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Encapsulated cell-based products are increasingly being investigated across a myriad of clinical applications, potentially overcoming a number of barriers associated with conventional treatment options
-- Chief Scientist, an Israel based small-sized company
The live cell encapsulation market is estimated to be worth $81 million in 2019 and is expected to grow at CAGR of 21% during the forecast period. Chronic disorders, such as diabetes, cancer, heart disease, obesity, and certain types of mental health problems, are considered among the leading causes of death and disability across the globe. According to a report published by the Center for Managing Chronic Disease at the University of Michigan in 2018, more than 50% of the global population lives with some form of chronic illness. In 2018, the global prevalence of diabetes (considered to be one of the fastest-growing clinical conditions) was estimated to be around 425 million; likewise, around 450 million people worldwide are suffering from some form of mental health problem and / or neurological disorder. In addition, the World Health Organization (WHO) reported that different forms of cancers account for about 0.6 million deaths annually in the US alone. Over the years, advances in cell biology and regenerative medicine have led to the development of various cell-based therapies, which claim to possess the potential to address several unmet needs related to the treatment of different chronic clinical conditions. In fact, experts believe that mesenchymal stem cells may have the potential to improve patients' resistance to the ongoing novel COVID-19 infections. However, there are certain evident challenges, such as scarcity of viable donors, inherent immunogenicity, complications related to supply of oxygen / essential nutrients to grafted cells, drug delivery limitations, and the need for frequent re-administration of cells, which have so far restricted the use of cell-based interventions.
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Extensive research on cell encapsulation strategies have enabled the development of a variety of technologies capable of confining therapeutic entities within biocompatible matrices / carriers. Encapsulated therapy products offer a myriad of advantages, and have been shown to be capable of addressing existing concerns related to cell sourcing, obviating the need for complex surgical procedures, and enabling targeted drug delivery without the need for immunosuppressive follow-on regimens. In fact, since 2013, over 3,000 patents have been published related to the aforementioned type of therapy, indicating the rapid pace of R&D activities in live cell encapsulation market. Stakeholders have also received significant support from both private and public investors. However, the commercial success of such products is still dependent on ongoing clinical studies, as no such therapy has yet been approved.
Several recent developments have taken place in the field of live cell encapsulation market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.
Examples of key encapsulation companies engaged in live cell encapsulation market (which have also been profiled in this market report; the complete list of encapsulation companies is available in the full report) include Beta-O2 Technologies, Diatranz Otsuka, Sernova, ViaCyte, Betalin Therapeutics, Defymed, Kadimastem, Seraxis, Azellon Cell Therapeutics, EryDel, Erytech Pharma, Gloriana Therapeutics, Living Cell Technologies, MaxiVAX, Neurotech Pharmaceuticals, PharmaCyte Biotech and Sernova. This market report includes an easily searchable excel database of all the encapsulation companies providing live cell encapsulation therapeutics and technologies, worldwide.
The ‘Live Cell Encapsulation Market: Focus on Therapeutics and Technologies, 2019-2030’ market report features an extensive study of the current market landscape, market size, market share, market growth, market trends, market value, market forecast, market outlook, statistics and future opportunities of the live cell encapsulation market. It is worth mentioning that the market research report also provides insights on therapy products wherein other active drug substances have been encapsulated within living cells.
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Amongst other elements, the market research report features:
The key objective of live cell encapsulation market report is to provide a detailed market analysis in order to estimate the existing market size, market share, market growth, market trends, market value, market forecast, market outlook, statistics and future opportunity for live cell encapsulation market during the forecast period. Based on likely licensing deal structures and agreements that are expected to be signed in the foreseen future, we have provided an informed estimate on the likely evolution of the market for the forecast period 2019-2030. In addition, we have provided information on (potential) sales-based revenues generated by encapsulated cell therapies that are currently in late stages of development for the treatment of different chronic disorders, based on parameters, such as target consumer segments, likely adoption rates and expected pricing. The market report features likely distribution of the current and forecasted opportunity across [A] different therapeutic areas (eye disorders, metabolic disorders, neurological disorders, and oncological disorders), [B] target disease indications (ataxia telangiectasia, breast cancer, diabetes, glaucoma, head and neck cancer, macular telangectasia, pancreatic cancer, Parkinson's disease, and retinitis pigmentosa), [C] type of encapsulation material used (alginate-based microcapsules, cellulose hydrogels, medical-grade plastics, and red blood cells), and [D] key geographical regions (North America, Europe and Asia Pacific). To account for the uncertainties associated with the development of novel therapy products and to add robustness to our model, we have provided three market forecast scenarios, portraying the conservative, base and optimistic tracks of the market’s evolution.
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The opinions and insights presented in this market research report were influenced by discussions conducted with several stakeholders in live cell encapsulation market. The market report features detailed transcripts of interviews held with the following individuals:
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All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this market research report are in USD, unless otherwise specified.