Bioprocessing Technology Market according to Roots Analysis

 

The opinions and insights presented in this market report were also influenced by discussions held with senior stakeholders in the industry. The market research report features detailed transcripts of interviews held with the following industry  players: 

  • Technical Director & Co-owner, Small Company, Netherland
  • R&D Staff Scientist and Engineer, Very Large Company, US

All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market research report are in USD, unless otherwise specified.

Frequently Asked Questions

Question 1: What is single use bioprocessing?

Answer: Single use bioprocessing refers to the biologic manufacturing process that utilizes single use systems / disposable systems which are used only once and then discarded.

Question 2: How big is the single-use bioprocessing industry?

Answer: The single use bioprocessing market size is estimated to be worth $3.4 billion in 2022.

Question 3: What is the projected market growth of the single use bioprocessing market?

Answer: The single use bioprocessing market is expected to grow at compounded annual growth rate (CAGR) of 12% during the forecast period 2022 - 2035.

Question 4: Who are the leading companies in the single use bioprocessing market?

Answer: Examples of key companies engaged in single use bioprocessing market (which have also been profiled in this market report; the complete list of companies is available in the full report) include Avantor, Cytiva, Eppendorf, Merck KGaA, Pall, Premas Biotech, REPROCELL, Saint-Gobain, Sartorius, Satake Multimix and Thermo Fisher Scientific.

Question 5: How many patents related to the single use upstream bioprocessing have been filed / granted till date?

Answer: Till date, over 1,800 patents have been filed / granted related to the single use upstream bioprocessing.

Question 6: How many products are currently developed by companies engaged in the single use bioprocessing industry?

Answer: Presently, more than 500 products are being developed by various companies engaged in the single use bioprocessing market.

Question 7: Which region is the hub for companies engaged in the single use bioprocessing industry?

Answer: North America emerged as the hub for companies engaged in the single use bioprocessing market, with over 45% of the players established in the region.

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