Fermenters and Bioreactors Market Size Anticipated to Reach USD 73.9 billion by 2035

Fermenters and bioreactors market growth is anticipated at a CAGR of 11.3% during the period 2023-2035

 

According to a recently published report by Roots Analysis, the rapid expansion of biopharmaceutical pipeline is driving the global bioreactors and fermenters market growth

Global Bioreactors and Fermenters Industry Overview

The global Fermenters and Bioreactors Market is anticipated to grow at a CAGR of 11.3% from 2023-2035, reaching USD 73.9 billion by 2035.

Bioreactors and fermenters play an indispensable role in upstream biomanufacturing by providing requisite conditions for producing high-value products, including recombinant proteins, tissue engineered constructs and in vitro cell-based models. The technique of culturing cells via bioreactors was developed in the early twentieth century. The usage and scalability of such instruments evolved with the ever-increasing demand for novel biological products. In fact, biopharma companies, CMOs, and non-industry players have significantly invested in bioreactors to meet the rising demand for various therapies, including vaccines, fusion proteins, antibodies, hormones, interleukins, interferons, enzymes, and advanced therapeutic medicinal products (ATMPs). In contrast to bioreactors, fermenters are used for the anaerobic cultivation of microbial (fungal or bacterial) cell populations to produce biologics that do not require significant post translational modifications. The overall growth of biopharmaceutical market, especially post the COVID-19 pandemic, has led to a rise in demand for advanced upstream bioprocessing technologies including bioreactors, offering lucrative opportunities to equipment manufacturers.

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Market Drivers

The biopharma industry is actively enhancing its capacity to meet the increasing demand for therapeutics. Over the years, this rise in demand for various types of biopharmaceuticals can be attributed to multiple factors including expanded vaccine recommendations, the approval of drugs for new therapeutic applications and public health crisis. For instance, in 2021, the International Federation of Pharmaceutical Manufacturers & Associations (IFPMA) reported a monthly global COVID-19 vaccine production of 1.5 billion doses. Parallel to the large-scale manufacturing initiatives, the market is constantly improving its technologies to manufacture orphan / rare drugs as well as personalized medicines which cater to relatively smaller targeted populations. As a result, single-use bioreactors are gaining prominence. Established manufacturers have been offering 2,000 L or larger single-use bioreactors for several years, and as the biopharmaceutical market expands, there will be an anticipated growing need for more large-scale single-use bioreactors, specifically for commercial-scale manufacturing. In addition to single-use bioreactors, equipment manufacturers are offering other novel bioreactor systems such as, rocker, perfusion, wave bed, bubble column, fixed-bed, fluidized bed, membrane bioreactor, packed bed, fibrous bed and photobioreactors. As industry players form partnerships or engage in mergers and acquisitions to consolidate the market and acquire new technologies, the bioprocessing industry is expected to experience substantial growth in the foreseen future.

Market Restraints

Bioreactor and fermenter manufacturers encounter several bottlenecks related to designing scalable and efficient systems, ensuring optimal mixing and mass transfer, developing robust control strategies, and meeting regulatory standards for bioprocess equipment. In addition, they face challenges in incorporating advanced sensor technologies, addressing issues with foam formation, maintaining sterility, and managing the complexity of bioprocessing automation. Particularly, for single-use bioreactor manufacturers, leaching is a prominent challenge. These disposable bioreactors are constructed using plastic materials that can release organic or inorganic chemicals into liquid pharmaceutical products, potentially jeopardizing the safety of the drug and the well-being of the patient. To minimize the hazards related to leaching, equipment manufacturers are relying on surface treatments / coatings as well as rigorous testing and validation, to ensure materials’ compatibility with bioprocess conditions.

Growth Factors

In order to increase the adoption of bioreactors and fermenters, equipment manufacturers are focused on lowering the cost of goods and services for biomanufacturing companies, while providing products having flexibility to respond to the fast-evolving demand. For instance, the introduction of high cell density prefusion cell cultures has downsized bioreactors, directly impacting operational footprint and consequently the capital expenditure (CAPEX). In fact, around 50-60% of companies are either exploring or have adopted perfusion technologies for seed train or production bioreactor stages. Furthermore, multi-compartment bioreactors can host different cell culture reactions within the same reactor, proving valuable for co-culturing different cell types. Utilizing 3D printing technology, customized bioreactor components can be produced, which are tailored to specific R&D needs. The bioreactors and fermenters market is witnessing the adoption of bioprocessing 4.0 solutions that leverage machine learning (ML) and artificial intelligence (AI) for real-time bioprocess monitoring. These transformative strategies are poised to shape the future landscape of bioreactors and fermenters, fostering a more effective and cost-efficient biomanufacturing environment.

Global Bioreactor and Fermenter Market Segments

Based on the type of product, the market is segmented into Bioreactors and Fermenters.

• The bioreactors segment led the global bioreactors and fermenters market, capturing the largest revenue share of over 70.0% in 2023.
• The fermenters segment is anticipated to show the highest market growth potential during the forecast period of over 11.5% annually.

Based on the fabrication material, the market is segmented into Glass, Stainless Steel and Single-use.

• The stainless steel segment led the global bioreactors and fermenters market, capturing the largest revenue share of close to 87.0% in 2023.
• The single-use segment is anticipated to show the highest market growth potential during the forecast period of nearly 17.0% annually.

Based on the type of bioprocess, the market is segmented into Batch and Fed-batch, and Continuous.

• The batch and fed-batch segment led the global bioreactors and fermenters market, capturing the largest revenue share of 85.0% in 2023.
• The continuous segment is anticipated to show the highest growth potential by growing at a CAGR of over 14.5% during the forecast period.

Based on the type of biologic, the market is segmented into Antibodies, Vaccines, Cell Therapies and Other Biologics.

• The antibodies segment led the global bioreactors and fermenters market, capturing the largest revenue share of close to 40.0% in 2023.
• The vaccines segment is anticipated to show the highest growth potential by growing at a CAGR of over 14.1% during the forecast period.

Based on the Regional Insights, the market is segmented into North America, Europe, Asia Pacific, and Rest of the World.

• Europe dominated the bioreactors and fermenters market and accounted for the largest revenue share of over 35.0% in 2023.
• In the same region, Europe, the bioreactors and fermenters market is anticipated to demonstrate lucrative growth during the forecast period.

Key Companies Profiled

The oral solid dosage contract manufacturing market report also includes detailed profiles of key players (listed below) which have been shortlisted based on strength of their service portfolio:

• Applikon Biotechnology
• Bionet
• Cytiva
• Eppendorf
• Merck
• Ollital Technology
• Parr Instrument Company
• Sartorius
• Shanghai Bailun Biological Technology
• Solaris Biotech
• Solida Biotech
• Zhengzhou Laboao Instrument Equipment (LABAO)

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About Roots Analysis

Roots Analysis is a global leader in the pharma / biotech market research. Having worked with over 750 clients worldwide, including Fortune 500 companies, start-ups, academia, venture capitalists and strategic investors for more than a decade, we offer a highly analytical / data-driven perspective to a network of over 450,000 senior industry stakeholders looking for credible market insights. All reports provided by us are structured in a way that enables the reader to develop a thorough perspective on the given subject. Apart from writing reports on identified areas, we provide bespoke research / consulting services dedicated to serve our clients in the best possible way.

Contact Details

Gaurav Chaudhary
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