TCR Therapy Market

Global TCR Therapy Market (2nd Edition): Distribution by Target Indication, Target Antigen, Key Players and Key Geographies (North America, Europe, Asia Pacific, Latin America, Middle East and North Africa, and Rest of the World): Industry Trends and Global Forecasts, 2022-2035

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Table Of Contents

1. PREFACE
1.1. Chapter Overview
1.2. Market Segmentations
1.3. Research Methodology
1.4. Key Questions Answered
1.5. Chapter Outlines

2. EXECUTIVE SUMMARY

3. INTRODUCTION
3.1. Chapter Overview
3.2. Pillars of Cancer Therapy
3.3. Overview of Immunotherapies
3.4. Fundamentals of Cancer Immunotherapy
3.5. Classification of Cancer Immunotherapies
3.5.1. By Mechanism of Action
3.5.1.1. Active Immunotherapy
3.5.1.2. Passive Immunotherapy
3.5.2. By Type of Target
3.5.3. By Approach
3.5.3.1. Activation and Suppression Immunotherapy
3.5.4. By Product Class
3.5.4.1. Monoclonal Antibodies
3.5.4.2. Bispecific Antibodies
3.5.4.3. Cytokines
3.5.4.4. Oncolytic Virus Therapy
3.5.4.5. Therapeutic Cancer Vaccines
3.5.4.6. Cell-based Therapies
3.6. T Cell Immunotherapies
3.6.1. Historical Evolution
3.6.2. Key Considerations for Developing T Cell Immunotherapies
3.6.3. Strategies Employed for the Redirection of T-Cells
3.6.4. Manufacturing of Engineered T Cells
3.6.5. T-Cell Transduction and Transfection Methods
3.6.5.1. Retroviral Vectors
3.6.5.2. Lentiviral Vectors
3.6.5.3. Non-viral Transfection Methods
3.7. T-Cell Receptor (TCR)-based Cell Therapy
3.7.1. Development History
3.7.2. Anatomical Layout of TCR
3.7.3. Development of TCR Therapy
3.7.4. Differences between CAR-T and TCR Therapies
3.8. Concluding Remarks

4. TCR THERAPIES: MARKET LANDSCAPE
4.1. Chapter Overview
4.2. TCR Therapies: Overall Market Landscape
4.2.1. Analysis by Type of Developer
4.2.2. Analysis by Phase of Development
4.2.3. Analysis by Therapeutic Area
4.2.4. Analysis by Phase of Development and Therapeutic Area
4.2.5. Analysis by Key Target Indication
4.2.6. Analysis by Key Target Antigen
4.2.7. Analysis by Source of T-Cells
4.2.8. Analysis by Route of Administration
4.2.9. Analysis by Phase of Development and Route of Administration
4.2.10. Analysis by Dosing Frequency
4.2.11. Analysis by Target Patient Segment
4.2.12. Analysis by Type of Therapy
4.2.13. Analysis by Phase of Development and Type of Therapy
4.2.14. Most Active Industry Players: Analysis by Number of TCR Therapies
4.2.15. Most Active Non-Industry Players: Analysis by Number of TCR Therapies

4.3. TCR Therapies: Overall Developer Landscape
4.3.1. Analysis by Year of Establishment
4.3.2. Analysis by Company Size
4.3.3. Analysis by Location of Headquarters

5. POPULAR TARGET ANTIGEN ANALYSIS
5.1. Chapter Overview
5.2. Competitive Analysis: Popular Target Antigens of TCR Therapies 
5.2.1. Popular Targets Related to Hematological Malignancies
5.2.2. Popular Targets Related to Solid Tumors

6. CLINICAL TRIAL ANALYSIS
6.1. Chapter Overview
6.2. Scope and Methodology
6.3. TCR Therapies: Clinical Trial Analysis
6.3.1. Analysis by Trial Registration Year
6.3.2. Analysis by Trial Registration Year and Enrolled Patient Population
6.3.3. Analysis by Trial Status
6.3.4. Analysis by Trial Registration Year and Trial Status
6.3.5. Analysis by Trial Phase
6.3.6. Analysis of Enrolled Patient Population by Trial Phase
6.3.7. Analysis by Target Patient Segment
6.3.8. Analysis by Type of Sponsor / Collaborator
6.3.9. Analysis by Study Design
6.3.10. Most Active Industry Players: Analysis by Number of Registered Trials
6.3.11. Most Active Non-Industry Players: Analysis by Number of Registered Trials
6.3.12. Word Cloud Representation Analysis: Emerging Focus Areas
6.3.13. Analysis of Clinical Trials by Geography
6.3.14. Analysis of Enrolled Patient Population by Geography

7. KEY OPINION LEADERS
7.1. Chapter Overview
7.2. Assumptions and Key Parameters
7.3. Methodology
7.4. TCR Therapies: Key Opinion Leaders
7.4.1. Analysis by Type of Organization
7.4.2. Analysis by Affiliated Organization
7.4.3. Analysis by Qualification
7.4.4. Analysis by Geographical Location of KOLs
7.4.5. KOL Activeness versus KOL Strength
7.4.6. Most Prominent KOLs: Analysis by RA score
7.4.7. Most Prominent KOLs: Comparison of RA Score and Third-Party Score

8. T CELL RECEPTOR THERAPY PROFILES
8.1. Chapter Overview
8.2. Kimmtrak® / IMCgp100 / Tebentafusp (Immunocore)
8.2.1. Therapy Overview
8.2.2. Clinical Trial Information
8.2.3. Clinical Trial Endpoints
8.2.4. Clinical Trial Results
8.2.5. Estimated Sales Revenues

8.3. GSK3377794 / NY-ESO-1C259 T-cells / Letetresgene Autoleucel (GlaxoSmithKline)
8.3.1. Therapy Overview
8.3.2. Clinical Trial Information
8.3.3. Clinical Trial Endpoints
8.3.4. Clinical Trial Results
8.3.5. Estimated Sales Revenues

8.4. ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics)
8.4.1. Therapy Overview
8.4.2. Clinical Trial Information
8.4.3. Clinical Trial Endpoints
8.4.4. Clinical Trial Results
8.4.5. Estimated Sales Revenues

8.5. JTCR016 (Juno Therapeutics)
8.5.1. Therapy Overview
8.5.2. Clinical Trial Information
8.5.3. Clinical Trial Endpoints

8.6. TBI-1301 (Takara Bio)
8.6.1. Therapy Overview
8.6.2. Clinical Trial Information
8.6.3. Clinical Trial Endpoints
8.6.4. Clinical Trial Results
8.6.5. Estimated Sales Revenues

8.7. MDG1011 (Medigene)
8.7.1. Therapy Overview
8.7.2. Clinical Trial Information
8.7.3. Clinical Trial Endpoints
8.7.4. Clinical Trial Results

9. PARTNERSHIPS AND COLLABORATIONS
9.1. Chapter Overview
9.2. Partnership Models
9.3. TCR Therapies: Partnerships and Collaborations
9.3.1. Analysis by Year of Partnership
9.3.2. Analysis by Type of Partnership
9.3.3. Analysis by Year of Partnership and Type of Partnership
9.3.4. Analysis by Type of Partner
9.3.5. Most Popular Products: Analysis by Number of Partnerships
9.3.6. Most Active Industry Players: Analysis by Number of Partnerships
9.3.7. Most Active Non-Industry Players: Analysis by Number of Partnerships

9.3.8. Analysis by Geography
9.3.8.1. Intercontinental and Intracontinental Deals
9.3.8.2. International and Local Deals

10 FUNDING AND INVESTMENT ANALYSIS
10.1. Chapter Overview
10.2. Types of Funding
10.3. TCR Therapies: Funding and Investment Analysis
10.3.1. Analysis of Instances by Year
10.3.2. Analysis of Amount Invested by Year
10.3.3. Analysis by Type of Funding
10.3.4. Analysis by Type of Investor
10.3.5. Most Active Players: Analysis by Number of Instances
10.3.6. Most Active Investors: Analysis by Amount Invested
10.3.7. Analysis of Amount Invested by Geography
10.3.8. Most Active Investors: Analysis by Number of Funding Instances

11. PATENT ANALYSIS
11.1. Chapter Overview
11.2. Scope and Methodology
11.3. TCR Therapies: Patent Analysis
11.3.1. Analysis by Patent Publication Year
11.3.2. Analysis By Patent Application Year
11.3.3. Analysis by Geography
11.3.4. Analysis by Type of Player
11.3.5. Analysis by CPC Symbols
11.3.6. Analysis by Key Focus Area
11.3.7. Leading Player: Analysis by Number of Patents
11.3.8. TCR Therapies: Patent Benchmarking
11.3.9. Analysis By Patent Characteristics
11.3.10. TCR Therapies: Patent Valuation

12. CASE STUDY: CELL THERAPY MANUFACTURING
12.1. Chapter Overview
12.2. Overview of Cell Therapy Manufacturing
12.3. Cell Therapy Manufacturing Models
12.3.1. Centralized Manufacturing Model
12.3.2. Decentralized Manufacturing Model
12.4. Scalability of Cell Therapy Manufacturing Processes
12.4.1. Scale-Up
12.4.2. Scale-Out
12.5. Types of Cell Therapy Manufacturers
12.6. Key Challenges Related to Manufacturing of Cell Therapies
12.7. Important Factors for Cell Therapy Manufacturing
12.7.1. Characterization
12.7.2. Cost of Goods
12.8. Automation of Cell Therapy Manufacturing Processes
12.9. Cell Therapy Manufacturing Supply Chain
12.10. Comparison of Player Having In-House Capabilities and Contract Manufacturers
12.11. Regulatory Landscape
12.12. Future Perspectives

13. COST PRICE ANALYSIS
13.1. Chapter Overview
13.2. Factors Contributing to the High Price of Cell / Gene Therapies
13.3. Pricing Models for T-Cell Immunotherapies
13.3.1. Based on Associated Costs
13.3.2. Based on Availability of Competing Products
13.3.3. Based on Patient Segment
13.3.4. Based on Opinions of Industry Experts
13.4. Reimbursement related Considerations for T-cell Immunotherapies
13.4.1. Case Study: The National Institute for Health and Care Excellence (NICE) Appraisal of CAR-T Therapies

14. MARKET FORECAST AND OPPORTUNITY ANALYSIS
14.1. Chapter Overview
14.2. Scope and Limitations
14.3. Key Assumptions and Forecast Methodology

14.4. Global TCR Therapy Market, 2022-2035
14.4.1. TCR Therapy Market: Analysis by Target Indication
14.4.2. TCR Therapy Market: Analysis by Target Antigen
14.4.3. TCR Therapy Market:  Analysis by Key Players
14.4.4. TCR Therapy Market: Distribution by Geography

14.4.5. Product Wise Sales Forecast
14.4.5.1. Kimmtrak® (IMCgp100 / Tebentafusp) (Immunocore)
14.4.5.1.1. Sales Forecast (USD Million)
14.4.5.1.2. Net Present Value (USD Million)
14.4.5.1.3. Value Creation Analysis
 
14.4.5.2. GSK3377794 (GlaxoSmithKline)
14.4.5.2.1. Sales Forecast (USD Million)
14.4.5.2.2. Net Present Value (USD Million)
14.4.5.2.3. Value Creation Analysis

14.4.5.3. YT-E001 (China Immunotech)
14.4.5.3.1. Sales Forecast (USD Million)
14.4.5.3.2. Net Present Value (USD Million)
14.4.5.3.3. Value Creation Analysis
 
14.4.5.4. ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics)
14.4.5.4.1. Sales Forecast (USD Million)
14.4.5.4.2. Net Present Value (USD Million)
14.4.5.4.3. Value Creation Analysis

14.4.5.5. EBV-specific TCR-T cell with Anti-PD1 Aauto-secreted Element (TCRCure Biopharma)
14.4.5.5.1. Sales Forecast (USD Million)
14.4.5.5.2. Net Present Value (USD Million)
14.4.5.5.3. Value Creation Analysis

14.4.5.6. NTLA-5001 (Intellia Therapeutics)
14.4.5.6.1. Sales Forecast (USD Million)
14.4.5.6.2. Net Present Value (USD Million)
14.4.5.6.3. Value Creation Analysis

14.4.5.7. TBI-1301 (Takara Bio)
14.4.5.7.1. Sales Forecast (USD Million)
14.4.5.7.2. Net Present Value (USD Million)
14.4.5.7.3. Value Creation Analysis

14.4.5.8. LMBP2-specific TCR-T (Xinqiao Hospital of Chongqing / TCR CURE Biopharma Technology)
14.4.5.8.1. Sales Forecast (USD Million)
14.4.5.8.2. Net Present Value (USD Million)
14.4.5.8.3. Value Creation Analysis
14.4.5.9. FH-MCVA2TCR (TCRCure Biopharma)
14.4.5.9.1. Sales Forecast (USD Million)
14.4.5.9.2. Net Present Value (USD Million)
14.4.5.9.3. Value Creation Analysis

15. PROMOTIONAL ANALYSIS
15.1. Chapter Overview
15.2. Channels Used for Promotional Campaigns
15.3. Kimmtrak: Promotional Analysis
15.3.1. Drug Overview
15.3.2. Product Website Analysis
15.3.2.1. Message for Healthcare Professionals
15.3.2.2. Message for Patients
15.3.2.3. Informative Downloads
15.3.3. Patient Support Services

16. COMPANY PROFILES
16.1. Chapter Overview
16.2. Adaptimmune Therapeutics
16.3. Alaunos Therapeutics
16.4. Company Profiles
16.5. Bristol Myers Squibb
16.6. Cellular Biomedicine Group
16.7. Gilead Sciences
16.8. Cellular Biomedicine Group
16.9. GlaxoSmithKline
16.10. Immatics
16.11. Immunocore
16.12. Lion TCR
16.13. Takara Bio
16.14. Zelluna immunotherapy

17. CONCLUDING REMARKS

18. EXECUTIVE INSIGHTS
18.1. Chapter Overview
18.2. Celyad
18.2.1. Interview Transcript: Vincent Brichard, Vice President, Immuno-Oncology
18.3. Kite Pharma
18.3.1. Interview Transcript: Adrian Bot, Vice President, Scientific Affairs
18.4. Lion TCR
18.4.1. Interview Transcript: Victor Lietao Li, Co-Founder and Chief Executive Officer
18.5. TxCell
18.5.1. Interview Transcript: Miguel Forte, Chief Operating Officer

19. APPENDIX 1: TABULATED DATA

20. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

List Of Figures

 Figure 2.1 Executive Summary: Overall Market Landscape
Figure 2.2 Executive Summary: Clinical Trial Analysis
Figure 2.3 Executive Summary: Partnerships and Collaborations
Figure 2.4 Executive Summary: Funding and Investment Analysis
Figure 2.5 Executive Summary: Patent Analysis
Figure 2.6 Executive Summary: Market Forecast and Opportunity Analysis
Figure 3.1 Pillars of Cancer Therapy
Figure 3.2 Differences between Active and Passive Immunotherapies
Figure 3.3 Differences between Specific and Non-Specific Immunotherapies
Figure 3.4 Strategies Employed for the Redirection of T-Cells
Figure 3.5 T-Cell Manufacturing: General Procedure
Figure 3.6 TCR Therapies: Development Process
Figure 4.1 TCR Therapies: Distribution by Type of Developer
Figure 4.2 TCR Therapies: Distribution by Phase of Development
Figure 4.3 TCR Therapies: Distribution by Therapeutic Area
Figure 4.4 TCR Therapies: Distribution by Phase of Development and Therapeutic Area
Figure 4.5 TCR Therapies: Distribution by Key Target Indications
Figure 4.6 TCR Therapies: Distribution by Key Target Antigens
Figure 4.7 TCR Therapies: Distribution by Source of T-Cells
Figure 4.8 TCR Therapies: Distribution by Phase of Development and Source of T-Cells
Figure 4.9 TCR Therapies: Distribution by Route of Administration
Figure 4.10 TCR Therapies: Distribution by Dosing Frequency
Figure 4.11 TCR Therapies: Distribution by Target Patient Segment
Figure 4.12 TCR Therapies: Distribution by Type of Therapy
Figure 4.13 Most Active Industry Players: Distribution by Number of TCR Therapies
Figure 4.14 Most Active Non-Industry Players: Distribution by Number of TCR Therapies
Figure 4.15 TCR Therapy Developers: Distribution by Year of Establishment
Figure 4.16 TCR Therapy Developers: Distribution by Company Size
Figure 4.17 TCR Therapy Developers: Distribution by Location of Headquarters (Region-wise)
Figure 4.18 TCR Therapy Developers: Distribution by Location of Headquarters (Country-wise)
Figure 5.1 TCR Therapies: Popular Targets in Hematological Malignancies
Figure 5.2 TCR Therapies: Popular Targets in Solid Tumors
Figure 6.1 Clinical Trial Analysis: Scope and Methodology
Figure 6.2 Clinical Trial Analysis: Cumulative Distribution of Trials by Trial Registration Year, Pre-2013-2022
Figure 6.3 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Trial Registration Year, Pre-2013-2022
Figure 6.4 Clinical Trial Analysis: Distribution by Trial Status
Figure 6.5 Clinical Trial Analysis: Distribution by Trial Registration Year and Trial Status, Pre-2013-2022
Figure 6.6 Clinical Trial Analysis: Distribution of Trials by Trial Phase
Figure 6.7 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Trial Phase
Figure 6.8 Clinical Trial Analysis: Distribution by Target Patient Segment
Figure 6.9 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
Figure 6.10 Clinical Trial Analysis: Distribution by Study Design
Figure 6.11 Most Active Industry Players: Distribution by Number of Registered Trials
Figure 6.12 Most Active Non-Industry Players: Distribution by Number of Registered Trials
Figure 6.13 Word Cloud Analysis: Emerging Focus Areas
Figure 6.14 Clinical Trial Analysis: Distribution of Trials by Geography
Figure 6.15 Clinical Trial Analysis: Distribution of Completed Clinical Trials by Geography
Figure 6.16 Clinical Trial Analysis: Distribution of Active Clinical Trials by Geography
Figure 6.17 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Geography
Figure 7.1 KOL Analysis: Distribution by Type of Organization
Figure 7.2 KOL Analysis: Distribution by Affiliated Organization
Figure 7.3 KOL Analysis: Distribution by Qualification
Figure 7.4 KOL Analysis: Distribution by Geography
Figure 7.5 TCR-based Therapies Scatter Plot: KOL Activeness versus KOL Strength
Figure 7.6 Most Prominent KOLs: KOL Activeness versus KOL Strength
Figure 7.7 Most Prominent KOLs: Distribution by RA Score
Figure 7.8 Most Prominent KOLs: Comparison of RA Score with Third-Party Score
Figure 7.9 Most Prominent KOLs: Comparison of RA Score with Third-Party Score (Scatter Plot)
Figure 8.1 Kimmtrak®: Estimated Sales Revenues
Figure 8.2 GSK3377794: Estimated Sales Revenues
Figure 8.3 ADP-A2M4: Estimated Sales Revenues
Figure 8.4 JTCR016: Estimated Sales Revenues
Figure 8.5 TBI-1301: Estimated Sales Revenues
Figure 8.6 MDG1011: Estimated Sales Revenues
Figure 9.1 Partnerships and Collaborations: Cumulative Year-Wise Trend, Pre-2015-2022
Figure 9.2 Partnerships and Collaborations: Distribution by Type of Partnership
Figure 9.3 Partnerships and Collaborations: Distribution by Type of Partnership, Pre-2015 and Post-2015
Figure 9.4 Partnerships and Collaborations: Distribution by Year and Type of Partnership, Pre-2015-2022
Figure 9.5 Partnerships and Collaborations: Distribution by Type of Partner
Figure 9.6 Partnerships and Collaborations: Year-Wise Distribution by Type of Partner, Pre-2015-2022
Figure 9.7 Most Popular Products: Distribution by Number of Partnerships
Figure 9.8 Most Active Industry Players: Distribution by Number of Partnerships
Figure 9.9 Most Active Non-Industry Players: Distribution by Number of Partnerships
Figure 9.10 Partnerships and Collaborations: Intercontinental and Intracontinental Deals
Figure 9.11 Partnerships and Collaborations: International and Local Deals
Figure 10.1 Funding and Investment Analysis: Cumulative Year-wise Distribution of Instances, Pre-2018-2022
Figure 10.2 Funding and Investment Analysis: Cumulative Year-wise Distribution of Amount Invested, Pre-2018-2022 (USD Million)
Figure 10.3 Funding and Investment Analysis: Distribution of Instances by Type of Funding
Figure 10.4 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding (USD Million)
Figure 10.5 Funding and Investment Analysis: Distribution by Type of Investor
Figure 10.6 Funding and Investment Analysis: Distribution of Amount Invested by Type of Investor (USD Million)
Figure 10.7 Most Active Players: Distribution by Number of Instances
Figure 10.8 Most Active Players: Distribution by Amount Invested (USD Million)
Figure 10.9 Funding and Investment Analysis: Distribution of Amount Invested by Geography
Figure 11.1 Patent Analysis: Distribution by Type of Patent
Figure 11.2 Patent Analysis: Cumulative Distribution by Patent Publication Year
Figure 11.3 Patent Analysis: Cumulative Distribution by Patent Application Year
Figure 11.4 Patent Analysis: Cumulative Year-wise Distribution of Granted Patents
Figure 11.5 Patent Analysis: Cumulative Year-wise Distribution of Filed Patent Applications
Figure 11.6 Patent Analysis: Year-wise Distribution of Filed Patent Applications and Granted Patents
Figure 11.7 Patent Analysis: Distribution by Geography
Figure 11.8 Patent Analysis: Distribution by Type of Player
Figure 11.9 Patent Analysis: Distribution by CPC Symbols
Figure 11.10 Patent Analysis: Key Focus Area
Figure 11.11 Leading Industry Players: Distribution by Number of Patents
Figure 11.12 Leading Non-Industry Players: Distribution by Number of Patents
Figure 11.13 Leading Patent Assignees: Distribution by Number of Patents
Figure 11.14 Leading Players: Benchmarking by Patent Characteristics (CPC Symbols)
Figure 11.15 Patent Analysis: Distribution by Patent Age
Figure 11.14 TCR-based Cell Therapies: Patent Valuation Analysis
Figure 12.1 Steps for Manufacturing Cell Therapies
Figure 12.2 Centralized Manufacturing: Process Model
Figure 12.3 Decentralized Manufacturing: Process Model
Figure 12.4 Cell Therapy Manufacturing: Types of Manufacturers
Figure 12.5 Cell Therapy: Challenges and Drivers
Figure 12.6 Cell Therapies: Potency as Critical Quality Attribute
Figure 12.7 Cell Therapy Manufacturing: Supply Chain Model
Figure 12.8 Cell Therapy Manufacturing: Supply Chain Risk Assessment Considerations
Figure 13.1 Approved T-Cell Therapies: Pricing Model based on Patient Segment
Figure 14.1 Global TCR-based Therapies Market, 2022-2035 (USD Billion)
Figure 14.2 TCR Therapy Market: Distribution by Target Indication, 2025 and 2035 (USD Billion)
Figure 14.3 TCR Therapy Market: Distribution by Target Antigen, 2025 and 2035 (USD Billion)
Figure 14.4 TCR Therapy Market: Distribution by Key Players, 2025 and 2035 (USD Billion)
Figure 14.5 TCR Therapy Market: Distribution by Geography, 2025 and 2035 (USD Billion)
Figure 14.6 Kimmtrak® (IMCgp100 / Tebentafusp) (Immunocore) Sales Forecast, till 2035 (USD Million)
Figure 14.7 GSK3377794 (GlaxoSmithKline) Sales Forecast, till 2035 (USD Million)
Figure 14.8 YT-E001 (China Immunotech) Sales Forecast, till 2035 (USD Million)
Figure 14.9 ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics) Sales Forecast, till 2035 (USD Million)
Figure 14.10 EBV-specific TCR-T cell with anti-PD1 auto-secreted element (TCRCure Biopharma) Sales Forecast, till 2035 (USD Million)
Figure 14.11 NTLA-5001 (Intellia Therapeutics) Sales Forecast, till 2035 (USD Million)
Figure 14.12 TBI-1301 (Takara Bio) Sales Forecast, till 2035 (USD Million)
Figure 14.13 LMBP2-specific TCR-T (Xinqiao Hospital of Chongqing / TCR CURE Biopharma Technology) Sales Forecast, till 2035 (USD Million)
Figure 15.1 Channels Used for Promotional Campaigns
Figure 15.2 Product Website Analysis: Kimmtrak®, Messages for Healthcare Professional
Figure 15.3 Product Website Analysis: Kimmtrak®, Messages for Patients
Figure 15.4 Product Website Analysis: Kimmtrak®, Kimmtrak Connect
Figure 17.1 Concluding Remarks: Market Landscape
Figure 17.2 Concluding Remarks: Clinical Trial Analysis
Figure 17.3 Concluding Remarks: Key Opinion Leaders
Figure 17.4 Concluding Remarks: Partnerships & Collaborations
Figure 17.5 Concluding Remarks: Funding and Investment Analysis
Figure 17.6 Concluding Remarks: Patent Analysis
Figure 17.7 Concluding Remarks: Market Forecast

List Of Tables

Table 3.1 Types of Immunotherapies and Affiliated Mechanisms of Action
Table 3.2 FDA Approved Antibody-based Cancer Therapeutics
Table 3.3 Retroviral Vectors: Salient Features
Table 3.4 Lentiviral Vectors: Salient Features
Table 3.5 CAR-T Cell and TCR Therapies: Key Differences
Table 4.1 TCR Therapies: Clinical Pipeline
Table 4.2 TCR Therapies: Information on Route of Administration, Source of T-Cells, Dosing Frequency, Target Patient Segment and Type of Therapy
Table 4.3 TCR Therapies: Preclinical Pipeline
Table 4.4 List of TCR-based Developers
Table 8.1 TCR Therapies: List of Therapies Profiled
Table 8.2 Therapy Profile: Kimmtrak (Immunocore)
Table 8.3 Kimmtrak: Clinical Trial Information
Table 8.4 Kimmtrak: Clinical Trial Endpoints
Table 8.5 Kimmtrak: Clinical Trial Results
Table 8.6 Therapy Profile: GSK3377794 (GlaxoSmithKline)
Table 8.7 GSK3377794: Clinical Trial Information
Table 8.8 GSK3377794: Clinical Trial Endpoints
Table 8.9 GSK3377794: Clinical Trial Results
Table 8.10 Therapy Profile: ADP-A2M4 (Adaptimmune Therapeutics)
Table 8.11 ADP-A2M4: Clinical Trial Information
Table 8.12 ADP-A2M4: Clinical Trial Endpoints
Table 8.13 ADP-A2M4: Clinical Trial Results
Table 8.14 Therapy Profile: JTCR016 (Juno Therapeutics (Bristol Myers Squibb))
Table 8.15 JTCR016: Clinical Trial Information
Table 8.16 JTCR016: Clinical Trial Endpoints
Table 8.17 Therapy Profile: TBI-1301 (Takara Bio)
Table 8.18 TBI-1301: Clinical Trial Information
Table 8.19 TBI-1301: Clinical Trial Endpoints
Table 8.20 TBI-1301: Clinical Trial Results
Table 8.21 Therapy Profile: MDG108 (Medigene)
Table 8.22 MDG108: Clinical Trial Information
Table 8.23 MDG108: Clinical Trial Endpoints
Table 8.24 MDG108: Clinical Trial Results
Table 9.1 List of Partnerships and Collaborations, 2005-2022
Table 10.1 List of Funding and Investments, 2007-2022
Table 10.2 Funding and Investment Analysis: Summary of Investments
Table 11.1 Patent Analysis: Prominent CPC Symbols
Table 11.2 Patent Analysis: Most Popular CPC Symbols
Table 11.3 Patent Analysis: List of Top CPC Symbols
Table 11.4 Patent Analysis: Summary of Benchmarking Analysis
Table 11.5 Patent Analysis: Categorization based on Weighted Valuation Scores
Table 12.1 Assessment Strategies for Different Manufacturing Processes
Table 12.2 Advantages and Disadvantages of Centralized and Decentralized Manufacturing Models
Table 12.3 Cell Therapy Manufacturing: Companies with In-House Capabilities and Contract Manufacturers
Table 13.1 Price of Marketed Gene / Cell Therapies
Table 13.2 Price of Marketed Targeted Drugs
Table 13.3 TCR Therapies: Expert Opinions on Pricing
Table 13.4 TCR Therapies: Reimbursement Landscape
Table 14.1 TCR Therapies: List of Forecasted Molecules
Table 14.2 Kimmtrak® (IMCgp100 / Tebentafusp) (Immunocore): Net Present Value (USD Million)
Table 14.3 Kimmtrak® (IMCgp100 / Tebentafusp) (Immunocore): Value Creation Analysis (USD Million)
Table 14.4 GSK3377794 (GlaxoSmithKline): Net Present Value (USD Million)
Table 14.5 GSK3377794 (GlaxoSmithKline): Value Creation Analysis (USD Million)
Table 14.6 YT-E001 (China Immunotech): Net Present Value (USD Million)
Table 14.7 YT-E001 (China Immunotech): Value Creation Analysis (USD Million)
Table 14.8 ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics): Net Present Value (USD Million)
Table 14.9 ADP-A2M4 / Afamitresgene Autoleucel / Afami-cel (Adaptimmune Therapeutics): Value Creation Analysis (USD Million)
Table 14.10 EBV-specific TCR-T cell with anti-PD1 auto-secreted element (TCRCure Biopharma): Net Present Value (USD Million)
Table 14.11 EBV-specific TCR-T cell with anti-PD1 auto-secreted element (TCRCure Biopharma): Value Creation Analysis (USD Million)
Table 14.12 NTLA-5001 (Intellia Therapeutics): Net Present Value (USD Million)
Table 14.13 NTLA-5001 (Intellia Therapeutics): Value Creation Analysis (USD Million)
Table 14.14 TBI-1301 (Takara Bio): Net Present Value (USD Million)
Table 14.15 TBI-1301 (Takara Bio): Value Creation Analysis (USD Million)
Table 14.16 LMBP2-specific TCR-T (Xinqiao Hospital of Chongqing / TCR CURE Biopharma Technology): Net Present Value (USD Million)
Table 14.17 LMBP2-specific TCR-T (Xinqiao Hospital of Chongqing / TCR CURE Biopharma Technology): Value Creation Analysis (USD Million)
Table 14.18 FH-MCVA2TCR (TCRCure Biopharma): Net Present Value (USD Million)
Table 14.19 FH-MCVA2TCR (TCRCure Biopharma): Value Creation Analysis (USD Million)
Table 15.1 Kimmtrak®: Drug Overview
Table 16.1 Leading TCR Therapy Developers
Table 16.2 Adaptimmune Therapeutics: Company Profile
Table 16.3 Alaunos Therapeutics: Company Profile
Table 16.4 Bristol Myers Squibb: Company Profile
Table 16.5 Cellular Biomedicine Group: Company Profile
Table 16.6 Gilead Sciences: Company Profile
Table 16.7 GlaxoSmithKline: Company Profile
Table 16.8 Immatics: Company Profile
Table 16.9 Immunocore: Company Profile
Table 16.10 Lion TCR: Company Profile
Table 16.11 Takara Bio: Company Profile
Table 16.12 Zelluna Immunotherapy: Company Profile
Table 19.1 TCR Therapies: Distribution by Type of Developer
Table 19.2 TCR Therapies: Distribution by Phase of Development
Table 19.3 TCR Therapies: Distribution by Therapeutic Area
Table 19.4 TCR Therapies: Distribution by Phase of Development and Therapeutic Area
Table 19.5 TCR Therapies: Distribution by Key Target Indications
Table 19.6 TCR Therapies: Distribution by Key Target Antigens
Table 19.7 TCR Therapies: Distribution by Source of T-Cells
Table 19.8 TCR Therapies: Distribution by Phase of Development and Source of T-Cells
Table 19.9 TCR Therapies: Distribution by Route of Administration
Table 19.10 TCR Therapies: Distribution by Dosing Frequency
Table 19.11 TCR Therapies: Distribution by Target Patient Segment
Table 19.12 TCR Therapies: Distribution by Type of Therapy
Table 19.13 Most Active Industry Players: Analysis by Number of TCR Therapies
Table 19.14 Most Active Non-Industry Players: Distribution by Number of TCR Therapies
Table 19.15 TCR Therapy Developers: Distribution by Year of Establishment
Table 19.16 TCR Therapy Developers: Distribution by Company Size
Table 19.17 TCR Therapy Developers: Distribution by Location of Headquarters (Region-wise)
Table 19.18 TCR Therapy Developers: Distribution by Location of Headquarters (Country-wise)
Table 19.19 Clinical Trial Analysis: Cumulative Distribution of Trials by Trial Registration Year, Pre-2013-2022
Table 19.20 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Trial Registration Year, Pre-2013-2022
Table 19.21 Clinical Trial Analysis: Distribution by Trial Status
Table 19.22 Clinical Trial Analysis: Distribution by Trial Registration Year and Trial Status, Pre-2013-2022
Table 19.23 Clinical Trial Analysis: Distribution of Trials by Trial Phase
Table 19.24 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Trial Phase
Table 19.25 Clinical Trial Analysis: Distribution by Target Patient Segment
Table 19.26 Clinical Trial Analysis: Distribution by Type of Sponsor / Collaborator
Table 19.27 Clinical Trial Analysis: Distribution by Study Design
Table 19.28 Most Active Industry Players: Distribution by Number of Registered Trials
Table 19.29 Most Active Non-Industry Players: Distribution by Number of Registered Trials
Table 19.30 Clinical Trial Analysis: Distribution of Trials by Geography
Table 19.31 Clinical Trial Analysis: Distribution of Completed Clinical Trials by Geography
Table 19.32 Clinical Trial Analysis: Distribution of Active Clinical Trials by Geography
Table 19.33 Clinical Trial Analysis: Distribution of Enrolled Patient Population by Geography
Table 19.34 KOL Analysis: Distribution by Type of Organization
Table 19.35 KOL Analysis: Distribution by Affiliated Organization
Table 19.36 KOL Analysis: Distribution by Qualification
Table 19.37 KOL Analysis: Distribution by Geography
Table 19.38 Most Prominent KOLs: Distribution by RA Score
Table 19.39 Most Prominent KOLs: Comparison of RA Score with Third-Party Score
Table 19.40 Kimmtrak®: Estimated Sales Revenues
Table 19.41 GSK3377794: Estimated Sales Revenues
Table 19.42 ADP-A2M4: Estimated Sales Revenues
Table 19.43 JTCR016: Estimated Sales Revenues
Table 19.44 TBI-1301: Estimated Sales Revenues
Table 19.45 MDG1011: Estimated Sales Revenues
Table 19.46 Partnerships and Collaborations: Cumulative Year-Wise Trend, Pre-2015-2022
Table 19.47 Partnerships and Collaborations: Distribution by Type of Partnership
Table 19.48 Partnerships and Collaborations: Distribution by Type of Partnership, Pre-2015 and Post-2015
Table 19.49 Partnerships and Collaborations: Distribution by Type of Partner
Table 19.50 Partnerships and Collaborations: Year-Wise Distribution by Type of Partner, Pre-2015-2022
Table 19.51 Most Popular Products: Distribution by Number of Partnerships
Table 19.52 Most Active Industry Players: Distribution by Number of Partnerships
Table 19.53 Most Active Non-Industry Players: Distribution by Number of Partnerships
Table 19.54 Partnerships and Collaborations: Distribution of Intercontinental and Intracontinental Deals
Table 19.55 Partnerships and Collaborations: Distribution of International and Local Deals
Table 19.56 Funding and Investment Analysis: Cumulative Distribution of Instances by Year, Pre-2018 - 2022
Table 19.57 Funding and Investment Analysis: Cumulative Distribution of Amount Invested by Year, Pre-2018 - 2022 (USD Million)
Table 19.58 Funding and Investment Analysis: Distribution of Instances by Type of Funding
Table 19.59 Funding and Investment Analysis: Distribution of Total Amount Invested by Type of Funding (USD Million)
Table 19.60 Funding and Investment Analysis: Distribution by Type of Investor
Table 19.61 Funding and Investment Analysis: Distribution of Amount Invested by Type of Investor (USD Million)
Table 19.62 Most Active Players: Distribution by Number of Instances
Table 19.63 Most Active Players: Distribution by Amount Invested (USD Million)
Table 19.64 Funding and Investment Analysis: Distribution of Amount Invested by Geography
Table 19.65 Patent Analysis: Distribution by Type of Patent
Table 19.66 Patent Analysis: Cumulative Distribution by Patent Publication Year
Table 19.67 Patent Analysis: Cumulative Distribution Patent Application Year
Table 19.68 Patent Analysis: Cumulative Distribution by Annual Granted Patents
Table 19.69 Patent Analysis: Cumulative Year-wise Distribution of Filed Patent Applications
Table 19.70 Patent Analysis: Year-wise Distribution of Granted Patents and Patent Applications
Table 19.71 Patent Analysis: Distribution by Geography
Table 19.72 Patent Analysis: Distribution by Type of Player
Table 19.73 Patent Analysis: Distribution by CPC Symbols
Table 19.74 Leading Industry Players: Distribution by Number of Patents
Table 19.75 Leading Non-Industry Players: Distribution by Number of Patents
Table 19.76 Leading Patent Assignees: Distribution by Number of Patents
Table 19.77 Patent Analysis: Distribution by Patent Age
Table 19.78 TCR Therapies: Patent Valuation Analysis

List Of Companies

The following companies and organizations have been mentioned in the report:

  1. 2seventy bio
  2. 6 Dimensions Capital
  3. A*STAR’s Genome Institute of Singapore
  4. AbVitro
  5. Actinium Pharmaceuticals
  6. Adaptimmune Therapeutics
  7. Adicet Bio
  8. AgonOx
  9. Alaunos Therapeutics
  10. Albert Einstein College of Medicine
  11. Alexandria Real Estate Equities
  12. Alex's Lemonade Stand Foundation
  13. Alpine Immune Sciences
  14. Altor BioScience
  15. Amgen
  16. Anocca
  17. Apdn Bvi
  18. Arbor Biotechnologies
  19. Astellas Pharma
  20. AstraZeneca
  21. Asymptote
  22. Athenex
  23. Atreca
  24. Autolus
  25. Axis Therapeutics
  26. Baylor College of Medicine
  27. Be The Match BioTherapies
  28. Beijing 302 Hospital
  29. Bellicum Pharmaceuticals
  30. Berlin Institute for Health
  31. Biocopy
  32. BioNTech
  33. bluebird bio
  34. Bristol Myers Squibb
  35. Broad Institute
  36. California Institute of Technology
  37. Cancer Institute and Hospital
  38. Cancer Research Technology
  39. Cardiff University
  40. Celgene
  41. Cell and Gene Therapy Catapult
  42. Cell Design Labs
  43. Cell Medica
  44. Cellares
  45. Cellular Biomedicine
  46. Cellular Therapeutics
  47. Changhai Hospital
  48. Charite-University Medicine Berlin
  49. China Immunotech (Beijing) Biotechnology
  50. Chinese PLA General Hospital
  51. Coolsingel Foundation
  52. Corregene Biotechnology
  53. Cryoport
  54. CTM CRC
  55. Cytovant Sciences
  56. Dana Farber Cancer Institute
  57. Duke-NUS Medical School
  58. Dutch Cancer Society
  59. Earle A. Chiles Research Institute
  60. Editas Medicine
  61. Ehime University
  62. Eli Lilly
  63. Erasmus Medical Center
  64. Etcembly
  65. Eutilex
  66. First Affiliated Hospital of Jinan University
  67. Fiverings
  68. Fosun Pharmaceutical
  69. Fred Hutchinson Cancer Research Center
  70. Fudan University
  71. Fujian Cancer Hospital
  72. Fujita Health University
  73. Gadeta
  74. GE Global Research
  75. GE Healthcare
  76. Genentech
  77. Genezen
  78. Genmab
  79. GigaGen
  80. Gilead Sciences
  81. GlaxoSmithKline
  82. Glycostem Therapeutics
  83. Gritstone Oncology
  84. Guangdong Xiangxue Precision Medical Technology
  85. Guangzhou FineImmune Biotechnology
  86. Guangzhou Institute of Respiratory Disease
  87. Hebei Yanda Ludaopei Hospital
  88. Helmholtz Zentrum Munich
  89. Henan Provincial People's Hospital
  90. HiFiBiO Therapeutics
  91. Howard Hughes Medical Institute
  92. Immatics
  93. Immunocore
  94. Immunotech Biopharma
  95. Imperial Innovations
  96. Intellia Therapeutics
  97. Intrexon Corporation
  98. IRICoR
  99. Janssen
  100. Jonsson Comprehensive Cancer Center
  101. Juno Therapeutics
  102. JW Therapeutics
  103. Karolinska Institute
  104. KBI Pharma
  105. Kite Pharma (a Gilead Sciences Company)
  106. Legend Biotech
  107. Leiden University Medical Center
  108. Life Technologies
  109. Lion TCR
  110. Longwood Fund
  111. Lonza
  112. Loyola University
  113. Ludwig Cancer Research
  114. Lyell Immunopharma
  115. Marker Therapeutics
  116. Massachusetts General Hospital
  117. MaSTherCell
  118. Max Delbrück Center for Molecular Medicine
  119. MaxCyte
  120. MD Anderson Cancer Center
  121. MediGene
  122. MedImmune
  123. Memorial Sloan Kettering Cancer Center
  124. Merck
  125. Mie University
  126. Miltenyi Biotec
  127. Nagoya University
  128. NantKwest
  129. National Cancer Institute
  130. National Heart, Lung and Blood Institute
  131. National Institutes of Health
  132. National Institutes of Health Clinical Center (CC)
  133. Neogene Therapeutics
  134. Noile-Immune Biotech
  135. Novartis
  136. Novartis Venture Fund
  137. Oslo University Hospital
  138. Ospedale Pediatrico Bambino Gesù (OPBG)
  139. Otsuka Pharmaceutical
  140. Oxford BioMedica
  141. PACT Pharma
  142. Peking University
  143. PharmaEssentia
  144. Poseida Therapeutics
  145. Precigen
  146. Precision BioSciences
  147. Progenitor Cell Therapy
  148. Providence Cancer Center
  149. Providence Health & Services
  150. QIAGEN
  151. RA Capital Management
  152. Redmile Group
  153. RedoxTherapeis
  154. Regeneron
  155. Regeneron Pharma
  156. Roche
  157. Roswell Park Cancer Institute
  158. Rutgers University
  159. RXi Pharmaceuticals
  160. SciLifeLab
  161. Seattle Children’s Research Institute
  162. Seattle Genetics
  163. Second Affiliated Hospital of Guangzhou Medical University
  164. Selexis
  165. Shanghai Zhongshan Hospital
  166. Shenzhen BinDeBio
  167. Shenzhen Institute for Innovation and Translational Medicine
  168. Shenzhen Second People's Hospital
  169. Shionogi
  170. SignalOne Bio
  171. Simcere
  172. Stage Cell Therapeutics
  173. Statcom
  174. Structured Immunity
  175. Sun Yat-sen University
  176. Syracuse Biopharma
  177. Tactiva Therapeutics
  178. Takara Bio
  179. T-Cell Factory
  180. TCR Biotherapeutics
  181. TCR2 Therapeutics
  182. TCRCure Biopharma
  183. TCRyption
  184. T-Cure Bioscience
  185. TeneoBio
  186. The First Affiliated Hospital of Guangzhou Medical University
  187. The Leukemia & Lymphoma Society
  188. The Netherlands Cancer Institute
  189. The University of California
  190. The University of Texas Health Science Center
  191. The University of Texas MD Anderson Cancer Center
  192. Thermo Fisher Scientific
  193. Tianjin Medical University
  194. TILT Biotherapeutics
  195. T-knife Therapeutics
  196. Tmunity Therapeutics
  197. Treadwell Therapeutics
  198. Triumvira Immunologics
  199. Tscan Therapeutics
  200. Twist Bioscience
  201. Universal Cells
  202. University College London
  203. University Health Network
  204. University Medical Center Utrecht
  205. University of California
  206. University of California San Francisco
  207. University of Chicago
  208. University of Connecticut
  209. University of Lausanne
  210. University of Montreal
  211. University of Pennsylvania
  212. University of Southern California
  213. University of Tokyo Hospital
  214. University of Virginia Patent Foundation
  215. Unum Therapeutics
  216. US Health
  217. venBio
  218. Vineti
  219. Wellington Management
  220. Woodford Investment Management
  221. WuXi AppTec
  222. X-Body
  223. Xiangxue Life Sciences
  224. Xiangxue Pharmaceutical
  225. Xinqiao Hospital of Chongqing
  226. Zelluna Immunotherapy
  227. Zhejiang Huahai Pharmaceutical
  228. Zhejiang University
  229. Zhujiang Hospital
  230. ZIOPHARM Oncology

Source 1: https://jhoonline.biomedcentral.com/articles/10.1186/s13045-021-01115-0
Source 2: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6391541/ 

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