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Report Description
The global cell free expression market is estimated to be USD 275 million in 2023 and is anticipated to grow at a CAGR of 7.5% till 2035. In recent years, cell free systems / cell free expression systems have emerged as a promising alternative for the conventional cell based biomanufacturing process. It is a well-known fact that traditional biomanufacturing is a complex process that requires living cells and specific conditions in order to maintain proper homeostasis for cell growth. Moreover, cell based biomanufacturing imposes inherent limitations on the effective production of biologics. On the other hand, cell free system / cell free expression system are in-vitro platforms that harness the transcription and translation machinery of living cells, in the form of cell lysates, to synthesize various types of biologics, particularly proteins.
Overall, cell free system offers several advantages over the traditional process, including the ability to produce a broad range of target molecules by altering components suited for their production, higher yield, shorter development times and low cost of production. Cell free expression is carried out using cell free system or commercially available cell free expression kits. Cell-free protein expression systems have demonstrated to be capable of enabling the synthesis of several complex proteins, including toxic proteins, membrane proteins and other post translationally modified proteins, which have been found to be challenging to express using cell based systems. Given the growing demand for biologic products, cell free expression has become a key focus area for stakeholders in the biopharmaceutical industry. Further, we have considered the ongoing activity and existing trends in the cell free system market to anticipate the global cell free expression market. The market is expected to witness healthy growth during the forecast period.
The Cell Free System Market: Cell free Expression Kits and Service Providers - Distribution by Type of Cell Free System (Crude Cell Lysate-Based Systems and Reconstituted Systems), Type of Host Organism (Microbial Cell Free Expression System, Mammalian Cell Free Expression System, Plant-based Cell Free Expression System and Other Cell Free Expression Systems), Type of Expression Method (Coupled Transcription and Translation Method and Translation Method), End-User (Pharmaceutical and Biotechnology Companies, Academic and Research Institutes and Other End-Users) and Key Geographical Regions (North America, Europe, Asia-Pacific and Rest of the World): Industry Trends and Global Forecasts, 2023-2035 report features an extensive market research of the current market landscape of cell free expression kits and contract manufacturers / research organizations offering cell free expression service, cell free expression market size and likely future potential associated with the industry, during the forecast period. The report answers many key questions related to this market.
Driven by several blockbuster products and a burgeoning pipeline, biologics (and consequently their manufacturing) have emerged as one of the key focus areas for stakeholders engaged in the pharmaceutical industry. However, biologic manufacturing is often fraught with several challenges, including inconsistencies related to quality of the final product, facility limitations, high attrition rate of pipeline candidates, prolonged development timelines, and regulatory / compliance-related issues. Therefore, biopharmaceutical firms are actively taking initiatives to identify approaches to overcome the existing challenges associated with biologic manufacturing. Amongst several alternatives, the use of various types of cell free expression systems, including microbial cell free expression systems, mammalian cell free expression systems, plant-based cell free expression systems and other cell free expression systems, has emerged as a viable option for the synthesis of biotherapeutics. This can be attributed to the fact that cell free expression systems enable faster and economical synthesis of complex molecules in shorter time.
Cell free system allows consistent manufacturing of products at varying scales of production (from very small (microliter) to very large (1000 L)), by using the same stockpile of reagents. Additionally, the absence of cell walls in cell free system helps in optimizing various steps of the overall biomanufacturing process by facilitating the addition / removal of enzymes and cofactors (which are continuously produced and degraded at varying rates by living cells), as well as enabling direct monitoring of the entire process. Further, cell free expression systems allow rapid manufacturing of time-sensitive products (such as the required therapies / vaccines during a pandemic) from the previously harvested active ribosomes and other necessary cellular machinery.
There are companies offering cell free expression kits or cell free expression services. The service providers landscape is fragmented, featuring a mix of several large, mid-sized and small companies. It is worth mentioning that, currently, more than 35 players across the world offer a range of cell free expression services. Majority of these players are based in the US, followed by those having headquarters in Europe and Asia Pacific. Further, over 90 cell free expression kits are presently available in the market for cell free expression of proteins, oligonucleotides and other biomolecules. Interestingly, most of these kits are used for cell-free protein expression. Given the inclination towards cutting-edge technologies, along with innovative approaches to tailor the cell free synthesis, we believe that the cell free expression market is likely to evolve at a rapid pace, during the forecast period 2023-2035.
Several stakeholders have been forging alliances with other industry / non-industry players in cell free expression market for product development, research and development and technology licensing purposes. It is worth highlighting that, since 2018, over 40 strategic partnerships have been inked in the industry. Majority of these agreements were signed for cell-free protein expression of complex proteins, including toxic proteins, membrane proteins and other post translationally modified proteins.
Owing to several advantages of cell free system, the stakeholders are also acquiring other industry players specializing in various aspects of cell free expression / biomanufacturing in order to expand their capabilities and build a comprehensive product / service portfolio. In January 2023, Moderna acquired OriCiro Genomics, a pioneer in cell free DNA synthesis and amplification technologies, to obtain best-in-class tools for cell free synthesis and amplification of plasmid DNA, a key building block in mRNA manufacturing.
Cell free expression system has emerged as potent technology in the field of synthetic biology for high-throughput production of proteins as well as enzymes and oligonucleotides (DNA/RNA). It is worth highlighting that Enzymit, a bioproduction firm, utilizes cell free technology to synthesize cost-effective enzymes. Further, Touchlight, a UK based company, claims to manufacture its proprietary dbDNA™ at exceptional speed and large scales using cell free synthesis process. The company claims to use its dbDNA™, as a critical synthesis material for development of DNA and mRNA vaccines and cell and gene therapies.
Owing to the several advantages offered by cell free synthesis over the traditional cell-based manufacturing process, the global cell free expression market is anticipated to grow at an annualized rate (CAGR) of 7.5% during the forecast period 2023-2035. It is worth highlighting that, in terms of type of cell free expression system, the microbial cell free expression system is expected to capture the majority share in the cell free expression market by 2035. Further, amongst the key geographical regions, North America is anticipated to represent the highest share of the cell free expression market in 2035.
Examples of companies providing cell free synthesis and other associated services include (which have also been captured in this report) BioLinker, CUSABIO, LenioBio and Touchlight. Additionally, examples of players engaged in the development of cell free expression kits include (which have also been captured in this report) biotechrabbit, CellFree Sciences, Creative Biolabs, Daicel Arbor Biosciences, Promega and Thermo Fisher Scientific.
Several recent developments have taken place in the field of cell free expression. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.
The market research presents an in-depth analysis of the various firms / organizations that are engaged in this industry, across different segments (as defined in the table below).
Key Report Attributes |
Details |
|
Forecast Period |
2023-2035 |
|
Base Year |
2022 |
|
Market Size 2023 |
$275 million |
|
CAGR |
7.5% |
|
Type of Cell Free System |
Crude cell lysate based systems, Reconstituted systems |
|
Type of Host Organism |
Microbial cell free expresion systems, Mammalian cell free expression systems, Plant-based cell free expression system, Other cell free expression systems |
|
Type of Expression Method |
Coupled transcription and translation method, Translation method |
|
End User |
Pharmaceutical and biotechnology companies, Academic and research institutes, Other end-users |
|
Key Geographical Regions |
North America, Europe, Asia-Pacific, Rest of the World |
|
Example Companies Profiled |
BioLinker, biotechrabbit, CellFreeSciences, Creative Biolabs, CUSABIO, Daicel Arbor Biosciences, LenioBio, Promega, Thermo Fisher Scientific, Touchlight |
|
Customizatiion Scope |
15% Free Customization Option (equivalent to 5 analyst working days) |
|
PowerpPoint Presentation (Complimentary) |
Available |
|
Excel Data Packs |
Market Landscape Analysis, Company Competitiveness Analysis, Product Competitiveness Analysis, Partnerships and Collaborations Analysis, Funding and Investment Analysis, Patent Analysis, Market Forecast an Opportunity Analysis |
The market report presents an in-depth analysis, highlighting the capabilities of various stakeholders engaged in this industry, across different regions. Amongst other elements, the research report includes:
One of the key objectives of this market report was to estimate the current market size and future growth potential of cell free expression over the forecast period. We have provided an informed estimate on the evolution of the market for the forecast period 2023-2035. Our year-wise projections of the current and forecasted opportunity have been further segmented based on relevant parameters, such as type of cell free systems (crude cell lysate-based systems and reconstituted systems), type of host organism (microbial cell free expression system, mammalian cell free expression system, plant-based cell free expression system and other cell free expression systems), type of expression methods (coupled transcription and translation method and translation method), end-users (pharmaceutical and biotechnology companies, academic and research institutes and other end-users), and key geographical regions (North America, Europe, Asia-Pacific and Rest of the World). In order to account for future uncertainties associated with some of the key parameters and to add robustness to our model, we have provided three market forecast scenarios, portraying the conservative, base and optimistic scenarios of the industry’s evolution.
The opinions and insights presented in the market report were also influenced by discussions held with senior stakeholders in the industry. The report features detailed transcripts of interviews held with the following individuals (in alphabetical order of company names):
All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.
Contents
1. PREFACE
1.1. Introduction
1.2. Key Market Insights
1.3. Scope of the Report
1.4. Research Methodology
1.5. Frequently Asked Questions
1.6. Chapter Outlines
2. EXECUTIVE SUMMARY
3. INTRODUCTION
3.1. Chapter Overview
3.2. Introduction to Cell Free Systems
3.3. Overview of Cell Free Biomanufacturing
3.3.1. Advantages
3.3.2. Challenges
3.4. Applications of Cell Free Biomanufacturing
3.4.1. Applications in Healthcare Domain
3.4.2. Applications in Other Domains
3.5. Future Perspectives
4. MARKET LANDSCAPE: CELL FREE EXPRESSION SERVICE PROVIDERS
4.1. Chapter Overview
4.2. Cell Free Expression Service Providers: Overall Market Landscape
4.2.1. Analysis by Year of Establishment
4.2.2. Analysis by Company Size
4.2.3. Analysis by Location of Headquarters
4.2.4. Analysis by Type of Cell Free Expression Service(s) Offered
4.2.5. Analysis by Type of Associated Service(s) Offered
4.2.6. Analysis by Type of Host Organism
4.2.7. Analysis by Type of Product(s) Synthesized
4.2.8. Analysis by Scale of Operation
4.2.9. Analysis by Type of Industry Served
5. MARKET LANDSCAPE: CELL FREE EXPRESSION KITS
5.1. Chapter Overview
5.2. Cell Free Expression Kits: Overall Market Landscape
5.2.1. Analysis by Type of Cell Free System
5.2.2. Analysis by Type of Host Organism
5.2.3. Analysis by Type of Expression Method
5.2.4. Analysis by Type of Product(s) Synthesized
5.2.5. Analysis by Type of Template(s) Used
5.2.6. Analysis by Type of Compatible Promoter(s)
5.2.7. Analysis by Type of Reaction Format
5.2.8. Analysis by Yield of Positive Control
5.2.9. Analysis by Reaction Volume
5.2.10. Analysis by Reaction Temperature
5.2.11. Analysis by Incubation Time
5.2.12. Analysis by Number of Reactions per Kit
5.2.13. Analysis by Kit Price
5.3. Cell Free Expression Kit Providers Landscape
5.3.1. Analysis by Year of Establishment
5.3.2. Analysis by Company Size
5.3.3. Analysis by Location of Headquarters
5.3.4. Most Active Players: Analysis by Number of Cell free Expression Kits Developed
6. CELL FREE EXPRESSION SERVICE PROVIDERS: COMPANY COMPETITIVENESS ANALYSIS
6.1. Chapter Overview
6.2. Assumptions and Key Parameters
6.3. Methodology
6.4. Company Competitiveness Analysis: Cell Free Expression Service Providers
6.4.1. Company Competitiveness Analysis: Small Service Providers
6.4.2. Company Competitiveness Analysis: Mid-sized Service Providers
6.4.3. Company Competitiveness Analysis: Large and Very Service Providers
7. CELL FREE EXPRESSION KITS: PRODUCT COMPETITIVENESS ANALYSIS
7.1. Chapter Overview
7.2. Assumptions and Key Parameters
7.3. Methodology
7.4. Product Competitiveness Analysis: Cell Free Expression Kits
7.4.1. Product Competitiveness Analysis: Cell Free Expression Kits Developed by Players based in North America
7.4.2. Product Competitiveness Analysis: Cell Free Expression Kits Developed by Players based in Europe
7.4.3. Product Competitiveness Analysis: Cell Free Expression Kits Developed by Players based in Asia-Pacific and Rest of the World
8. COMPANY PROFILES: CELL FREE EXPRESSION SERVICE PROVIDERS
8.1. Chapter Overview
8.2. BioLinker
8.2.1. Company Overview
8.2.2. Cell Free Expression Service Portfolio
8.2.3. Recent Developments and Future Outlook
8.3. CUSABIO
8.3.1. Company Overview
8.3.2. Cell Free Expression Service Portfolio
8.3.3. Recent Developments and Future Outlook
8.4. LenioBio
8.4.1. Company Overview
8.4.2. Cell Free Expression Service Portfolio
8.4.3. Recent Developments and Future Outlook
8.5. Touchlight
8.5.1. Company Overview
8.5.2. Cell Free Expression Service Portfolio
8.5.3. Recent Developments and Future Outlook
9. COMPANY PROFILES: CELL FREE EXPRESSION KIT PROVIDERS
9.1. Chapter Overview
9.2. biotechrabbit
9.2.1. Company Overview
9.2.2. Cell Free Expression Kit Portfolio
9.2.3 Recent Developments and Future Outlook
9.3. CellFree Sciences
9.3.1. Company Overview
9.3.2. Cell Free Expression Kit Portfolio
9.3.3 Recent Developments and Future Outlook
9.4. Creative Biolabs
9.4.1. Company Overview
9.4.2. Cell Free Expression Kit Portfolio
9.4.3 Recent Developments and Future Outlook
9.5. Diacel Arbor Biosciences
9.5.1. Company Overview
9.5.2. Cell Free Expression Kit Portfolio
9.5.3 Recent Developments and Future Outlook
9.6. Promega
9.6.1. Company Overview
9.6.2. Cell Free Expression Kit Portfolio
9.6.3 Recent Developments and Future Outlook
9.7. Thermo Fisher Scientific
9.7.1. Company Overview
9.7.2. Cell Free Expression Kit Portfolio
9.7.3. Recent Developments and Future Outlook
10. PARTNERSHIPS AND COLLABORATIONS
10.1. Chapter Overview
10.2. Partnership Models
10.3. Cell free System: Partnerships and Collaborations
10.3.1 Analysis by Year of Partnership
10.3.2. Analysis by Type of Partnership
10.3.3. Analysis by Year and Type of Partnership
10.3.4. Analysis by Focus Area
10.3.5. Analysis by Type of Partner
10.3.6. Most Active Players: Analysis by Number of Partnerships
10.3.7. Local and International Agreements
10.3.8. Intercontinental and Intracontinental Agreements
11. FUNDING AND INVESTMENT ANALYSIS
11.1. Chapter Overview
11.2. Types of Funding
11.3. Cell free System: Funding and Investment Analysis
11.3.1. Analysis of Instances by Year of Investment
11.3.2. Analysis of Amount Invested by Year of Investment
11.3.3. Analysis of Instances by Type of Funding
11.3.4. Analysis of Amount Invested by Type of Funding
11.3.5. Analysis by Instances of Type of Investor
11.3.6. Most Active Players: Analysis by Number of Instances
11.3.7. Most Active Players: Analysis by Amount Invested
11.3.8. Analysis of Amount Invested by Geography
11.3.8.1. Analysis by Region
11.3.8.2. Analysis by Country
12. PATENT ANALYSIS
12.1. Chapter Overview
12.2. Scope and Methodology
12.3. Cell free System: Patent Analysis
12.3.1. Analysis by Patent Publication Year
12.3.2. Analysis by Patent Application Year
12.3.3. Analysis by Annual Number of Granted Patents and Patent Applications
12.3.4. Analysis by Patent Jurisdiction
12.3.5. Analysis by CPC Symbols
12.3.6. Analysis by Type of Applicant
12.3.7. Leading Industry Players: Analysis by Number of Patents
12.3.8. Leading Non-Industry Players: Analysis by Number of Patents
12.3.9. Leading Individual Assignees: Analysis by Number of Patents
12.4. Cell free System: Patent Benchmarking Analysis
12.4.1. Analysis by Patent Characteristics
12.5. Cell free System: Patent Valuation
12.6. Leading Patents: Analysis by Number of Citations
13. MARKET FORECAST AND OPPORTUNITY ANALYSIS
13.1. Chapter Overview
13.2. Key Assumptions and Forecast Methodology
13.3. Global Cell Free Expression Market, 2023-2035
13.3.1. Cell Free Expression Market: Distribution by Type of Cell Free System, 2023 and 2035
13.3.1.1. Cell Free Expression Market for Crude Cell Lysate-based Systems, 2023-2035
13.3.1.2. Cell Free Expression Market for Reconstituted Systems, 2023-2035
13.3.2. Cell Free Expression Market: Distribution by Type of Host Organism, 2023 and 2035
13.3.2.1. Cell Free Expression Market for Microbial Cell Free Expression Systems, 2023-2035
13.3.2.2. Cell Free Expression Market for Mammalian Cell Free Expression Systems, 2023-2035
13.3.2.3. Cell Free Expression Market for Plant-based Cell Free Expression Systems, 2023-2035
13.3.2.4. Cell Free Expression Market for Other Cell Free Expression Systems, 2023-2035
13.3.3. Cell Free Expression Market: Distribution by Type of Expression Method, 2023 and 2035
13.3.3.1. Cell Free Expression Market for Coupled Transcription and Translation Method, 2023-2035
13.3.3.2. Cell Free Expression Market for Translation Method, 2023-2035
13.3.4. Cell Free Expression Market: Distribution by End-User, 2023 and 2035
13.3.4.1. Cell Free Expression Market for Pharmaceutical and Biotechnology Companies, 2023-2035
13.3.4.2. Cell Free Expression Market for Academic and Research Institutes, 2023-2035
13.3.4.3. Cell Free Expression Market for Other End-Users, 2023-2035
13.3.5. Cell Free Expression Market: Distribution by Key Geographical Regions, 2023 and 2035
13.3.5.1. Cell Free Expression Market in North America, 2023-2035
13.3.5.2. Cell Free Expression Market in Europe, 2023-2035
13.3.5.3. Cell Free Expression Market in Asia-Pacific, 2023-2035
13.3.5.4. Cell Free Expression Market in Rest of the World, 2023-2035
14. EXECUTIVE INSIGHTS
14.1. Chapter Overview
14.2. Gene Frontier
14.2.1. Company Snapshot
14.2.2. Interview Transcript: Takashi Ebihara, Chief Operational Officer
14.3. LenioBio
14.3.1. Company Snapshot
14.3.2. Interview Transcript: Remberto Martis, Founder and Chief Executive Officer
15. CONCLUDING REMARKS
16. APPENDIX 1: TABULATED DATA
17. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS
Figure 2.1 Executive Summary: Overall Market Landscape of Cell free Expression Service Providers
Figure 2.2 Executive Summary: Overall Market Landscape of Cell free Expression Kits
Figure 2.3 Executive Summary: Partnerships and Collaborations
Figure 2.4 Executive Summary: Funding and Investment Analysis
Figure 2.5 Executive Summary: Patent Analysis
Figure 2.6 Executive Summary: Market Forecast and Opportunity Analysis
Figure 3.1 Components of Cell free Reaction
Figure 3.2 Applications of Cell free Biomanufacturing
Figure 4.1 Cell free Expression Service Providers: Distribution by Year of Establishment
Figure 4.2 Cell free Expression Service Providers: Distribution by Company Size
Figure 4.3 Cell free Expression Service Providers: Distribution by Location of Headquarters
Figure 4.4 Cell free Expression Service Providers: Distribution by Type of Cell free Biomanufacturing Service(s) Offered
Figure 4.5 Cell free Expression Service Providers: Distribution by Type of Associated Service(s) Offered
Figure 4.6 Cell free Expression Service Providers: Distribution by Type of Host Organism
Figure 4.7 Cell free Expression Service Providers: Distribution by Type of Product(s) Synthesized
Figure 4.8 Cell free Expression Service Providers: Distribution by Scale of Operation
Figure 4.9 Cell free Expression Service Providers: Distribution by Type of Industry Served
Figure 5.1 Cell free Expression Kits: Distribution by Type of Cell free System
Figure 5.2 Cell free Expression Kits: Distribution by Type of Host Organism
Figure 5.3 Cell free Expression Kits: Distribution by Type of Expression Method
Figure 5.4 Cell free Expression Kits: Distribution by Type of Product(s) Synthesized
Figure 5.5 Cell free Expression Kits: Distribution by Type of Template(s) Used
Figure 5.6 Cell free Expression Kits: Distribution by Type of Compatible Promoter(s)
Figure 5.7 Cell free Expression Kits: Distribution by Type of Reaction Format
Figure 5.8 Cell free Expression Kits: Distribution by Yield of Positive Control
Figure 5.9 Cell free Expression Kits: Distribution by Reaction Volume
Figure 5.10 Cell free Expression Kits: Distribution by Reaction Temperature
Figure 5.11 Cell free Expression Kits: Distribution by Incubation Time
Figure 5.12 Cell free Expression Kits: Distribution by Number of Reactions per Kit
Figure 5.13 Cell free Expression Kits: Distribution by Kit Price
Figure 5.14 Cell free Expression Kit Providers: Distribution by Year of Establishment
Figure 5.15 Cell free Expression Kit Providers: Distribution by Company Size
Figure 5.16 Cell free Expression Kit Providers: Distribution by Location of Headquarters
Figure 5.17 Most Active Players: Distribution by Number of Cell free Expression Kits Developed
Figure 6.1 Company Competitiveness Analysis: Small Service Providers
Figure 6.2 Company Competitiveness Analysis: Leading Small Service Providers
Figure 6.3 Company Competitiveness Analysis: Mid-sized Service Providers
Figure 6.4 Company Competitiveness Analysis: Large and Very Large Service Providers
Figure 7.1 Product Competitiveness Analysis: Cell free Expression Kits Developed by Players based in North America
Figure 7.2 Product Competitiveness Analysis: Popular Cell free Expression Kits Developed by Players based in North America
Figure 7.3 Product Competitiveness Analysis: Cell free Expression Kits Developed by Players based in Europe
Figure 7.4 Product Competitiveness Analysis: Popular Cell free Expression Kits Developed by Players based in Europe
Figure 7.5 Product Competitiveness Analysis: Cell free Expression Kits Developed by Players based in Asia Pacific and Rest of the World
Figure 7.6 Product Competitiveness Analysis: Popular Cell free Expression Kits Developed by Players based in Asia Pacific and Rest of the World
Figure 10.1 Partnerships and Collaborations: Cumulative Year-wise Trend, 2019-2023
Figure 10.2 Partnerships and Collaborations: Distribution by Type of Partnership
Figure 10.3 Partnerships and Collaborations: Distribution by Year and Type of Partnership
Figure 10.4 Partnerships and Collaborations: Distribution by Focus Area
Figure 10.5 Partnerships and Collaborations: Distribution by Type of Partner
Figure 10.6 Most Active Players: Distribution by Number of Partnerships
Figure 10.7 Partnerships and Collaborations: Intercontinental and Intracontinental Agreements
Figure 10.8 Partnerships and Collaborations: Local and International Agreements
Figure 11.1 Funding and Investment Analysis: Cumulative Distribution of Number of Instances by Year, 2018-2023
Figure 11.2 Funding and Investment Analysis: Cumulative Distribution of Amount Invested by Year, 2018-2023 (USD Million)
Figure 11.3 Funding and Investment Analysis: Distribution of Instances by Type of Funding
Figure 11.4 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding (USD Million)
Figure 11.5 Funding and Investment Analysis: Distribution of Instances by Type of Investor
Figure 11.6 Most Active Players: Distribution by Number of Instances
Figure 11.7 Most Active Players: Distribution by Amount Invested (USD Million)
Figure 11.8 Funding and Investment Analysis: Distribution of Amount Invested by Region (USD Million)
Figure 11.9 Funding and Investment Analysis: Distribution of Amount Invested by Country (USD Million)
Figure 12.1 Patent Analysis: Distribution by Type of Patent
Figure 12.2 Patent Analysis: Distribution by Patent Publication Year, 2015-2023
Figure 12.3 Patent Analysis: Distribution by Patent Application Year, 2015-2023
Figure 12.4 Patent Analysis: Distribution of Granted Patents and Patent Applications by Publication Year, 2015-2023
Figure 12.5 Patent Analysis: Distribution by Patent Jurisdiction (Region-wise)
Figure 12.6 Patent Analysis: Distribution by Patent Jurisdiction (Country-wise)
Figure 12.7 Patent Analysis: Distribution by CPC Symbols
Figure 12.8 Patent Analysis: Cumulative Year-wise Distribution by Type of Applicant
Figure 12.9 Leading Industry Players: Distribution by Number of Patents
Figure 12.1 Leading Non-Industry Players: Distribution by Number of Patents
Figure 12.11 Leading Individual Assignees: Distribution by Number of Patents
Figure 12.12 Patent Benchmarking Analysis: Distribution of Leading Industry Players by Patent Characteristics (CPC Codes)
Figure 12.13 Patent Analysis: Distribution by Patent Age
Figure 12.14 Cell free System: Patent Valuation
Figure 13.1 Global Cell free Expression Market, 2023-2035 (USD Million)
Figure 13.2 Cell free Expression Market: Distribution by Type of Cell free System, 2023 and 2035
Figure 13.3 Cell free Expression Market for Crude Cell Lysate-based Systems, 2023-2035 (USD Million)
Figure 13.4 Cell free Expression Market for Reconstituted Systems, 2023-2035 (USD Million)
Figure 13.5 Cell free Expression Market: Distribution by Type of Host Organism, 2023 and 2035
Figure 13.6 Cell free Expression Market for Microbial Cell free Expression Systems, 2023-2035 (USD Million)
Figure 13.7 Cell free Expression Market for Mammalian Cell free Expression Systems, 2023-2035 (USD Million)
Figure 13.8 Cell free Expression Market for Plant-based Cell free Expression Systems, 2023-2035 (USD Million)
Figure 13.9 Cell free Expression Market for Other Cell free Expression Systems, 2023-2035 (USD Million)
Figure 13.10 Cell free Expression Market: Distribution by Type of Expression Method, 2023 and 2035
Figure 13.11 Cell free Expression Market for Coupled Transcription and Translation Method, 2023-2035 (USD Million)
Figure 13.12 Cell free Expression Market for Translation Method, 2023-2035 (USD Million)
Figure 13.13 Cell free Expression Market: Distribution by End-User, 2023 and 2035
Figure 13.14 Cell free Expression Market for Pharmaceutical and Biotechnology Companies, 2023-2035 (USD Million)
Figure 13.15 Cell free Expression Market for Academic and Research Institutes, 2023-2035 (USD Million)
Figure 13.16 Cell free Expression Market for Other End-Users, 2023-2035 (USD Million)
Figure 13.17 Cell free Expression Market: Distribution by Key Geographical Regions, 2023 and 2035
Figure 13.18 Cell free Expression Market in North America, 2023-2035 (USD Million)
Figure 13.19 Cell free Expression Market in Europe, 2023-2035 (USD Million)
Figure 13.20 Cell free Expression Market in Asia-Pacific, 2023-2035 (USD Million)
Figure 13.21 Cell free Expression Market in Rest of the World, 2023-2035 (USD Million)
Figure 15.1 Concluding Remarks: Cell free Expression Service Providers Market Landscape
Figure 15.2 Concluding Remarks: Cell free Expression Kits Market Landscape
Figure 15.3 Concluding Remarks: Partnerships and Collaborations
Figure 15.4 Concluding Remarks: Funding and Investment Analysis
Figure 15.5 Concluding Remarks: Patent Analysis
Figure 15.6 Concluding Remarks: Market Forecast and Opportunity Analysis
Table 4.1 Cell free Expression Service Providers: Information on Year of Establishment, Company Size, Location of Headquarters, Type of Host Organism, Type of Cell free Expression Service(s) Offered, and Type of Associated Service(s) Offered
Table 4.2 Cell free Expression Service Providers: Information on Type of Product(s) Synthesized, Scale of Operation and Type of Industry Served
Table 5.1 Cell free Expression Kits: Information on Type of Cell free System, Type of Host Organism, Type of Expression Method, and Type of Product(s) Synthesized
Table 5.2 Cell free Expression Kits: Information on Type of Template(s) Used, Type of Compatible Promoter(s), Type of Reaction Format, Yield of Positive Control, Reaction Volume, Reaction Temperature, Incubation Time, Number of Reactions per Kit and Kit Price
Table 5.3 Cell free Expression Kit Providers: Information on Year of Establishment, Location of Headquarters, Company Size and Type of Organization
Table 8.1 Leading Cell free Expression Service Providers
Table 8.2 BioLinker: Company Overview
Table 8.3 BioLinker: Cell free Expression Service Portfolio
Table 8.4 CUSABIO: Company Overview
Table 8.5 CUSABIO: Cell free Expression Service Portfolio
Table 8.6 LenioBio: Company Overview
Table 8.7 LenioBio: Cell free Expression Service Portfolio
Table 8.8 LenioBio: Recent Developments and Future Outlook
Table 8.9 Touchlight: Company Overview
Table 8.10 Touchlight: Cell free Expression Service Portfolio
Table 8.11 Touchlight: Recent Developments and Future Outlook
Table 9.1 Leading Cell free Expression Kit Providers
Table 9.2 biotechrabbit: Company Overview
Table 9.3 biotechrabbit: Cell free Expression Kit Portfolio
Table 9.4 CellFree Sciences: Company Overview
Table 9.5 CellFree Sciences: Cell free Expression Kit Portfolio
Table 9.6 Creative Biolabs: Company Overview
Table 9.7 Creative Biolabs: Cell free Expression Kit Portfolio
Table 9.8 Daicel Arbor Biosciences: Company Overview
Table 9.9 Daicel Arbor Biosciences: Cell free Expression Kit Portfolio
Table 9.10 Promega: Company Overview
Table 9.11 Promega: Cell free Expression Kit Portfolio
Table 9.12 Thermo Fisher Scientific: Company Overview
Table 9.13 Thermo Fisher Scientific: Cell free Expression Kit Portfolio
Table 9.14 Thermo Fisher Scientific: Recent Developments and Future Outlook
Table 10.1 Cell free System: List of Partnerships and Collaborations, 2018-2023
Table 11.1 Cell free System: List of Funding and Investments, 2018-2023
Table 12.1 Patent Analysis: Top CPC Symbols
Table 12.2 Patent Analysis: Top CPC Codes
Table 12.3 Patent Analysis: Summary of Benchmarking Analysis
Table 12.4 Patent Analysis: Categorization based on Weighted Valuation Scores
Table 12.5 Patent Portfolio: List of Leading Patents (by Highest Relative Valuation)
Table 12.6 Patent Portfolio: List of Leading Patents (by Number of Citations)
Table 14.1 Gene Frontier: Company Snapshot
Table 14.2 LenioBio: Company Snapshot
Table 14.3 Synthelis: Company Snapshot
Table 16.1 Cell free Expression Service Providers: Distribution by Year of Establishment
Table 16.2 Cell free Expression Service Providers: Distribution by Company Size
Table 16.3 Cell free Expression Service Providers: Distribution by Location of Headquarters
Table 16.4 Cell free Expression Service Providers: Distribution by Type of Cell free Expression Service(s) Offered
Table 16.5 Cell free Expression Service Providers: Distribution by Type of Associated Service(s) Offered
Table 16.6 Cell free Expression Service Providers: Distribution by Type of Host Organism
Table 16.7 Cell free Expression Service Providers: Distribution by Type of Product(s) Synthesized
Table 16.8 Cell free Expression Service Providers: Distribution by Scale of Operation
Table 16.9 Cell free Expression Service Providers: Distribution by Type of Industry Served
Table 16.10 Cell free Expression Kits: Distribution by Type of Cell free System
Table 16.11 Cell free Expression Kits: Distribution by Type of Host Organism
Table 16.12 Cell free Expression Kits: Distribution by Type of Expression Method
Table 16.13 Cell free Expression Kits: Distribution by Type of Product(s) Synthesized
Table 16.14 Cell free Expression Kits: Distribution by Type of Template(s) Used
Table 16.15 Cell free Expression Kits: Distribution by Type of Compatible Promoter(s)
Table 16.16 Cell free Expression Kits: Distribution by Type of Reaction Format
Table 16.17 Cell free Expression Kits: Distribution by Yield of Positive Control
Table 16.18 Cell free Expression Kits: Distribution by Reaction Volume
Table 16.19 Cell free Expression Kits: Distribution by Reaction Temperature
Table 16.20 Cell free Expression Kits: Distribution by Incubation Time
Table 16.21 Cell free Expression Kits: Distribution by Number of Reactions per Kit
Table 16.22 Cell free Expression Kits: Distribution by Kit Price
Table 16.23 Cell free Expression Kit Providers: Distribution by Year of Establishment
Table 16.24 Cell free Expression Kit Providers: Distribution by Company Size
Table 16.25 Cell free Expression Kit Providers: Distribution by Location of Headquarters
Table 16.26 Most Active Players: Distribution by Number of Cell free Expression Kits Developed
Table 16.27 Partnerships and Collaborations: Cumulative Year-wise Trend, 2019-2023
Table 16.28 Partnerships and Collaborations: Distribution by Type of Partnership
Table 16.29 Partnerships and Collaborations: Distribution by Year and Type of Partnership
Table 16.30 Partnerships and Collaborations: Distribution by Focus Area
Table 16.31 Partnerships and Collaborations: Distribution by Type of Partner
Table 16.32 Most Active Players: Distribution by Number of Partnerships
Table 16.33 Partnerships and Collaborations: Intercontinental and Intracontinental Agreements
Table 16.34 Partnerships and Collaborations: Local and International Agreements
Table 16.35 Funding and Investment Analysis: Cumulative Distribution of Number of Instances by Year, 2018-2023
Table 16.36 Funding and Investment Analysis: Cumulative Distribution of Amount Invested by Year, 2018-2023 (USD Million)
Table 16.37 Funding and Investment Analysis: Distribution of Instances by Type of Funding
Table 16.38 Funding and Investment Analysis: Distribution of Amount Invested by Type of Funding (USD Million)
Table 16.39 Funding and Investment Analysis: Distribution of Instances by Type of Investor
Table 16.40 Most Active Players: Distribution by Number of Instances
Table 16.41 Most Active Players: Distribution by Amount Invested (USD Million)
Table 16.42 Funding and Investment Analysis: Distribution of Amount Invested by Region (USD Million)
Table 16.43 Funding and Investment Analysis: Distribution of Amount Invested by Country (USD Million)
Table 16.44 Patent Analysis: Distribution by Type of Patent
Table 16.45 Patent Analysis: Distribution by Patent Publication Year, 2015-2023
Table 16.46 Patent Analysis: Distribution by Patent Application Year, 2015-2023
Table 16.47 Patent Analysis: Distribution of Granted Patents and Patent Applications by Publication Year, 2015-2023
Table 16.48 Patent Analysis: Distribution by Patent Jurisdiction (Region-wise)
Table 16.49 Patent Analysis: Distribution by Patent Jurisdiction (Country-wise)
Table 16.50 Patent Analysis: Distribution by CPC Symbols
Table 16.51 Patent Analysis: Cumulative Year-wise Distribution by Type of Applicant
Table 16.52 Leading Industry Players: Distribution by Number of Patents
Table 16.53 Leading Non-Industry Players: Distribution by Number of Patents
Table 16.54 Leading Individual Assignees: Distribution by Number of Patents
Table 16.55 Patent Benchmarking Analysis: Distribution of Leading Industry Players by Patent Characteristics (CPC Codes)
Table 16.56 Patent Analysis: Distribution by Patent Age
Table 16.57 Cell free System: Patent Valuation
Table 16.58 Global Cell free Expression Market: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.59 Cell free Expression Market: Distribution by Type of Cell free System, 2023 and 2035
Table 16.60 Cell free Expression Market for Crude Cell Lysate-based Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.61 Cell free Expression Market for Reconstituted Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.62 Cell free Expression Market: Distribution by Type of Host Organism, 2023 and 2035
Table 16.63 Cell free Expression Market for Microbial Cell free Expression Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.64 Cell free Expression Market for Mammalian Cell free Expression Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.65 Cell free Expression Market for Plant-based Cell free Expression Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.66 Cell free Expression Market for Other Cell free Expression Systems: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.67 Cell free Expression Market: Distribution by Type of Expression Method, 2023 and 2035
Table 16.68 Cell free Expression Market for Coupled Transcription and Translation Method: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.69 Cell free Expression Market for Translation Method: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.70 Cell free Expression Market: Distribution by End-User, 2023 and 2035
Table 16.71 Cell free Expression Market for Pharmaceutical and Biotechnology Companies: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.72 Cell free Expression Market for Academic and Research Institutes: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.73 Cell free Expression Market for Other End-Users: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.74 Cell free Expression Market: Distribution by Key Geographical Regions, 2023 and 2035
Table 16.75 Cell free Expression Market in North America: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.76 Cell free Expression Market in Europe: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.77 Cell free Expression Market in Asia-Pacific: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
Table 16.78 Cell free Expression Market in Rest of the World: Conservative, Base and Optimistic Scenarios, 2023-2035 (USD Million)
The following companies and organizations have been mentioned in the report.
Source 1: https://www.sciencedirect.com/science/article/abs/pii/S095816692030197X#
Source 2: https://www.knowledgeridge.com/c/ExpertsViewsDetails/654