// changes done below on July 01 2024 // till here on July 01 2024

Leading Companies in 4D Bioprinting Industry

Published: March 2024


4D bioprinting market has a promising future; the success will be primarily determined by the efforts of key industry stakeholders to capitalize on the growth trends and meet consumer expectations. We analyzed around 55 companies that are engaged in offering 4D bioprinters and smart biomaterials. In this article, discover 9 leading companies in 4D bioprinting industry and their capabilities.


3D printing is an additive manufacturing technology that prints an object layer by layer using digital files as a template. In addition, it can be used to print living cells and develop highly complex tissues that mimic the structure and performance abilities of desired organs within the body. Advancing the same, significant strides have been made to enhance 3D bioprinting to 4D bioprinting technology, with the addition of time as the fourth dimension. Smart materials enable this advancement with the ability to adapt to the spatiotemporal framework in the presence of different physical and chemical stimuli. It is worth noting that this new technology was introduced by Skylar Tibbits in 2014, allowing the researchers to study tissue engineering comprehensively.

4D bioprinting was first introduced by Massachusetts Institute of Technology’s (MIT) Self-Assembly Lab, in collaboration with Stratasys (3D printer manufacturer) and Autodesk (3D Software company). The extra dimension involved in the 4D bioprinting aids the 3D printed objects to change their shapes using the external stimuli (such as chemical, thermal, light, and magnetism) or the internal stimuli (referring to the inner force triggered shape deformations). Even though, this is a novel technology, it is capable of overcoming several real-time problems of the manufacturing industry.

Four-dimensional bioprinting uses cells and / or stimuli-responsive biomaterials to impart the ability for structural changes in printed structures in a controlled manner. Depending on the stimuli, such as heat, water, light, electricity, magnetic energy, stress, strain, and pressure, 4D structures can morph over time. Further, with the aid of 4D bioprinting, the printed structures have the ability to physically mimic the development path of biology and advance the idea of printing organs. In addition, these structures can put themselves together, repair themselves and adapt to changes on their own. It is important to highlight that the research and development of 4D printing technologies is still in its early phases. However, given the promising applications in the healthcare sectors (such as tissue engineering and chemotherapy), increasing research activities and interest of various industry stakeholders, the market for 4D bioprinters is likely to witness noteworthy growth in the near future.

Roots Analysis has conducted an exhaustive study on 4D Bioprinting Market featuring the current market landscape and future opportunity for the companies developing products and devices for 4D bioprinting, over a span of 12 years. This report also highlights the leading companies in 4D bioprinting industry.

Table of Contents

Below, we have listed (in alphabetical order), 9 leading companies in 4D bioprinting industry.

  1. DirectSync Surgical
  2. Enovis
  3. Ferentis
  4. Poietis
  5. REGENHU
  6. ROKIT Healthcare
  7. Sculpteo
  8. SMART3D
  9. Stratasys

Top 9 Leading Companies in 4D Bioprinting Industry

Interested in exploring all ~55 4D bioprinters and smart biomaterials developing companies and their recent initiatives, along with the leading companies in 4D bioprinting industry?

Discover Below the Details on 9 Leading Companies in 4D Bioprinting Industry

Let us deep dive to understand the activity of the 9 leading companies in 4D bioprinting industry (shortlisted on the basis of development of more than one 4D bioprinter or providing commercialized smart biomaterials) in the 4D bioprinting market. It is essential to note that the selection of leading companies in 4D bioprinting industry can differ substantially according to the defined criteria.

DirectSync Surgical, has Recently Received Breakthrough Device Designation from FDA for its Patient-powered Smart Implants

1. DirectSync Surgical

DirectSync Surgical, formerly known as Evoke Medical, is focused on developing human powered smart implants that improve the body’s natural ability to heal. The company claims to redefine spinal and orthopedic implantable devices by utilizing the natural biomechanical and biochemical feedback systems of a patient. In addition to this, the company aims to seek implant designs that mirror the body's osteoinductive healing processes and provide vital post-operative implant data to patients and healthcare professionals.

DirectSync Surgical: Company Details

Key Parameters Description
Company Logo DirectSync Surgical  - Logo
Year of Establisment   2014
Number of Employees  2-10
Headquarter DirectSync Surgical, Headquarter


DirectSync Surgical: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered Smart Biomaterial
Product Name Undisclosed
Type of Stimulus Used Electric Field
Application Areas Orthopedics


Partnership Signed by DirectSync Surgical Focusing on the Bioprinting Domain: In October 2023, DirectSync Surgical partnered with NanoHive Medical with an intend to redefine procedures related to spinal fusion with a stimulating/sensing 3D printed interbody fusion cage.

Further details on recent initiatives taken by DirectSync Surgical along with other leading companies in 4D bioprinting industry have been provided in the report.

Enovis is Focused on Developing Clinically Relevant Solutions to Improve Patient-related Outcomes

2. Enovis

Enovis, formerly known as Colfax, renamed itself after the separation of ESAB in April 2022. Enovis is a public traded company, practicing fabrication technology. It specializes in creating therapeutically unique solutions to improve patient outcomes and alter workflows through its innovative medical technology. As per the company’s website, it owns more than 10 facilities and offers a wide range of products, services, and integrated technologies to serve different sectors of healthcare.

Enovis: Company Details

Key Parameters Description
Company Logo Enovis  - Logo
Year of Establisment   1978
Number of Employees  5,001-10,000
Headquarter Enovis, Headquarter


Enovis: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  Smart Biomaterial
Product Name Altera
Type of Biomaterial Polymer
Form of Biomaterial Versatile
Application Area Orthopedics


Partnership Signed by Enovis Focusing on the Bioprinting Domain: Enovis acquired DJO in February 2019, expanding its medical device capabilities for a total consideration of USD 3.15 billion.

Further details on recent initiatives taken by Enovis along with other leading companies in 4D bioprinting industry have been provided in the report.

Ferentis has Been Granted European Patent for its Regenerative Prostheses Device, an Alternative for Cornea Donation

3. Ferentis

Ferentis is a Europe-based company engaged in the development of hydrogel-based kits and products that have applications across various areas, such as tissue culture engineering, regenerative medicine, cell research, testing and production of drugs and cosmetics. Further, the firm claims to be known globally for its customized technologies in the life sciences industry and academic research institutions. Additionally, the company offers unique biomimetic materials that can be used as templates to encourage the regeneration of certain tissues and organs for possible therapeutic use.

Ferentis: Company Details

Key Parameters Description
Company Logo Ferentis  - Logo
Year of Establisment   2013
Number of Employees  2-10
Headquarter Ferentis, Headquarter


Ferentis: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  Smart Biomaterial 
Product Name
  • Porcine collagen-based hydrogel
  • Collagen mimetic peptide-based hydrogel
Type of Biomaterial
  • Polymer
  • Natural
Form of Biomaterial Fibre
Application Area
  • Tissue Engineering and Regenerative Medicine
  • In-vitro cell Applications


Further details on recent initiatives taken by Ferentis along with other leading companies in 4D bioprinting industry have been provided in the report.

Poietis, a Spin-off of Institut du Recherche d’Environnement (INSERM) and University of Bordeaux, Where Laser-Assisted Bioprinting Technology was Initially Developed

4. Poietis

Poietis is a biotechnology company focused on the manufacturing and development of human tissues using 4D bioprinting. As per the company’s website, Poieskin® is the first commercialized bio-printed human tissue. Further, the company has been issued a patent titled “Laser printing method and device for implementing said method” by the European Patent Office. It is worth highlighting that this is the third patent received by the company for its bioprinting technology.

Poietis: Company Overview

Key Parameters Description
Company Logo Poietis  - Logo
Year of Establisment   2014
Number of Employees  11-50
Headquarter Poietis, Headquarter


Poietis: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  4D Bioprinters
Product Name
  • NGB-R
  • NGB-C
Type of Biomaterial
  • Natural
  • Polymer
  • Synthetic
Type of Technology
  • Extrusion-based Technology
  • Polymer-based Technology
  • Laser-based Technology
  • Micro-valve Technology
Application Area
  • Tissue Engineering and Regenerative Medicine
  • Wound Healing
  • Drug Discovery and Development
  • Industrial Applications
End User
  • Academic Institutes
  • Pharmaceutical and Biotechnology Companies


Partnership Signed by Poietis on the Bioprinting Domain: In February 2020, Poietis signed a clinical trial research agreement with Assistance Publique – Hôpitaux de Marseille to prepare the first clinical trial of bioprinted skin.

Further details on recent initiatives taken by Poietis along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

REGENHU Launched its First Instrument, BioFactory, an Eight Printhead Bioprinter in 2009

5. REGENHU

REGENHU is a medical technology company engaged in bringing innovation in the medical field by taking initiatives to improve and redefine the medicines. The company has recently launched its bioprinting instruments R-GEN series, along with a new software SHAPER, that is specifically designed for bio-fabrication. Further, the firm also develops tissue models that can be used in drug discovery and testing as well as printing tablets for personalized medicine.

REGENHU: Company Overview

Key Parameters Description
Company Logo REGENHU - Logo
Year of Establisment   2007
Number of Employees  11-50
Headquarter REGENHU, Headquarter


REGENHU: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  4D Bioprinters
Product Name
  • R-GEN 100 + Shaper
  • R-GEN 200 + Shaper
Type of Biomaterial
  • Ceramic
  • Natural
  • Polymers
  • Thermoplastics
Application Area
  • Tissue Engineering and Regenerative Medicine
  • Drug Discovery and Development


Partnership Signed by REGENHU Focusing on the Bioprinting Domain: In 2019, Tel Aviv University utilized REGENHU 3DDiscovery bioprinter to make cellularized hearts and cardiac patches for patients with heart failure, using patient specific hydrogel as bioink, to prevent rejection.

Further details on recent initiatives taken by REGENHU along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

ROKIT Healthcare Utilizes Artificial Intelligence and 3D Bioprinting Technology to Regenerate the Skin and Cartilage

6. ROKIT Healthcare

ROKIT Healthcare is a global healthcare company that claims to offer solutions for regenerative medicines for all applicable disorders through an efficient autologous organ regeneration platform using its proprietary bio-fabrication technology. As per the firm’s website, the firm is taking initiatives in the field of bioprinting, transforming the healthcare sector and producing living human cells or tissues for use in regenerative medicine. The company further claims to have completed organ regeneration clinical trials for diabetic foot ulcers (DFU) in India and Korea with 100% results. It is worth noting that the firm used its Dr. INVIVO 4D bioprinting technology for the treatment of the first human case of cartilage regeneration. Additionally, the company is working on HumaTein SKIN SPRAY, that can be used to treat burn injuries.

ROKIT Healthcare: Company Overview

Key Parameters Description
Company Logo ROKIT Healthcare - Logo
Year of Establisment   2012
Number of Employees  51-200
Headquarter ROKIT Healthcare, Headquarter


ROKIT Healthcare: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  4D Bioprinters
Product Name
  • Dr. INVIVO 4D2
  • Dr. INVIVO 4D6
Type of Biomaterial
  • Natural
  • Polymer
  • Synthetic
  • Thermoplastic
Type of Technology Extrusion-based Technology
Type of Stimulus Used
  • Heat
  • Moisture
Application Area
  • Tissue Engineering and Regenerative Medicine
  • Wound Healing
  • Drug Discovery and Development
  • Toxicology Testing
  • Modeling of Cancer Microenvironments
  • Soft Robotics
  • Bioink Development
End User
  • Academic Institutes
  • Pharmaceutical and Biotechnology Companies


Further details on recent initiatives taken by ROKIT Healthcare along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

Sculpteo Offers an Intuitive Online Platform to Optimize and Analyze the 3D Models

7. Sculpteo

Sculpteo is a service provider focused on accelerating services related to 3D printing. In November 2019, the company was acquired by BASF, enhancing its service spectrum. As per the company’s website, Sculpteo has been operating its 3D printing services online since 2009, connecting range of technologies and new materials with production and manufacturing of objects as per the demand of the clients. This acquisition helped the company to expand its market outreach, globally.

Sculpteo: Company Details

Key Parameters Description
Company Logo Sculpteo - Logo
Year of Establisment   2009
Number of Employees  51-200
Headquarter Sculpteo, Headquarter


Sculpteo: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  Smart Biomaterials
Product Name SLA Resins
Type of Biomaterial Polymer
Type of Technology Extrusion-based Technology
Type of Stimulus Used Light
Form of Biomaterial Liquid
Application Area Prosthetics


Partnership Signed by Sculpteo Focusing on the Bioprinting Domain: In November 2019, Sculpteo was acquired by BASF, in order to market and establish new industrial 3D printing materials in Paris and San Francisco.

Further details on recent initiatives taken by Sculpteo along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

SMART3D is Involved in the Development of Software Including Cloud and LAN Office Networks Connecting Macro 3D Printers Automatically

8. SMART3D

SMART3D is a US-based company developing a range of 3D printers, an approach of additive manufacturing. The company has designed its products taking into account the transition from development to production. The company claims to be involved in development of materials, maintaining the quality of the 3D prints, such as multi-material dryers which can swiftly dry a variety of materials considering the water content of 3D prints generated.

SMART3D: Company Details

Key Parameters Description
Company Logo SMART3D - Logo
Year of Establisment   2016
Number of Employees  11-50
Headquarter SMART3D, Headquarter


SMART3D: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  4D Bioprinters
Product Name
  • SMART3D Macro
  • SMART3D Macro HT
Type of Biomaterial Polymer
Type of Technology Fused Filament Fabrication
Type of Stimulus Used
  • Heat
  • Moisture
Application Area Tissue Engineering and Regenerative Medicine
End User
  • Academic Institutes
  • Pharmaceutical and Biotechnology Companies


Further details on recent initiatives taken by SMART3D along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

Stratasys, is an Israel-based Company That Develops Industrial Grade Additive Solutions

9. Stratasys

Stratasys provides services related to additive technology to a wide range of industries, including healthcare, aerospace, automotive, design, consumer products and education. The company claims to deliver industry-specific applications that help in optimizing value chains, accelerating business processes, thereby enhancing overall performance. It is worth highlighting that the company has recently introduced a new technology, GrabCAD Print™, that would help the users with file preparations and also with post printing analysis.

Stratasys: Company Details

Key Parameters Description
Company Logo Stratasys - Logo
Year of Establisment   1989
Number of Employees  1,001-5,000
Headquarter Stratasys, Headquarter


Stratasys: 4D Bioprinter / Smart Biomaterial Portfolio

Key Parameters Description
Type of Product Offered  4D Bioprinters
Product Name
  • J850 Digital Anatomy
  • NEO 450e
  • NEO 450s
  • NEO 800
  • Objet30 3D Printer
  • Objet 30 Prime 3D Printer
  • Objet 30 Pro 3D Printer
  • Origin One
  • Origin One Dental 3D Printer
Type of Biomaterial
  • Natural
  • Polymer
  • Synthetic
  • VeroUltra Clear transparent materials
Type of Technology
  • Laser-based Technology
  • Polymer-based Technology
Type of Stimulus Used
  • Heat
  • Light
  • Moisture
  • Pressure
Application Area
  • Tissue Engineering and Regenerative Medicine
  • Electronics
  • Drug Discovery and Development
End User
  • Academic Institutes
  • Pharmaceutical and Biotechnology Companies


Partnership Signed by Stratasys Focusing on the Bioprinting Domain: In February 2024, Stratasys collaborated with Express Dental Labs of Norman, Oklahoma to provide full and partial dentures to more than 55 people in need.

Further details on recent initiatives taken by Stratasys along with the details of other leading companies in 4D bioprinting industry have been provided in the report.

What About the Other 4D Bioprinters and Smart Biomaterials Developing Companies Around the World?

The above presentation features nine leading companies in 4D bioprinting industry selected from a pool of around 55 players, involved in developing around 70 4D bioprinters and smart biomaterials, that we have compiled. If you're interested, you can download the Sample Report on this topic by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

About Author

Shreeya_Agrawal

I am Shreeya Agrawal, a Senior Business Analyst working as an integral part of the Roots Analysis team since 2021. My educational background includes a Master's degree in Biotechnology (Integrated M.tech) from Jaypee University of Information Technology, which has provided me with a solid foundation in understanding the technological advancements in this industry. This has enabled me to understand the emerging trends providing comprehensive insights through syndicate reports and consulting. Throughout my professional journey, I have had the privilege of working with various pharmaceutical companies, leveraging my expertise to provide valuable insights and strategic guidance.

My commitment lies in staying updated with the dynamic pharmaceutical landscape, with the latest developments and regulatory landscape. This continuous learning equips me to offer innovative solutions that drive client success. I am deeply fascinated by the potential of data analytics and its transformative impact on decision-making. By delving into data, I can identify patterns, trends, and opportunities that might otherwise remain hidden.

My professional journey has been marked by a continuous quest for knowledge, an unrelenting passion for data-driven insights, and an unwavering commitment to guiding pharmaceutical companies towards success in an ever-changing world.

Email: shreeya.agrawal@rootsanalysis.org
LinkedIn: https://www.linkedin.com/in/shreeya-agrawal-078b00144/

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