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Dendritic Cell and CAR-T Therapies, 2014 - 2024

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  • Published
    November 2014

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    187

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Example Insights

  1. CreaVax-RCC (by JW CreaGene) became the first approved dendritic cell vaccine in 2007. However, its market has been restricted to South Korea. PROVENGE (by Dendreon) received FDA approval for launch in the US in 2010.
  2. In addition, we have identified 30 dendritic cell vaccines and 12 CAR-T therapies which are currently in clinical and preclinical development for different oncological indications. Of these, four dendritic cell vaccines are in Phase III trials. Majority of the CAR-T therapies are in early stages of development.
  3. The market is characterised by the presence of several small biotech firms; these firms are likely to benefit as more molecules reach advanced stages of development in the coming few years.
  4. There has been a growing interest from Venture Capital firms. In fact, in 2013 / 2014, several companies involved in DCT and CAR-T therapies have cumulatively raised over USD 500 million in venture funding rounds; this activity is likely to increase further and will help these companies drive their respective products to commercialisation.
  5. We expect dendritic cell and CAR-T therapies market to be a multi-billion dollar market over the coming decade; during the period 2014 – 2024, our forecast suggests that the market will witness an annualised rate of 29.8%.

Overview

The focus of drug developers is gradually moving towards immunotherapeutics, which make use of the body’s own immune system or its components to fight cancer. It is a relatively new concept, with the only success being targeted antibody based therapeutics (including monoclonal and conjugated antibodies). These antibody based drugs are passive immunotherapeutics. There has been a surge of interest in other classes of active immunotherapeutics including cell based therapies such as Dendritic Cell Therapy (DCT) and Chimeric Antigen Receptor T cell Therapy (CAR-T).

DCT makes use of autologous or allogenic Antigen Presenting Cells (APCs) to stimulate the immune system to recognise and act against the tumors. In April 2010, the FDA approval of Sipuleucel-T (PROVENGE, manufactured by Dendreon Corporation), a dendritic cell vaccine, gave a push to the concept of DCT. However, the vaccine hasn’t been able to meet the high expectations. Despite this, the overall DCT outlook is promising; late stage development vaccines such as AGS-003, DCVax-L, DCVAC/PCa and Eltrapuldencel-T are likely to carry forward the baton.

With the similar aim to stimulate the body’s immune system, CAR-T uses the patient’s autologous effector T-cells, modifying it with a synthetic receptor enabling it to increase the tumor specific immune response. This therapy is expected to first enter market with the launch of CTL019 by Novartis in the next few years. In recent trials, CTL019 has shown complete remission in children with advanced cases of treatment-resistant ALL. Apart from Novartis, some other big pharmaceutical companies including Pfizer have entered the space. Juno Therapeutics, Takara Bio and Kite Pharma are other active players.

We anticipate the market to continue to rise steadily as several DC vaccines and CAR-T cell therapies get approval, both as monotherapy and combination therapy.

 

Scope of the Report

The ‘Dendritic Cell and CAR-T Therapies Market, 2014-2024’ report provides an extensive study on the two Whole Cell based Immunotherapies: Dendritic Cell Therapy (DCT) and Chimeric Antigen Receptor (CAR) T-cell Therapy. These upcoming fields of therapeutics are still in infancy, with only two DCT vaccines commercially available in 2014. The report covers various aspects, such as, existing cancer immunotherapeutics, main players in the DCT and CAR-T industry, products in clinical / pre-clinical research, technological developments and upcoming opportunities for several stakeholders.

As pharma companies continue to expand their research programs in this area, one of the key objectives outlined for this report is to understand the future potential of the market. This is done by analysing:

  • DCT and CAR-T pipeline in terms of phase of development, target indications, types of molecule, etc.
  • Companies participating in the development of these products highlighting their product portfolio, financial performance, patents, recent collaborations and future outlook.
  • Interest of venture capital firms and recent funding rounds of small biotech firms developing whole cell based immunotherapies.
  • Competitive landscape and inherent threats to growth in the short and long term.
  • Development and sales potential based on target consumer segments, likely adoption rate and expected pricing.

The report gives an estimate of the short-mid term and long term markets for the period 2014 - 2024. The research, analysis and insights presented in this report include potential sales of the marketed DCT vaccine (PROVENGE) and eight pipeline products in late phases of development.

Owing to niche nature of the market, with most products in the pipeline, we have provided three market forecast scenarios to add robustness to our model. The conservative, base and optimistic scenarios represent three different tracks of industry evolution.

All actual figures have been sourced and analysed from publicly available information and discussions with industry experts. The figures mentioned in this report are in USD, unless otherwise specified.

Contents

Chapter 2  presents an executive summary of the report. The summary offers an insight to key highlights of the whole cell based immunotherapies and where the market is headed in the mid-long term.

Chapter 3  provides a general introduction to the market. In this section, we have briefly discussed the conventional therapies being used for oncology treatment, the advent of cancer immunotherapy and, specifically, the emergence DCT and CAR-T.

Chapter 4  provides a comprehensive landscape of the whole cell based immunotherapy market. This chapter includes information on over 40 molecules which are currently in different stages of development (both clinical and pre-clinical / discovery). The detailed analysis of this development pipeline includes information on therapy class, most commonly targeted indications and current phases of development.

Chapter 5  focuses on DCT and presents the current scenario and the future outlook of this specific class of vaccines. The chapter includes detailed profiles of marketed and late stage products. We have presented information on several parameters such as history of development, clinical trial results, manufacturing, cost and reimbursement. It includes the likely sales forecast of the drugs currently in Phase III or higher stage of development.

Chapter 6  focuses on CAR-T and presents the current scenario and the future outlook of this therapy. As with DCTs, this chapter provides a holistic view on the various cell therapy products belonging to CAR-Ts and their future sales potential.

Chapter 7  provides the detailed company profiles of the leading players in the market. Each company profile includes information on financial performance, geographical presence, marketed / pipeline drugs, recent collaborations and developments.

Chapter 8  is a collection of interview transcript(s)of the discussions which were held during the course of this study.

Chapter 9  summarizes the overall report. In this chapter, we provide a recap of the key takeaways and our independent opinion based on the research and analysis described in previous chapters.

Chapters 10 and 11  are appendices, which provide the list of companies and tabulated data for all the figures presented in the report.

Table of Contents

1. Preface
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
 
2. Executive Summary
 
3. Cancer Therapeutics and Immuno-Oncology
3.1. Chapter Overview
3.2. The Four Pillars of Cancer Therapy
3.3. Immunotherapy: Gaining A Strong Foothold
3.3.1. Activation and Suppression Immunotherapies
3.4. Immuno-Oncology (Cancer Immunotherapy)
3.5. Classification of Cancer Immunotherapies
3.5.1. By Mechanism of Action
3.5.2. By Product Class
3.5.2.1. Monoclonal Antibodies (mAbs)
3.5.2.2. Cytokines
3.5.2.3. Immune Checkpoint Inhibitors
3.5.2.4. Cell Based Therapies
 
4. Current Market Landscape
4.1. Scope and Observations
4.2. First DCT Reached the Market in 2007
4.3. Whole Cell Based Immunotherapies: Clinical and Preclinical Pipeline
4.3.1. DCTs are More Popular; CAR-Ts are Emerging
4.3.2. Four Products in Late Stage Clinical Development
4.4. DCT and CAR-Ts: A Comparison
4.5. DCT and CAR-Ts: Funding being Led by Venture Capital Firms
4.6. Overall Future Outlook
4.6.1. Scope and Forecast Methodology
4.6.2. Overall Market Size and Forecast, 2014 - 2024
 
5. Dendritic Cell Therapy: Key Molecules and Future Outlook
5.1. Introduction
5.2. Two Approved Products in the Market
5.3. Several Novel Molecules in the Pipeline
5.3.1. Focus on Solid Tumors
5.3.2. 50% of Molecules are in Phase II Clinical Trials and Above
5.3.3. Development Being Led by Small Biotech Firms
5.3.4. Gradual Evolution Towards Allogenic Dendritic Cells
 
5.4. PROVENGE (Dendreon Corporation)
5.4.1. Introduction
5.4.2. Mechanism of Action
5.4.3. Development Status
5.4.4. Key Clinical Trial Results
5.4.5. Manufacturing
5.4.6. Treatment Cost and Reimbursement
5.4.7. Historical Sales, 2010 – H1 2014
5.4.8. Competition for PROVENGE
5.4.9. PROVENGE Sales Forecast, 2014 - 2024
 
5.5. CreaVax-RCC (JW CreaGene)
5.5.1. Introduction
5.5.2. Development Status
5.5.3. Dosage, Treatment Cost and Manufacturing
 
5.6. AGS-003 (Argos Therapeutics)
5.6.1. Introduction
5.6.2. Arcelis: The Underlying Technology
5.6.3. Development Status
5.6.4. Key Clinical Trial Results
5.6.5. Dosage, Treatment Cost and Manufacturing
5.6.6. Target Population
5.6.7. Competition for AGS-003
5.6.8. Collaborations
5.6.9. AGS-003 Sales Forecast, 2014 - 2024
 
5.7. DCVax-L (Northwest Biotherapeutics)
5.7.1. Introduction
5.7.2. Prevalence of Disease
5.7.3. Mechanism of Action
5.7.4. Development Status
5.7.5. Dosage, Treatment Cost and Manufacturing
5.7.6. DCVax-L  Sales Forecast, 2014 – 2024
 
5.8. DCVAC/PCa (SOTIO)
5.8.1. Introduction
5.8.2. Active Cellular Immunotherapy: The Underlying Technology
5.8.3. Mechanism of Action
5.8.4. Prevalence of Disease
5.8.5. Development Status
5.8.6. Dosage, Treatment Cost and Manufacturing
5.8.7. DCVAC/PCa Sales Forecast, 2014 - 2024
 
5.9. Eltrapuldencel-T (NeoStem)
5.9.1. Introduction
5.9.2. Prevalence of Disease
5.9.3. Mechanism of Action
5.9.4. Development Status
5.9.5. Key Clinical Trial Results
5.9.6. Dosage, Treatment Cost and Manufacturing
5.9.7. Collaborations
5.9.8. Competitive Analysis
5.9.9. Eltrapuldencel-T Sales Forecast, 2014 - 2024
 
5.10. Overall Dendritic Cell Therapy Market, 2014 – 2024
5.11. Technological Developments
5.11.1. Allogenic Dendritic Cell Derived Therapies
5.11.2. Tolerogenic Dendritic Cells
5.12. Dendritic Cell Therapy: Roots Analysis’ Perspective
 
6. Chimeric Antigen Receptor-T Cell Therapy
6.1. Introduction
6.2. Structure of Chimeric Antigen Receptor
6.2.1. History of Development
6.2.2. No Marketed Product Yet; Novel Products in Pipeline
6.2.3. Development Being Led by Small Biotech Firms
6.2.4. CD19: The Most Sought After Target
6.2.5. Companies Moving Beyond Haematological Malignancies
 
6.3. CTL019 (Novartis)
6.3.1. Introduction
6.3.2. History of Development
6.3.3. Prevalence of Disease
6.3.4. Mechanism of Action
6.3.5. Development Status
6.3.6. Key Clinical Trial Results
6.3.7. Dosage, Treatment Cost And Manufacturing
6.3.8. Collaborations
6.3.9. CTL019 Sales Forecast, 2014 - 2024
 
6.4. JCAR (Juno Therapeutics)
6.4.1. Introduction
6.4.2. Mechanism of Action
6.4.3. Development Status
6.4.4. Key Clinical Trial Results
6.4.5. Dosage, Treatment Cost and Manufacturing
6.4.6. Collaborations
 
6.5. KTE-C19 (Kite Pharma)
6.5.1. Introduction
6.5.2. Mechanism of Action
6.5.3. Development Status
6.5.4. Key Clinical Trial Results
6.5.5. Dosage, Treatment Cost and Manufacturing
6.5.6. Collaborations
6.5.7. KTE-C19 Sales Forecast, 2014 - 2024
 
6.6. CD19 CAR (Takara Bio)
6.6.1. Introduction
6.6.2. Mechanism of Action
6.6.3. Development Status
6.6.4. Dosage, Treatment Cost and Manufacturing
6.6.5. Collaborations
6.6.6. CD19 CAR Sales Forecast, 2014 - 2024
 
6.7. EFGRvIII CAR (Kite Pharma)
6.7.1. Introduction
6.7.2. Mechanism of Action
6.7.3. Development Status
6.7.4. Dosage, Treatment Cost and Manufacturing Details
6.7.5. Collaborations
6.7.6. EGFRVIII CAR Sales Forecast, 2014 - 2024
 
6.8. ANTI-GD2 CAR (Bellicum Pharmaceuticals)
6.8.1. Introduction
6.8.2. Mechanism of Action
6.8.3. Development Status
6.8.4. Dosage
6.8.5. Collaborations
 
6.9. Overall CAR-T Therapy Market, 2014 – 2024
6.10. Technological Developments
6.10.1. Use of Safety Switch to Increase Safety
6.10.2. Use of Allogenic Sources
6.11. CAR-T Therapy: Roots Analysis’ Perspective
 
7. Company Profiles
7.1. Overview
7.2. Dendreon Corporation
7.2.1. Company Overview
7.2.2. Financial Information
7.2.3. Product Portfolio
7.2.4. Patent Portfolio
7.2.5. Partnerships
7.2.6. Future Outlook
 
7.3. JW CreaGene
7.3.1. Company Overview
7.3.2. Product Portfolio
7.3.3. Patent Portfolio
7.3.4. Partnerships
7.3.5. Future Outlook
 
7.4. Northwest Biotherapeutics
7.4.1. Company Overview
7.4.2. Financial Information
7.4.3. Product Portfolio
7.4.4. Patent Portfolio
7.4.5. Partnerships
7.4.6. Funding
7.4.7. Future Outlook
 
7.5. Argos Therapeutics
7.5.1. Company Overview
7.5.2. Financial Information
7.5.3. Product Portfolio
7.5.4. Patent Portfolio
7.5.5. Partnerships
7.5.6. Manufacturing
7.5.7. Funding
7.5.8. Future Outlook
 
7.6. NeoStem
7.6.1. Company Overview
7.6.2. Financial Information
7.6.3. Product Portfolio
7.6.4. Partnerships
7.6.5. Manufacturing
7.6.6. Future Outlook
 
7.7. SOTIO
7.7.1. Company Overview
7.7.2. Financial Information
7.7.3. Product Portfolio
7.7.4. Patent Portfolio
7.7.5. Partnerships
7.7.6. Manufacturing Facilities
 
7.8. Novartis
7.8.1. Company Overview
7.8.2. Financial Information
7.8.3. Product Portfolio
7.8.4. Partnerships
7.8.5. Manufacturing
7.8.6. Future Outlook
 
7.9. Juno Therapeutics
7.9.1. Company Overview
7.9.2. Financial Information
7.9.3. Product Portfolio
7.9.4. Patent Portfolio
7.9.5. Partnerships
7.9.6. Future Outlook
 
7.10. Kite Pharma
7.10.1. Company Overview
7.10.2. Financial Information
7.10.3. Product Portfolio
7.10.4. Partnerships
7.10.5. Future Outlook
 
7.11. Takara Bio
7.11.1. Company Overview
7.11.2. Financial Overview
7.11.3. Product Portfolio
7.11.4. Partnerships
7.11.5. Manufacturing
7.11.6. Future Outlook
 
7.12. Other Companies
7.12.1. Asterias Biotherapeutics
7.12.1.1. Stem cell and Regenerative Medicine Platform
7.12.1.2. DCT Pipeline
7.12.1.3. Partnerships
7.12.2. Bellicum Pharmaceuticals
7.12.2.1. CaspaCIDe Technology (Cell Elimination)
7.12.2.2. DeCIDe Technology (Cell Activation) / DCT Pipeline
7.12.3. Cellular Biomedicine Group
7.12.3.1. Regenerative Medicine and Cell Therapy
7.12.3.2. DCT Pipeline
7.12.3.3. Patent Portfolio
7.12.4. DCPrime BV
7.12.4.1. DCOne Platform
7.12.4.2. DCT Pipeline
7.12.4.3. Partnerships
7.12.5. Immunicum
7.12.5.1. COMBIG Platform /DCT Pipeline
7.12.5.2. CD70 Platform
7.12.5.3. Patent Portfolio
7.12.6. Kiromic
7.12.6.1. DCT Pipeline
7.12.6.2. Other Therapeutic and Diagnostic Technologies
7.12.7. MediGene
7.12.7.1. DCT Pipeline
7.12.7.2. T cell Immunotherapy Platform
7.12.7.3. Patent Portfolio
7.12.7.4. Partnerships
7.12.8. Prima BioMed
7.12.8.1. DCT Pipeline
7.12.8.2. Partnerships
7.12.9. bluebird bio
7.12.9.1. Gene Therapy Platform
7.12.9.2. CAR-T Pipeline
7.12.9.3. Partnerships
7.12.10. Cellectis
7.12.10.1. UCART Technology
7.12.10.2. CAR-T Pipeline
 
8. Interview Transcripts
 
9. Conclusion
9.1. Whole Cell Based Therapy: Expanding the Cancer Immunotherapeutics Market
9.2. The Emerging Market Reveals a Promising Future
9.3. Companies are Focussing on Development of In-house Technology/Platform
9.4. With A Healthy Growth Rate, We Expect It To Be A Multi Billion Market
9.5. Concluding Remarks
 
10. Appendix 1: Tabulated Data
 
11. Appendix 2: List of Companies and Organisations

List of Figures

Figure 2.1  DCT and CAR-T Clinical Trials: Market Map
Figure 3.1  Four Pillars of Cancer Therapy
Figure 3.2  Passive and Active Cancer Immunotherapies
Figure 4.1  Pipeline Analysis: Distribution by Type of Molecule
Figure 4.2  Pipeline Analysis: Distribution by Highest Phase of Development
Figure 4.3  Whole Cell based Therapy: Overall Sales Forecast, 2014 - 2024: Base Scenario (USD Million)
Figure 5.1 DCT Pipeline Analysis: Distribution of Molecules by Indication
Figure 5.2  DCT Pipeline Analysis: Distribution of Molecules by Highest Phase of Development
Figure 5.3  DCT Pipeline Analysis: Distribution of Molecules by Company
Figure 5.4  DCT Pipeline Analysis: Sources of Dendritic Cells
Figure 5.5  PROVENGE Sales, 2010 – H1 2014 (USD Million)
Figure 5.6  PROVENGE: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 5.7  AGS-003: Sales Forecast, 2014 – 2024, Base Scenario (USD Million)
Figure 5.8  DCVax-L: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 5.9  DCVAC/PCa: Sales Forecast, 2014 – 2024, Base Scenario (USD Million)
Figure 5.10 Geographical Distribution of Death Rate due to Skin Cancer (Cases per 100,000 Persons)
Figure 5.11 Eltrapuldencel-T: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 5.12 Overall DCT Forecast, 2014-2024 (USD Million)
Figure 5.13 Overall DCT Forecast (2014, 2019, 2024): Distribution by Vaccines
Figure 5.14 Drivers and Restraints of DCT
Figure 6.1  Development of CAR-T Cells
Figure 6.2  CAR-T Pipeline Analysis: Distribution of Molecules by Highest Phase of Development
Figure 6.3  CAR-T Pipeline Analysis: Distribution of Molecules by Company
Figure 6.4  CAR-T Pipeline Analysis: Distribution by Target
Figure 6.5  Incidence of Four Main Types of Leukaemia in the US, 2013 (%)
Figure 6.6  CTL019: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 6.7  KTE-C19: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 6.8  CD19 CAR: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Figure 6.9  EGFRVIII CAR: Sales Forecast 2014 - 2024: Base Scenario (USD Million)
Figure 6.10 Overall CAR-T Forecast, 2014-2024 (USD Million)
Figure 6.11 Overall CAR-T Forecast (2017, 2021, 2024): Distribution by Therapy
Figure 6.12 Drivers and Restraints of CAR-T Therapy
Figure 7.1  Dendreon Corporation: Revenues (USD Million), 2010–H1 2014
Figure 7.2  Northwest Biotherapeutics: Revenues (USD), 2003-2013
Figure 7.3  Argos Therapeutics: Revenues, 2011-2013 (USD Million)
Figure 7.4  NeoStem: Revenues, 2012- 2013 (USD Million)
Figure 7.5  PPF Group: Revenues, 2010-2013 (EUR Million)
Figure 7.6 Novartis Healthcare: Revenue, 2013: Distribution by Operating Segments (USD Million)
Figure 7.7  Novartis Pharmaceuticals: Revenues, 2009-2013 (USD Million)
Figure 7.8  Takara Bio: Revenue, 2010-2014 (YEN Million)
Figure 7.9  Takara Bio: Revenue, 2014:  Distribution by Operating Segments (YEN Million)
Figure 9.1  Whole Cell Therapy Market (USD Million), 2017, 2021 and 2024

List of Tables

Table 3.1 FDA Approved Antibody Based Therapeutics for Cancer
Table 4.1  DCT and CAR-Ts: Clinical and Preclinical Pipeline
Table 4.2  Comparison of DCT and CAR-Ts
Table 4.3  DCT and CAR-T Companies: Funding Rounds
Table 4.4  Whole Cell based Therapy: Current Development Phase and Expected Launch Years
Table 5.1  DCT: Clinical and Preclinical Pipeline
Table 5.2 PROVENGE: Current Status of Development
Table 5.3  Comparison of Recently Approved Drugs for mCRPC
Table 5.4  Advantages of PROVENGE Over Competitors
Table 5.5  CreaVax-RCC: Current Status of Development
Table 5.6  AGS-003: Current Status of Development
Table 5.7  Target Population for AGS-003 in the US, 2013
Table 5.8  Comparison of Drugs Approved for RCC
Table 5.9  AGS-003: Partnerships
Table 5.10  DCVax-L: Current Status of Development
Table 5.11  DCVAC/PCa: Current Status of Development
Table 5.12  Eltrapuldencel-T: Current Status of Development
Table 5.13  Comparison of Marketed Targeted Therapeutics for Melanoma
Table 5.14  Advantages of Eltrapuldencel-T
Table 5.15  DCT Forecast: Expected Launch Years
Table 6.1  CAR-T Therapy: Clinical and Preclinical Pipeline
Table 6.2  CTL019: Current Status of Development
Table 6.3  JCAR: Current Status of Development
Table 6.4  KTE-C19: Current Status of Development
Table 6.5  CD19 CAR: Current Status of Development
Table 6.6  EGFRvIII CAR-T: Current Status of Development
Table 6.7  Anti-GD 2-CAR: Current Status of Development
Table 6.8  CAR-T Forecast: Expected Launch Years
Table 7.1 Dendreon Corporation: Patent Portfolio
Table 7.2  JW CreaGene: Product Portfolio
Table 7.3  JW CreaGene: Patent Portfolio
Table 7.4  Northwest Biotherapeutics: Product Portfolio
Table 7.5  Northwest Biotherapeutics: Patent Portfolio
Table 7.6  AGS-003: Development Status
Table 7.7  Argos Therapeutics: Patent Portfolio
Table 7.8  Developmental status of DCVAC
Table 7.9  SOTIO: Patent Portfolio
Table 7.10  Asterias Biotherapeutics: DCT Pipeline, 2014
Table 7.11  Bellicum Pharmaceutical: DCT Pipeline, 2014
Table 7.12  CBMG: DCT Pipeline, 2014
Table 7.13  DCPrime: DCT Pipeline, 2014
Table 7.14  Immunicum: DCT Pipeline, 2014
Table 7.15  Kiromic: DCT Pipeline, 2014
Table 7.16  MediGene: DCT Pipeline, 2014
Table 7.17  PrimaBioMed: DCT Pipeline, 2014
Table 7.18 bluebird bio:CAR-T Pipeline, 2014
Table 7.19  Cellectis: CAR-T Pipeline, 2014
Table 10.1  Pipeline Analysis: Distribution by Type of Molecule
Table 10.2  Pipeline Analysis: Distribution by Highest Phase of Development
Table 10.3  Whole Cell based Therapy: Overall Sales Forecast, 2014 - 2024: Base Scenario (USD Million)
Table 10.4  Whole Cell based Therapy: Overall Sales Forecast, 2014 - 2024: Optimistic Scenario (USD Million)
Table 10.5 Whole Cell based Therapy: Overall Sales Forecast, 2014 - 2024: Conservative Scenario (USD Million)
Table 10.6  Pipeline Analysis: Distribution of Molecules by Indication
Table 10.7  Pipeline Analysis: Distribution of Molecules by Highest Phase of Development
Table 10.8  Pipeline Analysis: Distribution of Molecules by Company
Table 10.10  Pipeline Analysis: Sources of Dendritic Cells
Table 10.11  PROVENGE Sales, 2010 – H1 2014 (USD Million)
Table 10.12  PROVENGE: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.13  PROVENGE: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.14  PROVENGE: Sales Forecast, 2014 - 2024, Conservative Scenario (USD  Million)
Table 10.15  AGS-003: Sales Forecast, 2014 - 2024: Base Scenario (USD Million)
Table 10.16  AGS-003: Sales Forecast, 2014 - 2024: Optimistic Scenario (USD Million)
Table 10.17  AGS-003: Sales Forecast, 2014 - 2024: Conservative Scenario (USD Million)
Table 10.18  DCVax-L: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.19  DCVax-L: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.20  DCVax-L: Sales Forecast, 2014 - 2024, Conservative Scenario (USD Million)
Table 10.21  DCVAC/PCa: Sales Forecast, 2014 – 2024, Base Scenario (USD Million)
Table 10.22  DCVAC/PCa: Sales Forecast, 2014 – 2024, Optimistic Scenario (USD Million)
Table 10.23  DCVAC/PCa: Sales Forecast, 2014 – 2024, Conservative Scenario (USD Million)
Table 10.24  Geographical Distribution of Death Rate due to Skin Cancer (Cases per 100,000 Persons)
Table 10.25  Eltrapuldencel-T: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.26  Eltrapuldencel-T: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.27  Eltrapuldencel-T: Sales Forecast, 2014 - 2024, Conservative Scenario (USD Million)
Table 10.28  Overall DCT Forecast, 2014-2024 (USD Million)
Table 10.29  Overall DCT Forecast, 2014, 2019, 2024: Distribution by Vaccine
Table 10.30  CAR-T Pipeline Analysis: Distribution of Molecules by Highest Phase of Development
Table 10.31  CAR-T Pipeline Analysis: Distribution of Molecules by Company
Table 10.32  CAR-T Pipeline Analysis: Distribution by Target
Table 10.33  Incidence of Four Main Types of Leukaemia in the US, 2013 (%)
Table 10.34 CTL019: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.35  CTL019: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.36  CTL019: Sales Forecast, 2014 - 2024, Conservative Scenario (USD Million)
Table 10.37  KTE-C19: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.38  KTE-C19: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.39  KTE-C19: Sales Forecast, 2014 -2024, Conservative Scenario (USD Million)
Table 10.40  CD19 CAR: Sales Forecast, 2014 - 2024, Base Scenario (USD Million)
Table 10.41  CD19 CAR: Sales Forecast, 2014 - 2024, Optimistic Scenario (USD Million)
Table 10.42  CD19 CAR: Sales Forecast, 2014 - 2024, Conservative Scenario (USD Million)
Table 10.43  EGFRVIII CAR: Sales Forecast, 2014 - 2024: Base Scenario (USD Million)
Table 10.44  EGFRVIII CAR: Sales Forecast, 2014 – 2024, Optimistic Scenario (USD Million)
Table 10.45  EGFRVIII CAR: Sales Forecast, 2014 – 2024, Conservative Scenario (USD Million)
Table 10.46  Overall CAR-T Forecast, 2014-2024 (USD Million)
Table 10.47  Overall CAR-T Forecast, 2017, 2021, 2024: Distribution by Molecule
Table 10.48  Dendreon Corporation: Revenues (USD Million), 2010–H1 2014
Table 10.49  Northwest Biotherapeutics: Revenues (USD), 2003-2013
Table 10.50  Argos Therapeutics: Annual Revenues, 2011-2013 (USD Million)
Table 10.51  NeoStem: Annual Revenues 2012- 2013 (USD Million)
Table 10.52  PPF Group: Annual Revenues 2010-2013 (EUR Million)
Table 10.53  Novartis Healthcare: Distribution by Operating Segments, 2013 (USD Million)
Table 10.54  Novartis Pharmaceuticals: Annual Revenues, 2009-2013 (USD Million)
Table 10.55   Takara Bio: Annual Revenue, 2010-2014 (YEN Million)
Table 10.56  Takara Bio: Revenue Distribution by Operating Segment, 2014 (YEN Million)
Table 10.57  Whole Cell Therapy Market 2017, 2021 and 2024 (USD Billion)

Listed Companies

The following companies and organisations have been mentioned in this report.

  1. Activartis Biotech
  2. Argos Therapeutics
  3. Artecel
  4. Asterias Biotherapeutics
  5. Bayer Healthcare
  6. Bellicum Pharmaceuticals
  7. bluebird bio
  8. BMS
  9. Cabaret Biotech Limited
  10. California Stem Cell, Inc.
  11. Cancer Research UK
  12. Cancer Research Technology
  13. Celdara Medical
  14. Celgene Corporation
  15. Cellectis
  16. Cellular Biomedicine Group
  17. Centre Memorial Sloan- Kettering Cancer
  18. Ciba-Geigy
  19. City of Hope Medical Center
  20. Cognate
  21. DanDrit Biotech
  22. DCPrime
  23. Delta-Vir Immunotherapeutics
  24. Dendreon
  25. Duke University
  26. Fraunhofer Institute
  27. Fred Hutchinson Cancer Research Center
  28. Fujifilm Diosynth Biotechnologies
  29. Genentech
  30. Genetix Pharmaceuticals
  31. German Research Foundation
  32. Geron
  33. GlaxoSmithKline
  34. Green Cross Corporation
  35. Horizon Technology Finance
  36. Immunicum
  37. ImmunoCellular Therapeutics
  38. Jichi Medical University Hospital
  39. Johnson and Johnson
  40. Juno Therapeutics
  41. JW CreaGene
  42. Kings College
  43. Kiromic
  44. Kitasato Institute
  45. Kite Pharma
  46. Masonic Cancer Center
  47. Medical School of Charles
  48. MediGene
  49. Medinet
  50. Memorial Sloan Kettering Cancer Centre
  51. Merck
  52. National Cancer Institute
  53. NeoStem
  54. Northwest Biotherapeutics
  55. Novartis
  56. Onyx Pharmaceuticals
  57. OriBase Pharma
  58. Orpechem Peptide Chemicals
  59. Oxford BioMedica
  60. Paul Ehrlich Institute
  61. Pfizer
  62. PharmaCell
  63. Pharmstandard International
  64. PPF Group
  65. Prima BioMed
  66. Progenitor Cell Therapy LLC
  67. Regen BioPharma
  68. Roche
  69. Rockefeller University
  70. Sandoz
  71. Seattle Children’s Hospital
  72. Signifix
  73. SOTIO
  74. Takara Bio
  75. Technological Developments
  76. Tella
  77. TILT Biotherapeutics
  78. Trianta Immunotherapies
  79. University of Pennsylvania
  80. University of Wisconsin
  81. University of Antwerp
  82. University of Gent
  83. Vlaams Instituutvoor Biotechnologie
  84. VU University Medical Center

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