Dendritic Cell Therapies Market

Dendritic Cell Therapies Market Overview

The focus of drug developers is gradually moving towards immunotherapeutics, which make use of the body’s own immune system or its components to fight cancer. It is a relatively new concept, with the only success being targeted antibody based therapeutics (including monoclonal and conjugated antibodies). These antibody based drugs are passive immunotherapeutics. There has been a surge of interest in other classes of active immunotherapeutics including cell based therapies such as Dendritic Cell Therapy (DCT) and Chimeric Antigen Receptor T cell Therapy (CAR-T).

DCT makes use of autologous or allogenic Antigen Presenting Cells (APCs) to stimulate the immune system to recognise and act against the tumors. In April 2010, the FDA approval of Sipuleucel-T (PROVENGE, manufactured by Dendreon Corporation), a dendritic cell vaccine, gave a push to the concept of DCT. However, the vaccine hasn’t been able to meet the high expectations. Despite this, the overall DCT outlook is promising; late stage development vaccines such as AGS-003, DCVax-L, DCVAC/PCa and Eltrapuldencel-T are likely to carry forward the baton.

With the similar aim to stimulate the body’s immune system, CAR-T uses the patient’s autologous effector T-cells, modifying it with a synthetic receptor enabling it to increase the tumor specific immune response. This therapy is expected to first enter market with the launch of CTL019 by Novartis in the next few years. In recent trials, CTL019 has shown complete remission in children with advanced cases of treatment-resistant ALL. Apart from Novartis, some other big pharmaceutical companies including Pfizer have entered the space. Juno Therapeutics, Takara Bio and Kite Pharma are other active players.

We anticipate the market to continue to rise steadily as several DC vaccines and CAR-T cell therapies get approval, both as monotherapy and combination therapy.

Recent Developments in Dendritic Cell and CAR-T Therapies Market:

Several recent developments have taken place in the field of dendritic cell and CART-T therapies. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

• In August 2023, Celularity entered into a research collaboration with Regeneron focusing on targeted allogeneic gamma delta chimeric antigen receptor (CAR) T-cell therapy used to enhance proliferation and potency against solid tumor. 
• In June 2023, Mendus entered into a collaboration with NorthX Biologics with an aim to develop and commercialize Mendus’ lead asset, vididencel, an allogeneic dendritic cell vaccine.

Scope of the Report

The ‘Dendritic Cell and CAR-T Therapies Market, 2014-2024’ report provides an extensive study on the two Whole Cell based Immunotherapies: Dendritic Cell Therapy (DCT) and Chimeric Antigen Receptor (CAR) T-cell Therapy. These upcoming fields of therapeutics are still in infancy, with only two DCT vaccines commercially available in 2014. The report covers various aspects, such as, existing cancer immunotherapeutics, main players in the DCT and CAR-T industry, products in clinical / pre-clinical research, technological developments and upcoming opportunities for several stakeholders.

As pharma companies continue to expand their research programs in this area, one of the key objectives outlined for this report is to understand the future potential of the market. This is done by analysing:

• DCT and CAR-T pipeline in terms of phase of development, target indications, types of molecule, etc.
• Companies participating in the development of these products highlighting their product portfolio, financial performance, patents, recent collaborations and future outlook.
• Interest of venture capital firms and recent funding rounds of small biotech firms developing whole cell based immunotherapies.
• Competitive landscape and inherent threats to growth in the short and long term.
• Development and sales potential based on target consumer segments, likely adoption rate and expected pricing.

The report gives an estimate of the short-mid term and long term markets for the period 2014 - 2024. The research, analysis and insights presented in this report include potential sales of the marketed DCT vaccine (PROVENGE) and eight pipeline products in late phases of development.

Owing to niche nature of the market, with most products in the pipeline, we have provided three market forecast scenarios to add robustness to our model. The conservative, base and optimistic scenarios represent three different tracks of industry evolution.

All actual figures have been sourced and analysed from publicly available information and discussions with industry experts. The figures mentioned in this report are in USD, unless otherwise specified.