Organs-on-Chips Market Growth

Organs-on-Chips Market Growth to be Driven by Demand for Animal Free Testing Systems; Market Revenue to Cross USD 940 million by 2035  

According to a recently published report by Roots Analysis, the growing preference of human relevant pre-clinical testing models, which eliminates the need for animal-based models and the ongoing technological advancements, including improvements in design, functionality and usability of microfluidic devices are driving growth in the organs-on-chips market.

Organs-on-Chips Market Overview

The Organs-on-chips market is expected to reach USD 944 million by 2035, growing at a CAGR of 24.8% during the forecast period till 2035.

In recent years, the pharmaceutical industry has witnessed the emergence of novel organs-on-chips products, including technologies and models, and chips and plates, designed to accelerate drug discovery and the development of personalized medications. It is worth noting that these microfluidic products offer enhanced in vitro simulation of human physiology by precisely imitating the human microenvironment and exploring cellular or disease conditions. Interestingly, these products support both organ and disease-based models, offering improved design, functionality and usability over conventional animal models, which improves the effectiveness of pre-clinical drug testing and toxicology studies. Further, these products are highly versatile, in terms of compatibility with different types of organs, including complex multi organ models, various types of construction materials and wide application areas. This versatility has driven a notable shift towards organs-on-chips, leading to their increased acceptance and adoption.

Browse 175+ figures and 190+ market data tables spread across 300+ pages and detailed Table of Content on “Organs-on-Chip Market by Type of Product (organ based and disease based),  Type of Organ (single organ and multi organ), Type of Single Organ based Model (liver, lung, brain, heart, intestine, kidney and other organs), Type of Material of Construction (polydimethylsiloxane, other polymer, glass and others), Purpose (research and therapeutic), Application Area (drug discovery / toxicity testing, cancer research, stem cell research, tissue engineering / regenerative medicine and others), End User (pharmaceutical and biotech companies, academic and research players, cosmetic industry players and other end users), Geographical Regions (North America (US, Canada and Rest of North America), Europe (UK, Germany, France, Italy, Spain and Rest of Europe), Asia-Pacific (China, Japan, South Korea, Australia and Rest of Asia-Pacific), Latin America and Middle East and North Africa)” here: https://www.rootsanalysis.com/reports/organ-on-a-chip-market.html

Market Drivers

Several factors are propelling the organs-on-chips market growth. One of the key factors driving the future of the market is the rising demand for animal-free testing methods. With the increasing ethical concerns surrounding animal use in drug testing, organs-on-chips are revolutionizing pre-clinical research by offering a sophisticated, animal-free platform to assess drug efficacy and toxicity. Moreover, numerous funding and partnership initiatives between governmental and private organizations have also bolstered the overall growth of the market.

Market Restraints  

Market restraints are the factors or conditions that can limit the growth and progress of a market. While the molecular diagnostics market is experiencing substantial growth, it is not without its challenges. The primary limitation of organs-on-chips technology is that it is currently limited to pre-clinical drug discovery. This raises concerns about the reliability of data generated from these models for its validation / utilization in the succeeding clinical trials. Additionally, the lack of established protocols and standardized guidelines in this field impairs the reproducibility of in vitro cultures, limiting the cost-effective production of organs-on-chips. Further, organs-on-chips require tissue-specific physiological functions, which primary cells often struggle to maintain in vitro conditions. This limits their use in long-term studies due to declining functionality in chronic diseases, thereby acting as a restraint to the overall market growth.

Growth Factors

Despite the significant challenges, various factors continue to drive the organs-on-chip market growth. Over the years, an increasing interest in the development of multi-organ chip systems, has been observed among industry stakeholders. The highly complex nature of multi organ chip systems allows for more accurate prediction of drug fate through ADMET pathways, making it a promising tool for studying human physiology and drug responses. Consequently, more effective drug candidates are anticipated to successfully advance to clinical trials. Additionally, the ability of organs-on-chips to evaluate patient-specific immunotherapies using patient-derived cells is expected to significantly advance the field of personalized medicine over the next decade, paving the way for more tailored and effective treatment options.

Organs-on-Chips Market Segments  

Based on the type of product, the market is segmented into organ based models and disease based models

• The organ based model segment is likely to capture the largest revenue share of 74% in the organs-on-chips market.
• The disease based model segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 26.9% during the forecast period.

Based on the type of organ, the market is segmented into single organ based models and multi organ based models

• The single organ based model segment captures the largest revenue share of close to 75% in the organs-on-chips market.
• The multi organ based model segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 28.2% during the forecast period.

Based on the type of single organ based model, the market is segmented into liver based models, lung based models, brain based models, heart based models, intestine based models, kidney based models and other organ based models

• The liver based model segment captures the largest revenue share of over 25% in the organs-on-chips market.
• The brain based model segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 25.6% during the forecast period.

Based on the type of material of construction, the market is segmented into polydimethylsiloxane based models, other polymer based models, glass based models and other material based models

• The polydimethylsiloxane based model segment captures the largest revenue share of over 45% in the organs-on-chips market.
• The other material based model segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 27.2% during the forecast period.

Based on purpose, the market is segmented into research and therapeutic

• The research segment captures the largest revenue share of close to 55% in the organs-on-chips market.
• The therapeutic segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 27.3% during the forecast period.

Based on application area, the market is segmented into drug discovery and toxicity testing, cancer research, stem cell research and tissue engineering and regenerative medicines

• The cancer research segment captures the largest revenue share of 45% in the organs-on-chips market.
• The stem cell research segment is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 26.5% during the forecast period.

Based on the type of end user, the market is segmented into pharmaceutical and biotech companies, academic and research institutes, cosmetic industry players and other end users

• The pharmaceutical and biotech companies capture the largest revenue share of nearly 70% in the organs-on-chips market.
• The cosmetic industry is anticipated to be the fastest growing segment in this industry, with an annualized growth rate (CAGR) of 27.5% during the forecast period.

Based on geography, the market is segmented into North America, Europe, Asia-Pacific, Latin America and Middle East and North Africa

• North America is likely to dominate the organs-on-chips market, by capturing the largest revenue share of over 40%, in 2024.
• In Europe, the organs-on-chips market is likely to demonstrate considerable growth (CAGR) of 26.3% during the forecast period.

Key Companies Profiled  

• The organs-on-chips market report also includes profiles of key players (listed below, alphabetically) that are engaged in the organ-on-chip market:
• AIM Biotech
• Beonchip
• BiomimX
• CN Bio Innovations
• Draper
• Dynamic42
• Emulate
• Hesperos
• InSphero
• Mimetas
• NETRI
• React4life
• SynVivo
• TissUse
• Xona Microfluidics

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