Top 5 Companies Developing Tangential Flow Filtration Systems Used in Biologics Industry

Published: October 2023


Traditional purification and separation techniques have various challenges; to overcome these challenges, industry stakeholders rely on advanced filtration systems features. We analyzed over 80 biopharmaceutical filtration companies that have been involved in manufacturing and supply of various novel filtration systems. In this article, discover five leading tangential flow filtration systems companies and their respective product portfolio.


Filtration is the process of separating solid particulate matter from liquid or gaseous state of matter by using a porous filter medium. With the ability to remove / separate microscopic contaminants, pathogens and other particulate matter from fluids, filtration processes have profound implications in the pharmaceutical and associated industries. Biomanufacturing is one such industry where filtration forms an integral part of the process. Biopharmaceutical filtration systems are designed to purify biological products, such as vaccines, therapeutic proteins and monoclonal antibodies by removing unwanted particles, such as colloidal materials and microorganisms from cells, proteins, small molecules and nucleic acids, and obtain contaminant free products. Some of the novel biopharmaceutical filtration systems include membrane filtration, tangential flow filtration and depth filters. These filtration systems are also available as single use systems for both upstream bioprocessing and downstream bioprocessing steps.

Tangential flow filtration, also referred to as cross-flow filtration, is quite unique in nature. It allows solids to be kept in suspension and helps in minimizing the build-up of filter cake to plug or foul the membrane. This method is preferred for the continuous filtration and has the capability to perform in a reproducible manner. Owing to the various advantages of tangential flow filtration systems and other novel filtration systems, the global filtration market has been growing rapidly in recent years. However, stakeholders involved in the manufacturing of filtration systems face various challenges due to the high cell densities and initiatives of biopharmaceutical manufacturers to employ single-use technologies and sensor incorporated filtration systems at an increasingly larger scale. To mitigate the existing concerns, companies are expanding their capacity, employing high-performance filters (based on improved membrane materials, membrane structures and filter designs). Moreover, big biologic developers and companies in the biologics contract manufacturing market are moving away from immobile and rigid systems, with bulky stainless-steel vessels and fixed attachments, towards more flexible, automated, robust and scalable disposable systems. Owing to this, in the coming years, the global filtration market is expected to continue to grow. This increase is anticipated to be driven by the increasing demand for biologics and biosimilars, personalized medicines, as well as ongoing technological advancements to improve efficiency, reduce costs, and ensure regulatory compliance. 

Roots Analysis has conducted an exhaustive study on Global Filtration Market featuring the current market landscape and future opportunity for the companies involved in the manufacturing of depth filters, tangential flow filtration systems and other membrane systems, over a span of 12 years.

Table of Contents

The top five companies involved in the supply of tangential flow filtration systems are listed below (in alphabetical order):
1. Cobetter Filtration
2. Merck KGaA
3. Pall
4. Parker Hannifin
5. Sartorius

Top 10 Plasmid Manufacturers

Interested in exploring all 80+ Companies Supplying Biologics Filtration Systems?

Discover Below the Details on top 5 Tangential Flow Filtration Systems Suppliers

This article highlights the top five leading tangential flow filtration systems suppliers to watch out for in 2023. It presents details related to the key industry players engaged in the supply of filtration technologies. The companies presented in this article have more than 5,000 employee base, develop tangential flow filtration systems and have publicly revealed the financial information. It is essential to note that the selection of top players can differ substantially according to the defined criteria(s).

Cobetter Filtration, the First Filtration and Single-use System Supplier in China

Cobetter-Filtration - Tangential Flow Filtration Systems

Cobetter Filtration is a China-based biotechnology research firm engaged in the development of innovative filtration and purification solutions for a wide array of industries including biopharmaceutical, pharmaceutical, medical, microelectronics and food and beverage. The company claims to have subsidiaries which are located in different countries such as Japan, Shanghai, Taiwan, South Korea, and Singapore. According to company’s website its product portfolio includes depth filtration, virus filtration, tangential flow filtration and other membrane filtration systems. 

Tangential Flow Filtration Systems Portfolio

The approach used for filtration, type of filter, type of device and application area of tangential flow filtration systems is mentioned below:

Tangential Flow Filtration System                          Product Portfolio                                              
Type of TFF (based on approach) Conventional TFF
Type of Filter (based on use) Reusable
Type of TFF Device Cassettes    
Hollow Fiber Module
Application Area

Upstream Bioprocessing
Downstream Bioprocessing

 

Recent Developments and Future Outlook

In February 2023, the company announced that it has successfully joined BioPhorum and the Supply Partner Phorum and has become the first filtration and single use system supplier in China.1 Further in April 2021, the firm announced the launch of its single-use manufacturing factory and upgrade of its validation center, in order to ensure excellent customer service and technology development. Over the coming years, the company is likely to enter into similar partnerships with other suppliers to provide customers a seamless experience.

Further information related to biologic filtration product portfolio, financial performance and recent developments is available in the full report.

Merck KGaA, a German Company Making Strategic Investments Over the Past Years to Further Advance Its Filtration Capabilities

Merck - Tangential Flow Filtration Systems

Merck is a German pharmaceutical manufacturing firm that is engaged in the development and commercialization of solutions for research and production of biopharmaceutical and pharmaceutical therapies. The company claims to offer one of the broadest portfolios in the industry and prominent products for pharmaceutical manufacturing and development. As per company’s website, it is engaged in offering various types of filters, such as depth filtration, tangential flow filtration, virus filtration and other membrane filtration systems.

Tangential Flow Filtration Systems Portfolio

The approach used for filtration, type of filter, type of device and application area of tangential flow filtration systems is mentioned below:

Tangential Flow Filtration System                          Product Portfolio                                              
Type of TFF (based on approach) Single-Pass TFF
Type of Filter (based on use) Disposable / Single-Use 
Reusable
Type of TFF Device Capsule    
Cassette    
TFF Systems
Application Area Downstream Bioprocessing

 

Recent Developments and Future Outlook

In May 2022, the firm announced its plan to invest more than € 290 million to support the expansion of its membrane manufacturing facility in Carrigtwohill, Ireland. In addition, during the same time, the firm also announced its plan to invest € 150 million in order to build a new filtration manufacturing facility in Blarney Business Park, Ireland.2 Further, in December 2020, the firm stated that it has plans to expand its facility in Jeffrey by investing € 18.5 million in order to support the manufacturing of filtration devices and membrane products. Owing to the various initiatives, it is anticipated that the company is likely to undertake more such investment based initiatives to further expand its capabilities.

Further information related to biologics filtration product portfolio, financial performance and recent developments is available in the full report.

Pall, a US based Company, Expanding its Capabilities to Lead the Race of Filtration System Suppliers

Pall - Tangential Flow Filtration Systems

Pall, a subsidiary of Danaher, is a US-based biotechnology firm that is engaged in the development of filtration, separation, and purification solutions, across the globe. The company offers various depth filtration, tangential flow filtration, virus filtration and other membrane filtration systems to support the production of monoclonal antibodies, recombinant proteins, vaccines and gene therapy viral vectors.  As per the firm’s website, it serves clients across a multitude of industries, including aerospace, biotechnology, beverage, healthcare, oil and gas refineries, power plants, along with semiconductor fabrication facilities.

Tangential Flow Filtration Systems Portfolio

The approach used for filtration, type of filter, type of device and application area of tangential flow filtration systems is mentioned below:

Tangential Flow Filtration System                          Product Portfolio                                              
Type of TFF (based on approach) Single-Pass TFF
Type of Filter (based on use) Disposable / Single-Use 
Reusable
Type of TFF Device Capsule    
Cassette    
TFF Systems
Application Area Downstream Bioprocessing

 

Recent Developments and Future Outlook

In November 2022, the company participated in the 19th Annual BioProcessUK Conference, held in Scotland, UK. In addition, the company also participated in The Festival of Biologics, held in Basel, Switzerland. Further, in July 2021, the company announced the investment of more than $ 300 million to expand its single-use technology portfolio and another tranche of more than $ 200 million was invested to expand the manufacturing capabilities of company, across the globe. 

Further information related to biologics filtration product portfolio, financial performance and recent developments is available in the full report.

Parker Hannifin, Organizing Webinars to Showcase its Pharmaceutical Filtration Capabilities

Parker Hannifin - Tangential Flow Filtration Systems

Parker Hannifin is a US-based company engaged in offering scalable and automated filter systems ranging from systems that can be used for the purpose of drug discovery to systems that can be used for production scale operations. It is worth mentioning that the company has a proprietary single-use sensor technology to control and optimize various bioprocessing applications, such as virus filtration, diafiltration and ultrafiltration. In addition, Parker’s single-use solutions assist in improving the development timelines, enable reproducible quality and increases efficiency and safety. 

Tangential Flow Filtration Systems Portfolio

The approach used for filtration, type of filter, type of device and application area of tangential flow filtration systems is mentioned below:

Tangential Flow Filtration System                          Product Portfolio                                              
Type of TFF (based on approach) Conventional TFF
Type of Filter (based on use) Disposable / Single-Use 
Reusable
Type of TFF Device TFF Systems
Hollow Fiber Module
Others
Application Area Upstream Bioprocessing
Downstream Bioprocessing

 

Recent Developments and Future Outlook

In May 2021, the company announced the expansion of its manufacturing capabilities in order to support vaccine manufacturing operations in EMEA (Europe, Middle East, Africa). Further in June 2020, the company organized a webinar on optimization of cell culture media filtration in bioprocessing. The firm is expected to continue to expand its presence in various regions in order to consolidate its position as a global service provider.

Further information related to biologics filtration product portfolio, financial performance and recent developments is available in the full report.

Sartorius, Another German Biotech Company in the Race for Supply of Filtration Systems

Sartorius - Tangential Flow Filtration Systems

Sartorius is a German biotechnology research company and a leading player in the life science research and biopharmaceutical industry.  The company offers highly performance filtration solutions from process development to commercial manufacturing, in various upstream and downstream bioprocessing.  For the purpose of biologics filtration, it offers various types of filters, including depth filtration, tangential flow filtration, virus filtration and other membrane filtration systems. 

Tangential Flow Filtration Systems Portfolio

The approach used for filtration, type of filter, type of device and application area of tangential flow filtration systems is mentioned below:

Tangential Flow Filtration System                          Product Portfolio                                              
Type of TFF (based on approach) Conventional TFF
Type of Filter (based on use) Disposable / Single-Use 
Reusable
Type of TFF Device TFF Systems
Hollow Fiber Module
Others
Application Area Upstream Bioprocessing
Downstream Bioprocessing

 

Recent Developments and Future Outlook

In January 2023, the company announced its collaboration with RoosterBio in order to advance downstream purification processes for the manufacturing of exosomes.3 Further, in November 2021, the company announced the launch of Sartolab RF|BT, 150 – 1,000 vacuum filtration units with three different pore sizes. We believe that the company is likely to engage in more such collaborations in order to expand its existing capabilities and offer a wider range of services to its clients

Further information related to biologics filtration product portfolio, financial performance and recent developments is available in the full report.

What About the Other Tangential Flow Filtration Systems and Other Biologics Filtration Systems?

The above presentation features five promising suppliers selected from a pool of over 80 biologics filtration system suppliers that we have compiled. If you're interested, you can download the Sample Report on this topic by Roots Analysis. For personalized assistance in identifying the most relevant solutions based on your specific criteria, please don't hesitate to reach out to us at sales@rootsanalysis.com.

About Author

Ankita Kashyap

Ankita_Kashyap is a business research and competitive intelligence professional with over four years of experience in the pharmaceutical and healthcare industry. As an associate at Roots Analysis, she has authored numerous trending multidisciplinary market research reports, including viral vectors, aseptic manufacturing, continuous manufacturing, bioprinting, ADC technology, membrane filtration, liquid biopsy and more. She has continuously provided her valuable insights into the latest innovations in healthcare. During her professional journey, she has acquired good analytical skills in the pharmaceutical and biopharmaceutical industry, which in turn has contributed to the firm’s intellectual capital. This has allowed our clients to make informed decisions in the dynamic pharmaceutical landscape. She embarked upon her career with us. She started her journey as a business analyst with Roots Analyst and in such a short span of time, she has demonstrated amazing dedication. Till date, she has contributed to over 20 research reports.

Ankita holds a Master’s degree in Pharmacology from Chitkara University. While pursuing her education, she contributed her skills for various review and research literature. The impact of her learnings can be found   in her professional blogs, market research reports and social media profiles. 

Source: https://www.cobetterfiltration.com/news/366/

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