Photodynamic Therapy Market

Photoimmunotherapy, Photothermal Therapy and Photodynamic Therapy Market: Distribution by Target Indications, Key Players and Geographies: Industry Trends and Global Forecasts, 2021-2030

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Photodynamic Therapy Market Overview

The photodynamic therapy market is estimated to be worth $1.4 billion in 2025 and is expected to grow at CAGR of 6.4% during the forecast period 2025 - 2030. According to the World Health Organization, in a year, around 2 million to 3 million individuals suffer from various forms of skin cancers, across the globe. This type of cancer account for 33% of all the diagnosed tumors, globally. It is also worth highlighting that one in every five Americans is likely to develop some form of skin cancer in their lifetime. Although efforts are being made to develop safe and effective drugs for the treatment of different types of skin cancer, there is still a pressing need for more specific and potent drugs / therapies to combat this complex clinical condition. Amidst the current initiatives to develop more targeted anti-cancer therapies, light activated therapies (specifically photodynamic therapies, photoimmunotherapies and photothermal therapies) have emerged as a promising alternative, owing to their capability to eradicate diseased cells from the body with minimal side effects. Unlike chemotherapy or radiotherapy, light activated therapies only destroy cancerous cells without damaging the surrounding healthy tissues. Therefore, this novel therapeutic approach has various advantages over conventional treatments for cancer and various skin diseases, such as acne, actinic keratosis, microvesicles, warts and others.

Over time, several pharmaceutical companies have undertaken various initiatives to develop effective photodynamic therapies / photoimmunotherapies against multiple target indications. At present, the pipeline features close to 130 candidates, and this value is anticipated to grow further in the foreseen future. Of these, more than 10 therapies, including ASP-1929 (Rakuten Medical), VISUDYNE® (Novartis), Metvix® (Galderma), PHOTOFRIN® (ADVANZ PHARMA), Ameluz® (Biofrontera) and LEVULAN® KERASTICK™ (Sun Pharma), have already been marketed. Further, over 635 patents related to light activated therapies have been filed / granted in the past three years, demonstrating the continued innovation in this domain. The growing interest of pharmaceutical stakeholders in this field is also reflected from the recent rise in clinical trials of such therapy candidates. With multiple therapeutic leads in the mid to late stages of development (phase II and above), we are led to believe that the photodynamic therapy market is likely to witness significant market growth during the forecast period.

Key Companies in Photoimmunotherapy, Photothermal Therapy and Photodynamic Therapy Market

Examples of key companies engaged in photoimmunotherapy, photothermal therapy and photodynamic therapy market (which have also been profiled in this market report; the complete list of companies is available in the full report) include ADVANZ PHARMA, Biofrontera, Biolitec Pharma, Luzitin, Nanospectra Biosciences, Photoatomic, Rakuten Medical, Steba biotech and Theralase. This market report includes an easily searchable excel database of all the companies providing light activated therapies, worldwide.

Recent Developments in Photodynamic Therapy Market:

Several recent developments have taken place in the field of photodynamic therapy market. We have outlined some of these recent initiatives below. These developments, even if they took place post the release of our market report, substantiate the overall market trends that have been outlined in our analysis.

  • In May 2023, Rakuten Medical announced that the company has been granted permission from the Indian Central Drugs Standard Control Organization (CDSCO) to conduct its global, pivotal Phase III clinical trial evaluating Alluminox treatment (photoimmunotherapy) using ASP-1929 in patients with locoregional, recurrent head and neck squamous cell carcinomas (HNSCC) in India. 
  • In March 2023, Spring Laboratory at Northeastern University and  Heiko Enderling lab at MD Anderson Cancer Center and Moffitt Cancer Center have received a grant of USD 2.7 million from the National Cancer Institute to develop a new treatment for ovarian cancer that will use lasers to spot and target chemo-resistant cancer cells and boost a patient’s immune system.
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Scope of the Report

The “Photodynamic Therapy Market: Focus on Photodynamic Therapies, Photoimmunotherapies and Photothermal Therapies, 2021-2030 - Distribution by Target Indications (Head and Neck Cancer, Actinic Keratosis, Macular Degeneration, Polypoidal Choroidal Vasculopathy, Cervical Intraepithelial Neoplasia, Bladder Cancer, Barrett’s Esophagus, Gastric Cancer, Lung Cancer, Port-Wine Stain and Others), Key Players and Key Geographies (North America, Europe and Asia Pacific): Industry Trends and Global Forecasts” market report features an extensive study of the current market landscape, market size, market share, market forecast, market outlook and future opportunities for the photodynamic therapy market. The market research report features a detailed analysis of the key drivers and trends related to this evolving domain. Amongst other elements, the market research report includes:

  • A detailed assessment of the current market landscape of light activated therapies, with respect to current status of development (preclinical / discovery, phase I, phase I / II, phase II, phase II / III, phase III and approved), type of light activated therapy (photodynamic therapy, photoimmunotherapy and photothermal therapy), therapeutic area (oncological disorders (solid tumor), dental disorders, skin disorders,  oncological disorders (hematological cancer) and others), type of photosensitive dye (methylene blue, phthalocyanine dye, indocyanine green, toluidine blue and phenothiazine hydrochloride), type of light (red light, blue light, infrared light, near-infrared light, visible light, ultraviolet light and daylight), target patient segment (children, adults and elderly patients), type of therapy (monotherapy and combination therapy), type of developer (industry / non-industry) and popular target indications (periodontitis, actinic keratosis, basal cell carcinoma, head and neck cancer, lung cancer, cholangiocarcinoma, dental caries, squamous cell carcinoma, acne, bladder cancer, COVID-19, pancreatic cancer, prostate cancer and others). In addition, the chapter includes analysis on the light activated therapy developer(s) based on various relevant parameters, including year of establishment, company size, location of headquarters and most active players (in terms of number of pipeline candidates).
  • Detailed profiles of marketed and late stage (phase III) clinical products; each profile features an overview of the company, therapy overview, clinical development status, clinical trial endpoints, dosage information, key insights, clinical trial endpoints and estimated sales revenue (2021-2030). 
  • An in-depth analysis of completed, ongoing and planned clinical studies of various light activated therapies based on relevant parameters, such as trial registration year, study design and trial phase, type of masking and type of intervention model, year and trial recruitment status, type of sponsor, most active industry and non-industry players (in terms of number of registered trials conducted), purpose of study, emerging focus area, location of trial, and key geographical regions.
  • An analysis of patents filed / granted related to light activated therapies, till 2021. The instances have been analyzed based on various relevant parameters, such as publication year, type of patent, patent age, geographical location, CPC symbols, emerging focus areas, leading patent assignees, leading industry and non-industry players (in terms of number of patents filed / granted), patent benchmarking and valuation.  
  • Elaborate profiles of companies (shortlisted based on phase of development of the lead drug) including brief overview of the company, its financial information (if available), product portfolio, recent developments and an informed future outlook.

The key objective of photodynamic therapy market report is to provide a detailed market analysis in order to estimate the existing market size, market value, statistics and future opportunity for photodynamic therapy market during the forecast period. Additionally, it features market size projections for the overall photodynamic therapy market, wherein both the current and upcoming opportunity is segmented across [A] target indications (head and neck cancer, actinic keratosis, macular degeneration, polypoidal choroidal vasculopathy, cervical intraepithelial neoplasia, bladder cancer, Barrett’s esophagus, gastric cancer, lung cancer, port-wine stain and others), [B] key players and [C] key geographies (North America, Europe, Asia Pacific). In order to account for future uncertainties and to add robustness to our model, we have provided three market forecast scenarios, namely the conservative, base and optimistic scenarios, which represent different tracks of the industry’s evolution.

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Frequently Asked Questions

Question 1: What is photodynamic therapy?

Answer: Photodynamic therapy involves a drug called photosensitizer which is activated by direct exposure to artificial light at optimized wavelengths to treat a myriad of medical disorders, including cancers, and skin wound infections.

Question 2: What is the photodynamic therapy market size?

Answer: The photodynamic therapy market size is estimated to be worth $1.4 billion in 2025.

Question 3: What is the projected market growth of photodynamic therapy market?

Answer: The photodynamic therapy market is expected to grow at compounded annual growth rate (CAGR) of over 6.4% during the forecast period 2025 - 2030.

Question 4: Who are the leading companies in the photoimmunotherapy, photothermal therapy and photodynamic therapy market?

Answer: Examples of key companies engaged in photoimmunotherapy, photothermal therapy and photodynamic therapy market (which have also been profiled in this market report; the complete list of companies is available in the full report) include ADVANZ PHARMA, Biofrontera, biolitec Pharma, Luzitin, Nanospectra Biosciences, photoatomic, Rakuten Medical, Steba biotech and Theralase.

Question 5: How many light activated therapies are currently being marketed / evaluated by companies engaged in photoimmunotherapy, photothermal therapy and photodynamic market?

Answer: Over 125 therapies are currently being marketed / evaluated by companies engaged in photoimmunotherapy, photothermal therapy and photodynamic therapy market.

Question 6: How many patents related to photoimmunotherapy, photothermal therapy and photodynamic therapy have been filed / granted over the last few years?

Answer: More than 365 patents related to photoimmunotherapy, photothermal therapy and photodynamic therapy have been filed / granted over the last few years.

Question 7: Which region is the hub for companies engaged in the photoimmunotherapy, photothermal therapy and photodynamic therapy market?

Answer: North America emerged as the hub for companies engaged in the photoimmunotherapy, photothermal therapy and photodynamic therapy market, with over 30% of the players established in the region.

Question 8: Is PDT FDA approved?

Answer: Two photodynamic therapy are approved by FDA for treatment of cancer and associated conditions, including Photofrin and Levulan.

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