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HDAC Inhibitors Market, 2016 - 2026

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    August 2016

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Example Insights

  1. Nearly 90 HDAC inhibitors are currently in clinical / preclinical stages of development; the clinical molecules account for over 30% of the pipeline while over 60% is captured by molecules in the preclinical / discovery stage.
  2. With 66% of the pipeline molecules targeting oncological indications, cancer remains one of the most widely studied field for HDAC inhibitors. Within oncology, hematological malignancies such as PTCL and CTCL are popular targets; three HDAC inhibitors (Zolinza™, ISTODAX® and BELEODAQ®) are approved for these indications. Other therapeutic areas such as autoimmune disorders, infectious diseases, inflammatory disorders, neurological disorders, are also gradually gaining traction.
  3. Although the market was initially led by the large-size pharma players (such as Celgene, Merck, Novartis), the current market is characterized by the presence of several small / mid-sized pharma players. Notable examples of the small and mid-sized firms include 4SC, Chroma Therapeutics, CrystalGenomics, Curis, Evgen Pharma, FORUM Pharmaceuticals, Karus Therapeutics, Mirati Therapeutics, MEI Pharma, Shenzhen Chipscreen Biosciences, Syndax Pharmaceuticals and TetraLogic Pharmaceuticals.
  4. In addition, there are several non-industry institutes and universities that are primarily carrying out preclinical research. Examples of these include Harvard Medical School (BG45), Imperial College London (C1A), Kyoto University (Jδ, Sδ), National Taiwan University (Quinazolin-4-one derivatives), Taipei Medical University (MPT0E028), University of Messina (MC-1575, MC-1568).
  5. Four of the five approved drugs are pan-HDAC inhibitors targeting HDAC isoforms non-specifically. However, in the past few years, several class selective HDAC inhibitors have entered the clinic; these are associated with a higher efficacy and result in decreased toxicity from the treatment. Of the total HDAC inhibitors identified, 52% of the molecules are class specific; of these, 33% molecules target Class I specific isoforms and the rest target Class II specific isoforms of HDACs. Notable examples of molecules targeting class-specific HDACs includeentinostat (phase III), resminostat (phase II), SHP-141 (phase II), mocetinostat (phase II), CHR-3996 (phase I/II) and ricolinostat (phase I/II).
  6. The HDAC inhibitors market is expected to grow at a healthy annual rate of 32% over the next decade.With multiple potential target indications, Istodax® is expected to capture the largest market share (close to 21%) in 2026, followed by entinostat, Farydak® and Beleodaq®.

Report Description

Epigenetics is defined as a heritable change in the gene expression and its activity without alteration in the DNA sequence. The different epigenetic mechanisms through which gene expression can be modulated primarily include histone modification, DNA methylation, alteration of chromatin architecture and involvement of small-interfering or non-coding RNAs. Enzymes such as histone acetyltransferases (HATs), histone methyltransferases (HMTs), histone deacetylases (HDACs) and histone demethylases (DMTs) play significant role in epigenetic regulation. HATs and HDACs are the two major enzyme classes involved in post-translational modification of N-terminal tail of the histone proteins; HATs are responsible for acetylation of N-terminal histone tail whereas HDACs possess an opposite mode of action and act by removing the attached acetyl group.

Currently, HDACs are widely being studied as a promising therapeutic target. HDAC inhibitors can be classified into four main categories based on the structural characteristics of the Zn2+ binding domain. These include hydroxamic acids, cyclic peptides, short-chain fatty acids and benzamides. In addition to the synthetic HDAC inhibitors, the HDAC inhibitory role of various naturally occurring molecules has recently been discovered. These include molecules such as curcumin, depudecin, flavone and taipoxin.

There are five commercialized HDAC inhibitors, majority of which are primarily targeting hematological malignancies. Approval of the first HDAC inhibitor, Zolinza™(vorinostat), in 2006 for treatment of CTCL gave the market an initial impetus. The momentum was carried on by the other molecules that were marketed in 2009 (Istodax®), 2014 (Beleodaq®, Epidaza®) and 2015 (Farydak®). These drugs are currently being evaluated for several other indications as a single agent or as a combination therapy in lower stages of development.

 

Scope of the Report

The “HDAC Inhibitors Market, 2016-2026” report was commissioned to examine the current landscape and the future outlook of the growing pipeline of products in this area. HDACs have been studied in cellular processes such as apoptosis, autophagy, metabolism, DNA damage repair, cell cycle control and senescence. Altered expression of HDACs has been observed in different tumors; this makes them a potential target for treatment of cancer and other genetic or epigenetic related disorders. Inhibition of HDACs has shown positive results in disruption of multiple cell signaling pathways and prevention of tumor growth.

The HDAC inhibitors market has steadily evolved over the last few years with many drug candidates designed to address a wide range of oncological and non-oncological disorders. With five commercialized products, the market has gained attention from several industry and non-industry players. Initially, the market was led by big pharma players; however, the success of the marketed products has encouraged several start-ups and mid-sized firms to step into this lucrative space. We identified around 21 start-ups and 14 mid-sized companies that are exploring the opportunities presented by HDAC inhibitors. Currently, the HDAC inhibitors’ pipeline comprises of over 90 molecules under development. It is worth highlighting that over the last few years, the focus has shifted from pan-HDAC to class-specific HDAC inhibitors. Additionally, the research activity, with respect to the number of publications, has been highly promising. With an intense research framework, there have been over 9500 papers published in the last 10 years (as captured in PubMed). Further, increasing popularity on social media validates the growing interest in this field. The analysis conducted from 2009 to 2015 demonstrates a Compound Annual Growth Rate (CAGR) of 33% in the tweets registered on Twitter. Similar trends have been observed on Facebook.

As pharmaceutical companies continue to initiate and expand their research programs in this area, one of the key objectives outlined for this report was to understand the future potential of the market. This was done by analyzing:

  • The HDAC inhibitor pipeline (marketed, clinical and preclinical drugs) in terms of phase of development, HDAC class specificity and the evolving therapeutic areas / target indications.
  • The likely adoption of the HDAC inhibitors by understanding the competition posed by the current treatment regime in the coming few years.
  • The emerging trends and the popularity of HDAC inhibitors on social media such as Twitter and Facebook over the last few years.
  • The research activity in this field in terms of the focus of the publications / research articles granted across the globe in the last two years.

The study provides a detailed market forecast and opportunity analysis for the time period 2016-2026. The research, analysis and insights presented in this report include potential sales of the approved drugs and the ones in late stages of development (phase III and phase II). To add robustness to our model, we have provided three scenarios for our market forecast; these include the conservative, base and optimistic scenarios. Our opinions and insights, presented in this study were influenced by several discussions we conducted with experts in this area. All actual figures have been sourced and analyzed from publicly available information forums and primary research discussions. Financial figures mentioned in this report are in USD, unless otherwise specified.

Contents

Chapter 2  provides an executive summary of the report. It offers a high level view on where the HDAC inhibitors market is headed in the mid to long term.

Chapter 3  explains the central dogma of molecular biology and fundamentals of epigenetics. It elaborates on the effects of histone modifications such as methylation, acetylation, phosphorylation, ubiquitination and sumoylation on the biological processes such as DNA replication, transcription and repair. Additionally, the chapter highlights the classification of HDACs and HDAC inhibitors and discusses the specific role of HDAC inhibition in regulation of various biological processes. The chapter also provides an overview of the various disease indications across multiple therapeutic areas being targeted by HDAC inhibitors.

Chapter 4  includes information on over 90 molecules that are either approved or are being evaluated in different stages of development (clinical and preclinical/discovery). We have identified the companies that are active in this market and conducted a detailed pipeline analysis highlighting the most commonly targeted indications, target classes of HDAC, phases of development and specific geographical pockets where innovation is mostly concentrated.

Chapter 5  provides comprehensive profiles of the marketed, phase III and phase II drug candidates with a detailed understanding on the drug specification, mechanism of action, clinical development status, key clinical trial results, collaborations and overview of sponsors.

Chapter 6  presents key insights on HDAC inhibitors. It provides a schematic representation highlighting the distribution of HDAC inhibitors by target class, therapeutic area and highest phase of development. The chapter presents the landscape of industrial and non-industrial developers of HDAC inhibitors. Additionally, it presents a detailed comparative analysis on the key clinical trial endpoints for drugs that are marketed or in phase III and phase II of development.

Chapter 7  highlights the sales forecast and the associated monetary opportunity offered by this class of drugs. We have provided detailed insights covering target patient population, likely price points and the adoption rates of marketed, phase III and phase II HDAC inhibitors.

Chapter 8  presents publication analysis of the articles published on HDAC inhibitors in PubMed over the last two years. The chapter covers some important aspects of these publications such as the most studied disease areas, phase of the study and the drug combinations under investigation.

Chapter 9  provides the emerging trends on social media related to HDAC inhibitors. It presents an overview of the popularity of the keywords  histone deacetylase inhibitor  and  HDAC inhibitor  on Twitter and Facebook from 2009 to 2015.

Chapter 10  summarizes the overall report. In this chapter, we provide a recap of the key takeaways and our independent opinion based on the research and analysis described in previous chapters.

Chapter 11  is a collection of interview transcripts of the discussions that were held with key stakeholders in this market. We have presented the details provided to us by Dr. Simon Kerry (CEO of Karus Therapeutics), Dr. James Christensen (CSO and Senior VP of Mirati Therapeutics) and Dr. Hyung J. Chun (Associate Professor of Medicine, Yale School of Medicine)

Chapter 12  is an appendix, which provides tabulated data and numbers for all the figures provided in the report.

Chapter 13  is an appendix, which provides the list of companies and organizations mentioned in the report.

Table of Contents

1. PREFACE
1.1. Scope of the Report
1.2. Research Methodology
1.3. Chapter Outlines
 
2. EXECUTIVE SUMMARY
 
3. INTRODUCTION
3.1. The Central Dogma of Molecular Biology and Cell Cycle
3.2. DNA: Structure and Functions
3.3. Fundamentals of Epigenetics
3.3.1. Effect of Histone Modification on DNA Based Processes
3.3.2. Chromatin Structure Modification and its Enzymes
3.4. Histone Deacetylases (HDACs)
3.4.1. Classification of HDACs
3.4.2. Role of HDACs and HDAC Inhibitors in Cellular Processes
3.5. HDAC Inhibitors
3.5.1. Structure and Classification
3.5.2. Different Types of HDAC Inhibitors
3.5.3. Therapeutic Applications of HDAC Inhibitors
 
4. HDAC INHIBITORS: MARKET LANDSCAPE
4.1. Chapter Overview
4.2. Development Pipeline of HDAC Inhibitors
4.3. Distribution by Phase of Development
4.4. Distribution by Therapeutic Area
4.5. Distribution by Class Specificity
4.6. Distribution by Type of Developer
4.7. Distribution by Geography
4.8. Active Industry Players
 
5. DRUG PROFILES: MARKETED AND LATE-STAGE HDAC INHIBITORS
5.1. Chapter Overview
5.2. Company and Drug Profiles: Marketed and Phase III Molecules
5.2.1. Celgene Corporation
5.2.1.1. Company Overview
5.2.1.2. Financial Information
5.2.1.3. Product Profile: Istodax® (Romidepsin)
5.2.1.3.1. Drug Specifications
5.2.1.3.2. Mechanism of Action
5.2.1.3.3. Current Status of Development
5.2.1.3.4. Clinical Studies
5.2.1.3.5. Key Clinical Trial Results
5.2.1.3.6. Dosage Regimen, Manufacturing and Sales
 
5.2.2. Onxeo
5.2.2.1. Company Overview
5.2.2.2. Financial Information
5.2.2.3. Product Profile: Beleodaq® (Belinostat / PXD101)
5.2.2.3.1. Drug Specifications
5.2.2.3.2. Mechanism of Action
5.2.2.3.3. Current Status of Development
5.2.2.3.4. Clinical Studies
5.2.2.3.5. Key Clinical Trial Results
5.2.2.3.6. Dosage Regimen and Sales
5.2.2.3.7. Collaborations
 
5.2.3. Novartis
5.2.3.1. Company Overview
5.2.3.2. Financial Performance
5.2.3.3. Product Profile: Farydak® (Panobinostat / LBH589)
5.2.3.3.1. Drug Specifications
5.2.3.3.2. Mechanism of Action
5.2.3.3.3. Current Status of Development
5.2.3.3.4. Clinical Studies
5.2.3.3.5. Key Clinical Trial Results
5.2.3.3.6. Dosage Regimen
 
5.2.4. Shenzhen Chipscreen Biosciences
5.2.4.1. Company Overview
5.2.4.2. Product Profile: Epidaza® (Chidamide)
5.2.4.2.1. Drug Specifications
5.2.4.2.2. Mechanism of Action
5.2.4.2.3. Current Status of Development
5.2.4.2.4. Clinical Studies
5.2.4.2.5. Key Clinical Trial Results
5.2.4.2.6. Collaborations
 
5.2.5. Syndax Pharmaceuticals
5.2.5.1. Company Overview
5.2.5.2. Product Profile: Entinostat (SNDX-275 / MS-275)
5.2.5.2.1. Drug Specifications
5.2.5.2.2. Mechanism of Action
5.2.5.2.3. Current Status of Development
5.2.5.2.4. Clinical Studies
5.2.5.2.5. Key Clinical Trial Results
5.2.5.2.6. Collaborations
 
5.3. Drug Profiles: Phase II Molecules
5.3.1. Abexinostat (PCI-24781)
5.3.1.1. Drug Specifications and Mechanism of Action
5.3.1.2. Current Status of Development
5.3.1.3. Clinical Studies
5.3.1.4. Key Clinical Trial Results
5.3.1.5. Collaborations
 
5.3.2. CUDC-907
5.3.2.1. Drug Specifications and Mechanism of Action
5.3.2.2. Current Status of Development
5.3.2.3. Clinical Studies
5.3.2.4. Key Clinical Trial Results
5.3.2.5. Collaborations
 
5.3.3. FRM-0334 (EVP-0334)
5.3.3.1. Drug Specifications and Mechanism of Action
5.3.3.2. Current Status of Development
5.3.3.3. Clinical Studies
5.3.3.4. Collaborations
 
5.3.4. Givinostat (ITF2357)
5.3.4.1. Drug Specifications and Mechanism of Action
5.3.4.2. Current Status of Development
5.3.4.3. Clinical Studies
5.3.4.4. Key Clinical Trial Results
5.3.4.5. Collaborations
 
5.3.5. Mocetinostat (MGCD103)
5.3.5.1. Drug Specifications and Mechanism of Action
5.3.5.2. Current Status of Development
5.3.5.3. Clinical Studies
5.3.5.4. Key Clinical Trial Results
5.3.5.5. Collaborations
 
5.3.6. Pracinostat (SB939)
5.3.6.1. Drug Specifications and Mechanism of Action
5.3.6.2. Current Status of Development
5.3.6.3. Clinical Studies
5.3.6.4. Key Clinical Trial Results
5.3.6.5. Collaborations
 
5.3.7. Resminostat (4SC-201)
5.3.7.1. Drug Specifications and Mechanism of Action
5.3.7.2. Current Status of Development
5.3.7.3. Clinical Studies
5.3.7.4. Key Clinical Trial Results
5.3.7.6. Collaborations
 
5.3.8. SFX-01
5.3.8.1. Drug Specifications and Mechanism of Action
5.3.8.2. Current Status of Development
5.3.8.3. Clinical Studies
5.3.8.4. Collaborations
 
5.3.9. SHAPE (SHP-141)
5.3.9.1. Drug Specifications and Mechanism of Action
5.3.9.2. Current Status of Development
5.3.9.3. Clinical Studies
5.3.9.4. Key Clinical Trial Results
5.3.9.5. Collaborations
 
5.3.10. Tefinostat (CHR-2845)
5.3.10.1. Drug Specifications and Mechanism of Action
5.3.10.2. Current Status of Development
5.3.10.3. Clinical Studies
5.3.10.4. Key Clinical Trial Results
 
6. KEY INSIGHTS: THERAPEUTIC AREA, CLASS SPECIFICITY, CLINICAL ENDPOINTS
6.1. Clinical Development Analysis: Class Specificity and Therapeutic Areas
6.2. Clinical Development Analysis: Developer Landscape
6.3. Clinical Development Analysis: Trial Endpoint Comparison
 
7. MARKET FORECAST AND OPPORTUNITY ANALYSIS
7.1. Chapter Overview
7.2. Scope and Limitations
7.3. Forecast Methodology
7.4. Overall HDAC Inhibitors Market
 
7.5. HDAC Inhibitors Market: Individual Forecasts
7.5.1. Zolinza™ (Merck)
7.5.2. Istodax® (Celgene Corporation)
7.5.2.1. Target Patient Population
7.5.2.2. Sales Forecast
 
7.5.3. Beleodaq® (Onxeo)
7.5.3.1. Target Patient Population
7.5.3.2. Sales Forecast
 
7.5.4. Farydak® (Novartis)
7.5.4.1. Target Patient Population
7.5.4.2. Sales Forecast
 
7.5.5. Epidaza® (Shenzhen Chipscreen Biosciences)
7.5.5.1. Target Patient Population
7.5.5.2. Sales Forecast
 
7.5.6. Entinostat (Syndax Pharmaceuticals)
7.5.6.1. Target Patient Population
7.5.6.2. Sales Forecast
 
7.5.7. Abexinostat (Pharmacyclics)
7.5.7.1. Target Patient Population
7.5.7.2. Sales Forecast
 
7.5.8. CUDC-907 (Curis)
7.5.8.1. Target Patient Population
7.5.8.2. Sales Forecast
 
7.5.9. FRM-0334 (FORUM Pharmaceuticals)
7.5.9.1. Target Patient Population
7.5.9.2. Sales Forecast
 
7.5.10. Mocetinostat (Mirati Therapeutics)
7.5.10.1. Target Patient Population
7.5.10.2. Sales Forecast
 
7.5.11. Pracinostat (MEI Pharma)
7.5.11.1. Target Patient Population
7.5.11.2. Sales Forecast
 
7.5.12. Resminostat (4SC, Menarini, Yakult Honsha)
7.5.12.1. Target Patient Population
7.5.12.2. Sales Forecast
 
7.5.13. SFX-01 (Evgen Pharma)
7.5.13.1. Target Patient Population
7.5.13.2. Sales Forecast
 
7.5.14. SHP-141 (TetraLogic Pharmaceuticals)
7.5.14.1. Target Patient Population
7.5.14.2. Sales Forecast
 
7.5.15. Tefinostat (Chroma Therapeutics)
7.5.15.1. Target Patient Population
7.5.15.2. Sales Forecast
 
8. PUBLICATION ANALYSIS
8.1. Chapter Overview
8.2. HDAC Inhibitors: Publications
8.3. Publication Analysis: Quarterly Distribution
8.4. Publication Analysis: Distribution by HDAC Inhibitor Class
8.5. Publication Analysis: Distribution by Drugs Studied
8.6. Publication Analysis: Distribution by Therapeutic Area
8.7. Publication Analysis: Distribution by Journals
8.8. Publication Analysis: Distribution by Phase of Development
8.9. Publication Analysis: Distribution by Type of Therapy
 
9. SOCIAL MEDIA: EMERGING TRENDS
9.1. Chapter Overview
9.1.1. Trends on Twitter
9.1.2. Trends on Facebook
 
10. CONCLUSION
10.1. The Pipeline is Healthy with Several Molecules in Preclinical Stages of Development
10.2. HDAC Inhibitors Cater to a Wide Spectrum of Disease Areas
10.3. Class Specific HDAC Inhibitors Have Been Explored for a More Targeted Approach
10.4. The Interest is Gradually Rising Amongst Both Industry and Non-Industry Players
10.5. Supported by a Robust Preclinical Pipeline, HDAC Inhibitors are Expected to Emerge as A Multi-Billion Dollar Market
 
11. INTERVIEW TRANSCRIPTS
11.1. Chapter Overview
11.2. Dr. Simon Kerry, CEO, Karus Therapeutics
11.3. Dr. James Christensen, CSO and Senior VP, Mirati Therapeutics
11.4. Dr. Hyung J. Chun, MD, FAHA, Associate Professor of Medicine, Yale School of Medicine
 
12. APPENDIX 1: TABULATED DATA
 
13. APPENDIX 2: LIST OF COMPANIES AND ORGANIZATIONS

List of Figures

Figure 3.1 Central Dogma of Molecular Biology
Figure 3.2 Stages of the Cell Cycle
Figure 3.3 DNA Packaging: Key Steps
Figure 3.4 Key Epigenetic Mechanisms
Figure 3.5 Effects of HATs and HDACs on Chromatin Structure
Figure 3.6 Classification of HDACs
Figure 3.7 Role of HDACs in Regulation of Cellular Processes
Figure 3.8 Role of HDAC and HDAC Inhibitors in DNA Damage Repair
Figure 3.9 Role of HDAC and HDAC Inhibitors in Apoptosis
Figure 3.10 Role of HDAC and HDAC Inhibitors in Metabolism and Senescence
Figure 3.11 HDAC Inhibitors: Pharmacophore Model
Figure 3.12 Classification of HDAC Inhibitors
Figure 3.13 HDAC Inhibitors: Target Disease Areas
Figure 3.14 Role of HDACs in Cancer
Figure 3.15 Role of HDAC Inhibitors in Cardiovascular Disorders
Figure 4.1 HDAC Inhibitors: Distribution by Phase of Development
Figure 4.2 HDAC Inhibitors: Distribution by Therapeutic Area
Figure 4.3 HDAC Inhibitors: Distribution by HDAC Class Specificity
Figure 4.4 HDAC Inhibitors: Distribution by Type of Developer
Figure 4.5 HDAC Inhibitors: Distribution by Geography
Figure 4.6 HDAC Inhibitors: Regional Landscape
Figure 4.7 HDAC Inhibitors: Active Industry Players
Figure 5.1 Celgene Corporation: Annual Revenues, 2011-2015 (USD Billion)
Figure 5.2 Istodax®: Mechanism of Action
Figure 5.3 Istodax®: Annual Revenues, 2011-2015 (USD Million)
Figure 5.4 Beleodaq®: Quarterly Revenues, 2014-2015 (USD Million)
Figure 5.5 Novartis: Annual Revenues, 2011-2015 (USD Billion)
Figure 5.6 Novartis Annual Revenues, 2015: Distribution by Business Segments (USD Billion)
Figure 5.7 Syndax Pharmaceuticals: Funding, 2007-2015 (USD Million)
Figure 6.1 HDAC Inhibitors Analysis: Distribution by Target HDAC Class and Therapeutic Areas
Figure 6.2 HDAC Inhibitors Grid Analysis: Distribution by Target HDAC Class, Therapeutic Area and Phase of Development
Figure 6.3 HDAC Inhibitors Landscape Analysis: Distribution by Developer and Phase of Development
Figure 7.1 Overall HDAC Inhibitors Market (USD Million): 2016-2026 (Base Scenario)
Figure 7.2 HDAC Inhibitors: Market Distribution on Basis of Therapeutic Area, 2026 (USD Million)
Figure 7.3 HDAC Inhibitors: Market Distribution on Basis of Class Specificity, 2016, 2026 (USD Million)
Figure 7.4 HDAC Inhibitors: Distribution of Market Share, 2016, 2026 (USD Million)
Figure 7.5 Istodax® Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.6 Beleodaq® Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.7 Farydak® Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.8 Epidaza® Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.9 Entinostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.10 Abexinostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.11 CUDC-907 Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.12 FRM-0334 Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.13 Mocetinostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.14 Pracinostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.15 Resminostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.16 SFX-01 Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.17 SHP-141 Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 7.18 Tefinostat Sales Forecast (USD Million): 2016-2026 (Base Scenario)
Figure 8.1 Publication Analysis: Quarterly Distribution (2014-2015)
Figure 8.2 Publication Analysis: Distribution by HDAC Inhibitor Class
Figure 8.3 Publication Analysis: Distribution by Drugs Studied
Figure 8.4 Publication Analysis: Distribution by Therapeutic Area
Figure 8.5 Publication Analysis: Distribution by Journals
Figure 8.6 Publication Analysis: Distribution by Phase of Development
Figure 8.7 Publication Analysis: Distribution by Therapies Studied
Figure 9.1 HDAC Inhibitors Social Media Analysis: Twitter Trend, 2009-2015
Figure 9.2 HDAC Inhibitors Social Media Analysis: Twitter, Most Popular Words, 2009-2015
Figure 9.3 HDAC Inhibitors Social Media Analysis: Facebook Trend, 2009-2015
Figure 10.1 HDAC Inhibitors Market Summary (USD Million): 2016, 2021, 2026

List of Tables

Table 3.1 Histone Modification: Classification
Table 3.2 Transcription: Effect of Histone Modifications
Table 3.3 DNA Repair: Effect of Histone Modifications
Table 3.4 Euchromatin and Heterochromatin: Characteristic Features
Table 3.5 Zn2+ Dependent HDACs: Properties
Table 3.6 NAD+ Dependent HDACs: Properties
Table 3.7 Non-Histone Substrates of HDACs
Table 3.8 HDACs: Miscellaneous Functions
Table 3.9 HDAC Inhibitors: Natural and Synthetic
Table 3.10 Neurodegenerative Disorders: Epigenetic Changes
Table 4.1 HDAC Inhibitors: Development Pipeline
Table 5.1 HDAC Inhibitors: Marketed and Phase III Molecules
Table 5.2 Istodax®: Current Status of Development
Table 5.3 Istodax®: Clinical Trials
Table 5.4 Beleodaq®: Current Status of Development
Table 5.5 Beleodaq®: Clinical Trials
Table 5.6 Farydak®: Current Status of Development
Table 5.7 Farydak®: Clinical Trials
Table 5.8 Farydak®: Response Rate (Multiple Myeloma)
Table 5.9 Epidaza®: Current Status of Development
Table 5.10 Epidaza®: Clinical Trials
Table 5.11 Entinostat: Current Status of Development
Table 5.12 Entinostat: Clinical Trials
Table 5.13 Entinostat: List of Abstracts (2011-2016)
Table 5.14 HDAC Inhibitors: Phase II Molecules
Table 5.15 Abexinostat: Current Status of Development
Table 5.16 Abexinostat: Clinical Trials
Table 5.17 CUDC-907: Current Status of Development
Table 5.18 CUDC-907: Clinical Trials
Table 5.19 FRM-0334: Current Status of Development
Table 5.20 FRM-0334: Clinical Trials
Table 5.21 Givinostat: Current Status of Development
Table 5.22 Givinostat: Clinical Trials
Table 5.23 Mocetinostat: Current Status of Development
Table 5.24 Mocetinostat: Clinical Trials
Table 5.25 Pracinostat: Current Status of Development
Table 5.26 Pracinostat: Clinical Trials
Table 5.27 Resminostat: Current Status of Development
Table 5.28 Resminostat: Clinical Trials
Table 5.29 SFX-01: Current Status of Development
Table 5.30 SFX-01: Clinical Trials
Table 5.31 SFX-01: Preclinical Collaborations
Table 5.32 SHP-141: Current Status of Development
Table 5.33 SHP-141: Clinical Trials
Table 5.34 Tefinostat: Current Status of Development
Table 5.35 Tefinostat: Clinical Trials
Table 6.1 HDAC Inhibitors Endpoint Analysis: Primary Endpoints (Oncological Disorders)
Table 6.2 HDAC Inhibitors Endpoint Analysis: Secondary Endpoints (Oncological Disorders)
Table 6.3 HDAC Inhibitors Endpoint Analysis: Other Endpoints (Oncological Disorders)
Table 6.4 HDAC Inhibitors Endpoint Analysis: Non-Oncological Disorders
Table 7.1 HDAC Inhibitors: Potential Candidates
Table 7.2 Istodax®: Target Patient Population
Table 7.3 Beleodaq®: Target Patient Population
Table 7.4 Farydak®: Target Patient Population
Table 7.5 Epidaza®: Target Patient Population
Table 7.6 Entinostat: Target Patient Population
Table 7.7 Abexinostat: Target Patient Population
Table 7.8 CUDC-907: Target Patient Population
Table 7.9 FRM-0334: Target Patient Population
Table 7.10 Mocetinostat: Target Patient Population
Table 7.11 Pracinostat: Target Patient Population
Table 7.12 Resminostat: Target Patient Population
Table 7.13 SFX-01: Target Patient Population
Table 7.14 SHP-141: Target Patient Population
Table 7.15 Tefinostat: Target Patient Population
Table 8.1 HDAC Inhibitors: Publications (2014, 2015)
Table 12.1 HDAC Inhibitors: Distribution by Phase of Development
Table 12.2 HDAC Inhibitors: Distribution by Therapeutic Area
Table 12.3 HDAC Inhibitors: Distribution by Class Specificity
Table 12.4 HDAC Inhibitors: Distribution by Type of Developer
Table 12.5 HDAC Inhibitors: Distribution by Geography
Table 12.6 HDAC Inhibitors: Active Industry Players
Table 12.7 Celgene Corporation: Annual Revenues, 2011-2015 (USD Million)
Table 12.8 Istodax®: Annual Revenues, 2011-2015 (USD Million)
Table 12.9 Beleodaq®: Quarterly Revenues, 2014-2015 (USD Million)
Table 12.10 Novartis: Annual Revenues, 2011-2015 (USD Million)
Table 12.11 Novartis Annual Revenues, 2015: Distribution by Business Segments (USD Million)
Table 12.12 Syndax Pharmaceuticals: Funding, 2007-2015 (USD Million)
Table 12.13 Overall HDAC Inhibitors Market (USD Million): 2016-2026 (Base Scenario)
Table 12.14 HDAC Inhibitors: Market Distribution on Basis of Therapeutic Area, 2026 (USD Million)
Table 12.15 HDAC Inhibitors: Market Distribution on Basis of Class Specificity, 2026 (USD Million)
Table 12.16 HDAC Inhibitors: Distribution of Market Share, 2016 (USD Million)
Table 12.17 HDAC Inhibitors: Distribution of Market Share, 2026 (USD Million)
Table 12.18 Istodax® Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.19 Istodax® Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.20 Istodax® Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.21 Beleodaq® Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.22 Beleodaq® Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.23 Beleodaq® Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.24 Farydak® Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.25 Farydak® Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.26 Farydak® Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.27 Epidaza® Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.28 Epidaza® Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.29 Epidaza® Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.30 Entinostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.31 Entinostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.32 Entinostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.33 Pracinostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.34 Pracinostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.35 Pracinostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.36 Resminostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.37 Resminostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.38 Resminostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.39 Tefinostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.40 Tefinostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.41 Tefinostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.42 SHP-141 Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.43 SHP-141 Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.44 SHP-141 Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.45 FRM-0334 Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.46 FRM-0334 Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.47 FRM-0334 Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.48 SFX-01 Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.49 SFX-01 Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.50 SFX-01 Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.51 CUDC-907 Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.52 CUDC-907 Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.53 CUDC-907 Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.54 Mocetinostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.55 Mocetinostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.56 Mocetinostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.57 Abexinostat Sales Forecast (USD Million), 2016-2021 (Base Scenario)
Table 12.58 Abexinostat Sales Forecast (USD Million), 2016-2021 (Optimistic Scenario)
Table 12.59 Abexinostat Sales Forecast (USD Million), 2016-2021 (Conservative Scenario)
Table 12.60 Publication Analysis: Quarterly Distribution (2014-2015)
Table 12.61 Publication Analysis: Distribution by HDAC Inhibitor Class
Table 12.62 Publication Analysis: Distribution by Drugs Studied
Table 12.63 Publication Analysis: Distribution by Therapeutic Area
Table 12.64 Publication Analysis: Distribution by Journals
Table 12.65 Publication Analysis: Distribution by Phase of Development
Table 12.66 Publication Analysis: Distribution by Therapies Studied
Table 12.67 HDAC Inhibitors Market Summary (USD Million): 2016, 2021, 2026

Listed Companies

The following companies and organizations have been mentioned in the report.

  1. 4SC
  2. AACR
  3. AbbVie
  4. Acceleron Pharma
  5. Acetylon Pharmaceuticals
  6. Active Biotech
  7. Agios Pharmaceuticals
  8. ASH
  9. Arno Therapeutics
  10. Astellas Pharma
  11. Bayer Schering Pharma
  12. Baylor College of Medicine
  13. BioMarin
  14. Bionor Immuno
  15. bluebird bio
  16. Case Comprehensive Cancer Center
  17. Celera Genomics
  18. Celgene
  19. Celleron Therapeutics
  20. Centre de Recherche en Cancérologie
  21. CETYA Therapeutics
  22. CHDI Foundation
  23. Chipscreen Biosciences
  24. Chong Kun Dang Pharmaceutical
  25. Chroma Therapeutics
  26. Croix-Rousse Hospital
  27. CrystalGenomics
  28. Curis
  29. DAC
  30. Diaxonhit
  31. DNA Therapeutics
  32. Duke University
  33. ECOG-ACRIN Cancer Research Group
  34. Eddingpharm
  35. Eisai
  36. Epizyme
  37. Errant Gene Therapeutics
  38. European Calcified Tissue Society
  39. Evgen Pharma
  40. FORMA Therapeutics
  41. FORUM Pharmaceuticals
  42. Fudan University
  43. Genentech
  44. Genextra
  45. Gilead
  46. Gloucester Pharmaceuticals
  47. GNT Biotech
  48. GSK
  49. Harvard Medical School
  50. Henan Cancer Hospital
  51. HUYA Biosciences
  52. Ikerchem
  53. Imperial College London
  54. In2Gen
  55. International Bone and Mineral Society
  56. Israel Cancer Association and Bar Ilan University
  57. Italfarmaco
  58. Johnson and Johnson
  59. Kalypsys
  60. Karus Therapeutics
  61. King’s College, University of London
  62. Kyoto Prefectural University of Medicine
  63. Kyoto University
  64. Kyowa Hakko Kirin
  65. Leukemia and Lymphoma Society
  66. Lymphoma Academic Research Organization
  67. Massachusetts General Hospital
  68. Mayo Clinic
  69. MedImmune
  70. MEI Pharma
  71. Memorial Sloan-Kettering Cancer Center
  72. Menarini
  73. Merck
  74. MethylGene
  75. Mirati Therapeutics
  76. Morphosys
  77. Mundipharma-EDO
  78. National Brain Research Centre
  79. National Comprehensive Cancer Network
  80. National Taiwan University
  81. NCI
  82. Novartis
  83. NuPotential
  84. Oceanyx Pharma
  85. Oncolys Biopharma
  86. Onxeo
  87. Onyx
  88. Orchid Pharma
  89. Paterson Institute for Cancer Research
  90. Pfizer
  91. Pharmacyclics
  92. Pharmion Corporation
  93. Quimatryx
  94. Quintiles
  95. Repligen
  96. Respiratorius
  97. Roche
  98. Rodin Therapeutics
  99. Royal Veterinary College, University of London
  100. Ruijin Hospital
  101. S*Bio
  102. Sarcoma Alliance for Research through Collaboration
  103. Seattle Genetics
  104. Servier Canada
  105. Shape Pharmaceuticals
  106. Sidney Kimmel Comprehensive Cancer Center
  107. Sigma Tau Pharmaceuticals
  108. Signal Rx
  109. SpeBio
  110. Spectrum Pharmaceuticals
  111. Stanley Center for Psychiatric Research
  112. Sutro Biopharma
  113. Syndax Pharmaceuticals
  114. Synovo GmbH
  115. Taipei Medical University
  116. TetraLogic Pharmaceuticals
  117. University of Liverpool
  118. University of Messina
  119. University of Miami
  120. Vanderbilt University School of Medicine
  121. Ventana Medical Systems
  122. Vilnius University
  123. Yakult Honsha
  124. Yale University
  125. Yonsei University College of Medicine

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