// changes done below on July 01 2024 // till here on July 01 2024

Cell Free Protein Expression Market Revenue to Cross USD 625 million by 2035 | Roots Analysis

Published: December 2023


According to a recently published report by Roots Analysis, the growing pipeline of biologics and challenges associated with their manufacturing have prompted stakeholders in the biopharmaceutical industry to adopt cell free expression systems for effective synthesis of biotherapeutics.

Cell Free Protein Expression Industry Overview

The global cell free protein expression market is anticipated to grow at a CAGR of 7.1% from 2023-2035, reaching USD 627 million by 2035.

Cell free protein expression system offers several advantages over the traditional process, including the ability to produce a broad range of target molecules by altering components suited for their production, higher yield, shorter development times and low cost of production. Cell free protein expression is carried out using cell free system or commercially available cell free expression kits. Cell-free protein expression systems have demonstrated to be capable of enabling the synthesis of several complex proteins, including toxic proteins, membrane proteins and other post translationally modified proteins, which have been found to be challenging to express using cell based systems. Given the growing demand for biologic products, cell free expression has become a key focus area for stakeholders in the biopharmaceutical industry.

Browse 100+ figures and 115+ market data tables spread across 190+ pages and detailed Table of Content on “Cell Free System Market by Type of Cell Free System, Type of Host Organism, Type of Expression Method, End-User and Key Geographical Regions” here: https://www.rootsanalysis.com/reports/cell-free-expression-market.html

Market Drivers

Several factors are propelling the growth of the cell free protein expression market. Biopharmaceutical firms are actively taking initiatives to identify approaches to overcome the existing challenges associated with biologic manufacturing. Amongst several alternatives, the use of various types of cell free expression systems, including microbial cell free expression systems, mammalian cell free expression systems, plant-based cell free expression systems and other cell free protein expression systems, has emerged as a viable option for the synthesis of biotherapeutics. This can be attributed to the fact that cell free expression systems enable faster and economical synthesis of complex molecules in shorter time.

Market Restraints

While the cell free protein expression market is experiencing substantial growth, it is not without its challenges. One of the primary restraints is the high cost associated with individual components / reagents used in cell free biomanufacturing process due to their high purification costs. Further, there might be batch-to-batch variations in final products synthesized from cell free systems due to slight variations in lysates / fermentation media / manufacturing formats (batch, fed-batch, and semi-continuous / continuous exchange operational formats). Standardization of individual components is required in order to avoid difference in results.

Growth Factors

Despite the challenges, several growth factors continue to drive the cell free protein expression market forward. Cell free protein expression system allows consistent manufacturing of products at varying scales of production (from very small (microliter) to very large (1000 L)), by using the same stockpile of reagents. Additionally, the absence of cell walls in cell free system helps in optimizing various steps of the overall biomanufacturing process by facilitating the addition / removal of enzymes and cofactors (which are continuously produced and degraded at varying rates by living cells), as well as enabling direct monitoring of the entire process. Further, cell free expression systems allow rapid manufacturing of time-sensitive products (such as the required therapies / vaccines during a pandemic) from the previously harvested active ribosomes and other necessary cellular machinery.

Cell Free Protein Expression Market Segments

Based on the type of cell free protein expression system, the market is segmented into Crude Cell Lysate-based Systems and Reconstituted Systems.

  • The crude cell lysate-based systems segment led the market for cell free protein expression market, capturing the largest revenue share of more than 90% in 2023.
  • The reconstituted systems segment is anticipated to show the highest growth potential during the forecast period of close to 11% annually.

Based on the type of expression method, the cell free protein expression market is segmented into Coupled Transcription and Translation Method and Translation Method alone.

  • The coupled transcription and translation method led the market for cell free protein expression, capturing the largest revenue share of more than 90% in 2023.
  • The coupled transcription and translation method segment is anticipated to show the highest growth potential during the forecast period of over 7% annually.

Based on the type of cell free expression system, the cell free protein expression market is segmented into Microbial Cell-free Expression System, Mammalian Cell-free Expression System, Plant-based Cell-free Expression System, Other Cell-free Expression Systems.

  • The microbial cell free protein expression system led the market for cell free expression market, capturing the largest revenue share of close to 60% in 2023.
  • The mammalian cell free expression system segment is anticipated to show the highest growth potential during the forecast period of over 7.5% annually.

Based on the type of end-user, the cell free protein expression market is segmented into Academic and Research Institutes, Pharmaceutical and Biotechnology Companies and Other End-Users.

  • The pharmaceutical and biotechnology companies led the market for cell free expression, capturing the largest revenue share of more than 50% in 2023.
  • The pharmaceutical and biotechnology companies segment is anticipated to show the highest growth potential during the forecast period during the forecast period of over 8% annually.

Based on the Regional Insights, the cell free protein expression market is segmented into North America, Europe, Asia Pacific and Rest of the World

  • North America dominated the market and accounted for the largest revenue share of about 55% in 2023.
  • In Asia Pacific, the cell free protein expression market is anticipated to demonstrate lucrative growth during the forecast period.

Key Companies Profiled

The cell free expression market report also includes detailed profiles of key players (listed below) that have expertise in cell free manufacturing and players that synthesize cell free expression kits:

  • BioLinker
  • biotechrabbit
  • CellFree Sciences
  • Creative Biolabs
  • CusaBio
  • Daicel Arbor Biosciences
  • LenioBio
  • Promega
  • Thermo Fisher Scientific
  • Touchlight

You Can Download Free Sample PDF Copy Of This Report At:
https://www.rootsanalysis.com/reports/cell-free-expression-market/request-sample.html

About Roots Analysis

Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports provided by us are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research / consulting services dedicated to serve our clients in the best possible way.

Contact Details

Gaurav Chaudhary
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Email: Gaurav.chaudhary@rootsanalysis.com or sales@rootsanalysis.com
Blog: https://www.rootsanalysis.com/blog/cell-free-systems/

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